Abstract: A method for the reduction organic molecules comprising a Ruthenium-Triphosphine complex with aromatic ligands at the phosphors which are ortho or meta substituted.

Abstract: The invention provides a multimodal ultrasound and photoacoustic contrast agent based on polymeric microparticles having a gas core and carrying at least one photoacoustic agent in its shell that stabilizes the gas core, for use in ultrasound and photoacoustic imaging. Such multimodal ultrasound and photoacoustic contrast agent is also suitable as a carrier of drugs and for use in photodynamic therapy, and for tissue imaging ex vivo.

Abstract: A method of diagnosing a disease associated with a DNA repeat sequence is disclosed. The method comprises: (a) determining the number of repeats of a DNA sequence in DNA molecules of a sample of the subject; and (b) determining the CpG methylation status of the DNA molecules, wherein the number of repeats of the DNA sequence and the CpG methylation status of the DNA molecules is indicative of the disease.

Abstract: The invention relates to a for a targeted shaping of the magnetic field of a single permanent magnet or an arrangement of a plurality of permanent magnets, wherein magnetic material from selected locations of the single permanent magnet or at least one of said permanent magnets of the arrangement is removed by means of at least one of the following removal procedures for shaping the magnetic field: laser ablation using laser radiation, high-pressure waterblasting using high-pressure water jets and mechanical ablation using a non-magnetic tool.

Abstract: A method for the reduction organic molecules comprising a Ruthenium-Triphosphine complex with aromatic ligands at the phosphors which are ortho or meta substituted.

Abstract: The invention relates to an androgynous coupling device (10) for connecting modules, in particular for constructing a spacecraft of modular design, wherein, in order to connect the modules, the coupling device (10) can be coupled to an identically constructed further androgynous coupling device and has a plurality of coupling elements (30, 32). It is provided that the androgynous coupling device (10) has a covering element (18) which covers the coupling elements (30, 32) in a passive state of the coupling device (10), wherein a first of the coupling elements (30) can be moved outwardly through the covering element (18) for active coupling to the identically constructed further coupling device. The invention furthermore relates to a module, in particular a module for constructing a spacecraft of modular design, having at least one such coupling device (10).

Abstract: The subject of the invention is new membranes in which tailor-made membrane transport proteins (such as e.g. TCDB classified proteins) act as pore-forming proteins (e.g. FhuA) or peptides which act as pores in the membrane. The membranes can preferably be produced both by linking synthesised protein-polymer conjugates and by direct linking of the pore-forming proteins and peptides. Such membranes are distinguished by many outstanding features which existing membranes have not been able to offer to date.

Abstract: A transmitter (TX) for a WDM optical link includes a light source (CS) generating a plurality of discrete lines (EL) with different frequencies (f), a plurality of modulators (FSM, RRM, MZM), each modulator (FSM, RRM, MZM) being configured to modulate one of the discrete lines (EL) according to a data stream (c1-c4), at least one optical amplifier (SOA) configured to simultaneously amplify multiple lines (EL), wherein only a subset of the generated lines (EL) is routed to the optical amplifier (SOA) resp. to each one of the optical amplifiers (SOA). A receiver (RX) for an optical link adapted to work together with the transmitter (TX) is also described. An optical link including the transmitter (TX) and/or the receiver (RX), and a method to operate said link are also described.

Abstract: The present invention relates in a first aspect to new methods for diagnosing or identifying breast cancer or pre-forms thereof in a subject as well as methods for monitoring the development or progress of breast cancer or pre-forms thereof in a subject and methods for the stratification of the therapeutic regimen of a subject suspected to be afflicted with breast cancer or being at risk of developing breast cancer or pre-forms thereof whereby the level or amount of methylation of at least one of the promoters selected from SPAG6-, PER1- and NKX2-6-gene in a sample of said subject is determined followed by the step of diagnosing or identifying breast cancer or pre-forms thereof based on the level on amount of methylation of the at least one promoter. Further, the present invention relates to the use of a kit in a method according to the present invention.

Abstract: An apparatus may include a photonic device with at least a first waveguide having a light-conducting core bounded by at least one cladding layer, at least a second waveguide having a light-conducting core bounded by at least one cladding layer, wherein the first waveguide is aligned to couple with the second waveguide, wherein alignment of the first waveguide with the second waveguide with respect to at least one axis C coincides with at least one stop area of the photonic device resting on a stop surface of a corresponding support structure on a substrate, wherein the stop area is a stop in a recess from a surface of the photonic device. A method to fabricate the apparatus may include the recess is formed by etching of the photonic device, and/or the support structure is formed by etching of the substrate.

