Patents Assigned to Sandoz Inc.
  • 10-(2-Substituted-amino-ethyl)-10,11-dihydro-5-meth ylene-5H-dibenzo[a,d]cycloheptenes
    Patent number: 4083997
    Abstract: 10-(2-substituted-aminoethyl)-10,11-dihydro-5-methylene-2 or 3 7 or 8-substituted or unsubstituted-5H-dibenzo[a,d]cycloheptenes e.g., 10-(2-dimethylaminoethyl)-10,11-dihydro-5-methylene-5H-dibenzo[a,d]cyclohe ptene, prepared by various methods including acid dehydration of the corresponding dibenzo[a,d]cycloheptene-5-ols. The compounds are useful as anti-depressants.
    Type: Grant
    Filed: September 1, 1976
    Date of Patent: April 11, 1978
    Assignee: Sandoz, Inc.
    Inventors: William J. Houlihan, Jeffrey Nadelson
  • Preparation of 2-sec.-alkylaminobenzophenones
    Patent number: 4083871
    Abstract: 2-Sec.-alkylaminobenzophenones are prepared by reacting a corresponding 2-aminobenzophenone with a ketone, a borohydride and carboxylic acid.
    Type: Grant
    Filed: January 29, 1976
    Date of Patent: April 11, 1978
    Assignee: Sandoz, Inc.
    Inventors: William J. Houlihan, Paul G. Mattner, Joseph A. Smith
  • 1-Aryl-1-lower alkyl-1-buten-3-ols and ester derivatives
    Patent number: 4081476
    Abstract: The compounds are 1-aryl-1-lower alkyl-substituted-1-buten-3-ols, butan-3-ols, and acylation products thereof, e.g., (p-biphenylyl)-2-penten-4-ol and are useful as pharmaceuticals.
    Type: Grant
    Filed: November 19, 1975
    Date of Patent: March 28, 1978
    Assignee: Sandoz, Inc.
    Inventors: Paul L. Anderson, Darryl A. Brittain
  • Hypolipidemic allene carboxylic esters
    Patent number: 4073936
    Abstract: The compounds are 4-aryl substituted buta-2,3-dienoic acids and esters thereof which may also be lower alkyl-substituted at any of the 2- and 4- positions, e.g., 4-(p-methoxyphenyl)-2-methyl-buta-2,3-dienoic acid. The compounds are useful as pharmaceuticals, e.g., as antiinflammatory agents and hypolipidemic agents.
    Type: Grant
    Filed: November 17, 1976
    Date of Patent: February 14, 1978
    Assignee: Sandoz, Inc.
    Inventors: Eugene E. Galantay, Faizulla G. Kathawala
  • Preparation of 2-substituted aminophenyl ketones
    Patent number: 4071557
    Abstract: Substituted aminophenyl ketones such as 2-alkylaminobenzophenones are prepared by reacting a corresponding 2-aminophenyl ketone with a ketone or aldehyde, a borohydride and strong acid.
    Type: Grant
    Filed: January 29, 1976
    Date of Patent: January 31, 1978
    Assignee: Sandoz, Inc.
    Inventors: Paul G. Mattner, Joseph A. Smith
  • 4-(Acyloxyphenyl)-quinazolin-2(1H)-ones
    Patent number: 4071516
    Abstract: Anti-inflammatories and analgesics of the formula: ##STR1## wherein R.degree. is alkyl, R is hydrogen, alkyl, halo, nitro or R"' OOC--, R' is hydrogen, alkyl or halo, R" is a hydrolyzable carboxylic acid acyl group and R"' is hydrogen or alkyl.
    Type: Grant
    Filed: August 20, 1976
    Date of Patent: January 31, 1978
    Assignee: Sandoz, Inc.
    Inventor: Hans J. Schwarz
  • 2-Amino-quinolin-4-one-3-phosphonic acid esters
    Patent number: 4070468
    Abstract: Anti-allergic 2-amino-quinolin-4-one-3-phosphonic acid esters are prepared by reacting an isatoic anhydride with the carbanion resulting from the treatment of an organo-methane phosphate with a proton abstracting agent.
    Type: Grant
    Filed: March 1, 1976
    Date of Patent: January 24, 1978
    Assignee: Sandoz, Inc.
