Patents Assigned to RWTH Aachen
  • Patent number: 10765521
    Abstract: An artificial cartilage is provided whereby a fixed negative charged hydrogel has been infused within a restrictive swelling network, which limits and restricts the thickness of the artificial cartilage. At least 60% of the volume of the artificial cartilage is composed of the restricted and swollen hydrogel. The restrictive swelling network restricts the hydrogel to swell not more than 10% with respect to its maximum swelling capacity, i.e. a swelling capacity to swell 10-fold more is retained. The hydrogel within the restrictive swelling network has an equilibrium stiffness between 0.5 and 2 MPa to resist external loads applied to the top surface layer or the bottom surface layer of the artificial cartilage. The hydrogel has a fixed negative charge density of ?0.17 to ?0.23 mEg/ml and is capable of swelling between 2-15 times compared to the volume of the hydrogel without being restricted.
    Type: Grant
    Filed: October 19, 2017
    Date of Patent: September 8, 2020
    Assignees: Technische Universiteit Eindhoven, RWTH Aachen
    Inventors: Corrinus Cornelis van Donkelaar, Keita Ito, Tim Bolle
  • Publication number: 20200248265
    Abstract: A method of diagnosing a disease associated with a DNA repeat sequence is disclosed. The method comprises: (a) determining the number of repeats of a DNA sequence in DNA molecules of a sample of the subject; and (b) determining the CpG methylation status of the DNA molecules, wherein the number of repeats of the DNA sequence and the CpG methylation status of the DNA molecules is indicative of the disease.
    Type: Application
    Filed: April 15, 2020
    Publication date: August 6, 2020
    Applicants: Ramot at Tel-Aviv University Ltd., Rheinisch-Westfälische Technische Hochschule (RWTH) Aachen
    Inventors: Yuval EBENSTEIN, Elmar WEINHOLD, Assaf GRUNWALD, Tslil GABRIELI
  • Publication number: 20200208184
    Abstract: A method of producing 5-ketofructose using an acetic acid bacterium which is genetically modified to express a fructose dehydrogenase as well as to microorganisms which can be used in said method.
    Type: Application
    Filed: June 13, 2018
    Publication date: July 2, 2020
    Applicants: RWTH Aachen, Forschungszentrum Jülich GmbH, Rheinische Friedrich-Wilhelms-Universität Bonn
    Inventors: Elena Herweg, Jochen Büchs, Michael Bott, Ines Kiefler, Uwe Deppenmeier, Konrad Kosciow, Anna Siemen
  • Patent number: 10608522
    Abstract: An electrical circuit comprising an n-port m-phase active bridge converter with n?2 and m?1, where each port can be operated as an input or an output port, wherein each of the n ports has m phase legs with multiple active switches with parallel connected snubber or resonant capacitors, whereby the n ports can convert a DC-voltage into an AC voltage, the n ports connected via an m-phase transformer or over m separate transformers each connected to each of the m phase legs of each of the n ports to transfer power between the ports, wherein an auxiliary circuit is connected to the transformers to convert a part of a transformer input voltage and energy via an auxiliary voltage source into a DC mid-point capacitor of a DC-link of at least one of the n-port m-phase active bridge converters to recharge the DC mid-point capacitor.
    Type: Grant
    Filed: June 28, 2019
    Date of Patent: March 31, 2020
    Assignee: Rheinisch-Westfälische Technische Hochschule (RWTH) Aachen
    Inventors: Rik W. De Doncker, Johannes Voss
  • Patent number: 10584036
    Abstract: A method for producing an inorganic silica gel fiber or aerogel fiber, comprising the following steps: a) extrusion of a gel, in particular a hydrogel or alcogel, by means of a spinneret directly into a coagulation bath to form at least one filament, b) stretching of the filament in the coagulation bath, c) regeneration of the filament by extraction from the coagulation bath, and d) supercritical drying or freeze drying in order to convert the filament into a silica fiber, in particular an aerogel fiber.
