Patents Assigned to Sandoz Ltd.
  • Patent number: 5602176
    Abstract: The (S)-N-ethyl-3-[(1-dimethylamino)ethyl]-N-methyl-phenylncarbamate in free base or acid addition salt form is useful as pharmaceutical, particularly for systemic transdermal administration.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: February 11, 1997
    Assignee: Sandoz Ltd.
    Inventor: Albert Enz
  • Patent number: 5601746
    Abstract: Aqueous dispersions (D) of a wax (W) dispersed in the aqueous phase by means of a dispersant (B), wherein in (D)the wax (W) is(A) an oxidized hydrocarbon wax or a mixture of oxidized hydrocarbon waxesor a mixture or (A) and at least one non-oxidized hydrocarbon wax (P), the acid number of which is.gtoreq.5,and the dispersant (B) isa non-ionogenic, anionic, cationic or amphoteric surfactant or a mixture of two or more of these surfactants, which displays an HLB.gtoreq.7,and the dispersion (D) optionally contains at least one protective colloid (C), at least one agent (E) for pH-adjustment, at least one antifreeze agent (F) and/or at least one preserving agent (D), but is substantially free of other waxes than (A) and (P) and of other surfactants than (B) and (C),are eminently suitable as wet lubricants that are very stable to temperature modifications and to high electrolyte concentrations, especially as occurring in pretreatment and in dyeing of cellulosic substrates.
    Type: Grant
    Filed: September 26, 1994
    Date of Patent: February 11, 1997
    Assignee: Sandoz Ltd.
    Inventors: Bernard Danner, Francis Palacin
  • Patent number: 5599536
    Abstract: A method for ameliorating or suppressing the acute phase response in a patient receiving IL-6 treatment comprises co-administering with the IL-6 an effective amount of granulocyte colony stimulating factor.
    Type: Grant
    Filed: December 13, 1993
    Date of Patent: February 4, 1997
    Assignee: Sandoz Ltd.
    Inventor: Laurie A. Myers
  • Patent number: 5597903
    Abstract: Compounds of the formula ##STR1## salts thereof, and mixtures of such compounds and salts, wherein D.sub.1 is ##STR2## wherein R.sub.1 is hydrogen, halo, C.sub.1-4 alkyl, C.sub.1-4 alkoxy, --SO.sub.3 H or --COOH,R.sub.2 is --COOH, --CONR.sub.6 R.sub.7, --SO.sub.2 NR.sub.6 R.sub.7 or --SO.sub.2 --X, wherein each of R.sub.6 and R.sub.7 is independently hydrogen, C.sub.1-4 alkyl, C.sub.2-4 -hydroxyalkyl or C.sub.2-4 sulfatoalkyl, or--NR.sub.6 R.sub.7 is a saturated 5- or 6-membered heterocyclic ring containing no hetero atom in addition to the nitrogen atom to which R.sub.6 and R.sub.7 are attached or containing one hetero atom selected from nitrogen and oxygen in addition to said nitrogen atom, which ring is unsubstituted or substituted by 1 to 3 C.sub.1-4 alkyl groups, andm is 0, 1 or 2, andD.sub.2 is ##STR3## wherein R.sub.3 is hydrogen, --SO.sub.3 H or --COOH,R.sub.4 is hydrogen, C.sub.1-4 alkyl or C.sub.1-4 alkyl monosubstituted by hydroxy, halo, cyano, --SO.sub.3 H, --OSO.sub.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: January 28, 1997
    Assignee: Sandoz Ltd.
    Inventor: Markus Gisler
  • Patent number: 5596094
    Abstract: A process for alkylating the 2'-OH of N.sup.6 -modified adenosine comprising the reacting of an unprotected N.sup.6 -alkyl adenosine with dimethyl sulfate and tetrabutylammonium hydrogen sulfate in a non-polar solvent, preferably dichloromethane, and 5% sodium hydroxide. The products of the reaction are useful as anti-diabetic, hypolipidemic, and analgesic agents.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: January 21, 1997
    Assignee: Sandoz Ltd.
    Inventors: Mahavir Prashad, Prasad K. Kapa
  • Patent number: 5595175
    Abstract: An inhaler for administering powdered medicaments comprising a one-piece, elongate body that has an elongate magazine in a magazine passage extending through the elongate body. The elongate body also has an air inlet, a mouthpiece, and a capsule cutter. The elongate magazine has a plurality of capsule chambers defined in it and spaced along its length, each capsule chamber having an air inlet alignable with the air inlet to the elongate body and an air outlet alignable with the mouthpiece. The magazine is slidable step-wise along the magazine passage to align a capsule chamber with the air inlet to the elongate body, the mouthpiece and the capsule cutter. The capsule cutter, upon activation, pierces both ends of a capsule in the capsule chamber.
