Abstract: The present invention relates to a process for preparing a highly transparent plastic obtainable by free-radical copolymerization of a mixture containing compounds of the formula (I) and (II) where R1 is independently at each instance hydrogen or a methyl radical, R2 is independently at each instance a linear or branched, aliphatic or cycloaliphatic radical or a substituted or unsubstituted aromatic or heteroaromatic radical and m and n are each independently an integer of not less than 0 subject to the proviso that m+n>0, which is characterized in that it is obtainable from a mixture which contains more than 10 mol %, based on the total amount of the compounds of the formula (I) and (II), of compounds of the formula (II) where m+n=2. The present invention also relates to the mixture of the compounds (I) and (II), to processes for preparing the mixture and to particular uses for the highly transparent plastics.
Type:
Application
Filed:
June 13, 2003
Publication date:
July 14, 2005
Applicant:
ROEHM GMBH & CO. KG
Inventors:
Bardo Schmitt, Joachim Knebel, Patrik Hartmann
Abstract: The invention relates to an impact-modified moulding composition which has particularly high impact resistance at low temperatures (?20° C., ?40° C.). This low-temperature impact resistance is achieved by using a silicone elastomer.
Type:
Grant
Filed:
October 22, 2001
Date of Patent:
June 14, 2005
Assignee:
Roehm GmbH & Co. KG
Inventors:
Klaus Schultes, Michael Wicker, Werner Hoess, Klaus Albrecht, Hans-Juergen Kress
Abstract: The invention relates to a process for continuous preparation of alkyl (meth)acrylates by transesterification of methyl (meth)acrylate using alcohols which are high-boiling relative to methanol. A particular workup technique achieves product qualities which have hitherto not been attained. Very high space-time and overall yields can also be achieved.
Type:
Application
Filed:
December 6, 2002
Publication date:
June 2, 2005
Applicant:
ROEHM GMBH & CO. KG
Inventors:
Jochen Ackermann, Udo Gropp, Horst Hiltner, Hans-Rolf Rausch, Ingrid Lunt-Rieg, Hermann Siegert, Ruediger Carloff
Abstract: The invention relates to a multiparticulate drug form suitable for uniform release of an active pharmaceutical ingredient in the small intestine and in the large intestine, comprising at least two forms of pellets A and B which comprise an active pharmaceutical ingredient in the core and have different polymer coatings which determine the release of the active ingredient at different pH values, characterized in that pellet form A is provided with an inner polymer coating which enables continuous release of active ingredient, and has an outer enteric coating which rapidly dissolves above about pH 5.5, and pellet form B is provided with a polymer coating which, in the USP release test, releases less than 20% of the active ingredient at pH 6.8 in 6 hours and releases more than 50% of the active ingredient at pH 7.2 in 6 hours. The invention additionally relates to a process for producing the multiparticulate drug form and to the use of pellet forms A and B for producing the drug form.
Type:
Grant
Filed:
March 9, 2001
Date of Patent:
May 24, 2005
Assignee:
Roehm GmbH & Co. KG
Inventors:
Thomas Beckert, Hans-Ulrich Petereit, Jennifer Dressman, Markus Rudolph
Abstract: The aim of the invention is to produce a spray burner, starting from a conventional spray burner, for the atomisation and combustion of sulphur-containing residues, comprising a residue nozzle, for the introduction of sulphur-containing residue, which is surrounded by an outer nozzle, for the introduction of an atomising agent, whereby said burner is suitable for a method in which oxygen can be introduced in the cracking oven as additional oxidising agent to increase the capacity and improve the economic efficiency without the above disadvantages and limitations and is also optimised for a variable throughput of residue for atomising. Said aim is achieved whereby the residue nozzle comprises a multiplicity of individual nozzles which may be switched on and off, connected to an input for the residue, an inlet for fuel is provided and the outer nozzle is connected to an inlet for an oxygen-enriched gas stream.
Type:
Grant
Filed:
September 7, 2001
Date of Patent:
May 17, 2005
Assignees:
Messer Griesheim GmbH, Roehm GmbH & Co., KG
Abstract: The invention relates to an impact-modified molding composition which has particularly high impact resistance at low temperatures (?20° C., ?40° C.). This low-temperature impact resistance is achieved by using a silicone elastomer.
Type:
Grant
Filed:
October 22, 2001
Date of Patent:
May 10, 2005
Assignee:
Roehm GmbH & Co. KG
Inventors:
Klaus Schultes, Michael Wicker, Werner Hoess, Klaus Albrecht, Hans-Juergen Kress
Abstract: The invention relates to polymer beads having a high content of diacyl peroxides. A prolongation of the pot life in reaction resins based on high-boiling methacrylate esters is achieved due to this high content of peroxides.