    Type: Grant
    Filed: January 14, 2016
    Date of Patent: March 10, 2020
    Assignee: Rheinisch-Westfälische Technische Hochschulte (RWTH) Aachen
    Inventors: Davide Pico, Björn Schulz, Alexander Lüking, Thomas Gries
  • Patent number: 10500971
    Abstract: A circuit assembly for linking different electrical voltage levels in a motor vehicle, comprising: an electric machine containing induction coils in a star circuit connection with a star point; a first switch unit containing switch elements for generating an AC voltage for the electric machine from a DC voltage of a first voltage level; a DC voltage of a second voltage level; and a second switch unit for a bidirectional electrical energy flow between the DC voltage of the first voltage level and the DC voltage of the second voltage level, wherein the second switch unit has two switch elements arranged in series in an auxiliary switch branch, wherein the auxiliary switch branch is connected in parallel to the DC voltage of the first voltage level, and each connection of the switch elements is connected to the star point.
    Type: Grant
    Filed: August 31, 2016
    Date of Patent: December 10, 2019
    Assignee: RWTH Aachen
    Inventors: Murat Senol, Rik W. De Doncker
  • Patent number: 10434504
    Abstract: A method for the reduction organic molecules comprising a Ruthenium-Triphosphine complex with aromatic ligands at the phosphors which are ortho or meta substituted.
    Type: Grant
    Filed: November 27, 2018
    Date of Patent: October 8, 2019
    Assignee: RHEINISCH-WESTFÄLISCHE TECHNISCHE HOCHSCHULE (RWTH) AACHEN
    Inventors: Jürgen Klankermayer, Walter Leitner, Markus Meuresch
  • Patent number: 10391185
    Abstract: The invention provides a multimodal ultrasound and photoacoustic contrast agent based on polymeric microparticles having a gas core and carrying at least one photoacoustic agent in its shell that stabilizes the gas core, for use in ultrasound and photoacoustic imaging. Such multimodal ultrasound and photoacoustic contrast agent is also suitable as a carrier of drugs and for use in photodynamic therapy, and for tissue imaging ex vivo.
    Type: Grant
    Filed: November 26, 2015
    Date of Patent: August 27, 2019
    Assignees: Fujifilm VisualSonics, Inc., RWTH Aachen
    Inventors: Fabian Kiessling, Twan Lammers, Stanley Fokong Nyongamsen, Katrin Suppelt
  • Publication number: 20190194755
    Abstract: A method of diagnosing a disease associated with a DNA repeat sequence is disclosed. The method comprises: (a) determining the number of repeats of a DNA sequence in DNA molecules of a sample of the subject; and (b) determining the CpG methylation status of the DNA molecules, wherein the number of repeats of the DNA sequence and the CpG methylation status of the DNA molecules is indicative of the disease.
    Type: Application
    Filed: August 10, 2017
    Publication date: June 27, 2019
    Applicants: Ramot at Tel-Aviv University Ltd., Rheinisch-Westfalische Technische Hochschule (RWTH) Aachen
    Inventors: Yuval EBENSTEIN, Elmar WEINHOLD, Assaf GRUNWALD, Tslil GABRIELI
  • Patent number: 10297385
    Abstract: The invention relates to a for a targeted shaping of the magnetic field of a single permanent magnet or an arrangement of a plurality of permanent magnets, wherein magnetic material from selected locations of the single permanent magnet or at least one of said permanent magnets of the arrangement is removed by means of at least one of the following removal procedures for shaping the magnetic field: laser ablation using laser radiation, high-pressure waterblasting using high-pressure water jets and mechanical ablation using a non-magnetic tool.
    Type: Grant
    Filed: September 30, 2013
    Date of Patent: May 21, 2019
    Assignee: Rheinisch-Westfällsche Technische Hochschule (RWTH) Aachen
    Inventors: Ernesto Pablo Danieli, Bernhard Blumich, Wasif Zia, Holger Leonards
  • Publication number: 20190134618
    Abstract: A method for the reduction organic molecules comprising a Ruthenium-Triphosphine complex with aromatic ligands at the phosphors which are ortho or meta substituted.
