Abstract: A method of aseptically distributing fluid to a plurality of vessels includes securing the plurality of vessels relative to a hub and flowing fluid through an input tube into a plenum of the hub such that a substantially equal amount of fluid flows from the plenum into each of the vessels simultaneously. The vessels are positioned in the same plane relative to one another with each vessel having an inflow conduit extending from the hub to the vessel such that an arc segment is formed between the hub and the vessel.

Abstract: A fluid transfer assembly is described. The fluid transfer assembly includes a unitary junction having an upstream portion and a downstream portion, the unitary junction defining a plurality of curved fluid pathways between the upstream portion and the downstream portion. The assembly also includes at least one flexible fluid conduit sealed to the junction in fluid communication with at least one of the plurality of curved fluid pathways.

Abstract: The present invention relates to a method for removing biopolymer aggregates and viruses from a fluid. In a first step, the biopolymer aggregates are selectively removed by filtration through a porous, polyamide-comprising shaped body having a native surface. In a second step, the biopolymer aggregate-free fluid is filtered through at least one suitable virus-retentive membrane.

Abstract: A connector for facilitating fluid transfer includes first fitting, a second fitting, a rigid conduit, a first retaining connector, and a second retaining connector. The rigid conduit includes a flexible tube surrounded by a deformable sleeve. The rigid conduit is connected on a first end to the first fitting and on a second end to the second fitting. The first retaining connector connects the first fitting to the rigid conduit and the second retaining connector connects the second fitting to the rigid conduit. A lumen extends through the rigid conduit and is capable of being sealed. The rigid conduit and the flexible tube are capable of being severed while maintaining the seal of the lumen to separate the first fitting from the second fitting. The connections of the first fitting and the second fitting to the rigid conduit are capable of withstanding at least 1 bar of pressure without leaking.

Abstract: A fluid transfer assembly is described that includes a fitting comprising a lumen having an opening, and at least one barb, the at least one barb extending circumferentially around the lumen proximate to the opening. The assembly also includes a flexible conduit, a deformable sleeve, and an elastomeric liner disposed between the sleeve and the conduit. The fitting extends at least partially into the conduit such that the conduit extends over the at least one barb. The elastomeric liner applies substantially 360 degree radial pressure to the conduit such that the conduit is sealingly compressed around the at least one barb of the fitting. The assembly is fluid tight up to a burst pressure of the conduit.

Abstract: Summarizing the invention, a sensing element for monitoring the state of a single-use sterilizable element such as a single-use bioreactor, wherein the state of the single-use sterilizable element is determined by at least one environmental condition is provided. The sensing element comprises: a variable component having at least one physical property that is configured to change in response to the at least one environmental condition and/or a change thereof, wherein the variable component comprises a sensing material with changing absorption characteristics for electromagnetic radiation configured to change in response to the at least one environmental condition and/or a change thereof.

Abstract: A fluid distribution system is configured to distribute fluid from a first vessel to second vessels includes a hub assembly and a frame assembly. The hub assembly has an input cap, a distribution cap, a first clamp, and a second clamp. The input cap defines an inlet and the distribution cap is sealingly secured to the input cap with a plenum being defined between the input and distribution caps. The distribution cap includes conduit connectors that each defines an outlet in fluid communication with the plenum. The first clamp is disposed over the distribution cap and is engaged with the input cap to secure the input cap to the distribution cap and the second clamp is disposed over the input cap and engaged with the distribution cap to secure the distribution cap to the input cap. The frame assembly supports the hub assembly and is configured to secure each of the secondary vessels at a predetermined distance relative to the hub assembly.

Abstract: A composite article includes a lattice and an elastomeric section. The lattice includes a plurality of members that form an open-mesh frame defining a plurality of voids between the adjacent members of the frame. The elastomeric section is formed of an elastomer that is disposed about the lattice and within the voids of the lattice. The composite article may be a circular gasket, a gasket with a grip, a rectangular gasket, a vessel cap, a flask stand, and a handle for a hand tool.

Abstract: A flask stand is configured to support a flask and includes a base ring and a plurality of legs. The base ring is configured to support a lower portion of the flask. Each leg is secured to the base ring and extends outward from the base ring. Each leg includes a body, a lattice, and an elastomeric foot. The body includes a first end portion that is secured to the base ring with the foot portion being opposite the first end portion. The lattice is formed within the foot portion and includes a plurality of members that form an open-mesh frame that defines a plurality of voids between adjacent members of the frame. The elastomeric foot is formed of an elastomer and is disposed about the lattice and within the voids of the lattice. The foot is configured to engage a surface to support the body relative to the surface.

Abstract: The present invention relates to a method for purifying viruses or virus-like particles using a crosslinked cellulose hydrate membrane and to a kit for purifying viruses or virus-like particles and the use thereof.

