Patents Assigned to Sandoz Inc.
  • Method of promoting sleep
    Patent number: 4032637
    Abstract: The present invention concerns a novel therapeutic use as a sleep-promoting agent for the known pharmaceutical compound 10-[2-(1-methyl-2-piperidyl)ethyl]-2-methylsulphinylphenothiazine of the formula: ##STR1##
    Type: Grant
    Filed: October 31, 1974
    Date of Patent: June 28, 1977
    Assignees: Sandoz Ltd., Sandoz, Inc.
    Inventors: Rene Spiegel, John H. Gogerty, Dieter M. Loew, Phillip L. Eden
  • 1,4-Substituted-quinolin-2(1H)-ones as CNS agents
    Patent number: 4032528
    Abstract: Disclosed are compounds which are 1-alkyl-4-alkoxyquinolin-2(1H)-ones, e.g., 1-methyl-4-butoxyquinolin-2(1H)-one, and which are useful as CNS depressant agents. The compounds may be prepared, for example, by reacting a 1-alkyl-4-hydroxyquinolin-2(1H)-one with an alkyl halide in presence of base.
    Type: Grant
    Filed: September 18, 1975
    Date of Patent: June 28, 1977
    Assignee: Sandoz, Inc.
    Inventor: Goetz E. Hardtmann
  • Substituted 2H,3H-2,1-benzisothiazole-S-oxides, method of use and pharmaceutical compositions thereof
    Patent number: 4031227
    Abstract: The invention discloses substituted 2H,3H-2,1-benzisothiazole-S-oxides having pharmacological activity in animals and useful as CNS depressant agents. The compounds may be prepared by reacting a substituted 2H,3H-2,1-benzisothiazole with an oxidizing agent. The substituted 2H,3H-2,1-benzisothiazole may be prepared by reacting a substituted .alpha.-methylthio-o-toluidine with one equivalent of an oxidizing agent, followed by treatment with base.
    Type: Grant
    Filed: September 18, 1975
    Date of Patent: June 21, 1977
    Assignee: Sandoz, Inc.
    Inventor: Thomas E. Jackson
  • Phenoxyphenyl imidazolyl methanols and ketone derivatives thereof
    Patent number: 4031233
    Abstract: Imidazolyl-phenoxyphenyl-carbinols and ketones, e.g., .alpha.-(p-phenoxyphenyl)-1-methyl-2-imidazolylmethanol and p-phenoxyphenyl 1-methyl-2-imidazolyl ketone, are useful as hypolipidemic agents. The ketones are obtainable by oxidation of corresponding imidazolyl-phenoxyphenyl-carbinols.
    Type: Grant
    Filed: February 9, 1976
    Date of Patent: June 21, 1977
    Assignee: Sandoz, Inc.
    Inventor: Faizulla G. Kathawala
  • N-alkylcarbonyloxyalkyl isatoic and 3-azaisatoie anhydrides
    Patent number: 4025511
    Abstract: The compounds of this invention are N-alkylcarbonyloxyalkyl substituted isatoic and 3-azaisatoic anhydrides useful as intermediate for pharmacologically active compounds which are prepared by reaction of such an ahydride with a cyclic pseudothiourea.
    Type: Grant
    Filed: December 24, 1974
    Date of Patent: May 24, 1977
    Assignee: Sandoz, Inc.
    Inventor: Goetz E. Hardtmann
  • Substituted hydroxy pyridones
    Patent number: 4024262
    Abstract: Substituted hydroxy pyridones, e.g., 3-(1-iminopropyl)-4-hydroxy-6-phenyl-1-methyl-2-(1H)-pyridone, are prepared by reducing corresponding isoxazolo[4,5-c]pyridin-4(5H)-ones and are useful as minor tranquilizers, sleep inducers and neuroleptics.
    Type: Grant
    Filed: March 5, 1976
    Date of Patent: May 17, 1977
    Assignee: Sandoz, Inc.
    Inventor: Jeffrey Nadelson
  • Thiodimethylene bis(pivalophenone)
    Patent number: 4024283
    Abstract: Substituted or unsubstituted thiodimethylene bis(pivalophenone), e.g., 4',4'"-(thiodimethylene) bis(pivalophenone) are prepared by treating a corresponding .alpha.-halo-p-tert-alkanoyl toluene with an alkali metal sulfide and are useful as hypolipidemic agents.
    Type: Grant
    Filed: August 15, 1975
    Date of Patent: May 17, 1977
    Assignee: Sandoz, Inc.