    Type: Grant
    Filed: March 28, 1994
    Date of Patent: January 21, 1997
    Assignee: Sandoz Ltd.
    Inventors: Eric Malcher, Kurt Zechner
  • Patent number: 5595594
    Abstract: An anti-efflorescence admixture for concrete products comprising a tall oil fatty acid and a fatty acid, a portion of the acid content of the tall oil fatty acid and/or fatty acid optionally being present in salt form with an alkanolamine or alkylamine, which admixture is effective in controlling both primary and secondary efflorescence.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: January 21, 1997
    Assignee: Sandoz Ltd
    Inventors: Jie-Yi Dong, David F. Factor, Hamid Farzammehr, Kenneth Sroka
  • Patent number: 5596036
    Abstract: A hardenable composition suitable for flooring and for coating concrete surfaces comprising(a) an acrylic binder comprising a (meth)acrylic ester of the formula ##STR1## where R.sub.1 is C.sub.2-6 alkylene, n is 0-3 and R.sub.2 is a radical of an aromatic or alicyclic dicarboxylic acid ester or a dicyclopentenyl radical, n being 0 only when R.sub.2 is a dicyclopentenyl radical, and(b) a component which is one or both (preferably both) of carbon black and a polyfunctional aliphatic or aromatic polyester- or polyether- urethane oligomer. The composition also preferably comprises aggregate such as sand. The compositions have excellent impact resistance and flexural strength.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: January 21, 1997
    Assignee: Sandoz Ltd.
    Inventor: Karoly Disch o
  • Patent number: 5593686
    Abstract: The present invention provides a pharmaceutical composition for the transdermal systemic administration of an active agent characterized in that the active agent is bopindolol or methysergide. Also the present invention provides a pharmaceutical composition for the transdermal systemic administration of a pharmacologically active agent characterized in that it contains bopindolol, tizanidine, clemastine, ketotifen or methysergide as active agent in a reservoir comprising a hydrophilic polymer. Furthermore a pharmaceutical composition for the transdermal systemic administration of pharmacologically active agents characterized in that the pharmacologically active agent is in a reservoir comprising a polyacrylate polymer containing cationic ester groups.
    Type: Grant
    Filed: September 28, 1994
    Date of Patent: January 14, 1997
    Assignee: Sandoz Ltd.
    Inventors: Thomas Kissel, Henriette Schrank, Hans-Rainer Hoffmann
  • Patent number: 5591259
    Abstract: Rapid setting cementitious compositions comprise hydraulic cement and at least 4% by weight based on the weight of the cement of a water-soluble malate or citramalate such as an alkali metal malate or alkali metal citramalate.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: January 7, 1997
    Assignee: Sandoz Ltd.
    Inventors: Lan Huang, Stephen A. Farrington
  • Patent number: 5587312
    Abstract: Somatic embryo suspension cultures and pro-embryogenic mass suspension cultures (PEMs) comprising somatic embryos and PEMs having substantially similar ploidy levels, plants derived therefrom, and methods for obtaining said somatic embryos.
    Type: Grant
    Filed: March 20, 1995
    Date of Patent: December 24, 1996
    Assignee: Sandoz Ltd.
    Inventors: Gerrit J. van Holst, Marc Kreuger, Wiert van der Meer, Erik Postma, Rob Abbestee
  • Patent number: 5585051
    Abstract: Microcapsules containing a solution or dispersion of a colorant, especially a solution of an oil-solubilized sulfur dye, in an organic liquid having a vapor pressure below 20 mm Hg at 25.degree. C. can be coated on a side of a sheet of paper for use in pressure-sensitive carbonless copy systems. The solutions of the oil-solubilized sulfur dyes, i.e. 1) colored products of the oxidation of a leuco sulfur dye, leuco sulfurized vat dye or reaction product of a leuco dye or sulfurized vat dye with a cationic compound and 2) colored reaction products of a solubilized sulfur dye with a cationic compound also constitute an aspect of the invention, as do microcapsules whose walls contain an opacifying agent incorporated therein.
