Patents Assigned to Sangamo Biosciences, Inc.
  • Method of inactivating a glucocorticoid receptor gene in an isolated cell
    Patent number: 11884930
    Abstract: Disclosed herein are methods and compositions for inactivation of the human glucocorticoid receptor (GR) gene by targeted cleavage of genomic DNA encoding the GR. Such methods and compositions are useful, for example, in therapeutic applications which require retention of immune function during glucocorticoid treatment.
    Type: Grant
    Filed: December 18, 2020
    Date of Patent: January 30, 2024
    Assignees: Sangamo Biosciences, Inc., City of Hope
    Inventors: Andreas Reik, Michael Jensen, Michael C. Holmes, Philip D. Gregory, Dale Ando
  • Methods and compositions for treatment of a genetic condition
    Patent number: 9650648
    Abstract: Methods and compositions for a genetic disease are provided.
    Type: Grant
    Filed: August 29, 2013
    Date of Patent: May 16, 2017
    Assignee: SANGAMO BIOSCIENCES, INC.
    Inventors: Gregory J. Cost, Philip D. Gregory, Dmitry Guschin, Michael C. Holmes, Jeffrey C. Miller, David Paschon, Edward J. Rebar, Andreas Reik, Fyodor Urnov, Lei Zhang
  • Methods and compositions for treating hemophilia B
    Patent number: 9629930
    Abstract: Disclosed herein are methods and compositions for insertion of Factor IX (FIX) sequences into the genome of a cell for treating hemophilia B.
    Type: Grant
    Filed: October 8, 2015
    Date of Patent: April 25, 2017
    Assignees: Sangamo Biosciences, Inc., The Children's Hospital of Philadelphia
    Inventors: Philip D. Gregory, Katherine A. High, Michael C. Holmes, Hojun Li
  • Methods and compositions for targeted single-stranded cleavage and targeted integration
    Patent number: 9631186
    Abstract: Disclosed herein are methods and compositions for generating a single-stranded break in a target sequence, which facilitates targeted integration of one or more exogenous sequences.
    Type: Grant
    Filed: October 28, 2015
    Date of Patent: April 25, 2017
    Assignee: Sangamo BioSciences, Inc.
    Inventor: Jianbin Wang
  • Methods and compositions for gene correction
    Patent number: 9631187
    Abstract: Disclosed herein are methods and compositions for correction and/or mutation of genes associated with Parkinson's Disease as well as clones and animals derived therefrom.
    Type: Grant
    Filed: October 29, 2015
    Date of Patent: April 25, 2017
    Assignees: Sangamo BioSciences, Inc., Whitehead Institute for Biomedical Research
    Inventors: Rudolf Jaenisch, Josee Laganiere, Frank Soldner, Lei Zhang
  • Engineered zinc finger proteins targeting plant genes involved in fatty acid biosynthesis
    Patent number: 9631201
    Abstract: The present disclosure relates to engineered zinc finger proteins that target genes in plants involved in fatty acid biosynthesis. Methods of using such zinc finger proteins in modulating gene expression, gene inactivation, and targeted gene modification are also provided.
    Type: Grant
    Filed: November 25, 2013
    Date of Patent: April 25, 2017
    Assignees: Sangamo BioSciences, Inc., Dow AgroSciences LLC
    Inventors: Russell DeKelver, Manju Gupta, Jeffrey C. Miller, Stephen Novak, Joseph F. Petolino
  • Methods and compositions for regulation of zinc finger protein expression
    Patent number: 9624498
    Abstract: The present disclosure is in the field of genome engineering, particularly regulating targeted modification of the genome.
    Type: Grant
    Filed: March 18, 2015
    Date of Patent: April 18, 2017
    Assignee: SANGAMO BIOSCIENCES, INC.
    Inventors: Steven Froelich, Philip D. Gregory, H. Steve Zhang
  • Modulation of stem cells using zinc finger proteins
    Patent number: 9624509
    Abstract: Methods and compositions for modifying stem cells using one or more ZFPs are disclosed. Such methods and compositions are useful for facilitating processes such as, for example, dedifferentiating cells, differentiating stem cells into the desired phenotype, propagating stem cells and/or facilitating cloning.
    Type: Grant
    Filed: May 5, 2014
    Date of Patent: April 18, 2017
    Assignee: SANGAMO BIOSCIENCES, INC.
    Inventors: Alan P. Wolffe, Michael Moore, Timothy Farries, Trevor Collingwood, Fyodor Urnov
  • Gene correction of SCID-related genes in hematopoietic stem and progenitor cells
    Patent number: 9616090
    Abstract: The present disclosure is in the field of genome engineering, particularly targeted integration of a functional SCID-related genes (e.g., IL2RG, RAG1 and/or RAG2 gene) into the genome of a cell for provision of proteins lacking or deficient in SCID.
    Type: Grant
    Filed: July 30, 2015
    Date of Patent: April 11, 2017
    Assignee: Sangamo BioSciences, Inc.
    Inventors: Anthony Conway, Gregory J. Cost, Michael C. Holmes, Fyodor Urnov
  • T cell modifying compounds and uses thereof
    Patent number: 9597357
    Abstract: Methods and compositions for modifying T-cells in which PD1 and/or CTLA-4 is repressed and/or inactivated using fusion proteins such as artificial transcription factors and nucleases.
    Type: Grant
    Filed: October 10, 2013
    Date of Patent: March 21, 2017
    Assignee: Sangamo BioSciences, Inc.
