Patents Assigned to Sandoz Ltd.
  • Patent number: 5532164
    Abstract: Fungi which grow white/colorless and reduce pitch are used to protect structural wood before or after cutting from logs against color staining by staining fungi.
    Type: Grant
    Filed: May 20, 1994
    Date of Patent: July 2, 1996
    Assignee: Sandoz Ltd.
    Inventors: Robert A. Blanchette, Roberta L. Farrell, Chad J. Behrendt
  • Patent number: 5530181
    Abstract: This invention relates to inbred corn lines having the designation 899 and 901, seeds produced by said lines and hybrid corn seed produced by crossing said inbred corn lines
    Type: Grant
    Filed: July 8, 1994
    Date of Patent: June 25, 1996
    Assignee: Sandoz Ltd.
    Inventor: Monroe E. Howell
  • Patent number: 5530008
    Abstract: 5-HT.sub.3 Receptor antagonists are useful in treating panic disorders or obsessive compulsive disorders.
    Type: Grant
    Filed: January 24, 1994
    Date of Patent: June 25, 1996
    Assignee: Sandoz Ltd.
    Inventors: Alberto E. Azcona, Pamela Taylor
  • Patent number: 5527886
    Abstract: Fiber-reactive compounds of the formulaX-O.sub.2 S-W.sub.1 [F.sub.c ]W.sub.2 -NR-Z,and water-soluble salts thereof each cation of which is independently a non-chromophoric cation, and mixtures of such compounds or water-soluble salts,whereinFc is a chromophore-containing radical of a monoazo, disazo, polyazo, formazan, anthraquinone, dioxazine, phenazine or azomethine dye, which is in metal-free or metal complex form,each of W.sub.1 and W.sub.2 is independently a direct bond or a bridging group which is attached to a carbon atom of an aromatic carbocyclic ring or to a carbon or nitrogen atom of an aromatic heterocyclic ring present in F.sub.c,X is --CH.dbd.CH.sub.2 or --C.sub.2-4 alkylene--Y, wherein Y is hydroxy or a group which can be split off under alkaline conditions,R is hydrogen, C.sub.1-4 alkyl or C.sub.1-4 alkyl monosubstituted by hydroxy, halo, cyano, --SO.sub.3 H, --OSO.sub.3 H or --COOH, andZ is ##STR1## with the provisos as set forth herein.
    Type: Grant
    Filed: June 16, 1992
    Date of Patent: June 18, 1996
    Assignee: Sandoz Ltd.
    Inventors: Gunther Auerbach, Markus Dorr, Paul Doswald, Markus Gisler, Werner Koch, Helmut A. Moser, Roland Wald
  • Patent number: 5525590
    Abstract: Cyclosporins wherein the residue at the 1-position (typically -MeBmt- or -dihydro-MeBmt-) is 3'O-acylated or 3'-oxo or -C.sub.1-4 alkoxyimino substituted, or wherein the residue at the 2-position is .beta.-O-acyl or .beta.-oxo substituted, or wherein the residue at the 2-position is -Ile-, or wherein the residue at the 11-position is -MeAls-, -MeIle- or -MealloIle- as well as various naturally occurring cyclosporins/dihydro-derivatives thereof, are useful in reversing resistance to chemotherapy, in particular resistance to cytostatic or anti-neoplastic therapy. Various of these cyclosporins and intermediates for their production are novel. Intermediates wherein the residue (e.g. -MeBmt-, -dihydro-MeBmt- etc.) at the 1-position is 8'-alkoxy or 7'-desmethyl-7'-hydrocarbyl substituted are novel and useful as immunosuppressants, anti-inflammatory and anti-parasitic agents.
    Type: Grant
    Filed: November 10, 1994
    Date of Patent: June 11, 1996
    Assignee: Sandoz Ltd.
    Inventors: Pietro Bollinger, Johann J. Bolsterli, Trevor G. Payne
  • Patent number: 5523387
    Abstract: This invention relates to dyes in salt form which are useful for mass dyeing of synthetic polymers. In particular, this invention relates to ammonium or immonium salt-containing dyes that display good polymer affinity, and the methods for using those dyes to color polymeric substrates.
    Type: Grant
    Filed: June 14, 1994
    Date of Patent: June 4, 1996
    Assignee: Sandoz Ltd.
    Inventors: Jurgen Goldmann, Bansi L. Kaul
  • Patent number: 5522907
    Abstract: Pregerminated seeds comprising desiccation tolerant emerged radicles, processes for their production, and plants produced from such seeds.
    Type: Grant
    Filed: May 24, 1995
    Date of Patent: June 4, 1996
    Assignee: Sandoz Ltd.
    Inventors: Gerhard T. Bruggink, Peter Van der Toorn
  • Patent number: 5523085
    Abstract: Monoclonal antibody BR55-2 and fragments thereof having the specificity of monoclonal antibody BR55-2, and variants thereof, are useful in the treatment of small cell lung carcinoma.
