Patents Assigned to Sartorius
  • BIOREACTOR CONTAINER AND INTEGRITY CHECK METHOD FOR BIOREACTOR CONTAINERS
    Publication number: 20160040109
    Abstract: A bioreactor container comprising has an at least locally flexible wall and at least one container opening. The wall of the bioreactor container has a fluid-tight inner sheet, and an at least locally fluid-permeable or structured outer sheet. A method for testing the integrity of the bioreactor container also is provided.
    Type: Application
    Filed: October 19, 2015
    Publication date: February 11, 2016
    Applicant: Sartorius Stedim Biotech GmbH
    Inventors: Martin Dahlberg, Isabelle Gay, Lars Boettcher, Stefan Obermann, Rainer Sandrock
  • Bioreactor
    Patent number: 9255244
    Abstract: A bioreactor (1) having a container (2), a shaft housing (3) for guiding a shaft (5) through a wall (7), a stirrer (6) connected to the shaft (5) in the interior (9) of the container (2), and a drive (4) arranged outside the container (2) and connectable to the shaft (5). The shaft (5) is mounted in the shaft housing (3) via at least one ball bearing (23) and is sealed in relation to the shaft housing (3) by at least one seal (11, 20). The seal (11, 20) is configured as a radial shaft seal (28) having two sealing lips (30, 31) that are arranged one behind the other in the longitudinal direction of the shaft (5) and are able to run on the shaft (5) without lubricant.
    Type: Grant
    Filed: February 12, 2009
    Date of Patent: February 9, 2016
    Assignee: Sartorius Stedim Biotech GmbH
    Inventors: Juergen Van Den Boogaard, Gerhard Greller, Jens Ludwig, Oscar-Werner Reif
  • Plate heat exchanger
    Patent number: 9228784
    Abstract: The invention relates to a plate heat exchanger comprising a plurality of plates having flow channels, wherein a first plate has a front side having at least one flow channel for a first fluid and a second plate has a front side having at least one flow channel for a second fluid, and wherein the plates have through openings via which the flow channels for the same fluid are respectively connected to one another, wherein a front plate, which is placed in front of the front side of the first plate, has ports for the first fluid and for the second fluid, wherein an end plate forms the end of the aligned plates, wherein the plates and ports are formed from plastic, and wherein the plates are bonded or welded tightly together.
    Type: Grant
    Filed: June 10, 2010
    Date of Patent: January 5, 2016
    Assignee: Sartorius Stedim Biotech GmbH
    Inventors: Oscar-Werner Reif, Juergen van den Boogaard, Stefan Weisshaar
  • Filter element attachment, filter cartridge, and filter system
    Patent number: 9199202
    Abstract: A filter element attachment is provided and is attachable to a filter element. The filter element attachment includes a housing for receiving at least a part of the filter element; at least one display configured to display information associated with the filter element. The filter element attachment may be associated with a corresponding filter cartridge and a filter system.
    Type: Grant
    Filed: September 15, 2011
    Date of Patent: December 1, 2015
    Assignee: Sartorius Stedim Biotech GmbH
    Inventors: Frank Maggiore, Leon Vanwormer
  • Cleaning process for a test device, computer program product for performing such a process, and test device
    Patent number: 9174251
    Abstract: A cleaning process is provided for a test apparatus that has a switch, external connections and internal volumes that can come into contact with a fluid from a filter to be tested or a container to be tested. The cleaning process includes selecting one or more internal volumes to be cleaned, cleaning the selected internal volumes with a cleaning fluid by a corresponding switching of the switch, at least partially draining the cleaning fluid left in the selected internal volumes after cleaning, and flushing the selected internal volumes with a flushing fluid different from the cleaning fluid. Also provided are a computer program product for performing the cleaning process, a cleaning apparatus, and a test apparatus for testing filters and containers.
    Type: Grant
    Filed: April 19, 2011
    Date of Patent: November 3, 2015
    Assignee: Sartorius Stedim Biotech GMBH
    Inventors: Martin Dahlberg, Hartmut Langer, Jens Meyer, Sven-Oliver Otto
  • Disposable bioreactor for culturing cells in a nutrient medium
    Patent number: 9174181
    Abstract: Disposable bioreactor for culturing cells in a nutrient medium, consisting of a reagent container which is sealable with a lid and which is capable of being subjected to a shaking process in a shaking device, where the reagent container is equipped with at least one web adjacent to the internal wall of the container, the web being arranged running vertically from the bottom upward, preferably in the shape of a helix.
    Type: Grant
    Filed: December 20, 2006
    Date of Patent: November 3, 2015
    Assignee: Sartorius Stedim Biotech GmbH
    Inventors: Andreas Kocourek, Christopher Biddell, Oscar-Werner Reif, Florian Wurm
  • Closure for a nutrient medium container
    Patent number: 9156594
    Abstract: The invention relates to closure, in particular for a nutrient medium container, wherein a lower part can be covered by an upper part, wherein the lower part and the upper part can be locked against each other by means of at least one locking receptacle and at least one locking part by rotating the lower part and the upper part about a longitudinal axis, and wherein the locking receptacle has a receptacle groove that is covered by a shoulder and that extends perpendicularly to the longitudinal axis, in which receptacle groove the locking part engages, wherein the shoulder has at least one ramp surface extending at an angle from the longitudinal axis on the outer face of the shoulder facing away from the receptacle groove.