Type:
Application
Filed:
November 16, 2004
Publication date:
April 28, 2005
Applicant:
ROEHM GMBH & CO. KG
Inventors:
Peter Quis, Heike Heeb, Helmut Schwind, Harald Draeger
Abstract: The invention relates to a pharmaceutical formulation containing essentially a) an inner layer which can optionally be applied to a core, with the active substance budesonide, bound with a binding agent; b) a middle layer with a polymer covering agent which is soluble in intestinal juice or retardant; and c) an outer envelope or outer layer which is resistant to stomach juice, said layers being able to contain in a manner known per se other pharmaceutically usual adjutants. The inventive formulation is characterised in that the binding agent is a polymer or a copolymer with acid groups and the formulation of the inner layer without the middle and outer layer releases the bound active ingredient in a release test according to USP XXIII monography <711> dissolution with apparatus 2 (addle) at a rotational speed of 100/min in a phosphate buffer pH 7.5 after 30 min to a value of more than 80%.
Type:
Application
Filed:
March 6, 2003
Publication date:
April 28, 2005
Applicant:
ROEHM GMBH & CO.KG
Inventors:
Thomas Beckert, Jennifer Dressman, Markus Rudolph
Abstract: Asymmetric (meth)acrylate crosslinking agents may be prepared by reacting a hydroxyacrylate with methacrylic anhydride to give a crosslinking agent with acrylic and methacrylic groups. Asymmetric (meth)acrylate crosslinking agents can be employed in the production of superabsorbers and thickening agents.
Abstract: The invention relates to a method for producing a pharmaceutical dosage form as tablets, pellets and/or in the form of an active ingredient-containing matrix, whereby the tablets, pellets and/or active ingredient-containing matrix contain a pharmaceutical active ingredient and a copolymer serving as a coating agent and/or binding agent, and optionally contain a core and pharmaceutically common additives. According to the invention, the copolymer, the pharmaceutical active ingredient, the optionally present core and/or the pharmaceutically common additives are processed using known techniques by melting, injection molding, extrusion, wet granulation, casting, dipping, spreading out, spraying on, or pressing to form tablets, pellets and/or an active ingredient-containing matrix. The inventive method is characterized in that a copolymer is used that consists of 20 to 34 wt. % methacrylic acid, 20 to 69 wt. % methylacrylate and 0 to 40 wt. % ethylacrylate and, optionally, of 0 to 10 wt.
Type:
Application
Filed:
January 30, 2003
Publication date:
April 14, 2005
Applicant:
Roehm GMBH & CO. KG
Inventors:
Hans-Ulrich Petereit, Thomas Suefke, Christian Meier, Michael Schnabel, Ingrid Blesing, Stefan Grimm
Abstract: The invention relates to a pharmaceutical preparation consisting of: (a) a core containing an active substance, optionally an excipient and common pharmaceutical additives in addition to the salt of an inorganic acid whose proportion in the weight of the core ranges from 2.
Type:
Grant
Filed:
September 28, 1999
Date of Patent:
April 12, 2005
Assignee:
Roehm GmbH & Co KG
Inventors:
Hans-Ulrich Petereit, Thomas Beckert, Eva Lynenskjold
Abstract: The invention relates to a polycarbonate composite material which can be thermoplastically shaped and which comprises at least two layers. The invention is characterised in that at least one layer comprises an LOI value of lower than 29 and at least one layer comprises an LOI value of higher than 29. The invention also relates to methods for producing said material, the use of the same and flame-proof polycarbonate moulded parts.
Type:
Grant
Filed:
November 2, 2001
Date of Patent:
March 29, 2005
Assignee:
Roehm GmbH & Co., KG
Inventors:
Detlef Bumann, Andreas Fetzer, Michael Meier-Kaiser
Abstract: The invention relates to a multiparticulate drug form suitable for uniform release of an active pharmaceutical ingredient in the small intestine and in the large intestine, comprising at least two forms of pellets A and B which comprise an active pharmaceutical ingredient in the core and have different polymer coatings which determine the release of the active ingredient at different pH values, characterized in that pellet form A is provided with an inner polymer coating which enables continuous release of active ingredient, and has an outer enteric coating which rapidly dissolves above about pH 5.5, and pellet form B is provided with a polymer coating which, in the USP release test, releases less than 20% of the active ingredient at pH 6.8 in 6 hours and releases more than 50% of the active ingredient at pH 7.2 in 6 hours. The invention additionally relates to a process for producing the multiparticulate drug form and to the use of pellet forms A and B for producing the drug form.
