Patents Assigned to Riken
  • Patent number: 11747288
    Abstract: A non-destructive inspection system 1 includes a neutron radiation source 3 capable of emitting neutrons N, and a neutron detector 14 capable of detecting neutrons Nb produced via an inspection object 6a among neutrons N emitted from the neutron radiation source 3. The neutron radiation source 3 includes a linear accelerator 11 capable of emitting charged particles P accelerated; a first magnet section 12 including magnets 12a and 12b facing each other, the magnets 12a and 12b being capable of deflecting the charged particles P in a direction substantially perpendicular to a direction of emission of the charged particles P from the linear accelerator 11; and a target section 13 capable of producing neutrons N by being irradiated with the charged particles P that have passed through the first magnet section 12.
    Type: Grant
    Filed: September 25, 2019
    Date of Patent: September 5, 2023
    Assignees: Topcon Corporation, RIKEN
    Inventors: Shigenori Nagano, Hisashi Tsukada, Yoshie Otake, Koji Ikado, Yuichi Yoshimura, Hideyuki Sunaga
  • Publication number: 20230267610
    Abstract: An ophthalmic information processing apparatus includes an acquisition unit and a disease estimation unit. The acquisition unit is configured to acquire a plurality of images with different cross-sectional orientations from each other of a subject’s eye. The disease estimation unit is configured to output estimation information for estimating whether or not the subject’s eye is a glaucoma eye from the images, using a plurality of learned models obtained by performing machine learning for each type of the images.
    Type: Application
    Filed: May 2, 2023
    Publication date: August 24, 2023
    Applicants: Topcon Corporation, TOHOKU UNIVERSITY, RIKEN
    Inventors: Toru NAKAZAWA, Kazuko OMODAKA, Hideo YOKOTA, Guangzhou AN, Takuma UDAGAWA
  • Publication number: 20230263839
    Abstract: A composition for suppressing trypsin activity is disclosed. The composition contains a bacterium belonging to a genus Paraprevotella as an active ingredient.
    Type: Application
    Filed: March 15, 2023
    Publication date: August 24, 2023
    Applicant: RIKEN
    Inventors: Kenya HONDA, Seiko NARUSHIMA, Eiichiro WATANABE, Osamu OHARA, Yusuke KAWASHIMA, Youxian LI
  • Publication number: 20230263391
    Abstract: An ophthalmic information processing apparatus includes a determiner and a detector. The determiner is configured to determine a presence or absence of a disc hemorrhage for a front image of a fundus of a subject's eye, using a disc hemorrhage determination model obtained by performing machine learning using a plurality of fundus images labeled with labels indicating the presence or absence of a disc hemorrhage as first teaching data. The detector is configured to detect a disc hemorrhage region depicted in the front image that is determined to have the disc hemorrhage, using a disc hemorrhage region detection model obtained by performing machine learning using a plurality of pairs of image groups as second teaching data, each pair having a front image of a fundus and a disc hemorrhage region image representing a disc hemorrhage region depicted in the front image.
    Type: Application
    Filed: May 2, 2023
    Publication date: August 24, 2023
    Applicants: Topcon Corporation, TOHOKU UNIVERSITY, RIKEN
    Inventors: Toru NAKAZAWA, Kazuko OMODAKA, Hideo YOKOTA, Guangzhou AN, Tsutomu KIKAWA
  • Publication number: 20230258358
    Abstract: A temperature load management device is for use in exposing a user to a second environment for removing a first temperature load accumulated in a first environment. The temperature load management device includes the control unit as a main component. The control unit controls the second environment or makes a notification of a time to end the exposing of the user to the second environment, based on physiological information on the user.