    Type: Application
    Filed: November 27, 2018
    Publication date: May 9, 2019
    Applicant: RHEINISCH-WESTFÄLISCHE TECHNISCHE HOCHSCHULE (RWTH) AACHEN
    Inventors: Jürgen KLANKERMAYER, Walter Leitner, Markus Meuresch
  • Patent number: 10279933
    Abstract: The invention relates to an androgynous coupling device (10) for connecting modules, in particular for constructing a spacecraft of modular design, wherein, in order to connect the modules, the coupling device (10) can be coupled to an identically constructed further androgynous coupling device and has a plurality of coupling elements (30, 32). It is provided that the androgynous coupling device (10) has a covering element (18) which covers the coupling elements (30, 32) in a passive state of the coupling device (10), wherein a first of the coupling elements (30) can be moved outwardly through the covering element (18) for active coupling to the identically constructed further coupling device. The invention furthermore relates to a module, in particular a module for constructing a spacecraft of modular design, having at least one such coupling device (10).
    Type: Grant
    Filed: March 30, 2015
    Date of Patent: May 7, 2019
    Assignee: Rheinisch-Westfälische Technische Hochschule (RWTH) Aachen
    Inventors: Martin Anand Lakshmanan, Marc André Adomeit, Patric Seefeldt, Viktor Reimer
  • Publication number: 20190091636
    Abstract: The subject of the invention is new membranes in which tailor-made membrane transport proteins (such as e.g. TCDB classified proteins) act as pore-forming proteins (e.g. FhuA) or peptides which act as pores in the membrane. The membranes can preferably be produced both by linking synthesised protein-polymer conjugates and by direct linking of the pore-forming proteins and peptides. Such membranes are distinguished by many outstanding features which existing membranes have not been able to offer to date.
    Type: Application
    Filed: March 1, 2017
    Publication date: March 28, 2019
    Applicants: FRAUNHOFER-GESELLSCHAFT ZUR FÖRDERUNG DER ANGEWANDTEN FORSCHUNG E.V., RHEINISCH-WESTFÄLISCHE TECHNISCHE HOCHSCHULE (RWTH) AACHEN
    Inventors: Himanshu CHARAN, Ulrich GLEBE, Alexander BÖKER, Murat TUTUS, Ulrich SCHWANEBERG, Leilei ZHU, Marco BOCOLA, Tayebeh MIRZAEIGARAKANI, Julia KINZEL, Deepak ANAND
  • Patent number: 10225018
    Abstract: A transmitter (TX) for a WDM optical link includes a light source (CS) generating a plurality of discrete lines (EL) with different frequencies (f), a plurality of modulators (FSM, RRM, MZM), each modulator (FSM, RRM, MZM) being configured to modulate one of the discrete lines (EL) according to a data stream (c1-c4), at least one optical amplifier (SOA) configured to simultaneously amplify multiple lines (EL), wherein only a subset of the generated lines (EL) is routed to the optical amplifier (SOA) resp. to each one of the optical amplifiers (SOA). A receiver (RX) for an optical link adapted to work together with the transmitter (TX) is also described. An optical link including the transmitter (TX) and/or the receiver (RX), and a method to operate said link are also described.
    Type: Grant
    Filed: March 26, 2015
    Date of Patent: March 5, 2019
    Assignee: RWTH Aachen
    Inventors: Jeremy Witzens, Florian Merget, Juliana Mueller
  • Publication number: 20190017124
    Abstract: The present invention relates in a first aspect to new methods for diagnosing or identifying breast cancer or pre-forms thereof in a subject as well as methods for monitoring the development or progress of breast cancer or pre-forms thereof in a subject and methods for the stratification of the therapeutic regimen of a subject suspected to be afflicted with breast cancer or being at risk of developing breast cancer or pre-forms thereof whereby the level or amount of methylation of at least one of the promoters selected from SPAG6-, PER1- and NKX2-6-gene in a sample of said subject is determined followed by the step of diagnosing or identifying breast cancer or pre-forms thereof based on the level on amount of methylation of the at least one promoter. Further, the present invention relates to the use of a kit in a method according to the present invention.
