Abstract: The subject of the invention is new membranes in which tailor-made membrane transport proteins (such as e.g. TCDB classified proteins) act as pore-forming proteins (e.g. FhuA) or peptides which act as pores in the membrane. The membranes can preferably be produced both by linking synthesised protein-polymer conjugates and by direct linking of the pore-forming proteins and peptides. Such membranes are distinguished by many outstanding features which existing membranes have not been able to offer to date.

Abstract: A transmitter (TX) for a WDM optical link includes a light source (CS) generating a plurality of discrete lines (EL) with different frequencies (f), a plurality of modulators (FSM, RRM, MZM), each modulator (FSM, RRM, MZM) being configured to modulate one of the discrete lines (EL) according to a data stream (c1-c4), at least one optical amplifier (SOA) configured to simultaneously amplify multiple lines (EL), wherein only a subset of the generated lines (EL) is routed to the optical amplifier (SOA) resp. to each one of the optical amplifiers (SOA). A receiver (RX) for an optical link adapted to work together with the transmitter (TX) is also described. An optical link including the transmitter (TX) and/or the receiver (RX), and a method to operate said link are also described.

Abstract: The present invention relates in a first aspect to new methods for diagnosing or identifying breast cancer or pre-forms thereof in a subject as well as methods for monitoring the development or progress of breast cancer or pre-forms thereof in a subject and methods for the stratification of the therapeutic regimen of a subject suspected to be afflicted with breast cancer or being at risk of developing breast cancer or pre-forms thereof whereby the level or amount of methylation of at least one of the promoters selected from SPAG6-, PER1- and NKX2-6-gene in a sample of said subject is determined followed by the step of diagnosing or identifying breast cancer or pre-forms thereof based on the level on amount of methylation of the at least one promoter. Further, the present invention relates to the use of a kit in a method according to the present invention.

Abstract: A method for the reduction organic molecules comprising a Ruthenium-Triphosphine complex with aromatic ligands at the phosphors which are ortho or meta substituted.

Abstract: An apparatus may include a photonic device with at least a first waveguide having a light-conducting core bounded by at least one cladding layer, at least a second waveguide having a light-conducting core bounded by at least one cladding layer, wherein the first waveguide is aligned to couple with the second waveguide, wherein alignment of the first waveguide with the second waveguide with respect to at least one axis C coincides with at least one stop area of the photonic device resting on a stop surface of a corresponding support structure on a substrate, wherein the stop area is a stop in a recess from a surface of the photonic device. A method to fabricate the apparatus may include the recess is formed by etching of the photonic device, and/or the support structure is formed by etching of the substrate.

Abstract: An apparatus may include a photonic device with at least a first waveguide having a light-conducting core bounded by at least one cladding layer, at least a second waveguide having a light-conducting core bounded by at least one cladding layer, wherein the first waveguide is aligned to couple with the second waveguide, wherein alignment of the first waveguide with the second waveguide with respect to at least one axis C coincides with at least one stop area of the photonic device resting on a stop surface of a corresponding support structure on a substrate, wherein the stop area is a stop in a recess from a surface of the photonic device. A method to fabricate the apparatus may include the recess is formed by etching of the photonic device, and/or the support structure is formed by etching of the substrate.

Abstract: A transmitter (TX) for a WDM optical link includes a light source (CS) generating a plurality of discrete lines (EL) with different frequencies (f), a plurality of modulators (FSM, RRM, MZM), each modulator (FSM, RRM, MZM) being configured to modulate one of the discrete lines (EL) according to a data stream (c1-c4), at least one optical amplifier (SOA) configured to simultaneously amplify multiple lines (EL), wherein only a subset of the generated lines (EL) is routed to the optical amplifier (SOA) resp. to each one of the optical amplifiers (SOA). A receiver (RX) for an optical link adapted to work together with the transmitter (TX) is also described. An optical link including the transmitter (TX) and/or the receiver (RX), and a method to operate said link are also described.

Abstract: A method for the reduction organic molecules comprising a Ruthenium-Triphosphine complex with aromatic ligands at the phosphors which are ortho or meta substituted.

Abstract: The invention relates to a sequential broadband Doherty power amplifier with adjustable output power back-off The sequential broadband Doherty power amplifier has at least one input (I1, I2; RFin) for receiving at least one broadband HF signal, wherein the broadband HF signal or broadband HF signals (RFin) have at least an average power level (carrier/average) and a peak envelope power level (peak), with the average power level and the peak envelope power level defining a crest factor, and a first amplifier branch for amplifying the input signal, with the first amplifier branch providing the amplification substantially for the low and at least the average power level, at least one second amplifier branch for amplifying the input signal, wherein the second amplifier branch substantially provides the amplification for the peak envelope power level, wherein the output of the first amplifier branch is connected via an impedance inverter (ZT) to the output of the second amplifier branch, the junction (CN) being co

Abstract: A method for synthesizing a primary amine, having the steps of: a) providing at least one dianhydrohexitol, and b) aminating the dianhydrohexitol by reacting same with ammonia, the amination being performed by heterogeneous catalysis using a hydrogenation catalyst in the presence of hydrogen.

