Patents Assigned to Sciences
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Patent number: 10288560Abstract: Disclosed is a system for observing the conformational change in a protein, which includes a sensing element which is configured to amplify an electromagnetic wave of a specific frequency; a light irradiation unit which is configured to irradiate a photoreceptor protein solution coated on the sensing element with light; an electromagnetic wave irradiation unit which allows an electromagnetic wave to be incident in a direction perpendicular to the bottom surface of the sensing element; a detection unit which is configured to detect an electromagnetic wave reflected from the bottom surface of the sensing element; and a control unit which is configured to observe the conformational change in the photoreceptor protein based on the detected electromagnetic wave.Type: GrantFiled: June 5, 2018Date of Patent: May 14, 2019Assignee: Korea Institute of Science and TechnologyInventors: Minah Seo, Young Min Jhon, Chulki Kim
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Patent number: 10287549Abstract: Provided is a muscle stem cell in vitro culture method. A muscle stem cell is cultivated in vitro by using a cell culture medium of a cell factor added with a blood cell or a conditioned medium of the blood cell. Also provided is a culture medium used in the muscle stem cell in vitro culture method and an application thereof.Type: GrantFiled: May 21, 2014Date of Patent: May 14, 2019Assignee: Shanghai Institutes for Biological Sciences, Chinese Academy of SciencesInventors: Ping Hu, Xin Fu, Jun Xiao
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Patent number: 10285582Abstract: An imaging device for imaging an eye includes an eyepiece, an illumination system, an imaging system, and a controller. The illumination system includes a light source that emits illumination light along an illumination path through the eyepiece to the eye to produce a retinal diffuse reflection and a corneal specular reflection. The imaging system includes a first camera that captures a retinal image based on the retinal diffuse reflection and a first set of optical elements, a second camera that captures a corneal specular reflection image based on the corneal specular reflection and a second set of optical elements. The first camera captures at least some residual corneal specular reflection in the retinal image. The controller subtracts the residual corneal specular reflection from the retinal image based on the corneal specular reflection image.Type: GrantFiled: September 20, 2017Date of Patent: May 14, 2019Assignee: Verily Life Sciences LLCInventors: Sam Kavusi, Charles M. Santori, Seung Ah Lee, Scott Ettinger
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Patent number: 10287260Abstract: Provided is a material that, when compared with SAPd, exhibits the similar activity in cross-coupling (CC) reactions, can decrease the amount of catalytic metal that is mixed into the reaction product, and increases the number of times use can be repeated. Provided are a catalyst and a catalyst precursor that use a catalytic metal other than Pd and that exhibit the CC reaction activity similar to when Pd is used. Provided are a catalyst and a catalyst precursor that exhibit the similar CC reaction activity when using Pd or a catalytic metal other than Pd, without using a carrier such as metal and without using piranha solution. A composite wherein catalytic metal nanoparticles are dispersed in a continuous phase comprising a polymer having C2-6 alkylene group units and phenylene group units (an alkylene group unit being bonded to at least the first and fourth position of the phenylene group unit). The particle diameter of the catalytic metal nanoparticles is at most 20 nm.Type: GrantFiled: March 28, 2014Date of Patent: May 14, 2019Assignees: Japan Science and Technology Agency, Furuya Metal Co., Ltd.Inventors: Mitsuhiro Arisawa, Satoshi Shuto, Naoyuki Hoshiya, Satoshi Arai
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Patent number: 10286111Abstract: The present invention relates to hydrogels comprising a plurality of amphiphilic peptides and/or peptoids capable of self-assembling into three-dimensional macromolecular nanofibrous networks, which entrap water and form said hydrogels, wherein at least a portion of said plurality of amphiphilic peptides and/or peptoids is chemically cross-linked. The present invention further relates to methods for preparing such hydrogels and to various uses of such hydrogels, e.g. as cell culture substrates, for drug and gene delivery, as wound dressing, as an implant, as an injectable agent that gels in situ, in pharmaceutical or cosmetic compositions, in regenerative medicine, in tissue engineering and tissue regeneration, or in electronic devices. It also relates to a method of tissue regeneration or tissue replacement using a hydrogel in accordance with the present invention.Type: GrantFiled: January 4, 2017Date of Patent: May 14, 2019Assignee: Agency for Science, Technology and ResearchInventors: Charlotte Hauser, Wei Yang Seow
