Patents Assigned to Sartorius
  • Method for the sterilization of chromatographic material and chromatographic material sterilized according to said method
    Patent number: 10517973
    Abstract: The present invention relates to a method for sterilizing a chromatography material, more particularly microporous polymer membranes, to a chromatography material which has been sterilized by the method according to the invention, to the use of the chromatography material sterilized according to the invention for the chromatographic removal of contaminants from a fluid, and to a closed chromatographic filtration system comprising a chromatography material sterilized according to the invention.
    Type: Grant
    Filed: March 8, 2016
    Date of Patent: December 31, 2019
    Assignee: Sartorius Stedim Biotech GMBH
    Inventors: Martin Leuthold, Louis Villain, Florian Taft
  • System and method for receiving a single-use vessel
    Patent number: 10500554
    Abstract: A system for receiving a single-use vessel containing a mixing device has a support structure adapted to receive the single-use vessel and a drive-unit adapted to power, to control, or to power and control a mixing of contents of the single-use vessel when the single-use vessel is arranged in the support structure. The support structure and the drive-unit are provided as separate components that may be arranged both in an operating position, where the drive-unit is connectable to the mixing device of the single-use bag in the support structure, and in a separated position, where the drive-unit is separated from the support structure. The drive-unit comprises a tag reader that, in the operating position, is arranged to read a vessel tag of the single-use vessel arranged in the support structure.
    Type: Grant
    Filed: February 26, 2018
    Date of Patent: December 10, 2019
    Assignee: Sartorius Stedim Biotech GmbH
    Inventors: Lars Boettcher, Jonathan Cutting, Sharon D. West, Martin Oschwald
  • Filtration device
    Patent number: 10493407
    Abstract: A filtration device (1) has a housing (4) and a filter module (2) with hollow fibers (32) surrounded by an outer shell (5). The hollow fiber bundle (6) is sealed to the outer shell (5) at each end by an adhesive (11) transverse to the longitudinal direction (10). Each end of the hollow fibers (32) is unclosed. An unfiltered product chamber (20) is between the outer shell (5) and a wall (19) of the filter housing (4) and a filtered product chamber (13) is inside the filter module (2). The bottom end of the filter module (2) connects with an intermediate section (3) that connects with a receptacle (17) of a bottom portion (15) of the filter housing (4). The intermediate section (3) forms a connection chamber (26) facing the hollow fiber ends (29) and radial feed channels (28) connect the connection chamber (26) with the unfiltered product chamber (20).
    Type: Grant
    Filed: July 18, 2015
    Date of Patent: December 3, 2019
    Assignee: Sartorius Stedim Biotech GmbH
    Inventors: Wilhelm Requate, Gerid Hellwig
  • Filter module
    Patent number: 10493406
    Abstract: A filter module (1) has a housing (2) formed from a plastic and a filter (3) made from a plastic is arranged in the housing (2). The housing (2) is bonded adhesively to the filter (3) by an adhesive (15) via a first bonding surface (7, 18) made from a first plastic and via a second bonding surface (14, 19, 21) made from a second plastic. The adhesive bonding of the first bonding surface (7, 18) and the second bonding surface (14, 19, 21) is accomplished via an intermediate piece (10, 20) with the bonding surfaces (14, 18, 21) made from a plastic that is identical to or different from the first plastic. At least one of the bonding surfaces (7, 18, 19, 14, 21) has been activated by plasma or corona pre-treatment prior to the adhesive bonding.
    Type: Grant
    Filed: November 20, 2014
    Date of Patent: December 3, 2019
    Assignee: Sartorius Stedim Biotech GmbH
    Inventors: Ralf Lausch, Paschalis Nikoloudis, Wilhelm Requate, Johannes Wortmeyer
  • CHROMATOGRAPHY MEDIUM WITH BOUND MICROGLOBULES AND METHOD FOR THE PREPARATION THEREOF
    Publication number: 20190358609
    Abstract: The present invention relates to a chromatography medium which can be used in affinity chromatography and to a method for the preparation thereof.
