Abstract: A device (1) for accommodating a disposable container (44) has a receptacle (10) with at least one receptacle wall (16) that defines an interior of the receptacle (10) for accommodating the disposable container (44). The device includes a temperature control unit for controlling the temperature of the receptacle wall (16). A lighting device (50) is located on an inner face of the receptacle wall (16) that faces the interior of the receptacle (10) and that has the temperature controlled by the temperature control unit. The lighting device (50) is designed to emit light into the interior of the receptacle (10).

Abstract: A computer-implemented method for analyzing data obtained for a chemical and/or biological process comprises: obtaining a result of statistical data analysis on the data obtained with respect to the chemical and/or biological process; calculating, for values of process parameters obtained at groups of time points during batch processes of the chemical and/or biological process, a ratio of a correlation value to a confidence value of the correlation value, the correlation value indicating a correlation between the values of the process parameter and at a process output value; calculating, for process parameters, an average of absolute values of the ratios calculated for the values of the process parameter obtained at different groups of time points during the batch processes; excluding the values of one of the process parameters having a smallest average; and iterating, until at least one specified condition is met.

Abstract: Chromatography methods, methods of determining the concentration of at least one compound in a chromatography method and methods of obtaining at least one chromatography method parameter are provided. The chromatography methods include performance based on results obtained from the methods of determining the concentration of at least one compound or methods of obtaining at least one chromatography method parameter.

Abstract: A chromatography method, a method of determining the concentration of at least one compound in a chromatography method and a method of obtaining at least one chromatography method parameter are provided. The methods can include selecting at least one compound, a stationary phase, a mobile phase, and/or a chromatography device having a chromatography bed comprising the stationary phase and the mobile phase.

Abstract: The present invention relates to a method for producing a porous membrane, the method being characterized in that a solvent system comprising 2-pyrrolidone and N-alkyl-2-pyrrolidone is used, wherein the content ratio of 2-pyrrolidone to N-alkyl-2-pyrrolidone in the solvent system is from 90%:10% to 10%:90%, based on mass %, and wherein N-alkyl-2-pyrrolidone is N-propyl-2-pyrrolidone and/or N-butyl-2-pyrrolidone. Furthermore, the present invention relates to a porous membrane obtainable by said method. Moreover, the present invention relates to the use of a specific solvent system for the production of a porous membrane.

Abstract: A chromatography medium includes a porous matrix and nonporous globules bound on the inner and outer surfaces of the porous matrix. The average radius of the microglobules is not more than 30% of the average pore diameter of the porous matrix. The chromatography medium can be used in affinity chromatography. A method for preparing the chromatography medium may include providing a porous starting matrix, providing a polymerization solution, and initiating polymerization of the polymerization solution in the presence of the porous starting matrix to form insoluble nonporous microglobules that are bound to the inner and outer surfaces of the porous starting matrix.

Abstract: The present invention relates to a crossflow filtration method, a method for obtaining at least one crossflow filtration parameter and a system for obtaining at least one crossflow filtration parameter.

Abstract: A single-use chamber comprising a primary subchamber containing at least one primary component configured to perform an operation comprising at least one of generation and handling of a biological material; and a secondary subchamber containing at least one of a connection to equipment external to the single-use chamber and a secondary component, wherein the external equipment and the secondary component are configured to support the operation of the at least one primary component; wherein the primary subchamber and the secondary subchamber are configured to be connected to each other so that the at least one primary component is operatively coupled to at least one of the connection and the secondary component.

Abstract: A device (1) for producing a solution of at least one liquid first medium and at least one second medium has a first container (2) for the first medium and a second container (3) for the second medium. Each container (2, 3) is connected to a supply line of a static mixer (9) via a pump (4, 5) that can be regulated by a controller (6). A sensor (10) is connected to the controller (6) downstream of the static mixer (9) in the flow direction. A branching valve (17) is downstream of the static mixer (9) in the flow direction and is controlled by the controller (6). A sterile filter (11) is downstream of the static mixer (9) and has an RFID tag (15) that stores process-relevant data to at least be read by the controller (6). A method also is provided for producing a solution using the device.

Abstract: A container for storing, mixing and/or cultivating a medium, in particular a bioreactor for a medium, comprises a line system as a discharge line, feed line and/or bypass line of the bioreactor. The system can comprise a line body formed as a single piece for a medium to flow therethrough. The has a first and a second connection region for connecting in particular to the container and/or the line system and at least a first and a second coupling apparatus in the region between the connection regions.

Abstract: Aspects of the application relate to methods, a computer program and a process control device. According to one aspect, a computer-implemented method for determining a multivariate process chart is provided. The multivariate process chart is to be used to control a process to produce a chemical, pharmaceutical, biopharmaceutical and/or biological product. The multivariate process chart includes a first trajectory, an upper limit for the first trajectory and a lower limit for the first trajectory.

