Patents Assigned to Sandoz Inc.
  • Substituted hydroxy pyridones
    Patent number: 4158735
    Abstract: Substituted hydroxy pyridones, e.g., 3-(.alpha.-iminobenzyl)-4-hydroxy-6-phenyl-1-methyl-2(1H)-pyridone, are prepared by reducing corresponding isoxazolo[4,5-c]pyridin-4(5H)-ones and are useful as minor tranquilizers and sleep inducers.
    Type: Grant
    Filed: May 1, 1978
    Date of Patent: June 19, 1979
    Assignee: Sandoz, Inc.
    Inventor: Jeffrey Nadelson
  • Patient ventilator disconnect alarm
    Patent number: 4155357
    Abstract: Normal breathing cycles of a ventilator cause an alarm controller circuit to emit a periodic pulse which resets a timer circuit thereby maintaining an alarm device in an "off" condition. Patient disconnect is sensed by an alarm trigger circuit which sends an inhibit pulse to the controller circuit inhibiting the timer circuit reset pulse. This causes the timer to "time out" thereby turning on an alarm actuator circuit which causes an audible and/or visual alarm condition.
    Type: Grant
    Filed: February 27, 1978
    Date of Patent: May 22, 1979
    Assignee: Sandoz, Inc.
    Inventor: William R. Dahl
  • Substituted isoxazolo compounds
    Patent number: 4154928
    Abstract: An improved process for the preparation of substituted isoxazolo[4,5-c]pyridin-4(5H)-ones which are either useful as intermediates in the preparation of compounds having pharmaceutical activity or as hypolipidemic agents which comprises cyclizing a corresponding 5-(2-amino-2-phenyl- or substituted phenyl-ethenyl)-3-substituted-N-alkyl isoxazole-4-carboxamide under acidic conditions.
    Type: Grant
    Filed: June 19, 1978
    Date of Patent: May 15, 1979
    Assignee: Sandoz, Inc.
    Inventors: Max Denzer, Joseph A. Smith
  • Dilithiated 2-(o-tolyl)-2-imidazolines
    Patent number: 4140859
    Abstract: Imidazo[2,1-a]isoquinolines useful as anorexics and antidepressants are prepared from a dilithium derivative of a 2-(o-tolyl)-2-imidazoline.
    Type: Grant
    Filed: April 13, 1978
    Date of Patent: February 20, 1979
    Assignee: Sandoz, Inc.
    Inventor: William J. Houlihan
  • Hydroxyalkyl substituted-4,5-dihydropyridazin(2H)-3-ones and diazabicyclo-ene-ones
    Patent number: 4136184
    Abstract: Hydroxyalkyl and aryl or heterocyclic substituted-4,5-dihydropyridazin(2H)-3-ones and diazabicyclo-ene-ones e.g., 6-(p-chlorophenyl)-2-(2-hydroxybutyl)-4,5-dihydropyridazin(2H)-3-one are prepared by condensing 1-hydrazino-2-alkanols with aryl or heterocyclic-.gamma.-keto acids and are useful as central nervous system depressants.
    Type: Grant
    Filed: July 22, 1977
    Date of Patent: January 23, 1979
    Assignee: Sandoz, Inc.
    Inventor: William J. Houlihan
  • 2-Aminomethylene-5-hydroxy-N-alkyl-3-oxo-amides
    Patent number: 4136114
    Abstract: 2-Aminomethylene-5-hydroxy-N-alkyl-3-oxo-amides.
    Type: Grant
    Filed: August 5, 1977
    Date of Patent: January 23, 1979
    Assignee: Sandoz, Inc.
    Inventor: Jeffrey Nadelson
  • Substituted 3,1-benzazasilin-4-ones
    Patent number: 4132725
    Abstract: Benzazasilin-4-ones of the formula ##STR1## where R.sub.1 represents H or alkyl of 1-5 carbon atoms,R.sub.2 represents alkyl of 1-5 carbon atoms,R.sub.3 represents alkyl of 1-5 carbon atoms or ##STR2## where R.sub.5 represents H, alkyl of 1-5 carbon atoms, halo having an atomic weight of about 19-36, alkoxy having 1-5 carbon atoms, or ##STR3## where R.sub.6 and R.sub.7 each, independently, represent alkyl having 1-2 carbon atoms, andR.sub.4 represents alkyl having 1-3 carbon atoms, e.g., 1-(p-chlorophenyl)-2,3-dihydro-1,3-dimethyl-3,1-benzazasilin-4(1H)-one, are prepared from the appropriate lithiated N-alkyl benzamide and a halomethyl halosilane and are useful as antiobesity agents or sleep inducers.