    Inventors: Philip D. Gregory, Michael C. Holmes
  • Methods and compositions for prevention or treatment of a disease
    Patent number: 9574211
    Abstract: Methods and compositions for treatment of a genetic disease are provided.
    Type: Grant
    Filed: May 13, 2015
    Date of Patent: February 21, 2017
    Assignee: Sangamo BioSciences, Inc.
    Inventors: Philip D. Gregory, Michael C. Holmes
  • Methods and compositions for inhibiting viral entry into cells
    Patent number: 9566352
    Abstract: Disclosed herein are methods and compositions for inhibiting viral entry into cells.
    Type: Grant
    Filed: September 26, 2011
    Date of Patent: February 14, 2017
    Assignee: Sangamo BioSciences, Inc.
    Inventors: Michael C. Holmes, Jianbin Wang
  • Genome editing of a locus using nucleases
    Patent number: 9567573
    Abstract: Disclosed herein are methods and compositions for genome editing of a Rosa locus, using fusion proteins comprising a DNA binding domain and a cleavage domain or cleavage half-domain. Polynucleotides encoding said fusion proteins are also provided, as are cells comprising said polynucleotides and fusion proteins.
    Type: Grant
    Filed: April 25, 2011
    Date of Patent: February 14, 2017
    Assignee: Sangamo BioSciences, Inc.
    Inventors: Philip D. Gregory, Michael C. Holmes
  • Compositions for linking DNA-binding domains and cleavage domains
    Patent number: 9567609
    Abstract: Disclosed herein are compositions for linking DNA binding domains and cleavage domains (or cleavage half-domains) to form non-naturally occurring nucleases. Also described are methods of making and using compositions comprising these linkers.
    Type: Grant
    Filed: August 28, 2014
    Date of Patent: February 14, 2017
    Assignee: Sangamo BioSciences, Inc.
    Inventors: David Paschon, Lei Zhang
  • Engineered transcription activator like effector (TALE) proteins
    Patent number: 9522936
    Abstract: Disclosed herein are methods and compositions for design and use of engineered TALEs.
    Type: Grant
    Filed: April 24, 2015
    Date of Patent: December 20, 2016
    Assignee: Sangamo BioSciences, Inc.
    Inventors: Jeffrey C. Miller, Edward J. Rebar
  • Targeted modification of malate dehydrogenase
    Patent number: 9523098
    Abstract: Disclosed herein are methods and compositions for targeted modification of one or more endogenous plant malate dehydrogenase genes.
    Type: Grant
    Filed: May 2, 2013
    Date of Patent: December 20, 2016
    Assignees: Dow AgroSciences LLC, Sangamo BioSciences, Inc.
    Inventors: Vipula Shukla, Manju Gupta, Fyodor Urnov, Dmitry Guschin, Michiel Jan De Both, Paul Bundock, Lakshmi Sastry-Dent
  • Rapid in vivo identification of biologically active nucleases
    Patent number: 9506120
    Abstract: Disclosed herein are methods and compositions for rapidly identifying and ranking nucleases for specific cleavage of a target sequence.
    Type: Grant
    Filed: September 25, 2008
    Date of Patent: November 29, 2016
    Assignee: Sangamo BioSciences, Inc.
    Inventors: Yannick Doyon, Fyodor Urnov
  • Methods and compositions for treating Huntington's disease
    Patent number: 9499597
    Abstract: Disclosed herein are compositions comprising non-naturally occurring zinc finger domains, fusion proteins comprising these zinc finger domains, polynucleotides encoding these proteins, cells expressing these proteins and pharmaceutical compositions comprising these proteins or polynucleotides as well as methods of modifying an Htt gene using these compositions for treating or preventing Huntington's Disease.
    Type: Grant
    Filed: July 29, 2014
    Date of Patent: November 22, 2016
    Assignee: Sangamo BioSciences, Inc.
    Inventors: Jeffrey C. Miller, Edward J. Rebar, H. Steve Zhang
  • DNA-binding proteins and uses thereof
    Patent number: 9493750
    Abstract: Disclosed herein are polypeptides, polynucleotides encoding, cells and organisms comprising novel DNA-binding domains, including TALE DNA-binding domains. Also disclosed are methods of using these novel DNA-binding domains for modulation of gene expression and/or genomic editing of endogenous cellular sequences.
    Type: Grant
    Filed: October 28, 2013
    Date of Patent: November 15, 2016
    Assignee: Sangamo BioSciences, Inc.
    Inventors: Philip D. Gregory, Jeffrey C. Miller, David Paschon, Edward J. Rebar, Siyuan Tan, Fyodor Urnov, Lei Zhang
  • FAD2 performance loci and corresponding target site specific binding proteins capable of inducing targeted breaks
    Patent number: 9493779
    Abstract: Methods and compositions for gene disruption, gene editing or gene stacking within a FAD2 loci by cleaving, in a site directed manner, a location in a FAD2 gene in a soybean cell, to generate a break in the FAD2 gene and then optionally integrating into the break a nucleic acid molecule of interest is disclosed.
    Type: Grant
    Filed: September 5, 2013
    Date of Patent: November 15, 2016
    Assignees: Dow AgroSciences LLC, Sangamo BioSciences, Inc.
    Inventors: William Michael Ainley, Steven R. Webb, Pon Samuel, Dmitry Y. Guschin, Jeffrey C. Miller, Lei Zhang