Type:
Application
Filed:
September 27, 2004
Publication date:
March 10, 2005
Applicant:
ROEHM GMBH & CO. KG
Inventors:
Thomas Beckert, Hans-Ulrich Petereit, Jennifer Dressman, Markus Rudolph
Abstract: The invention relates to a method for the production of a coating and excipient agent for oral or dermal dosage forms, consisting of (a) 35-98% by weight of a copolymer consisting of radically polymerized C1-C4 esters of acrylic or methacrylic acid and additional (meth)acrylate monomers having functional tertiary amino groups and (b) 1-50% by weight of a softener and 1-15% by weight of an emulgator with an HLB value of less than 14, wherein constituents (a), (b) and (c) are mixed with or without adding water and optionally adding a pharmaceutical active substance and other conventional additives and the coating and excipient agent is produced by melting, casing, spreading or spraying. The invention is characterized in that the copolymer (a) is applied in powder form with a mean particle size of 1-40 ?m.
Type:
Grant
Filed:
June 18, 2003
Date of Patent:
January 25, 2005
Assignee:
Roehm GmbH & Co. KG
Inventors:
Hans-Ulrich Petereit, Christian Meier, Erna Roth
Abstract: The invention relates to a method for the production of active ingredient-containing pellets by the steps of a) suspending or dissolving a pharmaceutical active ingredient in a dispersion, which contains a cationic copolymer, b) dropping said dispersion, containing the pharmaceutical active ingredient and the copolymer in an aqueous polymer solution, which contains an anionic copolymer, incompatible with the cationic copolymer, so that active ingredient-containing pellets precipitate and c) separating said active ingredient-containing pellets from the aqueous polymer solution and then drying said pellets. The invention also relates to said pellets and the use thereof in diagnostics or cosmetics, as well as pharmaceutical forms which contain said pellets.
Type:
Application
Filed:
March 23, 2004
Publication date:
December 9, 2004
Applicant:
ROEHM GMBH & CO. KG
Inventors:
Hans-Ulrich Petereit, Guenter Bergmann, Klaus Lehmann
Abstract: Flat composites of plastic are manufactured by thermal adhesive bonding of at least two plastic parts which are heated at their surfaces and which comprise a base material coated with a plastic layer, wherein the Vicat softening point of the plastic of layer is 5 to 40° C. lower than that of the base material, wherein the base material has a thickness of 1 to 200 mm and the plastic layer has a thickness of 5 to 400 &mgr;m, and each of the parts is heated on the surfaces coated with the plastic layer and then welded under pressure.
Abstract: An extrusion die has a distributing tool; a profiling nozzle; and at least three melt-flow ducts; a first melt-flow duct is routed around a second melt-flow duct or the distributing tool using a branch and is merged again downstream from the branch; and a third melt-flow duct opens into the second melt-flow duct. The extrusion die is suitable for extrusion of a hollow-chamber profiled panel of a thermoplastic plastic with a layered structure which comprises a top and bottom layer of a first plastic melt; and an intermediate layer of a second plastic melt disposed in an interior of a hollow chamber profile. The first plastic melt is allocated to the first melt-flow duct and to the second melt-flow duct and the second plastic melt is allocated to the third melt-flow duct. During the extrusion the second plastic melt is deposited onto the first plastic melt upstream from or in the region of the branch, and a distribution of the deposited second plastic melt is regulated using the distributing tool.
Abstract: The present invention provides a process for preparing bead polymers having an average particle size of 1 to 40 &mgr;m, which includes:
contacting:
at least one polymerizable mix which includes at least 50% by weight of at least one (meth)acrylate monomer,
at least one aluminum compound, and
an aqueous phase,
to prepare a mixture;
dispersing the mixture at a shear rate≧103 s−1 to form a dispersion, wherein the dispersion is stabilized by the aluminum compound; and
polymerizing to produce bead polymers having an average particle size of 1 to 40 &mgr;m.
Type:
Grant
Filed:
December 28, 2001
Date of Patent:
October 26, 2004
Assignee:
Roehm GmbH & Co KG
Inventors:
Klaus Schultes, Thomas Suefke, Markus Parusel, Guenter Schmitt, Winfried Belzner
Abstract: A process for the production of hydrogen cyanide is provided, wherein hydrogen cyanide is synthesized by reacting methane or methane-containing natural gas, ammonia and oxygen-enriched air or oxygen in the presence of a catalyst comprising platinum or a platinum alloy; wherein the reactants are present in the following molar ratios 1 [ O 2 ] [ O 2 + N 2 ] = 0.25 ⁢ ⁢ to ⁢ ⁢ 1.0 ; [ CH 4 ] [ NH 3 ] = 0.95 ⁢ ⁢ to ⁢ ⁢ 1.