    Type: Grant
    Filed: February 27, 1978
    Date of Patent: January 2, 1979
    Assignee: Sandoz, Inc.
    Inventor: Sandor Barcza
  • Substituted 4-hydroxy pyridones
    Patent number: 4131679
    Abstract: This disclosure describes novel compounds of the formula: ##STR1## where R.sub.1 is straight chain lower alkyl or ##STR2## where R.sub.4 is hydrogen or halo having an atomic weight of about 19 to 36, andR.sub.2 is straight chain lower alkyl, andR.sub.3 is hydrogen or halo as defined above,Which are useful as minor tranquilizers and muscle relaxants.
    Type: Grant
    Filed: July 26, 1977
    Date of Patent: December 26, 1978
    Assignee: Sandoz, Inc.
    Inventor: Jeffrey Nadelson
  • 4-Hydroxy-pyrido[2,3-b]pyridine-2(1H)-one-3-carboxylic acids and esters
    Patent number: 4128649
    Abstract: Anti-allergic 4-hydroxy-pyrido[2,3-b]pyridine-2(1H)-one-3-carboxylic acids and esters are prepared by reacting a 3,4-dihydro-1,3-dioxo-1H-pyrido[2,3-d][1,3]oxazine (a 3-azaisatoic anhydride) with an alkali metal salt of a malonic ester.
    Type: Grant
    Filed: June 29, 1977
    Date of Patent: December 5, 1978
    Assignee: Sandoz, Inc.
    Inventor: Goetz E. Hardtmann
  • 4-Hydroxy-3-sulfonyl-quinolin-2(1H)-ones
    Patent number: 4127574
    Abstract: Anti-allergic 4-hydroxy-3-sulfonyl-quinolin-2(1H)-ones are prepared by reacting an isatoic anhydride with the carbanion resulting from the treatment of sulfonyl acetic acid alkyl esters with a proton abstracting agent.
    Type: Grant
    Filed: March 1, 1976
    Date of Patent: November 28, 1978
    Assignee: Sandoz, Inc.
    Inventors: Goetz E. Hardtmann, Gary M. Coppola
  • 1-Phenyl-2,3-butadien-1-ols and method of use
    Patent number: 4127658
    Abstract: Disclosed are compounds of the class 1-phenyl-2,3-butadien-1-ol e.g. 2-(p-biphenylyl)-3,4-pentadien-2-ol, which are useful by reason of their pharmacological activity in animals, e.g., as anti-inflammatory agents and tranquilizers. Said compounds can be prepared, e.g., by reduction of a corresponding 4-substituted-1-phenyl-2-butyne-1-ol with a complex hydride such as lithium aluminum hydride.
    Type: Grant
    Filed: March 23, 1978
    Date of Patent: November 28, 1978
    Assignee: Sandoz, Inc.
    Inventor: Eugene E. Galantay
  • 4-Hydroxy-3-sulfinyl-quinolin-2(1H)-ones
    Patent number: 4124587
    Abstract: Anti-allergic 4-hydroxy-3-sulfinyl-quinolin-2(1H)-ones are prepared by reacting an isatoic anhydride with the carbanion resulting from the treatment of sulfinyl acetic acid alkyl esters with a proton abstracting agent.
    Type: Grant
    Filed: March 1, 1976
    Date of Patent: November 7, 1978
    Assignee: Sandoz, Inc.
    Inventor: Goetz E. Hardtmann
  • Substituted hydroxy pyridones
    Patent number: 4124714
    Abstract: This disclosure describes novel compounds of the formula: ##STR1## where R.sub.3 is hydrogen or halo having an atomic weight of about 19 to 36, which are useful as minor tranquilizers, sleep inducers, muscle relaxants, neuroleptics and anti-ulcer agents.
