Abstract: A compound comprising three components A, B, and C, which components are covalently bound forming the compound having the structure A-B-C wherein component A has a specific binding affinity for antigens, component B is covalently linked to component A component C is a compound having an alkylated purine or pyrimidine moiety such as guanine, cytosine or a Coenzyme A moiety and linked thereto a moiety having a physiological effect with the proviso that component B has an catalytical or acceptor activity to couple component C with covalently coupled components A-B.

Abstract: A THz antenna array has a plurality of THz antennae, a THz antenna having a photoconductive region and a first electrode and a second electrode which are arranged interspaced from each other via a spacer region that extends laterally across at least a part of the photoconductive region. In order to simplify the structure and facilitate its production, a lateral region between adjacent THz antennae of the array is not photoconductive. It is especially free from photoconductive material.

Abstract: The present invention relates to a method for the preparation of a surface structured bulk hydrogel bearing a topographic and chemical pattern, comprising the steps of: (i) providing a primary master having a predetermined topographic pattern, (ii) replicating said primary master by an elastomeric secondary master to obtain a secondary master with said predetermined topographic pattern in its inverse form, (iii) replicating said secondary master by an imprintable curable material of hydrogel precursor molecules which are capable of forming a hydrogel once crosslinked by curing, and crosslinking said material to thereby yield a replica made of cross-linked bulk hydrogel bearing the topographic pattern identical to that of the primary master, and (iv) functionalizing, particularly biofunctionalizing, the bulk hydrogel replica.

Abstract: A phase noise detection apparatus comprises a laser beam, an optical resonator coupled thereto at a coupling point and a photodetector receiving light from the laser beam. The laser beam and the resonator coupled thereto convert phase noise of light transported by the laser beam prior to the coupling point into intensity noise of light transported by the laser beam thereafter. Intensity noise is converted into an electrical signal by the photodetector. The electrical signal is sent through a first signal path and a second signal path such that the first signal path transports a signal substantially proportional to the intensity noise, which is integrated in an integrator in the second path. Relative gain of the two signal paths can be adjusted and the overall gain of the signal path is preferably such that the optical phase modulator at least partially cancels said phase noise in the optical domain.

Abstract: A method and an apparatus for butt-coupling an input beam incoming from a photonic device of a second optical element to a primary photonic chip at an input interface of the primary photonic chip is disclosed. The primary photonic chip comprises a coupling apparatus. The light from the input beam is butt-coupled to the coupling apparatus. The coupling apparatus comprises a plurality of more than one single mode optical paths on the primary photonic chip. The single mode optical paths are strongly coupled to each other at the input interface of the primary photonic chip. Regions of strongly coupled single mode optical paths can correspond to one or both of distinct but highly coupled waveguides or waveguides fully merged into a multi-mode section.

Abstract: The invention relates to polypeptides of amino acid sequence SEQ ID NO: 1 according to formula (1), the use thereof for producing a medicament, and medicaments for the treatment of diseases related to monocyte recruitment.

Abstract: A photonic apparatus comprises an integrated waveguide, an integrated resonator in the form of a microtoroid and a thermally reflowable film. The reflowable film comprises a first film area and a second film area. The reflowable film is one of a thin film and a stack of thin films. The first film area is thermally reflown, the microtoroid is formed in the thermally reflown first film area. The second film area is not reflown in the immediate vicinity of the microtoroid. The microtoroid is optically coupled to the integrated waveguide located on or located within one of or both of the first or second film areas. The first and second film areas are directly connected to each other. The microtoroid has an edge extending along a circumference. The microtoroid can be a non-inverted or an inverted microtoroid, wherein the second film area is inside or outside of the circumference.

Abstract: The present invention relates to a label-free biosensor system, a method for manufacturing said label-free biosensor system, its use for detecting biochemical reactions and/or bindings, enzymatic reactions, nucleic acid hybridizations, protein-protein interactions and protein-ligand interactions, as well as an assay method for detecting and/or quantifying an analyte of interest in a biological sample which comprises detecting the Recognition Induced Birefringence (RIB) generated in the presence as opposed to the absence of said analyte by bringing said sample into contact with said label-free biosensor system.

Abstract: The invention relates to a method and a device for the recording of process parameters of reaction fluids in several microreactors which are continuously agitated, at least until the termination of the reaction in all the microreactors. The process parameters in the microreactor are recorded during the reaction by means of at least one sensor optical system. According to the invention, the reliability of the method may be increased, whereby, during the recording of the value of a process parameter, for example, on recording an instantaneous value of the auto-fluorescence of the reaction fluids, the sensor optical system is held stationary.

Abstract: The invention relates to a microtiter plate and use thereof for conducting fermentation under fed-batch conditions. In order to produce a microtiter plate which permits screening under fed-batch conditions, the invention proposes that the cavities (2) of the microtiter plate according to the invention be filled with a culturing fluid and nutrient solution and be designed in such a way that each of the cavities (2) of the microtiter plate which is filled with nutrient solution is connected by a channel (4) to at least one other further cavity (3) of the microtiter plate which is filled with a culturing fluid. A diffusion barrier (13) arranged in the material permeable channel (4) controls the kinetics of the material transfer of nutrients from the cavity containing the nutrient solution to the cavities containing the culturing fluid.

