Abstract: The invention relates to a connection device comprising —a line portion (10) having, at its end, a radially outwardly projecting abutment flange (14) for butting against a corresponding abutment flange of a further line portion which is to be coupled to the line portion (10), and —a ring-segment chain (42, 22, 38) comprising a plurality of ring segments (22, 38) connected to one another in a pivotable manner in a common ring plane, wherein the ring-segment ends which formed the chain ends can be latched to one another to give a ring-form connection clamp (42). The invention is distinguished in that the line portion is designed in the form of a tubular connection stub (10) with first thread means (16) spaced apart axially from the abutment surface (141) of its abutment flange (14), and in that each ring segment (22, 38) has a radially inwardly projecting clamping flange (24) and second thread means (26), which are spaced apart axially from said clamping flange and correspond with the first thread means (16).

Abstract: A platform has a filter system with a first set of filter modules and a second set of filter modules that is different from the first set of filter modules. Each set of filter modules includes an inflow channel and an outflow channel. A fluid inlet is connected to the first set of filter modules, a fluid outlet is connected to the second set of filter modules, and a separation interface separates the first and second sets of filter modules. The separation interface has a first interface channel to connect to the module outflow channel of the first set of filter modules, and a second interface channel to connect to the module inflow channel of the second set of filter modules. The filter system receives fluid through the fluid inlet and, after the fluid has passed through each set of filter modules, discharges the fluid through the fluid outlet.

Abstract: A method for the preparing mixtures of pharmaceutical or biopharmaceutical substances (11, 11?) includes arranging a preparation container (3, 3?, 3?) already made up with ingredients in a receptacle (2) of a device (1, 1?, 1?) feeding a fluid (10) from a storage container (4, 4?) into the preparation container (3, 3?) via a feed line (6), preparing the ingredients with the fluid (10, 10?) into a substance mixture (11, 11?), and removing the substance mixture (11, 11?) from the preparation container (3, 3?, 3?) into a receiving container via a discharge line (12, 12?, 12?). A device also is provided for carrying out the method.

Abstract: A fluid delivery system and process for fluid delivery is provided that is useful in in flow-injection based sensing measurements, wherein samples from a sample rack are introduced into a flow cell where sensing measurements are taken. The system and process utilize at least two holding lines where each holding line can retain one of the samples prior to injection of the thus retained sample into a flow cell. The introduction of the samples from the sample racks to the holding lines is alternated and the injection of the samples from the holding lines to the flow cell are alternated so that one holding line is loaded with one of the samples simultaneously with another sample being injected from the another holding line to the flow cell.

Abstract: A fluid transfer hub has a first vessel closure, a second vessel closure, a gasket arranged between the first vessel closure and the second vessel closure, and a clamp at least partially surrounding the first vessel closure, the second vessel closure, and the gasket. The first vessel closure has a first body, one or more apertures extending axially through the first body, one or more first inserts extending axially through the one or more apertures, and a cast seal disposed within the first body and surrounding each first insert. The second vessel closure has a second body, one or more apertures extending axially through the second body, one or more second inserts extending axially through the one or more apertures, and a cast seal disposed within the second body and surrounding each second insert.

Abstract: A system and method for transferring chemical, pharmaceutical, and/or biological material into or out of a container are provided. Further, a use of a transfer interface for accessing the interior of a disposable container is provided. The system comprises a disposable container having at least one port for accessing the interior of the container. The system further comprises a transfer interface connectable to the at least one port. The transfer interface comprises a plurality of extendable transfer elements for collecting samples from the disposable container in a sterile manner. The transfer elements may also be referred to as sampling elements, extractors, or probes. Each of the transfer elements has a corresponding biasing element for retracting the transfer element. The biasing element may be implemented as a spring or as another device capable of applying a biasing force.

Abstract: A device (1) is provided for ventilation and integrity testing of a filter unit (2) that can be supplied with pressure. The filter unit (2) has a filter element (9) arranged in a housing (6) between an inlet (7) and an outlet (8). The housing (6) can be ventilated by an air filter (3) connected to the housing interior (12). A filter valve (4) is arranged upstream of the air filter (3) facing the housing interior (12) and connects the air filter (3) to the housing interior (12). The air filter (3) can be connected on its side facing away from the housing interior (12) to a test line (14) for supplying pressure. An inlet valve (5) is arranged upstream of the inlet (7) and connects an inlet line (10) to the housing interior (12).

Abstract: The invention relates to a filtration device and to a method for characterizing a filter medium or a medium to be filtered. The filtration device comprises a plurality of filtration units. Each filtration unit comprises a first container, which is designed to receive a medium to be filtered, a second container, which is designed to receive a filtrate, at least one connecting line, which connects the first container to the second container, and a filter medium between the first container and the second container in order to filter the medium to be filtered. The first container is designed for the application of positive pressure thereto, and the second container is designed to receive a measurement instrument at ambient pressure.

Abstract: Vessel closure assemblies are provided. The vessel closure assemblies may be engaged with vessels. The vessel closure assemblies may each include a vessel closure, inserts such as anchors and fluid conduits extending through the vessel closure, and a respiratory assembly. The respiratory assembly may include a housing and one or more gas permeable membranes. The gas permeable membranes may be oriented substantially perpendicular to a top wall of the vessel closure through which the inserts extend.

