Patents Assigned to Sciences
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Patent number: 10292631Abstract: Body-mountable devices are provided to detect the presence or status of a tumor in a body by detecting one or more properties of a probe located in subsurface vasculature of the body. A wearable body-mountable device can be worn for a protracted period of time to detect a probe in the vasculature at low concentrations and/or at low rates. A body-mountable device can detect properties of the probe that are indicative of whether the probe has interacted with a tumor of the body and determine the presence or status of a tumor in the body based on such detected properties. Additionally or alternatively, the probe could be introduced into the body as a probe aggregate and released from if the probe aggregate is absorbed by a tumor. The presence of released probes could be detected to determine a presence or status of a tumor in the body.Type: GrantFiled: December 3, 2015Date of Patent: May 21, 2019Assignee: Verily Life Sciences LLCInventors: Andrew Homyk, Jerrod Joseph Schwartz, Alberto Clemente Vitari, Joshua Simon Klein, Mark Audeh
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Patent number: 10294479Abstract: Disclosed herein is Candida parapsilosis CGMCC 9630, the carbonyl reductase expressed by said strain and the encoding gene and amino acid sequence thereof, the recombinant expression vector and recombinant expression transformant containing said gene sequence, and use of whole cells of Candida parapsilosis, carbonyl reductase or corresponding recombinant transformant thereof as catalyst in catalyzing asymmetric reduction of prochiral carbonyl compounds, particularly reduction of 6-carbonyl-8-halogenocaprylate to prepare the synthetic precursor of (R)-?-lipoic acid, (R)-6-hydroxy-8-halogenocaprylate. In comparison to other methods of asymmetric reduction for preparing (R)-6-hydroxy-8-halogenocaprylate, the disclosure has advantages of high substrate concentration, mild reaction conditions, environmental friendship, high yield, and high optical purity of the product, and thus has good prospect in industrial production of (R)-?-?-lipoic acid.Type: GrantFiled: March 4, 2015Date of Patent: May 21, 2019Assignee: East China University of Science and TechnologyInventors: Jianhe Xu, Yujun Zhang, Gaowei Zheng, Jiang Pan
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Publication number: 20190144287Abstract: The present invention relates to an eco-friendly method for preparing a porous silicon carbide structure, which is capable of preparing a porous silicon carbide structure having meso- or macro-sized pores without using a harmful phenolic resin as a carbon source.Type: ApplicationFiled: October 26, 2018Publication date: May 16, 2019Applicant: Korea Institute of Science and TechnologyInventors: Sang Whan PARK, Mi Rae YOUM, Sung Il YUN
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Publication number: 20190144535Abstract: The present invention is directed to antigen binding proteins and in particular to IL-1? antigen binding proteins. The present invention further provides compositions comprising the antigen binding proteins, use of the antigen binding proteins and methods for production.Type: ApplicationFiled: November 15, 2018Publication date: May 16, 2019Applicant: Agency for Science, Technology and ResearchInventors: Cheng-l Wang, Angeline Goh, Siok Ping Yeo, Alessandra Mortellaro, Subhra Kumar Biswas, Florent Ginhoux, Pingyu Zhong
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Publication number: 20190150206Abstract: The present application is to provide a method and a device for establishing wireless connection through a first application on user equipment. The present application is based on the connection request sent by the second application that works in the same user equipment as the first application, establishes the wireless connection between the user equipment and the target wireless access point according to the access information of the target wireless access point corresponding to the connection request through the first application. Herein, executive codes corresponding to the connection operations are not needed to be embedded and executed in the second application, thereby security risks to the second application brought by executing unknown codes of other applications in the second application can be avoided. Meanwhile, risks of information leakage are avoided.Type: ApplicationFiled: January 9, 2019Publication date: May 16, 2019Applicant: Shanghai Zhangmen Science and Technology Co., Ltd.Inventors: Yong SU, Jian Yang
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Publication number: 20190147237Abstract: Provided are a human body posture data acquisition method and system, and a data processing device. The method comprises: obtaining feature data between pre-calibrated human body feature points; obtaining a rotational angle of the human body feature points; and obtaining human body posture data according to the rotational angle of the human body feature points and the feature data between the human body feature points. In the method, head rotation data is obtained by directly providing a head wearing device on the head. Accordingly, body rotation data is obtained by providing a body wearing device on the human chest, and then human body posture data is obtained via the head rotation data and the body rotation data, thereby alleviating the problem that an error in sensed data is caused with the existing human body posture identification methods due to a poor mobility, sensitivity to environmental impacts and susceptibility to disturbances.Type: ApplicationFiled: December 2, 2014Publication date: May 16, 2019Applicant: Wuhan Zhunwofei Science and Technology Co., LTDInventors: Yao Yao, Su Wang