Abstract: The invention relates to a method for the chromatographic purification of at least one cannabinoid compound, wherein the method comprises a main purification stage comprising the steps of: injecting an initial mixture comprising the at least one cannabinoid compound and one or more additional compounds onto a main stationary phase comprising silica particles, the silica particles comprising amino and/or diol groups; performing an elution with an elution solution, and collecting one or more elution fractions; and optionally, washing the main stationary phase with a washing solution and collecting one or more washing fractions; at least one of the elution fractions or washing fractions containing the at least one cannabinoid compound purified from the one or more additional compounds.

Abstract: Aspects of the application relate to computer-implemented methods, process control devices, and a computer program. According to one aspect, a computer-implemented method for controlling a process in a plurality of first scale vessels via a first process control device is provided. Each of the first scale vessels contains fluid and the process is for producing a chemical, pharmaceutical, biopharmaceutical and/or biological product. The method comprises controlling, by the first process control device and at least partially in parallel, the process in each of the first scale vessels. The method can include periodically determining, prior to an assigning decision and at a first frequency, first sets of process parameter values for each of the process parameters from each of the first scale vessels.

Abstract: A fluid distribution system is configured to distribute fluid from a first vessel to second vessels includes a hub assembly and a frame assembly. The hub assembly has an input cap, a distribution cap, a first clamp, and a second clamp. The input cap defines an inlet and the distribution cap is sealingly secured to the input cap with a plenum being defined between the input and distribution caps. The distribution cap includes conduit connectors that each defines an outlet in fluid communication with the plenum. The first clamp is disposed over the distribution cap and is engaged with the input cap to secure the input cap to the distribution cap and the second clamp is disposed over the input cap and engaged with the distribution cap to secure the distribution cap to the input cap. The frame assembly supports the hub assembly and is configured to secure each of the secondary vessels at a predetermined distance relative to the hub assembly.

Abstract: An imaging apparatus is provided to facilitate epifluorescent imaging of three (or more) color channels and to perform phase contrast and/or bright field imaging of samples without manual adjustment of the imaging apparatus. This allows for automated imaging, over extended periods of time, of a plurality of samples by a device located inside an incubator without disturbing the incubator environment to manually adjust the apparatus. Also provided are embodiments to facilitate user swapping of removable optical modules and/or transillumination modules to allow the imaging apparatus to be adapted to different combinations of assays and/or fluorescent indicators so as to increase the variety of experiments and/or fluorescent dyes that can be imaged using the imaging apparatus.

Abstract: A filtration system (1) has a filtration unit (2) with at least one filter element (4) for filtration of a fluid. The at least one filter element (4) has a main flow direction (C) for the fluid. The filtration unit (2) is configured to tilt the at least one filter element (4) around a tilting axis (B) to change an orientation of the main flow direction (C). A main unit (3) is fluidly connectable to the filtration unit (2) and includes a supply unit (18) configured to supply the fluid to the at least one filter element (4). A control unit is configured to control supplying and/or evacuating the fluid to/from the at least one filter element (4) and to control tilting of the at least one filter element (4) around the tilting axis (B).

Abstract: The invention relates to a bioprocess container (10) having an optical measuring device (100) for non-invasive spectroscopic measurement comprising: a container housing (12), a port housing (102), which is connected to the container housing (12) and is sealed off with respect to the interior (18) of the container housing (12); at least one radiation-emitting element (124), which is designed to transmit electromagnetic radiation through the at least one fluid contained in the container housing (12); at least one radiation-receiving element (126), which is designed to at least partly receive the radiation which was transmitted by the radiation-emitting element (124); and at least one measuring insert (122), which holds and supports the at least one radiation-emitting element (124) and/or the at least one radiation-receiving element (126).

Abstract: A chromatography method, a method of determining the concentration of at least one compound in a chromatography method and a method of obtaining at least one chromatography method parameter are provided. The methods can include selecting at least one compound, at least one stationary phase, at least one mobile phase, and at least one chromatography device having a chromatography bed comprising the at least one stationary phase and the at least one mobile phase.

Abstract: A protective device (5, 5?, 5?, 5??, 5??) is provided for a hose clip (4) that connects a hose end (2) to a hose connection (3). The protective device includes a protective body (8, 8?, 8?, 8??, 8??) made of a plastic. In the assembled state, the protective body (8, 8?, 8?, 8??, 8??) surrounds the circumference of the hose clip (4) and accommodates the hose clip (4) at least in its clamping region via a radially oriented molding (32), and covers the hose clip (4) over the width thereof extending in the longitudinal direction of the hose connection (3). The protective body (8, 8?, 8?, 8??, 8??) has ring segments (9, 10) that can be connected to one another at their free ends (12, 13), and the segments are connected moveably to one another at their ends (14, 17) facing away from the free ends (12, 13).