Abstract: The present invention provides the identification and use of EG261, homologs of EG261, orthologs of EG261, paralogs of EG261, and fragments and variations thereof for altering, e.g. increasing, pathogen tolerance and/or resistance in plants.
Abstract: The present invention relates to the field of proteomics and more specifically to a method for analyzing a sample possible containing peptides or modified peptides; in particular useful for biomarker discovery or validation of biomarkers. The method uses isoelectric focusing and mass spectrometry (MS) and enables identification of modified peptides with high resolution and predictability.
Type:
Grant
Filed:
July 4, 2016
Date of Patent:
March 3, 2020
Assignee:
GE Healthcare Bio-Sciences AB
Inventors:
Peter Mats Oliviusson, Janne Lehtio, Rui Miguel Mamede-Branca
Abstract: The present disclosure relates generally to modulators of Cot (cancer Osaka thyroid) and methods of use and manufacture thereof.
Type:
Grant
Filed:
July 25, 2018
Date of Patent:
March 3, 2020
Assignee:
Gilead Sciences, Inc.
Inventors:
Gayatri Balan, Chienhung Chou, Musong Kim, Thorsten A. Kirschberg, John O. Link, Gary Phillips, Roland D. Saito, Neil H. Squires, James G. Taylor, William J. Watkins, Nathan E. Wright
Abstract: Compositions and methods for inhibiting thrombosis without compromising hemostasis are described. Compositions include anti-factor XI monoclonal antibodies (aXIMabs) capable of binding to an epitope on the heavy chain of human FXI, particularly the A3 domain of the heavy chain of human FXI. Compositions also include epitope-binding fragments, variants, and derivatives of the monoclonal antibodies, cell lines producing these antibody compositions, and isolated nucleic acid molecules encoding the amino acid sequences of the antibodies. The disclosure further includes pharmaceutical compositions comprising the disclosed anti-factor XI monoclonal antibodies, or epitope-binding fragments, variants, or derivatives thereof, in a pharmaceutically acceptable carrier.
Type:
Grant
Filed:
July 30, 2018
Date of Patent:
March 3, 2020
Assignees:
Oregon Health & Science University, Vanderbilt University
Inventors:
Andras Gruber, Erik I. Tucker, Stephen Raymond Hanson, David Gailani
Abstract: Example embodiments include a method that improves calculations of surface roughness that map a planetary surface. The method includes calculating a V-system matrix with a size of ?×? in an interval [0,1]; transforming the V-system matrix into an orthogonal matrix; improving calculations of the surface roughness of the planetary surface by calculating the surface roughness of a digital elevation model generated from data captured from the planetary surface; and generating a map of the planetary surface based on the surface roughness.
Type:
Grant
Filed:
February 13, 2018
Date of Patent:
March 3, 2020
Assignee:
Macau University of Science and Technology
Abstract: A battery assembly may include bus strips located on one or more sides and displaced ends of battery cells. The battery assembly may comprise a heater. The battery assembly may comprise one or more refractory panels. A refractory panel may comprise weakened regions corresponding to battery cells.
Type:
Grant
Filed:
March 7, 2018
Date of Patent:
March 3, 2020
Assignee:
Science Applications International Corporation
Abstract: The present invention describes novel SCCmec right extremity junction sequences for the detection of methicillin-resistant Staphyloccocus aureus (MRSA). It relates to the use of these DNA sequences for diagnostic purposes.
Abstract: Various embodiments may provide an optical gyroscope. The optical gyroscope may include a ring resonator, an input source configured to generate or provide a first light beam and a second light beam to the ring resonator, and a switching pathway having an input end and an output end coupled to the ring resonator, and may include a plurality of switches. The optical gyroscope may include a control circuit configured to control the plurality of switches to allow the first light beam to propagate from the input end to the output end along the switching pathway during a first time interval, and allow the second light beam to propagate from the input end to the output end along the switching pathway during a second time interval. The optical gyroscope may additionally include a detector loop configured to receive the first light beam and the second light beam from the ring resonator.
Type:
Grant
Filed:
January 24, 2017
Date of Patent:
March 3, 2020
Assignee:
Agency for Science, Technology and Research
Inventors:
Guoqiang Wu, Jifang Tao, Alex Yuandong Gu, Junfeng Song
Abstract: An AM-EWOD device comprises: first and second substrates (72,36); first and second array element electrodes (38A, 38B) disposed on the first substrate (72) and defining first and second array elements in the AM-EWOD device; a reference electrode (28) disposed on the first substrate (72); a sensor; and a reference electrode drive circuit (50). The reference electrode drive circuit (50) is configured to drive the reference electrode with a first voltage waveform for actuating an array element or with a second voltage waveform different from the first voltage waveform when performing a sensing operation.
Abstract: Human therapeutic treatment compositions comprise at least two of a curcumin component, a harmine component, and an isovanillin component, and preferably all three in combination. The agents are effective for the treatment of human conditions, especially human cancers.
Abstract: An eye-mountable device, having an anterior convex side and a posterior concave side, is packaged in a container having a base and a wall. The wall extends from the base and defines an opening of the container. Disposed within the container is a pedestal, which has a first end attached to the base of the container and a second end opposite the first end. The eye-mountable device is mounted on the pedestal such that the posterior concave side contacts the second end of the pedestal and the eye-mountable device is elevated from the base of the container. The opening of the container can be sealed by a lidstock.