    Inventors: Goetz E. Hardtmann, Gary M. Coppola
  • 2-Alkylamino-.alpha.-phenyl-1-cyclohexene-1-methyleneimine, its salts and preparation
    Patent number: 4066665
    Abstract: Compounds of the formula ##STR1## wherein R and R.sup.o are lower alkyl, R' is optionally substituted phenyl or 2-thienyl and n is 0 to 2, and their salt forms, are prepared by reacting a compound of the formula: ##STR2## with an aromatic nitrile and strong base, and quenching with water when the free base form is desired, said first mentioned compounds being intermediates for quinazolinones.
    Type: Grant
    Filed: June 19, 1974
    Date of Patent: January 3, 1978
    Assignee: Sandoz, Inc.
    Inventor: William G. Salmond
  • P-Phenoxy-alkylphenones and corresponding alcohols
    Patent number: 4065503
    Abstract: Hypolipidemic agents of the formula: ##STR1## wherein X is C.dbd.O or CHOH,R.degree. is branched lower alkyl,R is hydrogen, alkyl, or halo,n is 1 or 2, andR' and R" are hydrogen, halo, alkyl or alkoxy, e.g., 4-phenoxy-pivalophenone.
    Type: Grant
    Filed: February 27, 1976
    Date of Patent: December 27, 1977
    Assignee: Sandoz, Inc.
    Inventor: Faizulla G. Kathawala
  • Hydroxymethyl-substituted-2(1H)-quinazolinones
    Patent number: 4064246
    Abstract: Hydroxymethyl-substituted-2(1H)-quinazolinones, e.g., 7-hydroxymethyl-1-isopropyl-4-phenyl-2(1H)-quinazolinone, are useful as anti-inflammatory agents.
    Type: Grant
    Filed: October 12, 1976
    Date of Patent: December 20, 1977
    Assignee: Sandoz, Inc.
    Inventor: Eugene A. Papp
  • Substituted hydroxy pyridones
    Patent number: 4064251
    Abstract: This disclosure describes novel compounds of the formula: ##STR1## where R is ##STR2## and R.sub.1 is straight chain lower alkyl, or ##STR3## where R.sub.3 is hydrogen or halo having an atomic weight of about 19 to 36,Which are useful as minor tranquilizers, sleep inducers and muscle relaxants.
    Type: Grant
    Filed: June 25, 1976
    Date of Patent: December 20, 1977
    Assignee: Sandoz, Inc.
    Inventor: Jeffrey Nadelson
  • Treating lipidemia with substituted diphenyl ether halides and compositions thereof
    Patent number: 4064273
    Abstract: Hypolipidemic agents of the formula: ##STR1## wherein R is branched lower alkyl,R' is hydrogen or alkyl,X is halo, andn is 2.
    Type: Grant
    Filed: January 16, 1976
    Date of Patent: December 20, 1977
    Assignee: Sandoz, Inc.
    Inventor: Faizulla G. Kathawala
  • Iminodimethylene di-tert-alkylophenones and phenols
    Patent number: 4061778
    Abstract: Substituted-iminodimethylene-di-tert-alkylophenones, e.g., 4",4"'-methyliminodimethylene-dipivalophenone, are prepared by treating a corresponding .alpha.-halo-p-tert-alkanoyl toluene with a substituted amine. The phenols are prepared from the corresponding phenones and both the phenones and the phenols are useful as hypolipidemic agents.
    Type: Grant
    Filed: November 17, 1976
    Date of Patent: December 6, 1977
    Assignee: Sandoz, Inc.
    Inventor: Jeffrey Nadelson
  • Apparatus for controlling blood flow
    Patent number: 4061142
    Abstract: This invention provides a single needle dialysis blood tubing occluder, comprising in a preferred aspect, a pair of pivotly mounted clamping arms having a leaf spring affixed to the non-pivot end of each occluder with the spring in slidable engagement with a symmetrical cam. Means are provided for actuating the cam, whereby the cam moves the tubing occluder to alternately occlude and non-occlude a pair of blood tubings.
    Type: Grant
    Filed: June 16, 1976
    Date of Patent: December 6, 1977
    Assignee: Sandoz, Inc.
    Inventor: Glenn L. Tuttle
  • Anthranilic acid amides
    Patent number: 4060638
    Abstract: Derivatives of trifluoromethyl-substituted anthranilic acid amides, e.g., N-methyl-o-amino-.alpha.,.alpha.,.alpha.-trifluoromethyl-p-toluamide, are useful as minor tranquilizers and muscle relaxants.
