Abstract: A monolithic weighing system including a base (12), a load holder (26), which is articulated on the base (12) through a parallel link arrangement (16, 20), and a lever (28), which is articulated on the load holder (26) and which has an attachment point for a force compensating arrangement and a target area (32) for an optical position sensor (34). The target area (32) has a slotted diaphragm (36) in a thin walled lever section of the lever (28) in the deflection plane thereof. A position sensor pedestal (38a, b), which is integrally connected to the base (12), is arranged laterally adjacent to the target area (32). The position sensor pedestal has a pedestal aperture (40a, b), which extends perpendicularly to the deflection plane. The slotted diaphragm (36) of the target area (32) is laser-machined through the pedestal aperture (40a, b).

Abstract: A pipette has a first chamber and a second chamber that connects to the first chamber and extends with an outlet channel to a pipette tip. The chambers are separated from one another by a longitudinally displaceable piston having a piston non-return valve. The second chamber has a chamber non-return valve which is arranged upstream of the outlet channel. An associated method includes recirculating the liquid in the first chamber, filling the first chamber with the liquid via a direct feed line, filling the second chamber with the liquid from the first chamber by pulling back the piston in the filling position toward the first chamber with the piston non-return valve open and with the chamber non-return valve closed, and emptying the second chamber by advancing the piston in the emptying position towards the outlet channel, with the piston non-return valve closed and the chamber non-return valve open.

Abstract: A device and a method for adjusting stirring blades on a stirring blade receptacle of a stirrer, wherein the stirring blades can be fixed with a stirring blade axis in receiving bores, which are arranged transversely to an axis of rotation and are a part of the stirring blade receptacle, at intended predetermined angle of attack relative to a virtual plane that is arranged transversely to the axis of rotation of the stirrer. An associated device body is provided with a receiving element for receiving the stirring blade receptacle with unfixed stirring blades. A stop is arranged on the device body for each lower face, which faces the receiving element and is a part of the stirring blades, outside the respective stirring blade axis. Each respective stirring blade is then brought into abutment against its associated stop, to place it into the predetermined angle of attack.

Abstract: A method and system for creating a design plan to test a product characteristic are described. One or more factors, level corresponding to the factors, and partitions for testing the product characteristic are determined. For each partition, an active matrix is generated. The product characteristic can be tested at each partition using the levels for the factors specified by the corresponding active matrix.

Abstract: The present invention relates to a method for quantitatively determining living and dead cells in a biological sample. The method according to the present invention is based on the determination of the amount of DNA in the sample with the aid of a DNA amplification reaction which does not impair the membrane integrity of living cells.

Abstract: A device (1) is provided for ventilation and integrity testing of a filter unit (2) that can be supplied with pressure. The filter unit (2) has a filter element (9) arranged in a housing (6) between an inlet (7) and an outlet (8). The housing (6) can be ventilated by an air filter (3) connected to the housing interior (12). A filter valve (4) is arranged upstream of the air filter (3) facing the housing interior (12) and connects the air filter (3) to the housing interior (12). The air filter (3) can be connected on its side facing away from the housing interior (12) to a test line (14) for supplying pressure. An inlet valve (5) is arranged upstream of the inlet (7) and connects an inlet line (10) to the housing interior (12).

Abstract: The present invention relates to a micro-porous filtration membrane with performance enhancing projections as well as a method for producing the same.

Abstract: An electromagnetically force-compensating force-measuring apparatus (100) that includes a force dependent support coil (2) and an integrating analog/digital converter (10; 10?) that converts the coil current (IS) into a digital output signal. A current/voltage converter (6) is connected downstream of the support coil (2), the output of the current/voltage converter being connected to a measurement voltage input (14) of the analog/digital converter (10; 10?) and to the input of a voltage amplifier (8). The resistance value of a first heating resistor (RSH) is equal to the resistance value of the support coil (2), the resistance value of a second heating resistor (RWH) is equal to the conversion factor (RW) of the current/voltage converter (6) and the gain factor of a voltage amplifier (8) is equal to the ratio of the resistance value of the first heating resistor to the resistance value of the second heating resistor.

Abstract: A pinch valve includes a clamping jaw (12) which displaces perpendicularly to an axial direction and forms a mouth (16) that receives a flexible tube (18) that extends in the axial direction, and an abutment (12; 21) which is opposite the clamping jaw in the jaw displacement direction. The clamping jaw and the abutment are disposed relative to one another such that the tube is pinched by the advancing clamping jaw against the abutment. The clamping jaw has a displaceable support element (14) and two claws (16a; 16b) located opposite one another and engaging around the tube at least in some regions. The claws are articulated on the support element by the respective rear ends thereof such as to pivot about pivot pins oriented parallel to the axial direction, whereby the mouth opens as the clamping jaw advances and closes as the clamping jaw retracts.