Abstract: A nuclear magnetic resonance (NMR) method for detecting hydrogen peroxide includes stimulating a spin signal in a liquid sample in a static magnetic field by exciting the sample with a first electromagnetic pulse having a frequency corresponding to a hydrogen NMR frequency; after a first time period, refocusing the spin signal by a series of second electromagnetic pulses also having the NMR-corresponding frequency and separated by a first echo time, while sampling a first train of spin signals; and refocusing the spin signal by a series of third electromagnetic pulses having the NMR-corresponding frequency and separated by a second echo time while sampling a second train of spin signals, the second echo time different from the first echo time. First and second spin-spin relaxation times are derived from the trains of spin signals, and a quotient of the spin-spin relaxation times indicates the presence of hydrogen peroxide.

Abstract: A magnet arrangement includes (a) a first and a second head ring magnet each having a substantially circular geometry with respect to a center axis and (b) a central ring magnet having a substantially circular geometry with respect to a center axis. The central ring magnet is disposed between the first and second head ring magnet in direction of the center axis. At least one of the magnets includes a first number of first magnets having at least one trapezoidal cross section and a second number of second magnets having at least one rectangular cross section. The second magnets are disposed in between the first magnets in circumferential direction. With this geometrical arrangement, magnets having a trapezoidal cross section include a guidance for a magnet having a rectangular cross section allowing the movements in radial direction of these last magnets.

Abstract: The invention relates to polypeptides of amino acid sequence SEQ ID NO: 1 according to formula (1), the use thereof for producing a medicament, and medicaments for the treatment of diseases related to monocyte recruitment.

Abstract: An apparatus for providing a sensitive volume for single-sided NMR includes: (i) at least one first permanent magnet for providing a first magnetic field at the sensitive volume; and (ii) at least one of the following means for superimposing at least one second magnetic field for homogenizing the first magnetic field in the sensitive volume: (A) at least one shim magnet, (B) at least one pair of shim magnets, and (C) at least one electrical conductor being connectable to an electric current source. The at least one second magnetic field is adjusted such that the magnetic field homogeneity in the sensitive volume is corresponding to a line width of hydrogen (1H) of less than 10 ppm.

Abstract: A method for performing magnetic resonance measurements on a sample includes applying a first predetermined number of pulse trains for excitation, each pulse train having a constant amplitude and including a second predetermined number of pulses spaced by a predetermined time interval. The pulse trains are modulated by a bent function. After each pulse, data is sampled. Preferably a square number of pulses is generated being constant in power, and the Walsh transform of the sequence of their phases is constant in power, so that the power of the excitation in time and frequency domain is constant. The method can reduce power requirements and may permit undercutting specific absorption rate (SAR) limits due to the small excitation power necessary to create time signals with reasonable signal to noise ratio.

Abstract: The present invention relates to a process for the preparation of composites from thermoplastic polymers and (semi)metal oxides, in particular silicon dioxide, wherein at least a part of the (semi)metal oxides is dispersed in the polymers in nanodispersed manner (nanocomposites). The invention relates to the composites obtainable by this process and their processing to give molded articles.

Abstract: S-Adenosyl-L-methionine analogs of formula (I): are disclosed wherein R comprises a carbon-carbon double bond, carbon-sulfur double bond, carbon-nitrogen double bond, -a carbon-carbon triple bond, carbon-nitrogen triple bond or an aromatic carbocyclic or heterocyclic system in ?-position to the sulfonium center, X{circle around (?)} is an organic or inorganic anion carrying one or more negative charges, Z is —CR1R2—, —O—, —S— or —NR3— and R1, R2 and R3 are independently selected from H, D and C1—C alkyl; as well as complexes with a methyltransferase, pharmaceutical compositions, methods for modifying a biomolecule, and methods for detecting sequences specific methylation of biomolecules.

Abstract: In a method for embedding steganographic information into the signal information of a signal encoder, a solution is to be created, which enables steganographic information being embedded into the signal information of a signal encoder such that a reduction of the voice quality is largely avoided.

Abstract: A THz antenna array has a plurality of THz antennae, a THz antenna having a photoconductive region and a first electrode and a second electrode which are arranged interspaced from each other via a spacer region that extends laterally across at least a part of the photoconductive region. In order to simplify the structure and facilitate its production, a lateral region between adjacent THz antennae of the array is not photoconductive. It is especially free from photoconductive material.

Abstract: The present invention relates to a label-free biosensor system, a method for manufacturing said label-free biosensor system, its use for detecting biochemical reactions and/or bindings, enzymatic reactions, nucleic acid hybridizations, protein-protein interactions and protein-ligand interactions, as well as an assay method for detecting and/or quantifying an analyte of interest in a biological sample which comprises detecting the Recognition Induced Birefringence (RIB) generated in the presence as opposed to the absence of said analyte by bringing said sample into contact with said label-free biosensor system.