Patents Assigned to Rutgers, The State University
  • Systems and Methods for Cognitive Diagnostics for Neurological Disorders: Parkinson's Disease and Comorbid Depression
    Publication number: 20220230755
    Abstract: A system for diagnosing a neurological disorder, Parkinson's Disease, and a comorbid mental health condition, major depressive disorder is provided. The system comprises a smart device and a device including a memory and a processor. The smart device allows a participant to perform a cognitive task and the device receives data collected from the smart device in connection with the cognitive task performed by the participant. The device determines whether the participant has Parkinson's Disease based on the data collected and via a classification algorithm. If the participant has Parkinson's Disease, the device determines whether the participant has comorbid major depressive disorder.
    Type: Application
    Filed: April 8, 2022
    Publication date: July 21, 2022
    Applicants: Rutgers, The State University of New Jersey, Al-Quds University
    Inventor: Mohammad Herzallah
  • THERAPEUTIC METHODS AND COMPOUNDS
    Publication number: 20220227735
    Abstract: The invention provides a compound of formula I: (I) or a pharmaceutically acceptable salt thereof, wherein R1-R5 Y have any of the values described in the specification, as well as compositions comprising a compound of formula I. The compounds are useful to treat malaria.
    Type: Application
    Filed: April 22, 2020
    Publication date: July 21, 2022
    Applicant: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: Purnima BHANOT, David J. AUGERI, John A. GILLERAN, Raheel FONDEKAR
  • Catnip cultivar ‘CR9’
    Patent number: 11390828
    Abstract: The invention provides seed and plants of catnip hybrid ‘CR9’. The invention thus relates to the plants, seeds, and tissue cultures of catnip hybrid ‘CR9’, and to methods for producing a catnip plant of the present invention by crossing such plants with themselves or with another catnip plant, such as a plant of another genotype, variety, or cultivar. The invention further relates to seeds and plants produced by such crossing. The invention further relates to parts of such plants.
    Type: Grant
    Filed: November 1, 2019
    Date of Patent: July 19, 2022
    Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: James E. Simon, William Reichert
  • Nuclease-independent targeted gene editing platform and uses thereof
    Patent number: 11390886
    Abstract: The present invention discloses a system for targeted gene editing and related uses.
    Type: Grant
    Filed: July 15, 2016
    Date of Patent: July 19, 2022
    Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: Shengkan Jin, Juan-Carlos Collantes
  • COMPOSITIONS AND METHODS FOR IMPROVING PLASTID TRANSFORMATION EFFICIENCY IN HIGHER PLANTS
    Publication number: 20220220493
    Abstract: Compositions and methods for improving plastid transformation in difficult to transform plants are disclosed.
    Type: Application
    Filed: November 22, 2021
    Publication date: July 14, 2022
    Applicant: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventor: Pal Maliga
  • Image processing neural network systems and methods with scene understanding
    Patent number: 11386655
    Abstract: An image processing neural network system includes a base net of at least one convolutional layer and at least one pooling layer; and a scenario block layer. The scenario block layer performs scene classification and generates a dictionary of scenarios and a vector of scenario encoding coefficients to output a probabilistic scene class assignment and the vector of scenario encoding coefficients. The vector of scenario encoding coefficients corresponds to reasoning for the scene classification.
    Type: Grant
    Filed: February 13, 2020
    Date of Patent: July 12, 2022
    Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: Dimitris Metaxas, Zachary A. Daniels
  • Methods of generating antibodies
    Patent number: 11384138
    Abstract: The invention describes a method of generating antibodies to a mixture of peptidogenic proteins wherein the peptidogenic protein has altered conformational dynamics as compared to a starting protein and wherein the peptidogenic protein has a similar conformation to the starting protein. The peptidogenic proteins can be used to induce an immune response, which can lead to the generation of antibodies and/or can be used to vaccinate a mammal.
    Type: Grant
    Filed: August 18, 2016
    Date of Patent: July 12, 2022
    Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: Stephen Anderson, Elliot Campbell
  • Scalable fabrication of pristine holey graphene nanoplatelets via dry microwave irradiation
    Patent number: 11377356
    Abstract: Disclosed are the methods for fabricating holey graphene nanoplatelets using microwave irradiation to treat a dry graphite powder. In particular, the methods can be used to treat graphite intercalation compounds either with or without partial oxidation to obtain holey graphene nanoplatelets with predetermined hole size, hole edge shape, thickness and lateral dimension. The method does not involve any toxic reagents or metal-containing compounds, and without generating toxic byproducts, thus enabling a variety of eco-friendly applications.
