Abstract: An object of the present invention is to provide clinically applicable aAVC-NY-ESO-1 cells stably expressing NY-ESO-1 in order to use aAVC-NY-ESO-1 cells in treating patients having a NY-ESO-1-expressing cancer. The present invention provides, for example, a human-derived cell comprising a polynucleotide encoding CD1d and a polynucleotide encoding NY-ESO-1 or a fragment thereof, wherein the polynucleotide encoding NY-ESO-1 or a fragment thereof is operably linked to an inducible promoter.

Abstract: To provide a manganese-iridium composite oxide, a manganese-iridium composite oxide and a manganese-iridium composite oxide electrode material, having high catalytic activity produced at low cost, to be used as an anode catalyst for oxygen evolution in water electrolysis, and their production methods. A manganese-iridium composite oxide, which has an iridium metal content ratio (iridium/(manganese+indium)) of 0.1 atomic % or more and 30 atomic % or less, and has interplanar spacings of at least 0.243±0.002 nm, 0.214±0.002 nm, 0.165±0.002 nm, 0.140±0.002 nm, and a manganese-iridium composite oxide electrode material comprising an electrically conductive substrate constituted by fibers at least part of which are covered with the above manganese-iridium composite oxide.

Abstract: A data interpretation apparatus including a platform configured to automatically execute type conversion of an object. The platform is provided in a control unit of the data interpretation apparatus, and includes an obtaining unit and an interpretation unit. The obtaining unit obtains input data as the object of the platform. The interpretation unit generates an initial graph with respect to the object, and performs interpretation by automatically growing a graph from the initial graph while executing, as necessary, the type conversion of the object associated with each node of the graph toward extension or toward intension.

Abstract: According to a medical system of an aspect example, an ophthalmic data acquiring unit includes at least one ophthalmic examination apparatus for acquiring ophthalmic data from a patient, and an internal medicine data acquiring unit includes at least one internal medicine examination apparatus for acquiring internal medicine data from the patient. An inference processor is configured to perform inference processing using a trained model constructed by machine learning using training data that includes ophthalmic data, internal medicine data, and diagnostic result data. The inference processor generates inferred diagnostic data by performing the inference processing based at least on the ophthalmic data of the patient acquired by the ophthalmic data acquiring unit and the internal medicine data of the patient acquired by the internal medicine data acquiring unit. An output unit outputs a result of the inference processing performed by the inference processor.

Abstract: The present invention relates to a clearing technique which uses a solution containing at least one of a compound having a delipidation ability, a compound having a biochrome decoloring ability, a compound having a decalcification ability, a compound having a refractive index adjusting ability, and a compound having a tissue swelling ability. The clearing technique is suitable for use in high-throughput and low-magnification imaging which involves a simple process.

Abstract: In one aspect, the present invention is an organic-inorganic hybrid membrane of a cerium oxide and an organic fluorine compound, the organic-inorganic hybrid membrane satisfying the following (a), (b), and (c): (a) the visible-light transmittance is 70% or higher; (b) the UV transmittance at a wavelength of 380 nm is 60% or lower; and (c) the water contact angle of the surface of the organic-inorganic hybrid membrane is 80° or higher. In another aspect, the present invention is an organic-inorganic hybrid membrane of a cerium oxide and an organic fluorine compound, the organic-inorganic hybrid membrane satisfying the following (a), (b), and (c?): (a) the visible-light transmittance is 70% or higher; (b) the UV transmittance at a wavelength of 380 nm is 60% or lower; and (c?) the water contact angle of the surface of the organic-inorganic hybrid membrane is 90° or higher. The organic fluorine compound may include a fluorine-based resin.

Abstract: A concentration detector includes: a neutron source emitting neutrons to a target; a gamma ray detector detecting and determining an amount of specific gamma rays that are among gamma rays generated in the target by interactions with the neutrons; and a concentration calculator calculating a concentration of the target at selected depths in the inspection target, based on the detected amount. A relational expression expressing a relation between a plurality of concentrations of the target in a plurality of virtual layers and a detected amount of the specific gamma rays is predetermined for each type of the specific gamma rays or each detection condition. The concentration calculator applies the detected amount for each gamma ray type or each detection condition, to the relational expression for the type or the detection condition, and calculates a concentration of the target component in the layer at each depth or the specific depth.

Abstract: The present disclosure provides a method for screening cells, the method including a step of preparing a plurality of cells which are tagged with a first barcode nucleic acid associated with a test target and treated with the test target, a step of sorting the plurality of cells based on cellular phenotype using an imaging cell sorter, and a step of identifying the test target used to treat each cell using the first barcode nucleic acid as an indicator.

Abstract: A compound represented by the general formula (I) given below or a pharmacologically acceptable salt thereof has been found to have a strong G9a inhibitory effect. The compound (I) or the pharmacologically acceptable salt thereof inhibits G9a and thereby has high usefulness for the treatment, prevention or suppression of various pathological conditions (proliferative disease such as cancer, ?-globin abnormality, fibrosis, pain, neurodegenerative disease, Prader-Willi syndrome, malaria, viral infection, myopathy, autism, etc.).

Abstract: In each trial, brain electrical activity at multiple points of a target person is measured. An acquirer of a determination device acquires response matrices for n trials under a first condition and response matrices form trials under a second condition. An analyzer performs canonical correlation analysis on the acquired response matrices to obtain first canonical variable time series. A distance calculator calculates a distance between the trials from the obtained first canonical variable time series to obtain a distance matrix. A determiner obtains a possibility that the n trials and the m trials are classified into two different clusters from the distance matrix and determines whether the first condition and the second condition are substantially different. It is possible to provide to a single target person a first content in n trials and a second content in m trials so as to determine a difference in interest of the single target person.