    Type: Application
    Filed: April 21, 2023
    Publication date: August 17, 2023
    Applicants: DAIKIN INDUSTRIES, LTD., RIKEN
    Inventors: Shiori EMOTO, Shouta HORI, Youko SAKATA, Miho IWASAKI, Yusuke MORITO, Yasuyoshi WATANABE, Kei MIZUNO
  • Publication number: 20230256130
    Abstract: The present invention provides an infection prevention device and an infection prevention method including a light source 11 for radiating light in specific wavelength range, and a beam-firming optical element 12 for forming the light radiated from the light source 11 on a radiant film 20 having a predetermined width, wherein pathogenic microorganism which levitates together with airborne droplets or particles or which levitates alone is inactivated or killed by the radiant film 20 formed in air, or moisture of the airborne droplets or the particles is evaporated. According to this, pathogenic microorganism which levitates in air can be inactivated or killed in air.
    Type: Application
    Filed: June 22, 2021
    Publication date: August 17, 2023
    Applicant: RIKEN
    Inventors: Satoshi WADA, Atsushi SHINJO, Takayo OGAWA
  • Publication number: 20230257413
    Abstract: Disclosed is a compound represented by formula (1) or a salt thereof wherein: “Base” represents an aromatic heterocyclic group which may have a substituent, or an aromatic hydrocarbon ring group which may have a substituent; A1 represents a single bond or an alkylene group; R1 to R5 represent an atom or a group disclosed in the specification.
    Type: Application
    Filed: March 24, 2023
    Publication date: August 17, 2023
    Applicant: RIKEN GENESIS CO., LTD.
    Inventors: Haruhisa YOSHIKAWA, Ikuya BAN, Takeshi IMANISHI
  • Patent number: 11724005
    Abstract: The invention provides a method for producing a ciliary marginal zone stem cell induced to differentiate from a pluripotent stem cell, including either the following step (1) or step (2), or both of these steps: (1) a step of floating culturing cells obtained from a cell aggregate containing a ciliary marginal zone-like structure induced to differentiate from pluripotent stem cells, thereby obtaining a retinosphere; and (2) a step of collecting stage specific embryonic antigen-1 positive cells from cells obtained from a cell aggregate containing a ciliary marginal zone-like structure induced to differentiate from pluripotent stem cells.
    Type: Grant
    Filed: October 16, 2014
    Date of Patent: August 15, 2023
    Assignees: SUMITOMO CHEMICAL COMPANY, LIMITED, RIKEN
    Inventors: Atsushi Kuwahara, Yoshiki Sasai
  • Publication number: 20230233156
    Abstract: There is a need for a technique to determine a presence or absence of morbidity of a lifestyle-related disease and a possibility of future morbidity (risk of morbidity) in a non-invasive manner for a subject. The present disclosure provides a blood abnormality prediction device including, a prediction unit configured to predict a presence or absence of a blood abnormality in a subject on the basis of the information of the image that captures a crown portion of a capillary, wherein the prediction unit is configured to measure one or more selected from the group consisting of an entire width, an apex width, a loop diameter, a venous limb width, and an arterial limb width of the crown portion of the capillary on the basis of the information of the image, to predict the presence or absence of the blood abnormality in the subject from a result of the measurement.
    Type: Application
    Filed: December 6, 2021
    Publication date: July 27, 2023
    Applicants: RIKEN, AT CO., LTD.
    Inventors: Kei MIZUNO, Yasuyoshi WATANABE, Dan TAKENO, Takao MACHITANI
  • Publication number: 20230236129
    Abstract: The Raman scattering spectroscopic method according to the present invention include: preparing a chip having a channel in which a nanostructure is formed; introducing an analyte solution into a part of the channel in the chip; irradiating an interface of the analyte solution with a laser beam; and measuring Raman scattering light induced by the irradiation of the laser beam. The measurement may be performed, with a fixed laser beam irradiation position, both in a state where the interface of the analyte solution is included in the laser-beam-irradiation area and in a state where the interface of the analyte solution is not included in the laser-beam-irradiation area, or may be performed keeping the state where the interface of the analyte solution is maintained in the laser-beam-irradiation area by controlling the laser-beam-irradiation area according to the movement of the interface due to evaporation of the analyte solution.