    Type: Grant
    Filed: October 4, 2011
    Date of Patent: October 13, 2015
    Assignee: Sartorius Stedim Biotech GmbH
    Inventors: Karl Pflanz, Andreas Graus
  • STIRRER INSTALLATION AID AND METHOD FOR INSTALLING A STIRRER ELEMENT IN A BIOREACTOR
    Publication number: 20150273416
    Abstract: A bioreactor has a stirrer shaft that is driveable by a drive and on which a stirrer element is positioned. The position of the stirrer element is determined by a stirrer installation aid. The stirrer installation aid has a free end with an abutment surface on which the free end of the stirrer element abuts. The stirrer installation aid is designed as a sleeve that comprises a slot extending between the axial ends of the sleeve. The slot is delimited by opposite flanks of a wall, and the sleeve is placed on the stirrer shaft. The stirrer installation aid can be pulled off laterally from the stirrer shaft. A method for installing the stirrer element on the stirrer shaft arranged in the bioreactor also is provided.
    Type: Application
    Filed: August 29, 2013
    Publication date: October 1, 2015
    Applicant: Sartorius Stedim Biotech GmbH
    Inventors: Thomas Dreher, Oliver Scheibe, Gerhard Greller, Ute Husemann, Oscar-Werner Reif
  • MIXING CONTAINER AND MIXING SYSTEM
    Publication number: 20150265985
    Abstract: A mixing container has a wall enclosing a mixing volume, an anchor fixed at the wall of the mixing container inside the mixing volume, and at least one mixing plate movably mounted to the anchor to allow a relative movement of the at least one mixing plate along a stir direction perpendicular to the extension of the mixing plate. Each of the at least one mixing plates is provided with at least one magnet.
    Type: Application
    Filed: March 18, 2014
    Publication date: September 24, 2015
    Applicant: Sartorius Stedim North America Inc.
    Inventor: Jonathan Cutting
  • Mounting for a side panel of a weighing machine, assembly for a windshield of a weighing machine, and method for removing a side panel of such an assembly
    Patent number: 9115534
    Abstract: A mounting (28) for a side panel (26) of a weighing machine (10) has two rails (30, 32) which lie opposite one another and extend substantially parallel to each other. The side panel (26) is guided between the rails and thereby moves between a closed position and an open position. A stop (46) on the first rail (30) co-operates with the side panel (26), such that the completely open position is defined, and the second opposite rail (32) lies opposite the first rail (30) with such a spacing that the side panel (26), when being located in the open position, can be moved away by lifting of the rear edge (29) of the side panel (26) over the stop (46), but the opposing front edge (27) of the side panel (26) cannot be lifted or can only be lifted insignificantly.
    Type: Grant
    Filed: June 14, 2014
    Date of Patent: August 25, 2015
    Assignee: Sartorius Lab Instruments GmbH & Co. KG
    Inventor: Otto Kuhlmann
  • Purification of vaccinia viruses using hydrophobic interaction chromatography
    Patent number: 9109201
    Abstract: The present invention relates to methods for purification of Vaccinia viruses (VV) and/or Vaccinia virus (VV) particles, which can lead to highly pure and stable virus preparations of predominantly biologically active viruses. The invention encompasses purifying a virus preparation in a sterilized way with high efficiency and desirable yield in terms of purity, biological activity and stability, aspects advantageous for industrial production.
    Type: Grant
    Filed: May 31, 2013
    Date of Patent: August 18, 2015
    Assignees: Bavarian Nordic A/S, Otto-von-Guericke-Universität, Sartorius Stedim Biotech GmbH
    Inventors: Sara Post Hansen, Rene Faber, Udo Reichl, Michael Wolff, Anders Peter Gram
  • Apparatus for producing surface enhanced membrane
    Patent number: 9108159
    Abstract: A membrane having a refined surface as well as to a process and an apparatus for producing such a membrane, and which is useful, in particular, for rapid diagnostic tests for identifying specific analytes in liquid media.
    Type: Grant
    Filed: September 3, 2010
    Date of Patent: August 18, 2015
    Assignee: Sartorius Stedim Biotech GmbH
    Inventors: Hans Beer, Klaus Froese, Lothar Knoechelmann, Duane B. Piechocki
  • Container having a sensor adapter
    Patent number: 9103703
    Abstract: A container having a sensor adapter for receiving a sensor arrangement for measuring at least one parameter of media contained in a container interior, wherein the sensor adapter is arranged on the wall to the container interior and has an externally accessible receiving opening in a receiving channel, which is bounded toward the container interior, for adapting the sensor arrangement, wherein toward the container interior the receiving channel in the sensor adapter has at least one boundary surface which is formed by a membrane and via which the medium or media to be measured can be supplied to the sensor arrangement.
