Abstract: A system for use in freezing, thawing, transporting or storing biopharmaceutical materials which includes a container, a holder and plurality of heat transfer members. The container is configured to hold biopharmaceutical materials therein. The holder has a cavity for receiving the container and includes an interior surface bounding the cavity. A plurality of pockets contact outer surfaces of the container and is received in the cavity. Each pocket of the plurality of pockets includes a pocket cavity. A heat transfer member actively controls the temperature of biopharmaceutical materials held in the container and is received in the pocket cavity.
Type:
Grant
Filed:
March 18, 2010
Date of Patent:
February 12, 2013
Assignee:
Sartorius Stedim North America Inc.
Inventors:
Jonathan Cutting, Isabelle Gay, Oscar Werner Reif
Abstract: The invention comprises a membrane and device and method for removing proteases from fluids, particularly from biological fluids and pharmaceutical solutions, which uses a microporous membrane body, whereby inhibitors that selectively bind proteases are coupled to the membrane body by chemically activated groups.
Type:
Grant
Filed:
May 17, 2006
Date of Patent:
January 1, 2013
Assignee:
Sartorius AG
Inventors:
Wolfgang Demmer, Dietmar Nussbaumer, Hans-Heinrich Hörl
Abstract: A vibrational mixer (1), in particular a single-path mixer for use in single-path bioreactors (4) with flexible walls, consisting of a mixer shaft (2) that can be set into longitudinal motions by a drive (8), with at least one mixing element (3), wherein at least one channel (13) is arranged in the mixer shaft with an opening to an interior reactor space (6).
Abstract: The invention comprises a membrane and device and method for removing proteases from fluids, particularly from biological fluids and pharmaceutical solutions, which uses a microporous membrane body, whereby inhibitors that selectively bind proteases are coupled to the membrane body by chemically activated groups.
Type:
Grant
Filed:
June 17, 2003
Date of Patent:
January 1, 2013
Assignee:
Sartorius AG
Inventors:
Wolfgang Demmer, Dietmar Nussbaumer, Hans-Heinrich Hörl
Abstract: A system element for releasably sealed connecting of a measurement recorder to a fluid system, having a measurement chamber that can be connected to the fluid system allowing flow through the same, wherein the measurement chamber is formed in a housing and a part of the wall of the measurement chamber is formed by a membrane, wherein the part of the wall adjacent to the membrane forms an outer wall having an edge whereon the membrane bears, and the membrane comprises a circumferential bead facing the measurement chamber, wherein the bead engages in a recess formed in the housing about the outer wall; and running around the measurement chamber, and protruding pins are disposed in the region of the recess about the outer wall, and wherein holes are provided in the bead of the membrane, so that the pins engage in the holes in the bead of the membrane.
Abstract: This invention relates to plunger operated liquid dispensers, such as hand held pipettors, which are used to portion liquids. Specifically the invention relates to a reliable removal of a liquid from the liquid dispenser. According to the invention the plunger of the liquid dispenser is arranged into a speeded up movement while removing the liquid. This change in speed is preferably sudden.
Abstract: The invention relates to a bioreactor, comprising a reactor vessel (2) with a housing support (20,20a), extending into the vessel interior (14), with a medium seal against the vessel interior (14) with a transparent sensor piece (34,34a) and an indicator tile (38,38a), arranged in the vessel interior (14), in contact with the vessel contents, which may be scanned by a fiber optic which may itself be introduced into the housing support (20,20a) and connected to a display device (24). In order that the reactor may be embodied as a bag, the housing support (20,20a) is arranged on the upper side of the reactor bag and provided with a flange piece (26) tightly sealed to the vessel wall (28). The flange piece is connected to the sensor piece (34,34a) by means of a preferably tubular connector piece (32,23a), whereby the length of the connector piece is such that the sensor piece (34,34a) permanently reaches into the reactant.
Abstract: A sensor protector is intended to reduce the sensitivity of the optical sensor (4) to radiation products which, for example, are formed during sterilization with gamma radiation and to ensure simple and cost-effective manufacture. The sensor protector includes an upper part (1), a lower part (3) and an optical sensor (4). The optical sensor (4) situated on the lower part is positionable in an offset manner with respect to an opening (2) situated in the upper part and movable by means of displacement toward the opening (2) of the upper part (1). The sensor protector is suitable for use in containers and laboratory products that are sterilized by gamma radiation, for example disposable bioreactors.
Type:
Application
Filed:
November 12, 2010
Publication date:
October 25, 2012
Applicant:
Sartorius Stedim Biotech GmbH
Inventors:
Stefan Weisshaar, Michael Bates, Christian Pradel, Volker Limpert
Abstract: A weighing scale, e.g. a top-pan scale, having a scale pan (01, 02) supported on a force transducer, and a corner load sensor (03, 04, 06, 08, 09) measuring the tilting of the scale pan (01, 02) relative to the force transducer. The corner load sensor includes a light beam source (03, 04, 06) emitting a first light beam and a second light beam. The first light beam and the second light beam are directed toward a reflecting surface on an underside of an arrangement that includes the scale pan (01, 02). The first light beam and the second light beam are respectively inclined relative to the reflecting surface of the untilted scale pan (01). The corner load sensor (03, 04, 06, 08, 09) of the scale also includes a first optical sensor (08) measuring the first light beam reflected by the reflecting surface. If no corner load exists, a predetermined proportion (12) of the reflected first light beam is directed to the first optical sensor (08).
Type:
Grant
Filed:
April 23, 2010
Date of Patent:
October 2, 2012
Assignee:
Sartorius Weighing Technology GmbH
Inventors:
Jochen Doerner, Christian Schrader, Ralf Mueller
Abstract: The invention relates to a waste gas system for bioreactors having a hydrophobic sterile filter, arranged at the end, and a heat exchanger which protects the sterile filter against blocking by liquid media. The gas outflow duct for discharging waste gas from a bioreactor vessel is divided in a cooling zone of the heat exchanger into a multiplicity of subducts and is extended in a heating zone of the heat exchanger to a calming zone. Due to the multiplicity of subducts, a considerably larger surface area for the removal of heat from the waste gas is available, with the result that in the case of laminar flow of the waste gas through the subducts a high effectiveness of the separation of liquids from the waste gas can be achieved.
Type:
Grant
Filed:
December 15, 2009
Date of Patent:
September 18, 2012
Assignee:
Sartorius Stedim Biotech GmbH
Inventors:
Juergen van den Boogard, Gerid Hellwig, Jens Ludwig, Oscar-Werner Reif, Stefan Weisshaar
Abstract: The invention relates to a disposable bioreactor comprising a reversible, externally attachable sensor arrangement for measuring a physical variable of a contained medium. A sensor adapter (28) for receiving an electronic sensor arrangement (34, 38; 42; 44a, 44b, 46, 48) interacting with the medium cross-flowing the peripheral lines (14, 16, 18), by means of an inner delimiting surface (32a, 32b; 42; 44a, 44b, 46, 48) of the sensor adapter, is integrated into at least one of the peripheral lines (14, 16, 18) of the bioreactor which is used to supply or discharge the medium. Said sensor adapter (28) is mounted on the peripheral line (14, 16, 18) as an insert extending the peripheral line (14, 16, 18) and which can be cross-flown by the contained medium.
Type:
Grant
Filed:
April 24, 2007
Date of Patent:
August 28, 2012
Assignee:
Sartorius Stedim Biotech GmbH
Inventors:
Reinhard Baumfalk, Oscar-Werner Reif, Thomas Scheper, Daniel Riechers, Russell Hayden, Philip Nuzzo