Abstract: The present invention is directed to the development of continuous processing technology for the purification of biopharmaceuticals and biological products, such as monoclonal antibodies, protein therapeutics, and vaccines. Methods for continuous processing of a biological product in a feed stream toward formulation of a purified bulk product are described.

Abstract: An apparatus for manipulating particles includes: a rotor rotatable at a speed about an axis, the rotor having an outer periphery and front and rear opposite sides; at least one chamber mounted on the rotor, each chamber having an inlet and an outlet; an umbilical assembly rotatable about the axis; and a drive mechanism configured to rotate the umbilical assembly at about one-half the speed of the rotor. The umbilical assembly includes: a curvilinear guide tube connecting to a drum at the rear side of the rotor; a flexible conduit residing in the guide tube; and first and second elongate passageways for each chamber extending through the conduit, wherein the first passageway is in fluid communication with the inlet of a respective chamber and the second passageway is in fluid communication with the outlet of the respective chamber. The passageways are held in a spaced-apart relationship relative to one another.

Abstract: A device may receive data related to a material. The data may permit an analysis of an exposure related to the material. The data may be received from another device. The device may process the data to determine a category of materials for the material. The category of materials may indicate a set of exposures, related to the material, to an organization. The device may process the data to determine an exposure preparedness level associated with the material. The exposure preparedness level may indicate a preparedness of the organization to handle the set of exposures related to the material. The device may determine a score for the material based on the category of materials and the exposure preparedness level associated with the material. The score may indicate the exposure related to the material. The device may perform an action related to the material based on the score for the material.

Abstract: A fluid transfer hub has a first vessel closure, a second vessel closure, a gasket arranged between the first vessel closure and the second vessel closure, and a clamp at least partially surrounding the first vessel closure, the second vessel closure, and the gasket. The first vessel closure has a first body, one or more apertures extending axially through the first body, one or more first inserts extending axially through the one or more apertures, and a cast seal disposed within the first body and surrounding each first insert. The second vessel closure has a second body, one or more apertures extending axially through the second body, one or more second inserts extending axially through the one or more apertures, and a cast seal disposed within the second body and surrounding each second insert.

Abstract: The present invention relates to a micro-porous filtration membrane with performance enhancing projections as well as a method for producing the same.

Abstract: A container having at least one wall protrusion for mounting at least one sensor from the outside for sensing at least one variable of a medium contained in a container interior is provided. The wall protrusion can be arranged on a container wall and configured to at least partly extend around the container interior and the medium. The wall protrusion can include at least one sensor region that is configured so that the at least one variable can be sensed through the sensor region by means of the sensor.

Abstract: A method for virtually configuring a piece of equipment comprises providing an augmented reality system having a computer unit and at least one sensor unit, detecting a sensor dataset associated with a physical environment by means of the at least one sensor unit, determining a virtual environment based on the sensor dataset by means of the computer unit, and determining a virtual arrangement of at least one virtual and/or physical equipment element relative to the virtual environment.

Abstract: A mixing vessel for accommodating components to be mixed has a container with at least one mounting depression in a side wall of the container. The mounting depression is adapted so that a mixing impeller housing of a mixing impeller is at least partly insertable, in which at least one magnet is housed for being magnetically connectable to a drive device to be driven. A locking assembly is attachable to the mounting depression from outside for locking the mixing impeller in a storage position, in which the mixing impeller is not rotatable. The locking assembly has a magnetically active element that is adapted to interact with the magnet of the mixing impeller.

Abstract: A fluid transport apparatus defining an aseptic pathway configured to direct fluids therethrough is provided. The fluid transport apparatus may include a conduit extending between a first terminus and a second terminus. The conduit may include platinum catalyzed silicone rubber having methyl and phenyl side groups. The conduit may have a storage modulus of 108 or less Pascals at ?75 degrees Celsius. At least one fitting may be connected to the first terminus. A fluid storage accessory may be engaged with the second terminus. A related flexible conduit, method of manufacturing a flexible conduit, and storage method are also provided.

Abstract: A method is provided for measuring status parameters of a fluid contained in a container (10). The container (10) is configured for single use and has a wall on which a sensor-carrier plate is fixed in a fluid-tight manner. The plate carries sensors (S1-S5) that are in operative contact with the internal chamber of the container (10) and connected for data exchange (14) with an external control unit (16) that receives and processes the measurement data from the sensors (S1-S5). The sensor plate also carries a temporarily inactive duplicate (D1-D5) of at least one of the sensors (S1-S5) that is activated if measurement data of the sensor (S1-S5) is classified as atypical in the context of an integrity or plausibility test carried out by the external control unit (16).