    Type: Grant
    Filed: June 14, 2018
    Date of Patent: July 5, 2022
    Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: Huixin He, Keerthi Savaram, Qingdong Li
  • Methods and apparatus for management of mosquito populations with habitat sharing heterospecific insects carrying insect growth regulators
    Patent number: 11375708
    Abstract: Compositions and heterodissemination methods for controlling unwanted target insect populations are disclosed. In preferred embodiments, the target insects are mosquitos or house flies and the heterospecific insects are non-biting midges and soldier flies respectively.
    Type: Grant
    Filed: June 4, 2018
    Date of Patent: July 5, 2022
    Assignee: Rutgers, The State University of New Jersey
    Inventors: Randy R. Gaugler, Devi S. Suman, Bo Tao, Yi Wang
  • Dispensers and methods of use thereof for dispensing solid mosquito larvicides and other materials of interest
    Patent number: 11370599
    Abstract: Dispenser devices suitable for use on unmanned aerial vehicles are described having utility for dispensing solid larvicides to difficult to reach insect habitats.
    Type: Grant
    Filed: November 8, 2019
    Date of Patent: June 28, 2022
    Assignee: Rutgers, The State University of New Jersey
    Inventors: Gregory M. Williams, Randy Gaugler
  • Method and system for freezing related separation processes utilizing biogenic ice nucleation proteins
    Patent number: 11363831
    Abstract: A novel method for freeze-related separations, involving the combination of water with a selected concentration of biogenic ice nucleation proteins, freezing the combination, and separating the ice, potentially via centrifugation or sublimation. In some instances, the freezing conditions and the concentration of the at least one biogenic ice nucleation protein are selected such that the aqueous solution, upon freezing, forms a lamellar ice crystal structure having at least one property selected from the group consisting of a solute inclusion volume at least 30% smaller than in the first material alone, a hydraulic diameter at least 30% larger than in the first material alone, an inclusion width that is less than 10% of a crystal dimension, a hydraulic diameter that is less more than 1.
    Type: Grant
    Filed: February 14, 2019
    Date of Patent: June 21, 2022
    Assignee: RUTGERS, the State University of New Jersey
    Inventor: Tung-Ching Lee
  • PHARMACEUTICAL COMPOUNDS AND THERAPEUTIC METHODS
    Publication number: 20220185827
    Abstract: The invention provides a complex comprising Zn2+ and a compound of formula (I): or a deuterated analog thereof, or an ion or poly-ion thereof, or a salt thereof that is useful for treating cancer, as well as compositions and kits comprising such complexes.
    Type: Application
    Filed: April 22, 2020
    Publication date: June 16, 2022
    Applicant: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: Spencer David KIMBALL, Darren R. CARPIZO, John A. GILLERAN
  • S309 CHIMERIC ANTIGEN RECEPTORS AND METHODS OF USE
    Publication number: 20220184125
    Abstract: Chimeric antigen receptors (CARs) including an scFv binding to coronavirus spike protein (S309 scFv), nucleic acids encoding the CARs, vectors including nucleic acids encoding the CARs, and cells expressing the CARs are provided. Methods of treating a subject with coronavirus are also provided, including administering to the subject a modified immune cell expressing a disclosed CAR.
    Type: Application
    Filed: December 14, 2021
    Publication date: June 16, 2022
    Applicant: Rutgers, The State University of New Jersey
    Inventors: Dongfang Liu, Minh Ma, Saiaditya Badeti
  • HIGH CONCENTRATION CELL PACKAGING AND SHIPPING
    Publication number: 20220175674
    Abstract: This invention relates to processes and products for packaging and shipping therapeutic cells for cell therapy.
    Type: Application
    Filed: May 12, 2020
    Publication date: June 9, 2022
    Applicants: Stemcyte Inc., Rutgers, The State University of New Jersey
    Inventors: Monica Chen, Richard Tonai, Wise Young, Dongming Sun, Jonas Wang
  • Phosphatidylserine targeting fusion molecules and methods for their use
    Patent number: 11352404
    Abstract: Fusion molecules of a cytokine or portion thereof and a polypeptide which targets the fusion protein to phosphatidylserine, pharmaceutical compositions thereof, and methods for their use in targeting a cytokine or portion thereof to a pathological site and treating a disease or condition responsive to cytokine treatment are provided.