Abstract: A method for synthesizing a primary amine, having the steps of: a) providing at least one dianhydrohexitol, and b) aminating the dianhydrohexitol by reacting same with ammonia, the amination being performed by heterogeneous catalysis using a hydrogenation catalyst in the presence of hydrogen.

Abstract: A method for the methylation of amines, amides and imines comprises the step of reacting these compounds with CO2 and H2 in the presence of a Ruthenium-phosphine complex.

Abstract: The invention relates to an androgynous coupling device (10) for connecting modules, in particular for constructing a spacecraft of modular design, wherein, in order to connect the modules, the coupling device (10) can be coupled to an identically constructed further androgynous coupling device and has a plurality of coupling elements (30, 32). It is provided that the androgynous coupling device (10) has a covering element (18) which covers the coupling elements (30, 32) in a passive state of the coupling device (10), wherein a first of the coupling elements (30) can be moved outwardly through the covering element (18) for active coupling to the identically constructed further coupling device. The invention furthermore relates to a module, in particular a module for constructing a spacecraft of modular design, having at least one such coupling device (10).

Abstract: An optically end-pumped amplifier with a plate-shaped optical gain medium has a plurality of pump laser units for optically pumping the gain medium through at least one of the narrow side surfaces thereof. The pump laser units are designed such that the pump laser radiation, upon passing through the gain medium, has an elongated beam cross section having a short axis and a long axis running parallel to the main surfaces of the gain medium and propagates freely through the gain medium with respect to the short axis. They are arranged such that in each case the principal axes of the beam bundles of the pump laser units impinge on one of the pumped side surfaces in a plane perpendicular to the short axis at an angle to one another, wherein the beam cross sections of the beam bundles are superimposed on one another.

Abstract: A lithographic manufacturing system produces periodic structures with feature sizes less than 10 nm and a direction of periodicity (D). A beam of radiation (1904) having a range of wavelengths in the EUV spectrum (1-100 nm or 1-150 nm) is focused into a spot (S) of around 5 ?m diameter. Reflected radiation (1908) is broken into a spectrum (1910) which is captured (1913) to obtain a target spectrum signal (ST). A reference spectrum is detected (1914) to obtain a reference spectrum signal (SR). Optionally a detector (1950) is provided to obtain a further spectrum signal (SF) using radiation diffracted at first order by the grating structure of the target. The angle of incidence (?) and azimuthal angle (?) are adjustable. The signals (ST, SR, SF) obtained at one or more angles are used to calculate measured properties of the target, for example CD and overlay.

Abstract: A method for reading out a non-volatile memory element having at least two stable states 0 and 1. This memory element comprises at least one resistive memory cell, which encodes the two states 0 and 1 into a state HRS having higher electrical resistance and a state LRS having lower electrical resistance. In the two states 0 and 1, the memory element has differing capacitances C0,1; this difference is used to determine which state is present. A memory element is selected in which a fixed capacitance that is independent of the state of the memory cell is connected in series with the memory cell. A series connection of a resistive memory cell with a fixed capacitance, instead of with a second resistive memory cell, improves the signal strength during capacitive read-out. The second memory cell becomes indispensable for the memory function when the memory element is read out capacitively.

Abstract: The application relates to a method for determining beam parameters of a charge carrier beam, a measuring device, and a charge carrier beam device. The charge carrier beam (4) from a charge carrier beam device (1) is guided, by means of a beam deflection unit (3), over a slit aperture arrangement which is provided in an aperture device (7) and which has one or more slit apertures (8). Measurement plane coordinates of the beam components that penetrate the slit aperture arrangement are determined. On the basis of the measurement plane coordinates, the aperture device automatically moves in such a way that a measuring aperture (9) arranged in the aperture device moves over a predefined measurement reference point. The beam parameter is measured by the measuring aperture. In a measuring device (5) suitable for carrying out said method, the slit aperture arrangement has at least two non-parallel slit aperture sections (12, 13, 15, 16) which can be part of a single continuous slit aperture.

Abstract: A method and an apparatus for butt-coupling an input beam incoming from a photonic device of a second optical element to a primary photonic chip at an input interface of the primary photonic chip is disclosed. The primary photonic chip comprises a coupling apparatus. The light from the input beam is butt-coupled to the coupling apparatus. The coupling apparatus comprises a plurality of more than one single mode optical paths on the primary photonic chip. The single mode optical paths are strongly coupled to each other at the input interface of the primary photonic chip. Regions of strongly coupled single mode optical paths can correspond to one or both of distinct but highly coupled waveguides or waveguides fully merged into a multi-mode section.

Abstract: A photonic apparatus comprises an integrated waveguide, an integrated resonator in the form of a microtoroid and a thermally reflowable film. The reflowable film comprises a first film area and a second film area. The reflowable film is one of a thin film and a stack of thin films. The first film area is thermally reflown, the microtoroid is formed in the thermally reflown first film area. The second film area is not reflown in the immediate vicinity of the microtoroid. The microtoroid is optically coupled to the integrated waveguide located on or located within one of or both of the first or second film areas. The first and second film areas are directly connected to each other. The microtoroid has an edge extending along a circumference. The microtoroid can be a non-inverted or an inverted microtoroid, wherein the second film area is inside or outside of the circumference.

Abstract: The invention relates to an amplifier assembly.