    Type: Grant
    Filed: August 5, 1977
    Date of Patent: November 7, 1978
    Assignee: Sandoz, Inc.
    Inventor: Jeffrey Nadelson
  • 4-Hydroxy-quinolin-2-one-3-phosphonic acid esters
    Patent number: 4124588
    Abstract: Anti-allergic 4-hydroxy-3-quinoline-2-one-3-phosphonic acid esters are prepared by reacting an isatoic anhydride with the carbanion resulting from the treatment of phosphono acetic acid alkyl esters with a proton abstracting agent.
    Type: Grant
    Filed: March 1, 1976
    Date of Patent: November 7, 1978
    Assignee: Sandoz, Inc.
    Inventors: Goetz E. Hardtmann, Gary M. Coppola
  • Substituted hydroxy pyridones
    Patent number: 4122182
    Abstract: Substituted hydroxy pyridones, e.g., 3-(.alpha.-N-methyliminobenzyl)-4-hydroxy-6-phenyl-1-methyl-2(1H)-pyridone , are prepared by reacting a corresponding substituted hydroxy pyridone carbonyl with an alkyl amine, and are useful as minor tranquilizers, sleep inducers, muscle relaxants, and neuroleptics.
    Type: Grant
    Filed: February 22, 1977
    Date of Patent: October 24, 1978
    Assignee: Sandoz, Inc.
    Inventor: Jeffrey Nadelson
  • Patient ventilator monitor
    Patent number: 4121581
    Abstract: A ventilator monitoring system wherein the ventilator is in simultaneous fluid communication with a patient circuit and an exhaust circuit. The patient circuit comprises an inspiratory branch and an expiratory branch. A first one-way valve in the patient circuit inspiratory branch permits ingress only of a gas to the patient circuit. A second one-way valve in the patient circuit expiration branch permits egress only of patient exhaust gas to an expiration valve in the exhaust circuit. A monitor in the patient circuit expiration branch, monitors only the gas actually expired by the patient and not a combination of patient expired gas and excess gas from the ventilator.
    Type: Grant
    Filed: November 1, 1976
    Date of Patent: October 24, 1978
    Assignee: Sandoz, Inc.
    Inventor: Ronald G. Schmader
  • Unsaturated esters of 4-hydroxy-2-quinolinone-3-carboxylic acids and salts thereof
    Patent number: 4119720
    Abstract: Disclosed are compounds which are unsaturated esters of 4-hydroxy-2-quinolinone-3-carboxylic acids, e.g., 1-allyl-6,7-dimethoxy-4-hydroxy-2-quinolinone-3-carboxylic acid allyl ester, useful as anti-allergic agents, and prepared by reacting an isatoic anhydride with an alkali metal salt of a malonic acid unsaturated ester.
    Type: Grant
    Filed: July 6, 1977
    Date of Patent: October 10, 1978
    Assignee: Sandoz, Inc.
    Inventor: Goetz E. Hardtmann
  • 2-Amino-pyridyl nitromethylketones and 2-amino-phenyl nitromethylketones
    Patent number: 4117137
    Abstract: 2-Amino-3-pyridyl (or phenyl) nitromethylketones are prepared eg by reacting a 3,4-dihydro-1,3-dioxo-1H-pyrido [2,3-d][1,3]oxazine (a 3-azaisatoic anhydride) with the carbanion resulting from the reaction of nitromethane with a porton abstracting agent. The compounds are useful as anti-allergic agents.
    Type: Grant
    Filed: July 6, 1977
    Date of Patent: September 26, 1978
    Assignee: Sandoz, Inc.
    Inventor: Goetz E. Hardtmann
  • Blood flow controller and the like
    Patent number: D250085
    Type: Grant
    Filed: September 22, 1976
    Date of Patent: October 31, 1978
    Assignee: Sandoz, Inc.
    Inventor: Glenn L. Tuttle
  • Specimen collection unit
    Patent number: D250129
    Type: Grant
    Filed: August 9, 1976
    Date of Patent: October 31, 1978
    Assignee: Sandoz, Inc.
    Inventor: Norman Skinner