Type:
Grant
Filed:
June 5, 2017
Date of Patent:
March 3, 2020
Assignee:
Verily Life Sciences LLC
Inventors:
Daniel Patrick Barrows, Jeffrey George Linhardt
Abstract: Provided is a method for preparing a grain boundary insulation-type dielectric. The method includes the steps of obtaining a titanic acid compound and a ferroelectric having a value less than a melting point of the titanic acid compound; obtaining a mixture by adding the ferroelectric material to the titanic acid compound; and sintering the mixture at a temperature equal to or more than a melting point of the ferroelectric material.
Type:
Grant
Filed:
May 7, 2018
Date of Patent:
March 3, 2020
Assignee:
Korea Advanced Institute of Science and Technology
Inventors:
Sung Yoon Chung, Hye In Yoon, Gi Young Jo
Abstract: A formulation to reduce the numbers of bacteria, particularly Gram positive bacteria, in a space such as a waste disposal bin, via the vapour phase, and active over a long period, typically several weeks. The product comprises one or more essential oils or essential oil components plus a mixture of volatile and non-volatile solvents, on a carrier such as a non-woven, sintered plastic or cardboard.
Abstract: A method for comparing videos of a surgical procedure is disclosed. The method comprising selecting a plurality of videos from a surgical video database. Each of the plurality of videos including video data of a first surgical procedure comprising a plurality of surgical steps. The method further including identifying a first surgical step included in the plurality of surgical steps within a first video segment in each of the plurality of videos. The method also including warping the first video segment to standardize a dimension of the first video segment in each of the plurality of videos.
Abstract: A method for pumping a fluid includes providing a peristaltic pump including a contact wall, an opposing, movable compression element, and a flexible tube interposed between the contact wall and the compression element in a compressing region. The flexible tube has a tube lengthwise axis and a through passage. The flexible tube is displaceable relative to the compressing region between a first position and a second position different from the first position. The method includes: with the flexible tube in the first position, compressing the flexible tube between the compression element and the contact wall to thereby force the fluid through the through passage; thereafter displacing the flexible tube into the second position from the first position; and thereafter, with the flexible tube in the second position, compressing the flexible tube between the compression element and the contact wall to thereby force the fluid through the through passage.
Type:
Grant
Filed:
April 7, 2017
Date of Patent:
March 3, 2020
Assignee:
PerkinElmer Health Sciences, Inc.
Inventors:
Tak Shun Cheung, Chui Ha Cindy Wong, Andrew Icasiano
Abstract: Provided is a cutter apparatus for machining a difficult-to-machine material, the cutter apparatus including: a cutting tool body which has a fastening portion formed at a center thereof; one or more cutters which are installed on the cutting tool body, and have superhard insert tips fixed to end portions thereof, respectively; and an angle adjusting unit which is installed in an internal space of the cutters, and adjusts angles of the cutters by spreading or retracting the cutters, so that angles of the cutters may be easily adjusted in accordance with a condition for cutting a difficult-to-machine material, in order to prevent damage to the superhard insert tips when machining a difficult-to-machine material having high hardness and high toughness.
Type:
Grant
Filed:
December 21, 2016
Date of Patent:
March 3, 2020
Assignees:
POSCO, Research Institute of Industrial Science and Technology
Abstract: A thermal insulation structure is disposed at an exterior of a chamber of a heating device. The thermal insulation structure includes a heat conduction layer, a heat storage layer and a reflection layer. The heat conduction layer is adapted to conduct heat from the chamber to the heat storage layer. The heat storage layer is adapted to store heat. The reflection layer is adapted to reflect radiation heat back to the chamber, whereby a temperature of the chamber could be kept at a constant so as to reduce heat dissipation of the chamber.
Type:
Grant
Filed:
September 4, 2018
Date of Patent:
March 3, 2020
Assignees:
National Chung-Shan Institute of Science & Technology, Ten Wing Scientific Co., Ltd.
Abstract: Provided herein is a water- and sweat-resistant transdermal drug delivery system for application to the skin of a mammal that comprises a patch having a diameter between 1 and 8 cm in length and a surface area between 4 and 8 cm2. Also provided are methods of producing the transdermal drug delivery system and methods of treatment comprising the use of the transdermal drug delivery system.
Abstract: The present invention provides an estimate of the prior requested in a crop allocation model. The crop allocation model is a mathematical modelling to estimate crop area, yield and production for 42 major crops in the world across a global 5 arc minute grid. The model uses a downscaling approach that accounts for spatial variation in the biophysical conditions influencing the productivity of individual crops, and uses crop gross revenue potential of alternate crops when considering how to prioritize the allocation of specific crops to individual gridcells. The proposed methodology is an entropy-based optimization procedure that imposes a range of consistency and aggregation constraints. A particular feature of this method is the explicit inclusion of error terms. There is inherent uncertainty in many aspects of the model, such as input data, incomplete information on farmers' behavior, spatial heterogeneity of crop varieties and managements cross regions in the world.
Type:
Grant
Filed:
June 17, 2017
Date of Patent:
March 3, 2020
Assignee:
Institute of Agricultural Resources and Regional Planning Chinese Academy of Agricultural Sciences