    Type: Application
    Filed: January 16, 2018
    Publication date: November 28, 2019
    Applicant: Sartorius Stedim Biotech GmbH
    Inventors: Adrian Ley, Florian Taft, Jan Schwellenbach, Louis Villain
  • Fluid transfer interface
    Patent number: 10486959
    Abstract: Fluid transfer interfaces for transferring fluid into or out of vessels, namely flexible polymeric bags. The fluid transfer interfaces have a body for use in connection with a vessel, or combined therewith, one or more apertures extending through the body, and one or more fluid transfer conduits secured to the body by way of a cast seal and extending continuously and axially through the one or more apertures. Also disclosed is a vessel closure having one or more fluid transfer conduits extending through the closure, the fluid transfer conduits affixed to the closure by a cast seal.
    Type: Grant
    Filed: June 2, 2016
    Date of Patent: November 26, 2019
    Assignee: Sartorius Stedim North America Inc.
    Inventor: Michael A. Zumbrum
  • Electron beam induced modification of membranes by polymers
    Patent number: 10471394
    Abstract: A method for producing a microporous membrane includes providing a microporous starting membrane having outer surfaces and pores with inner surfaces extending between the outer surfaces of the membrane and having a microporous starting membrane permeability. The method impregnates the membrane with an impregnating solution consisting essentially of a solvent and a polymer. The polymer is an organic substance with an average molecular weight of at least 500 g/mol and may be selected from the group consisting of poly(2-ethyloxazoline), polyvinylpyrrolidone-vinyl acetate (PVP-VA) and mixtures thereof. The method then includes irradiating the impregnated membrane with electron beam radiation to provide a crosslinked reaction product constituting a three-dimensional network formed of the microporous starting membrane and the polymer without any decomposition of the microporous starting membrane.
    Type: Grant
    Filed: February 19, 2015
    Date of Patent: November 12, 2019
    Assignee: Sartorius Stedim Biotech GmbH
    Inventors: Volkmar Thom, Bjoern Hansmann, Tobias Foster
  • Reliability of an integrity or leak test of a sample
    Patent number: 10473677
    Abstract: A method for improving reliability of an integrity or leak test includes determining at least one first parameter indicative of: a first volume of a sample, a first temperature of the sample, a first pressure of the sample and/or a first assessment of integrity of the sample. The method further determines at least one second parameter indicative of a deviation from the first parameter and at least one third parameter indicative of a second assessment of the integrity of the sample. The second assessment provides an indication of a passed or failed test. The method further determines whether the deviation has an impact on the indication of the second assessment. When the deviation is determined to have an impact on the indication of the second assessment, the method comprises identifying a possibility that the indication of the second assessment is incorrect.
    Type: Grant
    Filed: August 2, 2017
    Date of Patent: November 12, 2019
    Assignee: Sartorius Stedim Biotech GmbH
    Inventor: Magnus Stering
  • SHEET MATERIAL AND FILTER ELEMENT WITH HYDROPHOBIC SEPARATING LAYER, USE THEREOF AND PROCESS FOR PRODUCTION OF SAME
    Publication number: 20190329172
    Abstract: The present invention relates to a sheet material and filter element, where the sheet material and the filter element have a hydrophobic separating layer, and also to use thereof and to a process for production of same.
    Type: Application
    Filed: April 25, 2019
    Publication date: October 31, 2019
    Applicant: Sartorius Stedim Biotech GmbH
    Inventors: Eberhard Wünn, Thomas Friese, Benjamin Schneider, Mario Strauss
  • Mixing vessel with locking assembly for locking a mixing assembly in storage position and mixing impeller with central disc-like member
    Patent number: 10434481
    Abstract: A mixing vessel for accommodating components to be mixed has a container with at least one mounting depression in a side wall of the container. The mounting depression is adapted so that a mixing impeller housing of a mixing impeller is at least partly insertable, in which at least one magnet is housed for being magnetically connectable to a drive device to be driven. A locking assembly is attachable to the mounting depression from outside for locking the mixing impeller in a storage position, in which the mixing impeller is not rotatable. The locking assembly has a magnetically active element that is adapted to interact with the magnet of the mixing impeller.