    Type: Grant
    Filed: January 24, 1995
    Date of Patent: June 4, 1996
    Assignee: Sandoz Ltd.
    Inventors: Hans Loibner, Dieter Scholz
  • Patent number: 5520948
    Abstract: Improved nutritional formulations based on the total formulation calories, of about 40 to 90% of calories as carbohydrates, about 2 to 30% of calories as protein, about 0 to 35% of calories as fat, and about 0 to 17% of calories as fiber. The formulations may also contain 100% of U.S. RDA of vitamins and minerals. The formulations have a high acid (low pH) content (e.g., pH 3.5-3.9). The formulations may be carbonated or non-carbonated. The formulations are preferably used as an oral nutritional supplement providing about 1.0 calorie/ml.
    Type: Grant
    Filed: February 28, 1995
    Date of Patent: May 28, 1996
    Assignee: Sandoz Ltd.
    Inventor: Candis D. Kvamme
  • Patent number: 5520827
    Abstract: Aqueous microemulsions of protonated aminopolysiloxanes (.alpha.) comprising an amphoteric surfactant (.beta.) and optionally at least one non-ionic emulsifier (.gamma.) and optionally hydrotropics (.delta.) and/or cationic emulsifiers (.eta.) and the pH of which is .ltoreq.7 are suitable as finishing agents of good stability, in particular stability to shearing forces, for the treatment of fibrous material, in particular textile material.
    Type: Grant
    Filed: November 15, 1994
    Date of Patent: May 28, 1996
    Assignee: Sandoz Ltd.
    Inventor: Bernard Danner
  • Patent number: 5519044
    Abstract: The invention provides use of a 5HT-3 antagonist in the manufacture of a medicament suitable for the prevention or reduction of dependence on a dependence-inducing agent.
    Type: Grant
    Filed: December 7, 1993
    Date of Patent: May 21, 1996
    Assignee: Sandoz Ltd.
    Inventors: Assunta Imperato, Dietmar Romer
  • Patent number: 5516767
    Abstract: Compounds of the formula ##STR1## where X.sub.1 and X.sub.2 are independently O or S, andR.sub.1 is as defined in the descriptionR.sub.2, R.sub.3, and R.sub.4 are each independently straight orbranched chain (C.sub.1-4)alkyl, and pharmaceutically acceptable salts, physiological hydrolysable esters, and pro-drug forms thereof are useful as hypoglycemic agents.
    Type: Grant
    Filed: January 17, 1995
    Date of Patent: May 14, 1996
    Assignee: Sandoz Ltd.
    Inventors: Robert C. Anderson, James D. Fraser, Howard C. Smith, Jeffrey W. Hughes, Edwin B. Villhauer, Gregory R. Bebernitz
  • Patent number: 5514783
    Abstract: The invention provides a process for the production of azodyes and their derivatives by diazotization and coupling reactions and optionally further modification reactions, wherein a compound of formula ##STR1## in which E signifies an aromatic bivalent radical,X.sub.1 signifies hydroxy or a primary amino group,Y.sub.1 signifies hydroxy or a primary amino groupand in whichthe aminogroup linked to the --SO.sub.2 -bound phenyl radical may optionally be acylated,or a mixture of compounds of formula (I), is employed as a coupling component or/and--in the non-acylated form--as a diazo component,the invention in particular relates also to the novel dyes and their use and to the novel intermediates.
    Type: Grant
    Filed: April 28, 1995
    Date of Patent: May 7, 1996
    Assignee: Sandoz Ltd.
    Inventors: Jordi B. Barra, Jose R. Sorolla
  • Patent number: 5514685
    Abstract: The invention concerns the compounds of formulae ##STR1## wherein the substituents have various significances. They can be prepared by various methods, e.g. acylation, reduction, alkylation, etc. They are indicated for use as pharmaceuticals, in particular as immunosuppressant, antiproliferative and antiinflammatory agents.
    Type: Grant
    Filed: May 15, 1995
    Date of Patent: May 7, 1996
    Assignee: Sandoz Ltd.
    Inventor: Karl Baumann
  • Patent number: 5513766
    Abstract: Improvements in the etching of aluminum and aluminum alloys is obtained by etching the workpiece in a caustic etching bath in the presence of an anionic surfactant of the sulfate or sulfonate type. Satisfactory results are achieved with reduced amounts of dissolved aluminum.
    Type: Grant
    Filed: November 30, 1993
    Date of Patent: May 7, 1996
    Assignee: Sandoz Ltd.
    Inventors: Richard L. Ranieri, Pinakin Patel
  • Patent number: 5512060
    Abstract: A process for the treatment of a textile material comprisinga) applying evenly a liquor solution (hereinafter referred to as "the liquor") for performing the treatment to the material in such a manner that the dry weight uptake of the solution at the end of this step is no more than 200%;b) then passing the material into a high frequency field of 10-50 MHz for 1 to 120 seconds; andc) optionally maintaining the material at the temperature that the material reaches in the high frequency field for up to 15 minutes (preferably 1-5 minutes).