    Type: Application
    Filed: October 28, 2016
    Publication date: January 17, 2019
    Applicant: RHEINISCH-WESTFÄLISCHE TECHNISCHE HOCHSCHULE (RWTH) AACHEN
    Inventors: Edgar DAHL, Vera KLOTEN, Jolein MIJNES
  • Patent number: 10166534
    Abstract: A method for the reduction organic molecules comprising a Ruthenium-Triphosphine complex with aromatic ligands at the phosphors which are ortho or meta substituted.
    Type: Grant
    Filed: February 11, 2015
    Date of Patent: January 1, 2019
    Assignee: RHEINISCH-WESTFALISCHE TECHNISCHE HOCHSCHULE (RWTH) AACHEN
    Inventors: Jürgen Klankermayer, Walter Leitner, Markus Meuresch
  • Patent number: 10168497
    Abstract: An apparatus may include a photonic device with at least a first waveguide having a light-conducting core bounded by at least one cladding layer, at least a second waveguide having a light-conducting core bounded by at least one cladding layer, wherein the first waveguide is aligned to couple with the second waveguide, wherein alignment of the first waveguide with the second waveguide with respect to at least one axis C coincides with at least one stop area of the photonic device resting on a stop surface of a corresponding support structure on a substrate, wherein the stop area is a stop in a recess from a surface of the photonic device. A method to fabricate the apparatus may include the recess is formed by etching of the photonic device, and/or the support structure is formed by etching of the substrate.
    Type: Grant
    Filed: June 15, 2015
    Date of Patent: January 1, 2019
    Assignee: RWTH Aachen
    Inventors: Florian Merget, Jeremy Witzens, Alvaro Moscoso-Martir
  • Publication number: 20180180826
    Abstract: An apparatus may include a photonic device with at least a first waveguide having a light-conducting core bounded by at least one cladding layer, at least a second waveguide having a light-conducting core bounded by at least one cladding layer, wherein the first waveguide is aligned to couple with the second waveguide, wherein alignment of the first waveguide with the second waveguide with respect to at least one axis C coincides with at least one stop area of the photonic device resting on a stop surface of a corresponding support structure on a substrate, wherein the stop area is a stop in a recess from a surface of the photonic device. A method to fabricate the apparatus may include the recess is formed by etching of the photonic device, and/or the support structure is formed by etching of the substrate.
    Type: Application
    Filed: June 15, 2015
    Publication date: June 28, 2018
    Applicant: RWTH Aachen
    Inventors: Florian Merget, Jeremy Witzens, Alvaro Moscoso-Martir
  • Publication number: 20180054257
    Abstract: A transmitter (TX) for a WDM optical link includes a light source (CS) generating a plurality of discrete lines (EL) with different frequencies (f), a plurality of modulators (FSM, RRM, MZM), each modulator (FSM, RRM, MZM) being configured to modulate one of the discrete lines (EL) according to a data stream (c1-c4), at least one optical amplifier (SOA) configured to simultaneously amplify multiple lines (EL), wherein only a subset of the generated lines (EL) is routed to the optical amplifier (SOA) resp. to each one of the optical amplifiers (SOA). A receiver (RX) for an optical link adapted to work together with the transmitter (TX) is also described. An optical link including the transmitter (TX) and/or the receiver (RX), and a method to operate said link are also described.
    Type: Application
    Filed: March 26, 2015
    Publication date: February 22, 2018
    Applicant: RWTH Aachen
    Inventors: Jeremy Witzens, Florian Merget, Juliana Mueller
  • Publication number: 20180008972
    Abstract: A method for the reduction organic molecules comprising a Ruthenium-Triphosphine complex with aromatic ligands at the phosphors which are ortho or meta substituted.
    Type: Application
    Filed: February 11, 2015
    Publication date: January 11, 2018
    Applicant: RHEINISCH-WESTFÄLISCHE TECHNISCHE (RWTH) AACHEN
    Inventors: Jürgen KLANKERMAYER, Walter Leitner, Markus Meuresch