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Patent number: 10286110Abstract: The present invention relates to hydrogels comprising a plurality of amphiphilic peptides and/or peptoids capable of self-assembling into three-dimensional macromolecular nanofibrous networks, which entrap water and form said hydrogels, wherein at least a portion of said plurality of amphiphilic peptides and/or peptoids is chemically cross-linked. The present invention further relates to methods for preparing such hydrogels and to various uses of such hydrogels, e.g. as cell culture substrates, for drug and gene delivery, as wound dressing, as an implant, as an injectable agent that gels in situ, in pharmaceutical or cosmetic compositions, in regenerative medicine, in tissue engineering and tissue regeneration, or in electronic devices. It also relates to a method of tissue regeneration or tissue replacement using a hydrogel in accordance with the present invention.Type: GrantFiled: January 4, 2017Date of Patent: May 14, 2019Assignee: Agency for Science, Technology and ResearchInventors: Charlotte Hauser, Wei Yang Seow
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Patent number: 10290478Abstract: Certain embodiments described herein are directed to detectors and systems using them. In some examples, the detector can include a plurality of dynodes, in which one or more of the dynodes are coupled to an electrometer. In some instances, an analog signal from a non-saturated dynode is measured and cross-calibrated with a pulse count signal to extend the dynamic range of the detector.Type: GrantFiled: June 1, 2016Date of Patent: May 14, 2019Assignee: PerkinElmer Health Sciences, Inc.Inventors: Hamid Badiei, Steven A. Beres
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Patent number: 10287233Abstract: The present invention provides a method for producing methyl acetate, and the method comprises a step in which dimethyl ether and a raw gas containing carbon monoxide and hydrogen go through a reactor loaded with a catalyst for carrying out a carbonylation reaction; wherein the catalyst contains an acidic EMT zeolite molecular sieve. The present invention has provided a new method for producing methyl acetate. In the method of the present invention, the carbonylation is carried out in the presence of the catalyst containing the acidic EMT zeolite molecular sieve, and the reaction activity is high, and the stability has been significantly improved, meeting the requirement of industrial production.Type: GrantFiled: December 8, 2015Date of Patent: May 14, 2019Assignee: Dalian Institute of Chemical Physics, Chinese Academy of SciencesInventors: Hongchao Liu, Wenliang Zhu, Yong Liu, Youming Ni, Zhongmin Liu, Linying Wang, Peng Tian
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Patent number: 10291458Abstract: A hybrid data transmission frame format for a hybrid single-carrier modulation and OFDM carrier modulation MIMO system and corresponding transmission/reception methods and devices. A transmitter employs single-carrier modulation for preambles and signaling fields via a single-carrier signal generator to produce single-carrier transmission sequences of transmission links. While to employs the same sampling rate to process all the data so as to match a receiver, the sampling rate of the single-carrier transmission sequences needs to be processed into being identical to that of OFDM via a pulse shaping multiphase filter before entering a digital-to-analog converter; the transmitter employs an OFDM modulation mode to transmit data field segments via an OFDM signal generator; and a data receiving process of the receiver is opposite to a data transmitting process of the transmitter.Type: GrantFiled: December 29, 2014Date of Patent: May 14, 2019Assignee: ZTE Wavestone Science and Technology Ltd.Inventors: Shiwen He, Bo Wu, Haiming Wang, Yongming Huang, Jun Zhang