    Type: Application
    Filed: June 7, 2021
    Publication date: July 27, 2023
    Applicant: RIKEN
    Inventors: Koji SUGIOKA, Shi BAI
  • Publication number: 20230218742
    Abstract: The present invention provides a vaccine against a coronavirus. According to the present invention, there is provided a peptide consisting of the amino acid sequence set forth in SEQ ID NO: 1 or a partial peptide of a coronavirus spike protein consisting of the amino acid sequence corresponding to the amino acid sequence of SEQ ID NO: 1 and a multiple antigen peptide containing a plurality of any of these peptides.
    Type: Application
    Filed: May 21, 2021
    Publication date: July 13, 2023
    Applicants: RIKEN, ANIMAL ALLERGY CLINICAL LABORATORIES INC.
    Inventors: Kenichi MASUDA, Takashi SAITO
  • Publication number: 20230213462
    Abstract: A cable inspection device non-destructively inspects a cable used for supporting a bridge. The cable inspection device includes a neutron source and a neutron detection device. The neutron source emits neutrons to the cable. The neutron detection device includes a detection surface arranged outside the cable, and detects target neutrons and measures the number of the detected target neutrons when neutrons are emitted to the cable. The target neutrons are among the neutrons released from the cable and incident on the detection surface, and each have an energy equal to or lower than a predetermined value that is lower than an energy of a fast neutron.
    Type: Application
    Filed: June 18, 2021
    Publication date: July 6, 2023
    Applicant: RIKEN
    Inventors: Yoshie OTAKE, Yoshimasa IKEDA, Yuichi YOSHIMURA, Takao HASHIGUCHI, Maki MIZUTA, Hirokazu KITAGAWA, Kenta KATO
  • Patent number: 11692015
    Abstract: The present invention relates to a modified fibroin including a domain sequence represented by Formula 1: [(A)nmotif-REP]m or Formula 2: [(A)nmotif-REP]m?(A)n motif, in which the domain sequence has an amino acid sequence with a reduced content of a glutamine residue equivalent to an amino acid in which one or a plurality of glutamine residues in REP are deleted or substituted with other amino acid residues, as compared with a naturally occurring fibroin.
    Type: Grant
    Filed: July 25, 2018
    Date of Patent: July 4, 2023
    Assignees: Spiber Inc., Riken
    Inventors: Keisuke Morita, Yunosuke Abe, Takehisa Maekawa, Koichi Kotaka, Junichi Sugahara, Keiji Numata
  • Publication number: 20230203600
    Abstract: The present invention provides a method for treating a cell population and a method for analyzing a cell population (e.g., microbiota). The present invention can comprise obtaining a droplet population from a cell dispersion comprising an isolated cell population, the droplet population comprising aqueous droplets, at least some of which each comprise one cell and one-molecule cellular barcode.
    Type: Application
    Filed: May 28, 2021
    Publication date: June 29, 2023
    Applicant: RIKEN
    Inventors: Katsuyuki SHIROGUCHI, Jianshi JIN, Reiko YAMAMOTO
  • Publication number: 20230200642
    Abstract: A medical system according to an aspect example includes a data acquiring unit and a data processor. The data acquiring unit is configured to acquire from a patient two or more types of data among blood oxygen saturation data, auscultatory sound data, ocular image data, and ocular blood flow data. The data processor is configured to process the two or more types of data acquired by the data acquiring unit to detect a conditional change in a circulatory system associated with an infectious disease.
    Type: Application
    Filed: April 21, 2021
    Publication date: June 29, 2023
    Applicants: RIKEN, Topcon Corporation
    Inventors: Satoshi WADA, Masayuki MARUYAMA, Norihito SAITO, Kei TANEISHI, Yasufumi FUKUMA, Masahiro AKIBA, Gaku TAKEUCHI, Kana MINAMIDE
  • Publication number: 20230203450
    Abstract: A method of producing an organoid derived from a lung epithelial cell or a lung cancer cell, comprising culturing a sample including the lung epithelial cell or the lung cancer cell in a culture medium, wherein the culture medium contains 0-10% (v/v) extracellular matrix, and a combination of at least one selected from the group consisting of keratinocyte growth factor (KGF), fibroblast growth factor (FGF) 10, and hepatocyte growth factor (HGF); bone morphogenetic protein (BMP) inhibitor; and TGF? inhibitor, and the culture medium is substantially free of feeder cells.