    Type: Grant
    Filed: May 7, 2010
    Date of Patent: August 11, 2015
    Assignee: Sartorius Stedim Biotech GmbH
    Inventors: Reinhard Baumfalk, Wolfgang Kahlert, Gerhard Greller
  • Container having flexible walls with connecting piece for mixer shaft and coupling piece for drive device fixed magnetically to opposite inner and outer surfaces of container wall
    Patent number: 9095828
    Abstract: A container has flexible walls defining an interior. A mixer is arranged in the interior of the container and includes a mixer shaft with opposite first and second ends. A mixing element is mounted to the first end of the mixer shaft. The second end of the mixer shaft is fixed magnetically to a coupling piece disposed on the exterior of the flexible wall of the container. The coupling piece is connected operatively to a force introducing device that generates movement of the mixer.
    Type: Grant
    Filed: March 13, 2007
    Date of Patent: August 4, 2015
    Assignee: Sartorius Stedim Biotech GmbH
    Inventors: Heyo Mennenga, Oscar-Werner Reif, Gerhard Greller, Reinhard Baumfalk
  • Filter device test apparatus, filter integrity testing method and computer program product
    Patent number: 9095801
    Abstract: An apparatus automatically carries out an integrity test on a filter device having a fluid inlet, a fluid outlet and a venting port. The apparatus includes a filter integrity testing device having a pressure sensor and/or a flowmeter. An inlet connector is connectable to the fluid inlet, is connected via a wetting liquid supply valve to a wetting liquid supply, and is connected via a drainage valve to a first drain. An outlet connector is connectable to the fluid outlet and via an outlet valve to the first or a second drain. A venting port connector is connectable to the venting port and via a measurement valve to the pressure sensor and/or flowmeter. The venting port connector also is connected via a venting valve to a venting pipe, and via a measurement gas valve to a measurement gas source. The valves are controlled by the filter integrity testing device.
    Type: Grant
    Filed: August 11, 2011
    Date of Patent: August 4, 2015
    Assignee: Sartorius Stedim Biotech GmbH
    Inventor: Magnus Stering
  • Method For Differentiating Between Living And Dead Cells
    Publication number: 20150203898
    Abstract: The present invention relates to a method for quantitatively determining living and dead cells in a biological sample. The method according to the present invention is based on the determination of the amount of DNA in the sample with the aid of a DNA amplification reaction which does not impair the membrane integrity of living cells.
    Type: Application
    Filed: May 27, 2013
    Publication date: July 23, 2015
    Applicant: Sartorius Stedim Biotech GmbH
    Inventor: Alexandra Scholz
  • Method and apparatus for carrying out integrity tests of a non-wetted filter element
    Patent number: 9072996
    Abstract: A method and an apparatus are provided for carrying out integrity tests of at least one filter element, arranged within a filter housing, with porous filter materials. Sensors are provided for measuring the sound generated by a test fluid when it flows through the filter element. The method includes applying a test fluid to a first side of the filter materials of the filter element while maintaining a constant fluid pressure, measuring the body-borne sound and/or the vibrations caused by test fluid flowing through the filter materials by sensors, and comparing the body-borne sound and/or the vibrations with the body-borne sound and/or the vibrations of an integral, identical filter element, measured under identical conditions.
    Type: Grant
    Filed: October 21, 2009
    Date of Patent: July 7, 2015
    Assignee: Sartorius Stedim Biotech GmbH
    Inventors: Maik Jornitz, Jens Meyer
  • Electron beam induced modification of membranes by polymers
    Patent number: 9045602
    Abstract: A method and an apparatus are provided for carrying out integrity tests of at least one filter element, arranged within a filter housing, with porous filter materials. Sensors are provided for measuring the sound generated by a test fluid when it flows through the filter element. The method includes applying a test fluid to a first side of the filter materials of the filter element while maintaining a constant fluid pressure, measuring the body-borne sound and/or the vibrations caused by test fluid flowing through the filter materials by sensors, and comparing the body-borne sound and/or the vibrations with the body-borne sound and/or the vibrations of an integral, identical filter element, measured under identical conditions.
    Type: Grant
    Filed: December 11, 2009
    Date of Patent: June 2, 2015
    Assignee: Sartorius Stedim Biotech GmbH
    Inventors: Volkmar Thom, Bjoern Hansmann, Tobias Foster
  • Filter assembly
    Patent number: D740391
    Type: Grant
    Filed: August 12, 2014
    Date of Patent: October 6, 2015
    Assignee: Sartorius Stedim Biotech GmbH
    Inventors: Alexander Mueller, Dirk Lamprecht, Thomas Krumbein, Stefan Weisshaar, Michael Bates
  • Filter assembly
    Patent number: D741983
    Type: Grant
    Filed: August 12, 2014
    Date of Patent: October 27, 2015
    Assignee: Sartorius Stedim Biotech GmbH
    Inventors: Alexander Mueller, Dirk Lamprecht, Thomas Krumbein, Stefan Weisshaar, Michael Bates