    Inventor: Jeffrey Nadelson
  • Preparation of aryl-butadienoic acids
    Patent number: 4024182
    Abstract: Aryl-butadienoic acids, e.g., 4-(p-tetradecyloxyphenyl)-2-methyl-buta-2,3-dienoic acid, are prepared by a process comprising converting an acyl halide of an aryl lower alkanoic acid to its corresponding .beta.,.beta.,.beta.-trichloroethyl ester of the desired aryl-butadienoic acid which is then treated with zinc to obtain the corresponding free arylbutadienoic acid.
    Type: Grant
    Filed: August 15, 1975
    Date of Patent: May 17, 1977
    Assignee: Sandoz, Inc.
    Inventor: Faizulla G. Kathawala
  • Substituted oxazoles and thiazoles as herbicides
    Patent number: 4022607
    Abstract: Substituted oxazoles and thiazoles are useful as herbicides.
    Type: Grant
    Filed: June 9, 1975
    Date of Patent: May 10, 1977
    Assignee: Sandoz, Inc.
    Inventor: Thomas E. Jackson
  • Dibromination process
    Patent number: 4021492
    Abstract: The .alpha.,.alpha.-dibromo-substituted or unsubstituted-4-pivaloyl toluenes, e.g., .alpha.,.alpha.-dibromo-4-pivaloyl toluene, are prepared by bromination of a corresponding p-pivaloyl toluene with liquid bromine at a temperature of at least 125.degree. C.
    Type: Grant
    Filed: November 12, 1975
    Date of Patent: May 3, 1977
    Assignee: Sandoz, Inc.
    Inventors: Jerome Linder, William J. Houlihan
  • N-(Substituted carbonylmethyl) isatoic anhydrides
    Patent number: 4020062
    Abstract: Isatoic anhydrides of the formula: ##STR1## wherein R is alkyl, phenyl or phenalkyl and R.sub.1 and R.sub.2 are hydrogen, halo, alkyl, alkoxy or together methylenedioxy are intermediates reactable with an acyclic 5-methyl-thiopseudourea and acetonitrile to pharmaceutical agents, for example, analgetic and hypotensive agents, of the formula: ##STR2## wherein R, R.sub.1 and R.sub.2 are as defined and R.sup.o is hydrogen, alkyl, .omega.-alkenyl or phenyl.
    Type: Grant
    Filed: January 3, 1975
    Date of Patent: April 26, 1977
    Assignee: Sandoz, Inc.
    Inventor: Goetz E. Hardtmann
  • 5-(2-Aminophenyl)-s-triazoles
    Patent number: 4020083
    Abstract: Anti-inflammatory agents of the formula: ##STR1## wherein R.degree. is hydrogen, halo, alkoxy, alkyl, or CF.sub.3 or two adjacent R.degree. together may also form methylenedioxy,R is hydrogen or lower alkyl, andn is 1 or 2.
    Type: Grant
    Filed: July 8, 1975
    Date of Patent: April 26, 1977
    Assignee: Sandoz, Inc.
    Inventor: Faizulla G. Kathawala
  • 6H(1)-Benzopyrano(3,2-c)quinolines
    Patent number: 4017499
    Abstract: Anti-inflammatory agents of the formula: ##STR1## wherein R is lower alkyl, lower alkenyl, lower alkynyl, benzyl, alkyl or halo-substituted benzyl or cycloalkylalkyl, X is CH or N, R' is hydrogen, halo, lower alkyl or lower alkoxy when X is CH and hydrogen and alkyl when X is N, and R" is hydrogen or lower alkyl.
    Type: Grant
    Filed: April 5, 1976
    Date of Patent: April 12, 1977
    Assignee: Sandoz, Inc.
    Inventors: Goetz E. Hardtmann, Gary M. Coppola
  • Pressure indicators for inflatable cuff-type catheters
    Patent number: 4016885
    Abstract: Inflatable cuff-type catheters, e.g., endotracheal and tracheotomy tubes, with cuff pressure indicators are provided. One indicator means comprises an expandable chamber with an open-ended spring about the mid-section of the chamber. As the chamber expands, the spring also expands to indicate the gas pressure in the cuff.
    Type: Grant
    Filed: June 30, 1975
    Date of Patent: April 12, 1977
    Assignee: Sandoz, Inc.
    Inventor: James D. Bruner
  • Synergistic insecticidal compositions containing .beta.-exotoxin
    Patent number: 4016265
    Abstract: A synergistic insecticidal composition comprises as a first ingredient the .beta.-exotoxin of Bacillus thuringiensis or a metal salt thereof and has a second ingredient of one or more of the following chemical insecticides:O,o-diethyl-O-(2-isopropyl-4-methyl-6-pyrimidyl) thionophosphate,O,o-dimethyl, .alpha.,.alpha.,.alpha.-trichloro-1-hydroxyethyl phosphonate,.alpha.-methoxy-4H-1,3,2-benzodioxaphosphorin-2-thione,O,o,-dimethyl S-(.alpha.-(ethoxycarbonyl)benzyl) phosphorodithioate,O,o-dimethyl S-(4-chlorophenyl) phosphorothioateThe first and second ingredients are used generally in a ratio of about 0.5:1 to 2.0:1 and may be dispersed in a major portion of an agronomically acceptable carrier.