Abstract: A first node and a second node transmit packets to a third node via a switch. The packets are buffered in a Tx buffer in the switch and then transmitted to the third node. When the third node detects a sign of congestion at the Tx buffer based on the reception frequency of the packets, it is recognized, from transmitter addresses included in the received packets, that the nodes transmitting the packets to the third node are the first node and the second node, and a control packet for a transmission stop request is transmitted to the first node and the second node. On receiving the control packet for a transmission stop request, the first node stops transmission of only packets addressed to the third node. On receiving the control packet for a transmission stop request, the second node stops transmission of only packets addressed to the third node.

Abstract: The object of the invention is to provide a novel olefin-based molded product useful for various applications. An olefin-based molded product comprising a polymer including a structural unit of at least one polar olefin monomer represented by the general formula (I) CH2=CH—R2—Z(R1)n is provided. In the formula, Z is a hetero atom selected from the group consisting of nitrogen, oxygen, phosphorus, sulfur, and selenium; R1 is a substituted or unsubstituted hydrocarbyl group having 1 to 30 carbon atoms; n is an integer of 1 or 2 depending on the atomic species of Z; and R2 is a substituted or unsubstituted hydrocarbylene group having 2 to 20 carbon atoms.

Abstract: [Problem to be Solved] Provided is an effective and safe method for treating or preventing a cancer using aAVC. [Solution] The present invention finds suitable ranges of the dose of ?-GalCer loaded on aAVC cell surface, and the amount of ?-GalCer loaded on aAVC cell surface in a pharmaceutical composition comprising aAVC, which are preferred in terms of securing effectiveness and safety in the treatment and prevention of a cancer using aAVC, and provides an effective and safe method for treating or preventing a cancer using aAVC, aAVC for effective and safe treatment or prevention of a cancer, and a pharmaceutical composition comprising the same, etc.

Abstract: Pluripotent stem cells are suspension-cultured with the undifferentiated state thereof maintained. In suspension culture of pluripotent stem cells, the undifferentiated state is maintained by the presence of a PKC inhibitor, especially, a PKC? inhibitor, and a tankyrase inhibitor (TNKS inhibitor).

Abstract: A non-destructive inspection system includes: a neutron emission unit 12 capable of emitting neutrons pulsed; a neutron detector capable of detecting the neutrons emitted from the neutron emission unit and penetrating through an inspection object; a storage unit storing attenuation information indicating a relationship between a material of the inspection object and attenuation of the neutrons; and a calculation unit capable of calculating distance information indicating a position of a specific portion in the inspection object in accordance with time change information which is information on a change over time in an amount of the neutrons detected by the neutron detector. The calculation unit is capable of generating information related to an amount of the specific portion from information based on the amount of the neutrons according to the time change information, using the distance information and the attenuation information.

Abstract: It was found that it is possible to construct a genome-edited plant in which no exogenous gene is incorporated in a genome by performing negative selection using morphological defects and the like as indices in a regenerated plant originated from a plant cell in which a gene that induces regeneration of the plant and a gene of the genome editing enzyme are introduced.

Abstract: The non-destructive inspection method includes: a water absorbing or drying step of changing a water-content state of a test piece; a transmission image capturing step of irradiating, with a radiation, the test piece absorbed water or dried for a predetermined time in the water absorbing or drying step and capturing a transmission image created by visualizing the radiation transmitted through the test piece; and an evaluation step of evaluating the test piece on the basis of the water-content state of the test piece determined from the transmission image captured in the transmission image capturing step.

Abstract: Nuclear spins of particular atoms (14N) which distinctively exist in a crystal of an active pharmaceutical ingredient is manipulated, so that an initial magnetization (modulated magnetization) is caused in nearby hydrogen atoms which exist near the particular atoms in the crystal. The initial magnetization of the nearby hydrogen atoms is spread to peripheral hydrogen atoms which exist at a periphery of the nearby hydrogen atoms in the crystal. A magnetization which is spread in the crystal is directly or indirectly observed.

Abstract: An object of the present invention is to provide a novel method of producing a nonpolar olefin polymer (e.g., a copolymer of a nonpolar olefin and a polar olefin). The present invention provides a method of producing a polar olefin polymer or copolymer, the method including the polymerization step of polymerizing a polar olefin monomer using, as a catalyst, a polymerization catalyst composition containing: 1) a metallocene complex represented by Formula (I), which contains a central metal M that is scandium (Sc) or yttrium (Y), a ligand Cp* containing a cyclopentadienyl derivative and being bound to the central metal, monoanionic ligands Q1 and Q2, and W neutral Lewis bases L wherein W is an integer of 0 to 3; and 2) an ionic compound composed of a non-coordinating anion and a cation.

Abstract: A vehicle knuckle 1 includes a main body 10, a strut junction 11 that is positioned at a first side in an extending direction of an axle supported by the main body and fastens a strut damper, and an arm 12 that couples the main body to the strut junction. The vehicle knuckle has a continuous space 17 formed inside the strut junction and the arm. The arm has a first through-hole 17a on a wall 12a that couples an end 10d at the first side of the main body to the strut junction. The first through-hole is formed, with being adjacent to the end at the first side, at the side of the main body with respect to the center of a coupling position of the wall and the main body and a coupling position of the wall and the strut junction and is communicated with the space.