    Type: Grant
    Filed: July 24, 2018
    Date of Patent: June 7, 2022
    Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: Sergei V. Kotenko, Raymond B. Birge, Viralkumar Rameshkumar Davra
  • METHODS FOR ENRICHING POPULATIONS OF CELLS
    Publication number: 20220169979
    Abstract: This disclosure describes efficient methods for separating desired populations of cells, including Multilineage-Differentiating Stress-Enduring (MUSE) cells. Also described are the methods for isolating and enriching MUSE cells through a sorting, expanding, and re-sorting procedure. The enriched cells or cell populations can be used for treating cancer, repairing various tissues, and treating various degenerative or inherited diseases.
    Type: Application
    Filed: April 9, 2020
    Publication date: June 2, 2022
    Applicants: Rutgers, The State University of New Jersey, Life Science Institute, Inc.
    Inventors: Wise Young, Dongming Sun, Iman Tadmori, Zikuan Leng, Mari Dezawa
  • NOVEL ANTI-LAM AND ANTI-PIM6/LAM MONOCLONAL ANTIBODIES FOR DIAGNOSIS AND TREATMENT OF MYCOBACTERIUM TUBERCULOSIS INFECTIONS
    Publication number: 20220168420
    Abstract: The present invention broadly provides different compositions, kits, vectors, and methods including monoclonal antibodies directed to epitopes found within lipoarabinomannan (LAM) and phosphatidyl-myo-inositol mannoside 6 (PIM6) for the diagnosis and treatment of Mycobacterium tuberculosis infections.
    Type: Application
    Filed: February 17, 2022
    Publication date: June 2, 2022
    Applicant: Rutgers, The State University of New Jersey
    Inventors: Abraham Pinter, Alok K. Choudhary
  • Compositions for reducing sarcolipin expression and preventing and treating muscular dystrophy and cardiomyopathy and methods of use
    Patent number: 11345927
    Abstract: Compositions, recombinant viruses, and recombinant viral vectors for inhibiting sarcolipin (SLN) expression or activity in a cell and for preventing or treating Duchenne Muscular Dystrophy (DMD) in a subject (e.g., a human patient having or predisposed to having DMD) and in some embodiments additionally cardiomyopathy, include a therapeutically effective amount of an inhibitor of SLN. Methods of using these compositions, recombinant viruses, and recombinant viral vectors are also described herein. These compositions, recombinant viruses, and recombinant viral vectors and methods of use provide novel therapies for DMD and associated cardiomyopathy based on the reduction of SLN expression and/or activity.
    Type: Grant
    Filed: January 22, 2018
    Date of Patent: May 31, 2022
    Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventor: Gopal J. Babu
  • Formulation and manufacture of pharmaceuticals by impregnation onto porous carriers
    Patent number: 11344494
    Abstract: The present invention provides an impregnated porous carrier material comprising at least one active pharmaceutical ingredient (API) impregnated throughout the internal surface of a porous carrier. The present invention further provides immediate release and sustained release pharmaceutical dosage forms comprising the impregnated porous carrier material disclosed herein such that any single active pharmaceutical ingredient (API) content variability in the finished drug product has a relative standard deviation of less than 3%.
    Type: Grant
    Filed: May 21, 2018
    Date of Patent: May 31, 2022
    Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: Fernando J. Muzzio, Benjamin J. Glasser, Plamen I. Grigorov
  • Value-based information flow tracking in software packages
    Patent number: 11347887
    Abstract: A computer-implemented method, computer system, and computer program product are directed to improving computer security of a device using value based information flow tracking. Embodiments automatically capture raw data values from a data source of the device and store in memory the captured raw data values in a collection of sensitive data. Embodiments determine whether computed values of functions of a data flow are included in the collection of sensitive data. Based upon the determining, embodiments prevent values of the collection of sensitive data from being transmitted from a sink of the device. Embodiments may determine whether string representations of computed operand and return values of numerical or arithmetic operations of the functions of the data flow are included in the collection of sensitive data.
    Type: Grant
    Filed: October 2, 2018
    Date of Patent: May 31, 2022
    Assignees: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY, THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Saman Aliari Zonouz, Gabriel Salles-Loustau, Mani Srivastava, Moustafa Alzantot