Abstract: The invention relates to a container device (1), comprising: a container receiving portion (4) for receiving a container; at least one valve (6) for controlling a flow of fluid in a fluid line connected to said container; a pump device (8) for generating a conveyor pressure of the fluid in the fluid line; a control device (10) which can be connected to the valve (6) and/or the pump device (8) in order to control the valve (6) and/or pump device (8); and a frame (2) which supports said container receiving portion (4), valve (6), pump device (8) and control device (10).

Abstract: One aspect relates to a bioreactor and/or mixing container that includes an outer wall and a spectroscopy cell arranged in and/or on the outer wall. The spectroscopy cell includes a first optical area and a second optical area arranged opposite the first optical area. The first optical area and the second optical area can be set at at least two different distances from one another. A specimen-receiving area is located between the first optical area and the second optical area.

Abstract: Systems and a method for transferring chemical, pharmaceutical, and/or biological material into or out of a container are provided. One system comprises a disposable container having at least one port for accessing the interior of the container, the port comprising at least one connecting protrusion extending parallel to the container. The system further comprises a transfer interface connectable to the port. The transfer interface comprises a plate, and at least one connecting flange extending from the plate, the connecting flange to be arranged under the respective connecting protrusion to connect the transfer interface to the port, such that when the transfer interface is connected to the port the plate is parallel to a surface of the container.

Abstract: A method of aseptically distributing fluid to a plurality of vessels includes securing the plurality of vessels relative to a hub and flowing fluid through an input tube into a plenum of the hub such that a substantially equal amount of fluid flows from the plenum into each of the vessels simultaneously. The vessels are positioned in the same plane relative to one another with each vessel having an inflow conduit extending from the hub to the vessel such that an arc segment is formed between the hub and the vessel.

Abstract: The present invention relates to a device for separating and/or isolating substances in or from a mixture with improved utilization of the capacity of chromatographic media, the device comprising a first chromatography system, a second chromatography matrix downstream of the first chromatography system, and a sensor for detecting the substances present in the fluid. Furthermore, the present invention relates to both the use of said device and a method for separating and/or isolating substances in or from a mixture in a fluid.

Abstract: Fluid transfer interfaces for transferring fluid into or out of vessels, namely flexible polymeric bags. The fluid transfer interfaces have a body for use in connection with a vessel, or combined therewith, one or more apertures extending through the body, and one or more fluid transfer conduits secured to the body by way of a cast seal and extending continuously and axially through the one or more apertures. Also disclosed is a vessel closure having one or more fluid transfer conduits extending through the closure, the fluid transfer conduits affixed to the closure by a cast seal.

Abstract: A mixing method, a controller and a mixing device for mixing components in a mixing vessel are provided. The mixing method includes providing a mixing impeller in the mixing vessel; accelerating the mixing impeller from an inactive state to a rotating state in which the mixing impeller rotates at a first desired speed in a first rotation direction; rotating the mixing impeller at the first desired speed for a first time tsteady,1 in the first rotation direction; changing the rotation direction of the mixing impeller, so that the mixing impeller rotates in a second rotation direction at a second desired speed; and rotating the mixing impeller at the second desired speed for a second time tsteady,2.

Abstract: A bioreactor for culturing of microorganisms or cells comprising: a casing defining an interior space of the bioreactor, wherein said interior space is configured to receive and hold a culture medium with microbial or cellular liquid cultures; and at least one coupling element provided on the casing for coupling with a foam mitigation device for mitigation of foam built-up in the interior space of the bioreactor during use of the bioreactor for culturing of microorganisms or cells; wherein the coupling element is configured to allow ultrasonic waves generated by the foam mitigation device act upon foam built-up in the interior space of the bioreactor.

Abstract: Fluid transfer assemblies for transferring fluid into or out of a single vessel and distributing the fluid to multiple other vessels are provided. The fluid transfer assemblies are customizable, substantially aseptic, and single-use. The fluid transfer assemblies may be manufactured by solidifying polymeric materials to form a body around a mandrel with protrusions engaged to fluid conduits and leaving recesses in the solidified polymeric material to stretch the resultant body and remove the mandrel with protrusions. The resultant fluid transfer assembly may be surrounded by a rigid housing and valves may be engaged with the conduits and/or body to control the fluid flow within the fluid transfer assembly.

Abstract: The present invention relates to a porous sheet product, to a filter element comprising the porous sheet product, to a method for producing the porous sheet product, to a method for producing the filter element, and to the use of the sheet product and of the filter element.

Abstract: A connecting system (1) has at least one connector (2) for a filter cassette (4) that can be inserted into a filter holder and has filter layers (5) between two end plates (6), and seals (7) between the filter layers (5) and/or between the end plates (6) and an adjacent filter layer (5). The connector has tensioning parts that engage in one another in a longitudinally displaceable manner and that can be fixed to the end plates (6) via their ends facing away from one another. The connector exerts a pretensioning force onto the end plates (6) when it is deflected to its maximum extent. The pretensioning force pulls the end plates (6) towards the filter layers (5), and when a contact-pressure force superimposed on the pretensioning force is applied to the end plates (6), the tensioning parts can be pushed towards one another correspondingly with the end plates (6).