Abstract: One aspect relates to a container for inserting into a holding device, comprising: a wall that is flexible at least in some areas, which wall is squashed, at least in some areas, in a transport condition in a direction opposite to a stretching direction; a handling unit connected to the wall, which is designed to come into engagement with a complementary handling unit of a transport device; a securing unit which in a transport condition hinders stretching of the wall of the bioreactor container along the stretching direction, wherein the container can, when the securing unit is released, be extended at least in some areas along the stretching direction, as well as a transport device, a use and a method.

Abstract: One aspect of the invention relates to a filter module comprising: —a filter element having at least one filter medium which separates a filtrate side and a retentate side of the filter element from one another, and having a filter medium holder to which the filter medium is attached and which has at least one holder intake channel and at least one holder discharge channel, —a first filter cartridge part having at least one first cartridge intake channel and at least one first cartridge discharge channel, —a second filter cartridge channel having at least one second cartridge intake channel and at least one second cartridge discharge channel, wherein the filter medium holder is arranged in an arrangement position between the first filter cartridge part and the second filter cartridge part in a fluid-tight manner, wherein the at least one holder intake channel has a fluid connection with the at least one first cartridge intake channel and the at least one second cartridge intake channel, in order to form a mod

Abstract: A bioreactor has a reactor bag (12) with a predominantly flexible bag wall (121) that has a rigid bearing area. A stirrer arrangement (14) is in the bearing area and includes rigid profile ring (16) made of a non-magnetic material and fixed in the bearing area. The stirrer arrangement (14) also includes a shaftless stirrer (18) rotatably engaged with the profile ring (16) and having parts that are permanently magnetic. An electric coil arrangement (20) is outside the reactor bag (12) and can produce a rotating magnetic field that interacts with the permanent-magnetic areas of the stirrer (18) to produce a torque that rotates the stirrer (18) and circulates the contents of the bag (12).

Abstract: A method for calibrating a pressure sensor includes connecting the pressure sensor to first and second fluid storage vessels; providing an initial fluid pressure at the pressure sensor and at the fluid storage vessels; and carrying out a pressure measurement of the initial fluid pressure at a time t0. The method then disconnects the second fluid storage vessel from the pressure sensor and the first fluid storage vessel; provides a first fluid pressure at the second fluid storage vessel; and carries out a pressure measurement of the first fluid pressure at a time t1. The method then connects the second fluid storage vessel with the pressure sensor and the first fluid storage vessel, so that a second fluid pressure between the initial and first fluid pressures is provided at the pressure sensor; and carries out a pressure measurement of the second fluid pressure at a time t2.

Abstract: The invention relates to a filter housing for exchangeable filters, having a housing base for accommodating the filter and having a housing dome which engages over the filter, wherein the housing base and the housing dome are connected to one another by means of an aseptic clamping connection which has a groove-type clamping fitting on the housing base and has a flange-type clamping fitting on the housing dome, these being fixed against one another in their connected position by means of a clamp, wherein the groove-type clamping fitting has a seal groove with a seal by means of which the groove-type clamping fitting can be sealed off with respect to the flange-type clamping fitting, wherein the housing base has a port for the supply of liquid to be filtered and has a port for the discharge of filtered liquid, and wherein the housing base has, transversely with respect to the housing longitudinal axis, a base surface which is adjacent to the face surface of the inserted filter.

Abstract: The invention relates to a system and a method for cell separation via a filter, with a powder bag which can be arranged in a recirculation circuit and is partly filled with a pulverulent filter aid and to which a cell solution containing the cells to be separated can be delivered from a bioreactor via a pump arranged in the recirculation circuit, the bioreactor, which has an agitator, being arranged in the recirculation circuit, and, when the recirculation circuit is interrupted, the bioreactor being connectable to the filter.

Abstract: A scale with a weighing system (14), a weighing chamber (16) that is delimited by a windshield (18), and a drive for opening and closing the windshield (18). The scale has a load transferring part (32, 34) with which the weight of the load is transferred onto the weighing system (14). A decoupling mechanism is mechanically connected to the drive for rotating the windshield (18) such that the weighing system (14) is mechanically decoupled from the load transferring part in the load direction if the windshield (18) is open in order to not introduce transverse forces into the weighing system (14) during loading of the weight.