Patents Assigned to Sandoz Inc.
  • 2-Keto-4,5-dihydro-3 (2H)-pyridazinones, and their use in treating muscle tension
    Patent number: 4228166
    Abstract: Ketone derivatives of 4,5-dihydro-3(2H)-pyridazinones of the formula ##STR1## where R.sub.1 is halo having an atomic weight of from 19 to 36, andR.sub.2 is a branched chain lower alkyl having 3 to 4 carbon atomsare useful as central nervous system depressants, in particular, as muscle relaxants.
    Type: Grant
    Filed: March 5, 1979
    Date of Patent: October 14, 1980
    Assignee: Sandoz, Inc.
    Inventor: William J. Houlihan
  • Pyrano[4,3-e]-as-triazines and corresponding 4-oxides
    Patent number: 4228280
    Abstract: This disclosure describes novel compounds of the formula ##STR1## wherein R.sub.1 and R.sub.2 each independently represent hydrogen, halo having an atomic weight of about 19 to 36, lower alkyl, straight chain lower alkoxy, amino, nitro or trifluoromethyl, andX represents ##STR2## which are useful as minor tranquilizers and sleep inducers.
    Type: Grant
    Filed: May 16, 1979
    Date of Patent: October 14, 1980
    Assignee: Sandoz, Inc.
    Inventor: Gregory B. Bennett
  • Substituted 1-oxa-4-aza-2,6-disilacyclohexanes and use thereof
    Patent number: 4224317
    Abstract: This disclosure describes compounds of the formula ##STR1## wherein R.sub.1 represents ##STR2## and R.sub.2, R.sub.3, R.sub.4 and R.sub.5 each independently represent lower alkyl having 1 to 2 carbon atoms, andn is 1 or 2,which are useful as muscle-relaxant agents.
    Type: Grant
    Filed: August 27, 1979
    Date of Patent: September 23, 1980
    Assignee: Sandoz, Inc.
    Inventor: Sandor Barcza
  • Methods with 1-substituted-4-aryl-quinazolin-2(1H)-ones and thiones and pyrido[2,3-d]pyrimidin-2-ones as platelet aggregation inhibitors
    Patent number: 4224328
    Abstract: 1-substituted-4-aryl-quinazolin-2(1H)-ones and thiones and pyrido[2,3-d]pyrimidin-2-ones, eg. 1-isopropyl-7-methyl-4-phenyl-quinazolin-2(1H)-one, are useful as platelet aggregation inhibitors.
    Type: Grant
    Filed: April 11, 1979
    Date of Patent: September 23, 1980
    Assignee: Sandoz, Inc.
    Inventor: Edward I. Takesue
  • Dihydroquinoline-one derivatives
    Patent number: 4221797
    Abstract: The compounds are amino- or cyano-bearing dihydroquinolines, which have either of the combinations of (a) 2-amino, 3-carboxylic and 4-oxo functions, or (b) 2-oxo, 3-cyano and 4-hydroxy functions, and may be optionally substituted at 1 or 2 of the 5, 6, 7 or 8 positions, eg 1-allyl-2-amino-1,4-dihydro-6,7-dimethoxy-4-oxo-quinoline-3-carboxylic acid ethyl ester, and 1-allyl 3-cyano-1,2-dihydro-4-hydroxy-6,7-dimethoxy-2-oxo-quinoline. The compounds are useful as pharmaceuticals.
    Type: Grant
    Filed: August 14, 1978
    Date of Patent: September 9, 1980
    Assignee: Sandoz, Inc.
    Inventors: Goetz E. Hardtmann, Gary M. Coppola
  • 1-Phenyl-pyrazole derivatives
    Patent number: 4220792
    Abstract: Anti-diabetic agents of the formula: ##STR1## wherein R is CHO or COOR.sub.1, where R.sub.1 is hydrogen or C.sub.1-6 alkyl,R.sub.o is C.sub.1-4 alkyl, C.sub.1-4 alkoxy, bromo, chloro, fluoro, trifluoromethyl, nitro or ##STR2## where R.sub.2 is hydrogen or C.sub.1-4 alkyl, andn is 0 or 1,and the non-toxic, pharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: January 25, 1979
    Date of Patent: September 2, 1980
    Assignee: Sandoz, Inc.
    Inventors: Paul L. Anderson, Nicholas A. Paolella
  • Polyoxyalkylene bridged phosphate esters
    Patent number: 4220611
    Abstract: The invention relates to novel, polymeric phosphate esters containing at least two orthophosphate groups bridged by a polyoxyalkylene radical, and to the use of said esters as emulsifiers, surfactants, dispersants and fiber finishing agents.