    Type: Grant
    Filed: January 29, 2016
    Date of Patent: October 8, 2019
    Assignee: Sartorius Stedim Biotech GmbH
    Inventors: Lars Boettcher, Jonathan E. Cutting, Sharon D. West, Martin Oschwald, Mike Bates
  • SERVICE UNIT AND METHOD FOR MONITORING AND DOCUMENTING MAINTENANCE WORK
    Publication number: 20190303884
    Abstract: The invention relates to a service unit that can be carried on the body of a user by means of a carrying system, having at least one power source for supplying power to electrically operated tools connectable to the power source, the power source being formed from at least one rechargeable battery. The invention also relates to a method for monitoring and documenting maintenance work. The invention is distinguished in that the carrying system has an integrated computation and documentation unit for monitoring and documenting maintenance work, wherein the computation and documentation unit is powered from the power source, wherein the computation and documentation unit is connected to at least one motion sensor and/or locating sensor and wherein the motion sensor is arranged on the tool or the hand of the user.
    Type: Application
    Filed: June 2, 2017
    Publication date: October 3, 2019
    Applicant: Sartorius Stedim Biotech GmbH
    Inventor: Lars BÖTTCHER
  • Mixing device for mixing the contents of a container
    Patent number: 10428299
    Abstract: A mixing device for mixing contents of a container has a support for supporting the container and a moving device connected to the support for moving the support and mixing the contents of the container. The support has a positioning device to position the container so that a removal side of the container is arranged substantially along a predetermined line of the support. The support is pivotable about a removal pivot axis to move the container into a removal position. The removal pivot axis is at an angle of over 0° to 45° to the predetermined line of the support so that the container can be moved from the mixing position by pivoting the support about the removal pivot axis into the removal position where the removal side is on a lower side of the container and inclined toward a removal region of the container.
    Type: Grant
    Filed: May 13, 2015
    Date of Patent: October 1, 2019
    Assignee: Sartorius Stedim Biotech GmbH
    Inventors: Marcel Roell, Daniel Hoepli
  • Integrity and functionality test for adsorptive depth filter layers with an inorganic layered double hydroxide
    Patent number: 10386285
    Abstract: The present invention relates to a method for determining the functionality and integrity of depth filter sheets and depth filter sheet systems comprising inorganic layered double hydroxide for contaminant removal in biotechnological processes.
    Type: Grant
    Filed: September 3, 2014
    Date of Patent: August 20, 2019
    Assignee: Sartorius Stedim Biotech GMBH
    Inventors: Rebecca Petersen, Axel Thiefes, Katrin Köhler, Wolfgang Demmer, Sven Dankenbrink
  • Membrane with performance enhancing multi-level macroscopic cavities
    Patent number: 10384168
    Abstract: The present invention relates to a micro-porous filtration membrane with performance enhancing multi-level macro-scopic cavities as well as a method for producing the same.
    Type: Grant
    Filed: July 15, 2015
    Date of Patent: August 20, 2019
    Assignee: Sartorius Stedim Biotech GmbH
    Inventors: Ashok Mundrigi, Jahnavi Gowda, Ramesh Mundlamuri, Thomas Loewe, Holger Linne, Sebastian Handt
  • Mixing and thawing device
    Patent number: 10363528
    Abstract: A mixing and thawing device (1) has a rocker drive (2) and a bag holder (3) for holding a bag (7). The bag holder (3) has a base part (8) and a lid part (9) that enclose a holding space (10) for the bag (7). A heating element (11) is arranged in the base part (8). Thus, the holding space (10) is designed as a heat-insulating closed chamber. Interconnected intermediate spaces (14, 15) are arranged between the bag (7) and the base part (8) and between the bag (7) and the lid part (9). One or more flow generators (16) are provided to generate a circulating fluid flow (17).
    Type: Grant
    Filed: April 16, 2015
    Date of Patent: July 30, 2019
    Assignee: Sartorius Stedim Biotech GmbH
    Inventors: Lars Boettcher, Marcel Roell, Martin Dahlberg, Swen Weitemeier
  • CONTROLLING AND MONITORING A PROCESS TO PRODUCE A CHEMICAL, PHARMACEUTICAL OR BIOTECHNOLOGICAL PRODUCT
    Publication number: 20190219992
    Abstract: A computer system and computer-implemented method are described for controlling and monitoring a process to produce a chemical, pharmaceutical or biotechnological product. The method includes providing a database that stores sets of process parameters to control and monitor a plurality of processes performed in order to produce products, receiving a set of characterizing process parameters that characterize the process, identifying a first set process parameters from the stored sets of process parameters, and controlling and monitoring the process using a successful trajectory that includes a time-based profile of measurements.