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Patent number: 10287569Abstract: The invention provides a polypeptide capable of using 4-hydroxy-3-methyl-but-2-enyl pyrophosphate (HMBPP) as a substrate to produce isoprene, a nucleic acid encoding the polypeptide, and a vector and a cell comprising the nucleic acid. In addition, the invention also provides a method for producing isoprene using the polypeptide, and a method for preparing the polypeptide.Type: GrantFiled: February 4, 2016Date of Patent: May 14, 2019Assignee: Institute of Microbiology, Chinese Academy of SciencesInventors: Yanhe Ma, Deyong Ge, Yanfen Xue
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Patent number: 10289150Abstract: A micro-movement subassembly as a precise driving screw for angle adjustment, comprising a shank, a turnbuckle, and a central cylindrical shaft. The subassembly is precise for linear displacement, good orientation, stable and reliable adjustment, which can be used for a variety of precision-oriented precision micro-angle adjustment of the drive screw.Type: GrantFiled: June 9, 2017Date of Patent: May 14, 2019Assignee: Shanghai Institute of Optics And Fine Mechanics, Chinese Academy of SciencesInventors: Jianqiang Zhu, Gengxiu Tang, Zhigang Liu
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Patent number: 10287392Abstract: Disclosed is a method for preparing a poly(L-lactic acid) composite. According to the method, PLLA can be processed without losing its physical properties during thermal processing and can be effectively used to manufacture a final product with improved thermal properties. In addition, the monomer is not thermally decomposed during high-temperature polymerization. Therefore, the poly(L-lactic acid) composite can be prevented from browning. Also disclosed is a poly(L-lactic acid) composite prepared by the method.Type: GrantFiled: September 27, 2017Date of Patent: May 14, 2019Assignee: Korea Institute of Science and TechnologyInventors: Soo Hyun Kim, Young Mee Jung, Seung Hyuk Im
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Publication number: 20190134609Abstract: A catalyst comprising: a titanium oxide having an anatase-type crystal structure, and having the vertices and the ridge lines, wherein in a single titanium oxide particle, a vertex density per unit surface area is 8.0×10?4 nm?2 or more, and a ridge line density per unit surface area is 5.0×10?2 nm or more, or a ridge line density per unit volume is 8.0×10?3 nm?2 or more. A complex comprising: a material having a porous structure; and said catalyst. A membrane electrode assembly comprising: an anode; cathode; and an electrolyte membrane, wherein the cathode carries said catalyst on at least a surface of the cathode.Type: ApplicationFiled: March 2, 2017Publication date: May 9, 2019Applicant: Japan Science and Technology AgencyInventors: Miho Yamauchi, Masaaki Sadakiyo, Sho Kitano, Shinichi Hata
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Publication number: 20190135976Abstract: Aqueous compositions of carboxylic acids, carboxylate esters, and carboxylate salts are generally disclosed, including methods of using such compounds to make various polymers, including, but not limited to, polyesters, polyamides, and polycarbamates. In certain embodiments, the carboxylic acids, carboxylate esters, and carboxylate salts are derived from a renewable source, such as a natural oil.Type: ApplicationFiled: August 28, 2018Publication date: May 9, 2019Applicant: Elevance Renewable Sciences, Inc.Inventors: Kamlesh Mody, Daniel Mubima
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Publication number: 20190137495Abstract: A method and a kit are provided for predicting a favorable or a non-favorable response of a cancer patient to treatment with a cancer therapy by determining in a biological sample obtained from the cancer patient, before and after the treatment, the changes of the levels of factors/biomarkers generated by the cancer patient in response to said treatment, and a method for treatment of a cancer patient.Type: ApplicationFiled: December 12, 2018Publication date: May 9, 2019Applicant: Rappaport Family Institute for Research in the Me dical SciencesInventors: Yuval Shaked, Ziv Raviv, Dror Yeger