Abstract: A method for the reduction organic molecules comprising a Ruthenium-Triphosphine complex with aromatic ligands at the phosphors which are ortho or meta substituted.

Abstract: An apparatus may include a photonic device with at least a first waveguide having a light-conducting core bounded by at least one cladding layer, at least a second waveguide having a light-conducting core bounded by at least one cladding layer, wherein the first waveguide is aligned to couple with the second waveguide, wherein alignment of the first waveguide with the second waveguide with respect to at least one axis C coincides with at least one stop area of the photonic device resting on a stop surface of a corresponding support structure on a substrate, wherein the stop area is a stop in a recess from a surface of the photonic device. A method to fabricate the apparatus may include the recess is formed by etching of the photonic device, and/or the support structure is formed by etching of the substrate.

Abstract: A transmitter (TX) for a WDM optical link includes a light source (CS) generating a plurality of discrete lines (EL) with different frequencies (f), a plurality of modulators (FSM, RRM, MZM), each modulator (FSM, RRM, MZM) being configured to modulate one of the discrete lines (EL) according to a data stream (c1-c4), at least one optical amplifier (SOA) configured to simultaneously amplify multiple lines (EL), wherein only a subset of the generated lines (EL) is routed to the optical amplifier (SOA) resp. to each one of the optical amplifiers (SOA). A receiver (RX) for an optical link adapted to work together with the transmitter (TX) is also described. An optical link including the transmitter (TX) and/or the receiver (RX), and a method to operate said link are also described.

Abstract: A method for the reduction organic molecules comprising a Ruthenium-Triphosphine complex with aromatic ligands at the phosphors which are ortho or meta substituted.

Abstract: The invention relates to a sequential broadband Doherty power amplifier with adjustable output power back-off The sequential broadband Doherty power amplifier has at least one input (I1, I2; RFin) for receiving at least one broadband HF signal, wherein the broadband HF signal or broadband HF signals (RFin) have at least an average power level (carrier/average) and a peak envelope power level (peak), with the average power level and the peak envelope power level defining a crest factor, and a first amplifier branch for amplifying the input signal, with the first amplifier branch providing the amplification substantially for the low and at least the average power level, at least one second amplifier branch for amplifying the input signal, wherein the second amplifier branch substantially provides the amplification for the peak envelope power level, wherein the output of the first amplifier branch is connected via an impedance inverter (ZT) to the output of the second amplifier branch, the junction (CN) being co

Abstract: A method for synthesizing a primary amine, having the steps of: a) providing at least one dianhydrohexitol, and b) aminating the dianhydrohexitol by reacting same with ammonia, the amination being performed by heterogeneous catalysis using a hydrogenation catalyst in the presence of hydrogen.

Abstract: A method for synthesizing a primary amine, having the steps of: a) providing at least one dianhydrohexitol, and b) aminating the dianhydrohexitol by reacting same with ammonia, the amination being performed by heterogeneous catalysis using a hydrogenation catalyst in the presence of hydrogen.

Abstract: A method for the methylation of amines, amides and imines comprises the step of reacting these compounds with CO2 and H2 in the presence of a Ruthenium-phosphine complex.

Abstract: The invention relates to an androgynous coupling device (10) for connecting modules, in particular for constructing a spacecraft of modular design, wherein, in order to connect the modules, the coupling device (10) can be coupled to an identically constructed further androgynous coupling device and has a plurality of coupling elements (30, 32). It is provided that the androgynous coupling device (10) has a covering element (18) which covers the coupling elements (30, 32) in a passive state of the coupling device (10), wherein a first of the coupling elements (30) can be moved outwardly through the covering element (18) for active coupling to the identically constructed further coupling device. The invention furthermore relates to a module, in particular a module for constructing a spacecraft of modular design, having at least one such coupling device (10).

Abstract: An optically end-pumped amplifier with a plate-shaped optical gain medium has a plurality of pump laser units for optically pumping the gain medium through at least one of the narrow side surfaces thereof. The pump laser units are designed such that the pump laser radiation, upon passing through the gain medium, has an elongated beam cross section having a short axis and a long axis running parallel to the main surfaces of the gain medium and propagates freely through the gain medium with respect to the short axis. They are arranged such that in each case the principal axes of the beam bundles of the pump laser units impinge on one of the pumped side surfaces in a plane perpendicular to the short axis at an angle to one another, wherein the beam cross sections of the beam bundles are superimposed on one another.