    Type: Grant
    Filed: June 29, 1978
    Date of Patent: September 2, 1980
    Assignee: Sandoz, Inc.
    Inventor: Harold P. Wolf
  • Piperidine and pyrrolidine alcohols
    Patent number: 4219560
    Abstract: This disclosure describes novel compounds of the formula: ##STR1## where A is --CH.sub.2 OH or ##STR2## wherein R.sub.4 and R.sub.5 each independently represent hydrogen or lower alkyl having 1 to 2 carbon atoms or together with N represent ##STR3## and, R.sub.1 is hydrogen or lower alkyl having 1 to 2 carbon atoms, andR.sub.2 and R.sub.3 each independently represent hydrogen, chloro, fluoro, methyl, methoxy or together, represent methylenedioxy, andn is 1 or 2, provided that one of R.sub.2 and R.sub.3 is other than hydrogen which are useful as hypolipidemic agents.
    Type: Grant
    Filed: April 17, 1978
    Date of Patent: August 26, 1980
    Assignee: Sandoz, Inc.
    Inventor: William J. Houlihan
  • Method of producing multicolor dyeings
    Patent number: 4218217
    Abstract: Multicolored substrates, particularly nylon carpeting, are produced by applying combinations of a colorless reserving agent and an acid, direct or basic dye or mixture of dyes and fixing the reserving agent and the dye(s) simultaneously.
    Type: Grant
    Filed: March 11, 1976
    Date of Patent: August 19, 1980
    Assignee: Sandoz, Inc.
    Inventor: Lewis M. Redd, Jr.
  • Benzoxazine herbicides
    Patent number: 4214889
    Abstract: 2-amino-4H-3,1 benzoxazines, eg 6-chloro 2-dimethylamino-4H, 3,1-benzoxazine, are useful as herbicides. The compounds may be prepared by reacting an amine with a 2-halomethylphenyl isocyanate.
    Type: Grant
    Filed: April 16, 1979
    Date of Patent: July 29, 1980
    Assignee: Sandoz, Inc.
    Inventors: Stewart W. Myers, Homer K. Spencer
  • Process for the preparation of optionally substituted 2,3-indolinediones
    Patent number: 4212804
    Abstract: An improved process for the preparation of optionally substituted 2,3-indolinediones which are useful as intermediates in the preparation of compounds having pharmacological activity which comprises reacting a 3,1-benzoxazine with an alkali or alkaline earth metal cyanide or a tetra-(C.sub.1-4) alkylammonium cyanide to obtain a 2-imino-3-indolinone, which is then subjected to hydrolysis.
    Type: Grant
    Filed: December 4, 1978
    Date of Patent: July 15, 1980
    Assignee: Sandoz, Inc.
    Inventor: Gary M. Coppola
  • Substituted or unsubstituted 2-phenylbenzimidazoles as anti-obesity agents
    Patent number: 4212876
    Abstract: Certain substituted or unsubstituted 2-phenylbenzimidazoles, e.g., 1-methyl-2-phenylbenzimidazole, are useful as anti-obesity agents.
    Type: Grant
    Filed: June 21, 1978
    Date of Patent: July 15, 1980
    Assignee: Sandoz, Inc.
    Inventor: William J. Houlihan
  • Process for preparing 9H-dibenz[c,f]imidazo[1,2-a][1]azepin-9-ones
    Patent number: 4210585
    Abstract: Dibenz[c,f]imidazo[1,2-a][1]azepin-9-ols of the general formula ##STR1## where R.sub.1 represents H or mono or di-chloro or fluoro, andR.sub.2 represents H, chloro, fluoro, alkyl of 1-3 carbon atoms, e.g., methyl, ethyl or isopropyl, alkoxy of 1-3 carbon atoms, e.g., methoxy or ethoxy, or trifluoromethyl,prepared by borohydride hydrogenation of the corresponding 9-ones are useful as anti-convulsant agents.
    Type: Grant
    Filed: June 18, 1979
    Date of Patent: July 1, 1980
    Assignee: Sandoz, Inc.