    Type: Application
    Filed: May 11, 2017
    Publication date: July 18, 2019
    Applicant: Sartorius Stedim Biotech GmbH
    Inventors: Christian Grimm, Mario Becker, Lars Böttcher, Thorsten Adams
  • Reactor plant and process for culturing phototropic microorganisms
    Patent number: 10344254
    Abstract: Reactor plant and process for culturing phototropic microorganisms with a reactor vessel and a photosynthetic module, which are connected with one another in a circulation circuit by a pump and can be controlled via a control unit, where in the circulation circuit or in the reactor vessel, a homogenizer is provided, where a light-intensity control of the photosynthetic module is provided, and where a bypass of the circulation circuit or of the reactor vessel with a filter device which is arranged externally of the reactor vessel for separating off extracellular products during the fermentation is provided.
    Type: Grant
    Filed: March 6, 2007
    Date of Patent: July 9, 2019
    Assignee: Sartorius AG
    Inventors: Wolfgang Kahlert, Bernd-Ulrich Wilhelm, Wolf-Dietrich Linke
  • Container system with one container with a flexible partition
    Patent number: 10322388
    Abstract: Container system with one container (1) with a flexible partition, in particular a disposable container, that can be inserted into a carrying container that supports its lateral container partition (10) and in which liquid medium (8) that has been poured in can be mixed, with the carrying container (4) featuring at least one baffle (15, 15?, 15?, 15??) on the internal support partition (11) that forms the lateral container partition.
    Type: Grant
    Filed: April 12, 2007
    Date of Patent: June 18, 2019
    Assignee: Sartorius Stedim Biotech GmbH
    Inventors: Oscar-Werner Reif, Reinhard Baumfalk, Gerhard Greller
  • Hot stamping method
    Patent number: 10307937
    Abstract: A method for implementing a channel (56) includes providing a preform (20) having a recess (22) therein and heating a channel implementation element (30?) to a temperature greater than a melting temperature of a material of the preform (20). An external contour of the channel implementation element (30?) at least regionally corresponds to an internal contour of the channel (56) to be implemented. The method then moves the heated channel implementation and/or the preform (20) in relation to one another so that the heated channel implementation element (56) at least regionally moves into the recess (22) in a moving-in direction. The material of the preform (20) is at least partially melted in a region around the recess (20) and is at least partially displaced by the channel implementation element (30?), wherein at least a part of the channel (56) to be implemented is thus implemented.
    Type: Grant
    Filed: December 4, 2013
    Date of Patent: June 4, 2019
    Assignee: Sartorius Stedim Biotech GmbH
    Inventors: Thomas Regen, Sebastian Purmann, Nikoloudis Paschalis, Christian Grimm
  • INSTALLATION FOR BIOTECHNOLOGICAL APPLICATIONS, WITH CARRIER FOR THE MOUNTING OF COMPONENTS
    Publication number: 20190144811
    Abstract: The invention relates to an installation for biotechnological applications (1, 101), comprising an improved holder system (4) with at least one carrier (10) for the mounting of components (5) of the installation (1, 101) on the installation (1, 101). The carrier (10), which comprises a frame (12) with two arms (14) and with a recess (16) and includes a deformable element (30) with at least two fastening sections (32), which may be understood to have a flat base (20) by which the carrier (10) can be fastened to the installation (1, 101). The deformable element (30) is designed to assume the following states: a receiving state AUZ, in which the deformable element (30) is available for receiving a component (5) of the installation (1, 101); and a locking state ARZ.
    Type: Application
    Filed: March 16, 2017
    Publication date: May 16, 2019
    Applicant: Sartorius Stedim Biotech GmbH
    Inventors: Robin Heese, Andreas Migge, André Grebe, Michael Rodenberg