    Type: Application
    Filed: May 26, 2021
    Publication date: June 29, 2023
    Applicants: OTSUKA PHARMACEUTICAL CO., LTD., RIKEN
    Inventors: Mitsuru MORIMOTO, Takashi FUJIMURA
  • Publication number: 20230208134
    Abstract: A DC bus control system for controlling power fluctuations in a DC bus connecting an input power source and a load, comprising: a main stabilization device including a first charging/discharging element and a first power converter; a plurality of the sub stabilization devices including a second charging/discharging element, a charging element, or a discharging element and a second power converter, wherein the plurality of the sub stabilization devices includes a first sub stabilization device having a charging/discharging element and a second power converter and at least one second sub stabilization device having a charging element or a discharging element and a second power converter, and a response speed of the first sub stabilization device is set such that a charging amount of the charging element or a discharging amount of the discharging element of the second sub stabilization device changes with a predetermined time constant.
    Type: Application
    Filed: May 10, 2021
    Publication date: June 29, 2023
    Applicant: RIKEN
    Inventors: Katsuhiko TSUNO, Katsushi FUJII, Kayo KOIKE, Satoshi WADA
  • Patent number: 11684698
    Abstract: A sphere-like cell aggregate according to one embodiment of the present invention comprises: a core part containing neural retina; and a covering part continuously or discontinuously covering at least a portion of a surface of the core part.
    Type: Grant
    Filed: September 7, 2018
    Date of Patent: June 27, 2023
    Assignees: Riken, Sumitomo Pharma Co., Ltd.
    Inventors: Masayo Takahashi, Michiko Mandai, Suguru Yamasaki
  • Patent number: 11676361
    Abstract: A method includes: acquiring data including moving image obtained by photographing a target and annotation images each indicative of a region of the target in each of frame images in the moving image; executing a process using the data. The process includes: detecting the target in the frame images; inputting, to an auto-encoder, an image obtained by combining partial images including the target and peripheral region images of the target detected in a given number of preceding and succeeding second frame images in a time series of the moving image of a first frame image; inputting a partial image corresponding to the first frame image to a neural network performing a segmentation; updating parameter of the auto-encoder and the neural network based on a difference between an image obtained by combining images from the auto-encoder and the neural network and a partial image of the annotation image.
    Type: Grant
    Filed: January 8, 2021
    Date of Patent: June 13, 2023
    Assignees: FUJITSU LIMITED, RIKEN, NATIONAL CANCER CENTER
    Inventors: Akira Sakai, Masaaki Komatsu, Ai Dozen
  • Patent number: 11674927
    Abstract: The eddy current flaw detection apparatus includes: a pair of detecting coils 10a, 10b arranged in coaxial and spaced relation with a specimen 3; and a bridge circuit two sides of which are constituted by the detecting coils so that magnetic fields generated by these detecting coils 10a, 10b are in opposite phases to each other. A pair of exciting coils 11a, 11b are arranged coaxially with the detecting coils 10a, 10b in a manner to sandwich the pair of detecting coils 10a, 10b therebetween. A distance D between the detecting coil and the exciting coil adjacent thereto is set to a distance where a vibrational noise signal excited in the exciting coil and detected by its adjacent detecting coil is in opposite phase to that of a vibrational noise signal excited in the detecting coil and detected by the detecting coil.
    Type: Grant
    Filed: January 13, 2021
    Date of Patent: June 13, 2023
    Assignee: Tex Riken Co., Ltd.
    Inventors: Yuji Kumakura, Nobuhiko Konishi