    Inventor: William J. Houlihan
  • Substituted 1-oxa-4-aza-2,6-disilacyclohexanes
    Patent number: 4208408
    Abstract: This disclosure describes novel compounds of the formula: ##STR1## where R.sub.1 and R.sub.2 each independently represent hydrogen, halo having an atomic weight of about 19 to 36, lower alkyl, lower alkoxy,trifluoromethyl or R.sub.1 is ##STR2## and R.sub.2 is hydrogen, whereinR.sub.7 and R.sub.8 are each independently hydrogen or lower alkyl andn is 0 or 1, andR.sub.3, R.sub.4, R.sub.5 and R.sub.6 each independently represent lower alkyl, which are useful as muscle relaxants.
    Type: Grant
    Filed: November 30, 1978
    Date of Patent: June 17, 1980
    Assignee: Sandoz, Inc.
    Inventor: Sandor Barcza
  • 5-Phenacyl-3-phenyl-4-isoxazole carboxamides
    Patent number: 4208532
    Abstract: Substituted hydroxy pyridones, e.g., 3-(.alpha.-iminobenzyl)-4-hydroxy-6-phenyl-1-methyl-2-(1H)-pyridone, are prepared by reducing corresponding isoxazolo[4,5-c]pyridin-4(5H)-ones and are useful as minor tranquilizers and sleep inducers.
    Type: Grant
    Filed: March 8, 1979
    Date of Patent: June 17, 1980
    Assignee: Sandoz, Inc.
    Inventor: Jeffrey Nadelson
  • Prolactin secretion inhibitors
    Patent number: 4202897
    Abstract: Certain known imidazo[2,1-a]isoindoles and isoquinolines, e.g., 5-(p-chlorophenyl)-5-hydroxy-2,3-dihydro-5H-imidazo[2,1-a]isoindole (mazindol), have been found to be useful as inhibitors of prolactin secretion, and may be so utilized alone or as an agent which enhances the action of other chemical compounds having activity in inhibiting prolactin secretion.
    Type: Grant
    Filed: May 11, 1978
    Date of Patent: May 13, 1980
    Assignee: Sandoz, Inc.
    Inventors: Ronald G. Babington, F. Eugene Harrington
  • Cyclopropanyl-bearing hydrazides
    Patent number: 4201785
    Abstract: Cyclopropanyl-group-bearing-hydrazides, e.g. cis-2-octyl-cyclopropanoctanoic acid, 2-(o-methylphenyl)-hydrazide, are useful as pharmaceutical agents and are obtainable by reacting a derivative, e.g. mixed anhydride, of a cyclopropanyl-group bearing-long chain carboxylic acid with an appropriate hydrazine.
    Type: Grant
    Filed: April 4, 1979
    Date of Patent: May 6, 1980
    Assignee: Sandoz Inc.
    Inventor: Faizulla G. Kathawala
  • Cholesterol ester-reducing amides of hexahydroindolinols
    Patent number: 4194002
    Abstract: Long chain fatty acid amides of styryl hexahydroindolinols in which the amido portions have ethyleneically unsaturated positions or cyclopropanyl rings, eg 1-(1-oxo-9-cis-octadecenyl)-(3aRS, 4RS, 7aRS)-4-(Z)-(3,4-dimethoxy)-styryl-hexahydro-4-indolinol, are useful as cholesterol ester-reducing agents and are obtainable by reacting corresponding long chain carboxylic acids (or derivatives thereof) with appropriate 4-styryl-4-hexahydroindolinols.
    Type: Grant
    Filed: March 29, 1978
    Date of Patent: March 18, 1980
    Assignee: Sandoz, Inc.
    Inventor: Faizulla G. Kathawala
  • 4-Hydroxy-3-nitro-quinoline-2(1H)-ones
    Patent number: 4192876
    Abstract: Anti-allergic 4-hydroxy-3-nitro-quinoline-2(1H)-ones are prepared by reacting an isatoic anhydride with the carbanion resulting from the treatment of nitro acetic acid alkyl esters with a proton abstracting agent.
    Type: Grant
    Filed: June 20, 1977
    Date of Patent: March 11, 1980
    Assignee: Sandoz, Inc.
    Inventor: Goetz E. Hardtmann
  • Substituted 4-hydroxy pyridones
    Patent number: 4191827
    Abstract: This disclosure describes novel compounds of the formula: ##STR1## where R.sub.1 is straight chain lower alkyl or ##STR2## where R.sub.4 is hydrogen or halo having an atomic weight of about 19 to 36, andR.sub.2 is straight chain lower alkyl, andR.sub.3 is hydrogen or halo as defined above,which are useful as minor tranquilizers and muscle relaxants.
    Type: Grant
    Filed: September 18, 1978
    Date of Patent: March 4, 1980
    Assignee: Sandoz, Inc.
    Inventor: Jeffrey Nadelson