    Type: Grant
    Filed: May 12, 1995
    Date of Patent: April 30, 1996
    Assignee: Sandoz Ltd.
    Inventors: Saverio Fornelli, Illa Souren
  • Patent number: 5510483
    Abstract: The invention provides a process for the production of azodyes and their derivatives by diazotization and coupling reactions and optionally further modification reactions, wherein a compound of formula ##STR1## in which E signifies an aromatic bivalent radical,X.sub.1 signifies hydroxy or a primary amino group,Y.sub.1 signifies hydroxy or a primary amino group and in which the aminogroup linked to the --SO.sub.2 --bound phenyl radical may optionally be acylated,or a mixture of compounds of formula (I), is employed as a coupling component or/and--in the non-acylated form--as a diazo component, the invention in particular relates also to the novel dyes and their use and to the novel intermediates.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: April 23, 1996
    Assignee: Sandoz Ltd.
    Inventors: Jordi B. Barra, Jose R. Sorolla
  • Patent number: 5510467
    Abstract: Salts of the formulaF.sub.n .multidot.A,wherein F is an anion of a metal-free anionic dye having m acid groupswherein m is 1 to 4, inclusive,A is a cation of an amine containing 1 to 4 sterically hindered amine groups, andn is 1 or 2,with the proviso that the salt contains 1 to n.times.m groups selected from ammonium and immonium groups, useful as pigments, particularly for the coloring of solvent-free and solvent-containing plastic materials, lacquers and printing inks.
    Type: Grant
    Filed: December 13, 1993
    Date of Patent: April 23, 1996
    Assignee: Sandoz Ltd.
    Inventors: Bansi L. Kaul, Angelos-Elie Vougioukas
  • Patent number: 5510403
    Abstract: A process for dyeing synthetic polyamide comprising applying to the polyamide a compound of formula I or II ##STR1## in which R.sub.2 is hydrogen, trifluoromethyl, halogen, C.sub.1-4 alkyl, C.sub.1-4 alkoxy, cyano, nitro, hydroxyl, amino, C.sub.1-4 alkylamino, di-(C.sub.1-4)alkylamino, phenylamino, N-C.sub.1-4 alkyl-N-phenylamino; benzoylamino, acyl, acyloxy or acylamino,Me is a divalent metal atom;R.sub.1 is 1,2-phenylene, 1,2-, 2,3- or 1,8-naphthalene or 2,2'-diphenylene, the phenylene and naphthalene groups of R.sub.1 being unsubstituted or mono- or di-substituted by R.sub.2a where R.sub.2a has a significance of R.sub.2 other than hydrogen or by 3 or 4 halogen atoms; or in the naphthalene group two adjacent carbon atoms can be bridged by --NH--CO--NH--, --N.dbd.C(CH.sub.3)--NH--, --N.dbd.C(C.sub.6 H.sub.5)--NH--, --CO--N(C.sub.6 H.sub.5)--CO--, --CO--NH--CO--, ##STR2## R.sub.3 is ##STR3## where R is hydrogen or C.sub.1-4 alkyl unsubstituted or substituted by 1 to 4 groups selected from halogen, cyano, C.
    Type: Grant
    Filed: January 7, 1991
    Date of Patent: April 23, 1996
    Assignee: Sandoz Ltd.
    Inventor: Bansi L. Kaul
  • Patent number: 5510353
    Abstract: Compounds of formulaA--X--Y--NH--Bwherein A is derived from optionally substituted benzothiophene, indole, 4-aza-and 7-aza-benzothiophene or-indole, A bearing in position 5 hydrogen, halogen, optionally substituted alkyl, hydroxy, nitro, amino, alkylamino, acylamino, alkoxycarbonyl, sulfamoyl, cyano, trimethylsilyl, carboxy, carbamoyl, phosphate, oxycarbamoyl, heterocyclic radical or ether or ester group, X-Y is --CR.sub.8 .dbd.N-- or CH(R.sub.8)--NH-- wherein R.sub.8 is -H or alkyl and attached at position 3 of A, and B is a heterocyclic radical or a residue ##STR1## wherein R.sub.10 is H, optionally substituted alkyl, cycloalkyl, aryl, adamantyl, acyl or carbamoyl and X.sub.2 is alkylthio or NR.sub.3 R.sub.10 wherein R.sub.3 is H or alkyl or R.sub.3 and R.sub.10 together with the nitrogen atom to which they are attached form a heterocyclic radical, in free form or in salt form, have pharmacological activity, e.g. for treating gastrointestinal disorders.
    Type: Grant
    Filed: January 9, 1995
    Date of Patent: April 23, 1996
    Assignee: Sandoz Ltd.
    Inventors: Rudolf K. A. Giger, Henri Mattes