    Type: Grant
    Filed: November 8, 1971
    Date of Patent: April 5, 1977
    Assignee: Sandoz, Inc.
    Inventors: Tadahiko Inoue, Gosaburo Dowke, Hideo Itoh
  • Oxadiazolyl benzamides
    Patent number: 4016170
    Abstract: Substituted or unsubstituted oxadiazolyl benzamides, e.g., o-(3-phenyl-1,2,4-oxadiazol-5-yl)-N-methyl-benzamide, are prepared by reacting a corresponding substituted or unsubstituted oxadiazoyl benzoic acid alkyl ester with an amine and are useful as minor tranquilizers and sleep inducers.
    Type: Grant
    Filed: November 18, 1975
    Date of Patent: April 5, 1977
    Assignee: Sandoz, Inc.
    Inventor: Jeffrey Nadelson
  • 1,2,5,6-Tetrahydro-4H-pyrrolo(3,2,1-j)quinolin-2-ones
    Patent number: 4015005
    Abstract: The invention discloses 1,2,5,6-tetrahydro-4H-pyrrolo-(3,2,1-ij)quinolin-2-ones having pharmacological activity in animals and useful as CNS depressant agents. The compounds may be prepared by treating a haloacetyl derivative of 1,2,3,4-tetrahydroquinoline with a Friedel-Crafts catalyst. The haloacetyl derivative of 1,2,3,4-tetrahydroquinoline may be prepared by reacting 1,2,3,4-tetrahydroquinoline with a haloacetyl halide at a mole ratio of 2:1 in the presence of an inert, organic solvent.
    Type: Grant
    Filed: June 23, 1975
    Date of Patent: March 29, 1977
    Assignee: Sandoz, Inc.
    Inventor: Goetz E. Hardtmann
  • Alkanoyl substituted benzoic acids and esters
    Patent number: 4015010
    Abstract: Alkanoyl substituted benzoic acids and esters, e.g., p-pivaloyl ethyl benzoate, are prepared by oxidizing alkanoyl substituted toluene and reacting with lower alkanols and are useful as hypolipidemic, anti-obesity, and anti-diabetic agents.
    Type: Grant
    Filed: March 3, 1975
    Date of Patent: March 29, 1977
    Assignee: Sandoz, Inc.
    Inventors: William J. Houlihan, Jeffrey Nadelson
  • 1-(.omega.-HALOALKYL)-ISATOIC ANHYDRIDES
    Patent number: 4013646
    Abstract: CNS depressants of the formulae IA and IB: ##STR1## in which n and p are each 0 or 1, Z.sup.- is an anion and R.sub.1, R'.sub.1, R.sub.2, R'.sub.2, R.sub.3 and R.sub.4 are optional substituents. Compounds IB may be prepared by reducing compounds IA which may be made by reacting a N-(.omega.-haloalkyl) isatoic anhydride with a cyclic pseudothiourea such as a 2-organomercapto-4,5-dihydroimidazole. Compounds IB may be also prepared by cyclizing a 1-(.omega.-haloalkyl)-2,3-dihydro-imidazo[2,1-b]quinazolin-1H-5-one. The compounds are anti-inflammatory, analgesic and immunosuppressant agents.
    Type: Grant
    Filed: August 6, 1975
    Date of Patent: March 22, 1977
    Assignee: Sandoz, Inc.
    Inventor: Goetz E. Hardtmann
  • 3-Pyridyl and pyridyl-N-oxide-furo[3,4-e]-as-triazines
    Patent number: 4013767
    Abstract: Substituted or unsubstituted-3-pyridyl and pyridyl-N-oxide-furo[3,4-e]-as-triazines, e.g., 5,7-dihydro-3-(2-pyridyl)-5,5,7,7-tetramethyl-furo[3,4-e] -as-triazine are prepared by reacting 2,2,5,5-tetramethyl-3,4(2H,5H)furandiones with substituted or unsubstituted pyridylcarboxamidic acid hydrazides and are useful as sleep inducers and minor tranquilizers.
    Type: Grant
    Filed: August 15, 1975
    Date of Patent: March 22, 1977
    Assignee: Sandoz, Inc.
    Inventor: Gregory B. Bennett