    Type: Grant
    Filed: March 2, 1995
    Date of Patent: December 17, 1996
    Assignee: Sandoz Ltd.
    Inventors: Lynn Hosie, Niraj Agarwal, Maria W. Sie, David A. Whitley
  • Patent number: 5585540
    Abstract: Polyploid Fragaria plants propagatable from seed wherein substantially each plant is capable of a fruit productivity within its first year, F1 hybrid Fragaria plants, methods for producing F1 hybrid Fragaria plants, F1 hybrid Fragaria seed, and Fragaria berries thereof.
    Type: Grant
    Filed: May 9, 1995
    Date of Patent: December 17, 1996
    Assignee: Sandoz Ltd.
    Inventors: Gerardus C. M. Bentvelsen, Willem Sterk
  • Patent number: 5585536
    Abstract: Pregerminated seeds comprising desiccation tolerant emerged radicles, processes for their production, and plants produced from such seeds.
    Type: Grant
    Filed: February 15, 1995
    Date of Patent: December 17, 1996
    Assignee: Sandoz Ltd.
    Inventors: Gerhard T. Bruggink, Peter Van der Toorn
  • Patent number: 5583207
    Abstract: Fibre-reactive 1:1 copper complexes of the formula ##STR1## which compounds are in free acid or salt form, and mixtures thereof, are useful for dyeing or printing hydroxy group- or nitrogen-containing organic substrates, for example leather and fibre material comprising natural or synthetic polyamides or natural or regenerated cellulose; the most preferred substrate is a textile material comprising cotton.
    Type: Grant
    Filed: May 2, 1995
    Date of Patent: December 10, 1996
    Assignee: Sandoz Ltd.
    Inventors: Rainer Nusser, Roland Wald
  • Patent number: 5578301
    Abstract: A method for reducing or suppressing the acute phase response in a patient receiving IL-6 treatment which comprises co-administering with the IL-6 an effective amount of granulocyte macrophage colony stimulating factor (GM-CSF).
    Type: Grant
    Filed: December 14, 1993
    Date of Patent: November 26, 1996
    Assignee: Sandoz Ltd.
    Inventor: Laurie A. Myers
  • Patent number: 5578712
    Abstract: Fibre-reactive monoazo compounds of the formula ##STR1## which compounds are in free acid or salt form, and mixtures thereof, are useful for dyeing or printing hydroxy group- or nitrogen-containing organic substrates, for example leather and fibre material comprising natural or synthetic polyamides or natural or regenerated cellulose; the most preferred substrate is a textile material comprising cotton.
    Type: Grant
    Filed: May 2, 1995
    Date of Patent: November 26, 1996
    Assignee: Sandoz Ltd.
    Inventors: Markus Doerr, Roland Wald
  • Patent number: 5578567
    Abstract: A pharmaceutical composition adapted for nasal administration and comprising hPTH or a N-terminal fragment thereof. Preferred carriers are optionally coated celluloses.
    Type: Grant
    Filed: August 25, 1993
    Date of Patent: November 26, 1996
    Assignee: Sandoz Ltd.
    Inventors: Fran.cedilla.ois Cardinaux, Christine Oechslein, Andreas Rummelt
  • Patent number: 5573694
    Abstract: Aqueous microemulsions of protonated aminopolysiloxanes (.alpha.) comprising an amphoteric surfactant (.beta.) and optionally at least one non-ionic emulsifier (.gamma.) and optionally hydrotropics (.delta.) and/or cationic emulsifiers (.eta.) and the pH of which is .ltoreq.7 are suitable as finishing agents of good stability, in particular stability to shearing forces, for the treatment of fibrous material, in particular textile material.
    Type: Grant
    Filed: March 3, 1995
    Date of Patent: November 12, 1996
    Assignee: Sandoz Ltd.
    Inventor: Bernard Danner
  • Patent number: 5573653
    Abstract: An improved electrochemical process for thiocyanating aminobenzene compounds (e.g., 3,4-dichloroaniline), and in particular a process for preparing 2-aminobenzothiazole compounds, is disclosed which provides attractive yields under relatively favorable temperature conditions, and with reduced or minimal cyanide formation. In a further aspect, use of quaternary ammonium salts in the thiocyanation medium has been found to inhibit cathodic corrosion.
    Type: Grant
    Filed: April 18, 1995
    Date of Patent: November 12, 1996
    Assignee: Sandoz Ltd.
    Inventor: Baldev K. Bandlish