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Publication number: 20190136341Abstract: The invention relates to a process for selectively and continuously extracting a series of desired species from a matrix, comprising the steps of:—injecting a plasma (310) in an extraction chamber by means of a plasma torch,—continuously monitoring (320) the excited elements extracted from the matrix and contained in the plasma by optical emission spectroscopy, and for each species of the series,—setting a distance (330) between the support and the plasma torch, and the composition of the injected plasma as a function of the monitored excited elements so that only one desired species of the series of species is being extracted from the matrix under molecular form, and—providing (400) a plate in the extraction chamber, exterior to the plasma, causing collection of molecules comprising said desired species by deposition onto the surface of the plate.Type: ApplicationFiled: June 8, 2017Publication date: May 9, 2019Applicants: Paris Sciences Et Lettres - Quartier Latin, Centre National de la Recherche Scientifique (CNRS)Inventors: Frédéric Rousseau, Olivier Lesage, Jonathan Cramer, Frédéric Prima, Daniel Morvan
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Publication number: 20190135774Abstract: Molecular characterization of disease has become the dominant trend in modern medicine, and it has recently become increasingly important to obtain qPCR, microarray, and next-generation sequencing (NGS) data for both research and clinical applications. Formalin-fixed, paraffin-embedded (“FFPE”) samples have become the standard way of storing clinical biopsies throughout the world. Unfortunately, the poor quality and quantity of nucleic acids obtained from such specimens has posed severe limitations on the types of studies that can be accomplished. Existing methods for retrieval of the biomolecules from their crosslinked matrices are poorly effective and rely on harsh conditions which further damage the biomolecules being extracted. The invention provides compositions and methods for retrieval, analysis and use of biomolecules, including nucleic acids, from such samples.Type: ApplicationFiled: April 21, 2017Publication date: May 9, 2019Applicant: Cell Data Sciences, Inc.Inventor: Lucian Orbai
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Publication number: 20190134535Abstract: Emulsion breaking and phase separation is achieved by droplet adhesion. An emulsion breaking device includes a channel having distinct adjacent zones with distinctly different surface wettability characteristics, namely, solvophilic and solvophobic surfaces. The device is positioned such that the upstream portion of the device is configured to be wetted by the continuous phase of the emulsion, and the downstream portion of the device is configured to be wetted by the dispersed phase of the emulsion. As the emulsion flows from the upstream zone to the downstream zone, the change in surface wettability characteristics promotes adhesion of the dispersed phase as the dispersed phase wets the surface of the downstream portion of the channel, which results in breaking of the emulsion. Subsequent collection of the broken emulsion in a collection vessel results in separation of the disparate phases to facilitate their recapture and recycling.Type: ApplicationFiled: November 2, 2018Publication date: May 9, 2019Applicants: The Trustees of Princeton University, TSINGHUA UNIVERSITY, UNIVERSITY OF SCIENC AND TECHNOLOGY BEIJINGInventors: Howard A. Stone, Jiang Li, Haosheng Chen
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Publication number: 20190135974Abstract: Polyester compositions are disclosed herein, as well as methods of making and using such polyesters. In some embodiments, the polyesters are formed from monomers derived from natural oils. In some embodiments, the polyesters have lower glass transition temperatures than polyesters of comparable molecular weight.Type: ApplicationFiled: August 13, 2018Publication date: May 9, 2019Applicant: Elevance Renewable Sciences, Inc.Inventors: Ashley M. Nelson, Keren Zhang, Timothy E. Long, Paul A. Bertin
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Publication number: 20190137175Abstract: Disclosed is an adiabatic collector for recycling gas, a liquefier for recycling gas, and a recovery apparatus for recycling gas using the same. More specifically, gas to be recycled is collected in an adiabatic manner, cooled to a temperature lower than the dew point thereof, and stored in the liquid state through a phase change, thereby saving energy required for re-cooling the gas. Particularly, the present invention relates to an adiabatic collector for recycling gas, a liquefier for recycling gas, and a recovery apparatus for recycling gas using the same, in which recycling gas is compressed through a natural inducement method using a difference in temperature and pressure while being collected and liquefied, thereby reducing noise, vibration, and size of the collector.Type: ApplicationFiled: January 3, 2019Publication date: May 9, 2019Applicant: Korea Basic Science InstituteInventors: Seung Young Park, Yeon Suk Choi, Min Su Seo, Myung Su Kim