    Type: Grant
    Filed: May 27, 1975
    Date of Patent: November 29, 1977
    Assignee: Sandoz, Inc.
    Inventor: Paul L. Anderson
  • Pyranone carboxamides
    Patent number: 4060533
    Abstract: Pyranone carboxamides, e.g., 2,6-diphenyl-N-methyl-4-oxo-4H-pyran-3-carboxamide, are prepared by cyclizing and dehydrogenating 2-aminomethylene-5-hydroxy-N-methyl-3-oxo-alkylamides and are useful as anti-allergic agents.
    Type: Grant
    Filed: June 25, 1976
    Date of Patent: November 29, 1977
    Assignee: Sandoz, Inc.
    Inventor: Jeffrey Nadelson
  • Substituted or unsubstituted p-alkanoyl toluenes as male anti-fertility agents
    Patent number: 4057646
    Abstract: Certain substituted or unsubstituted p-alkanoyl toluenes, e.g., p-alkanoyl toluene, are useful as male anti-fertility agents.
    Type: Grant
    Filed: August 25, 1976
    Date of Patent: November 8, 1977
    Assignee: Sandoz, Inc.
    Inventors: Francis E. Harrington, Robert S. Ho
  • Hydroxyalkyl substituted-4,5-dihydropyridazin(2H)-3-ones
    Patent number: 4055644
    Abstract: Hydroxyalkyl and aryl or heterocyclic substituted-4,5-dihydropyridazin(2H)-3-ones and diazobicyclo-ene-ones, e.g., 6-(p-chlorophenyl)-2-(2-hydroxybutyl)-4,5-dihydropyridazin(2H)-3-one are prepared by condensing 1-hydrazino-2-alkanols with aryl or heterocyclic-.gamma.-keto acids and are useful as central nervous system depressants.
    Type: Grant
    Filed: September 18, 1975
    Date of Patent: October 25, 1977
    Assignee: Sandoz, Inc.
    Inventor: William J. Houlihan
  • 4-Alkyl-2,6-di-(secondary or tertiary alkyl)amino-3-formylpyridines pharmaceutical compositions thereof and their use in the treatment of obesity and diabetes
    Patent number: 4055649
    Abstract: Compounds of the formula ##STR1## wherein R is secondary alkyl of 3 to 7 carbon atoms or tertiary alkyl of 4 to 7 carbon atoms,R' is secondary alkyl of 3 to 7 carbon atoms or tertiary alkyl of 4 to 7 carbon atoms,R.sub.1 is primary or secondary alkyl of 1 to 5 carbon atoms, andR.sub.2 is hydrogen, chloro or bromo,And the pharmaceutically acceptable acid addition salts thereof, are useful as anti-obesity and anti-diabetic agents. The compounds wherein R and R' are tertiary alkyl of 4 to 7 carbon atoms and R.sub.2 is hydrogen are synthesized from ketenimines and amidines, all of the compounds wherein R.sub.2 is hydrogen are synthesized by reduction of the corresponding 3-cyanopyridines, and the compounds wherein R.sub.2 is chloro or bromo are synthesized from the corresponding compounds wherein R.sub.2 is hydrogen and an N-halosuccinimide.
    Type: Grant
    Filed: February 5, 1976
    Date of Patent: October 25, 1977
    Assignee: Sandoz, Inc.
    Inventors: William R. Simpson, Robert J. Strohschein
  • Furo(3,4-E)-as-triazines and corresponding 4-oxides as sleep inducers and minor tranquilizers
    Patent number: 4055643
    Abstract: 5,5,7,7-tetramethyl-3-substituted or unsubstituted-phenylfuro[3,4-e]-as-triazines and corresponding 4-oxides, e.g., 5,7-dihydro-5,5,7,7-tetramethyl-3-phenylfuro[3,4-e]-as-triazine and 5,7-dihydro-5,5,7,7-tetramethyl-3-phenylfuro[3,4-e]-as-triazine-4-oxide, are prepared from 2,2,5,5-tetramethyl-3,4(2H,5H)-furandione-3-hydrazone-4-oximes and are useful as sleep inducers and minor tranquilizers.
    Type: Grant
    Filed: March 10, 1976
    Date of Patent: October 25, 1977
    Assignee: Sandoz, Inc.
    Inventor: Gregory B. Bennett