Abstract: Disclosed herein are methods and compositions for generating immunotherapeutic cells (e.g., NK and T cells) with enhanced cytotoxicity and capacity for expansion thereof. The methods and compositions disclosed herein can further be used for enhanced expansion of CAR-modified NK and T cells with increased cytotoxicity.

Abstract: Modified single chain variable fragments (scFv) that specifically bind CD147 are provided. Also provided are chimeric antigen receptors (CARs) including the modified CD147 scFv, nucleic acids encoding the CARs, vectors including the nucleic acids encoding the CARs, and immune cells expressing the CARs. Methods of treating a subject with cancer including administering to the subject an immune cell expressing a disclosed CD147-CAR are also provided.

Abstract: The present invention relates to solvothermal vapor synthesis methods for the crystallization of a phase from a mixture of selected inorganic or organic precursors in an unsaturated vapor-phase reaction medium.

Abstract: The invention provides compounds of formula I: and salts thereof wherein R1-R5 have any of the meanings described in the specification. The compounds are useful for treating bacterial infections (e.g. tuberculosis).

Abstract: The present invention provides novel methods of diagnosing and determining treatment strategies for Lyme disease and other tick-borne illnesses.

Abstract: Various embodiments comprise systems, methods, architectures, mechanisms, and apparatus providing location safety management implemented by cooperating mobile devices that operate in a privacy-secured manner to identify respective proximate infectious areas, build corresponding local datasets of the infectious areas, and share the datasets or relevant portions thereof with each other, such as in response to hierarchical location-based requests for such data. The datasets may be used to adapt the operation of navigation applications and the like so as to avoid routes, seats or locations associated with infectious areas and/or persons.

Abstract: Methods and kits are described for testing for the presence or absence of any fungus in a sample. Examples of fungi that can be detected include, but are not limited to, those belonging to the genera Candida, Aspergillus and Pneumocystis. The methods include obtaining a sample suspected of containing fungal nucleic acid, including at least one universal region of fungal nucleic acid, and testing for the presence or absence in the sample of the at least one universal region of fungal nucleic acid. Samples may be biological or non-biological.

Abstract: Embodiments are directed to a flexible high voltage thin film transistor (f-HVTFT) with a center-symmetric circular configuration. The f-HVTFT includes a ring-shaped oxide semiconductor channel, a ring-shaped gate, a ring-shaped source, and a circular drain. The source and gate each have multiple connections to respective electrode pads, enabling stable and identical electrical characteristics and blocking voltage while the f-HVTFT is subject to bending from random directions. The f-HVTFT enables a high blocking voltage over 100 V, on-current over 100 ?A, and low off-current of 0.1 pA, which makes it suitable for power management of self-powered wearable electronic systems.

Abstract: A nanocarrier containing a combination of bioactive agents is provided. The nanocarrier allows for targeted delivery of the agents to cancer cells with minimized side effect.

Abstract: This disclosure provides a system and method for generating an ultrasound image. The method includes receiving a raw ultrasound signal output from an ultrasound device and performing operations to transform the raw ultrasound signal into an enhanced ultrasound image. The enhanced ultrasound image may be further processed by radial symmetry filtering to generate a radial symmetry image. Both the enhanced image and the radial symmetry image can be by a medical practitioner to make a liver or kidney cancer diagnosis exclusively based on ultrasound data.

Abstract: This application discloses the compositions comprising biologically active synthetic nanoparticle constructs and methods of use thereof to modify gene expression including transcriptional activation and transcriptional repression.

Abstract: This patent document discloses novel compounds and methods of preventing or treating diseases or conditions related to Keap1-Nrf2 interaction activity by use of the novel compounds. As direct inhibitors of Keap1-Nrf2 interaction, the compounds disclosed herein are more specific and free of various undesirable effects than existing indirect inhibitors, and are potential dmg candidates of chemopreventive and therapeutic agents for treatment of various diseases or conditions involving oxidative stress and/or inflammation, including but not limited to cancers, diabetes, Alzheimer's, Parkinson's, and inflammatory bowel disease including ulcerative colitis.

Abstract: Disclosed are sensor materials and sensors prepared from thermoplastic polymers filled with 2D nanoparticles. The thermoplastic polymers filled with 2D nanoparticles are prepared by a method in which a thermoplastic polymer is melt-blended with at least one layered material under shear sufficient to exfoliate the layered material in the thermoplastic polymer until 2D nanoparticles are formed, to provide covalently linked 2D nanoparticle-filled thermoplastic polymers. Such filled thermoplastic polymers have utility for preparing various types of sensors which are useful in a variety of practical applications and devices.

Abstract: Methods for predicting the response of prostate cancer to androgen deprivation therapy (ADT) using a gene signature of five genes (CSPG5, FKBP6, FOSB, STMN1, and TTC27) is provided. Also provided are sets containing specific binding molecules for each of CSPG5, FKBP6, FOSB, STMN1, and TTC27 and kits containing such sets.

Abstract: A biomimetic composite material includes a bioactive cement material, an autologous dentin matrix, and an inorganic nano-reinforcement material. A dental implant includes a body including a biomimetic composite material, wherein the biomimetic composite material includes a bioactive cement material, an autologous dentin matrix, and an inorganic nano-reinforcement material.

Abstract: Fusion molecules composed of a type I interferon protein or portion thereof and a type III interferon protein or portion thereof, pharmaceutical compositions containing the fusion molecules, and methods for their use in inhibiting infection, inhibiting or treating cancer, inducing signaling of transcription of IFN-stimulated genes through an IFN-?R2 chain in a subject suffering from an infection which degrades or downregulates an IFN-?R1 chain, and treating various diseases or conditions are provided.

Abstract: Provided herein are transition metal complexes that are useful in the acceptorless dehydrogenation of various substrates, including alkanes. Also provided are methods of dehydrogenating substrates to provide unsaturated products such as olefins.

Abstract: A multi-port single screw extruder combining a heated plastication barrel having a first entrance port and an exit port on opposing ends of the barrel and a second entrance port intermediately positioned therebetween; a first hopper positioned to deliver ingredients to the first entrance port of said barrel; a second hopper positioned to deliver ingredients to the second entrance port and a helical plastication screw rotatably carried within the barrel and running the length thereof between the first entrance port and exit port that is operable to rotate and transmit the ingredients along the length of the barrel; wherein the plastication screw includes a distributive mixing element located between at least one additional entrance port and the exit port, the minor diameter of the plastication screw is reduced in advance of each additional entrance port sufficient to reduce the barrel pressure at each entrance port to a level that permits the addition of ingredients to the barrel through the entrance port, and

Abstract: Disclosed is a method of treating a tumor in a patient, comprising (a) administering riluzole in an amount effective to sensitize the tumor cells to ionizing radiation, and (b) irradiating the tumor cells with ionizing radiation in a dose effective to reduce tumor cell growth. The method can further comprise administering an effective amount of one or more additional therapeutic agents.

Abstract: The invention provides a complex comprising Zn2+ and a compound of formula (I): or a deuterated analog thereof, or an ion or poly-ion thereof, or a salt thereof that is useful for treating cancer, as well as compositions and kits comprising such complexes.