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Publication number: 20190145386Abstract: A magnetic piston shoe pair for an axial piston pump and the motor includes: pistons, coil suites, piston shoes and a swash plate, wherein the interior of the coil suite is a closed coil; the bearing surface that the end surface of the swash plate abuts the piston shoe is provided with micro-molding holes; the micro-molding holes are hemispherical; the back surface of the swash plate is provided with a primary iron core and two secondary iron cores; the iron cores are wound with coil; the coil is connected to an external alternating current power supply. When the pump/motor is working, the coil is energized to generate a magnetic field, thereby adsorbing the piston shoe on the swash plate. Meanwhile, the coil suite generates an inductive magnetic field.Type: ApplicationFiled: November 29, 2018Publication date: May 16, 2019Applicant: Anhui University of Science and TechnologyInventors: Haishun DENG, Yongkang YANG, Haifeng WANG, Qingchun WANG, Feiyu MAO, Chunyan WANG, Shiju HE, Tao WANG
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Publication number: 20190144584Abstract: Alkoxylated fatty acids are disclosed herein, as well as methods of making and using such compounds. In some embodiments, the alkoxylated fatty acids are formed from monomers derived from natural oils. In some embodiments, the alkoxylated fatty acids are used as surfactants for making synthetic latex by emulsion polymerization. In some other embodiments, the alkoxylated fatty acids are used as surfactants for making synthetic rubber, such as styrene-butadiene rubber. In some other embodiments, the alkoxylated fatty acids are used as surfactants in a composition for treatment of gas or oil wells, for cleaning applications, for use in various laundry-related applications, for use in personal care compositions, or for use as solvents for coating applications, such as reactive and non-reactive waterborne coating applications.Type: ApplicationFiled: September 10, 2018Publication date: May 16, 2019Applicant: Elevance Renewable Sciences, Inc.Inventors: Ryan Littich, Charles Coburn, Paul A. Bertin
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Publication number: 20190145964Abstract: Provided is a composition comprising an analyte bound covalently or through a first binding pair to a polymer. In this composition, the analyte is less than about 2000 MW; the polymer further comprises more than one signal or first member of a second binding pair; and the analyte is not a member of the first binding pair or the second binding pair. Also provided is an assay for an analyte. The assay comprises: combining a sample suspected of containing the analyte with the above-described composition and a binding agent that binds to the analyte; and detecting the signal or the first member of the second binding pair that is bound to the binding agent. Additionally provided is a multisignal labeling reagent comprising a first polymer covalently bound to (a) a reactive group or a first member of a first binding pair, and (b) more than one digoxigenin molecule.Type: ApplicationFiled: November 28, 2018Publication date: May 16, 2019Applicant: Enzo Life Science, Inc. c/o Enzo Biochem, Inc.Inventors: Jack Coleman, Maciej Szczepanik, Richard Jin
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Publication number: 20190144354Abstract: Improved urease inhibitors comprise one or more polymers containing alkenylphenyl sulfonate repeat units, which may be applied to or mixed with a variety of urea-containing fertilizers in order to substantially prevent urea decomposition when applied to soil. The inhibitors may be in the form of homopolymers such as polystyrene sulfonate, or as copolymers containing alkenylphenyl sulfonate and other, different repeat units. The inhibitor polymers may be in free acid, partial salt, or complete salt forms, and are water soluble.Type: ApplicationFiled: May 12, 2017Publication date: May 16, 2019Applicant: Verdesian Life Science, U.S., LLCInventors: Jacob Mazo, Grigory Mazo
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Publication number: 20190145943Abstract: A chromatographic data system processing apparatus includes a liquid feeder, a sample injector, a column that separates samples, a detector, a controller that processes a detected result of the detector, and a data processor that examines and sets operations of the liquid feeder, the column and the detector, and a measurement condition. The data processor generates a three-dimensional graph having three axes related to a pressure, a time, and a number of theoretical plates based on data or variables indicating a relationship between the number of theoretical plates and a flow rate, and data or variables indicating a relationship between the pressure and the flow rate. The chromatographic data system processing apparatus can easily obtain a separation condition for obtaining performance from a three-dimensional graph including a pressure drop, a hold-up time and a number of theoretical plates.Type: ApplicationFiled: November 15, 2018Publication date: May 16, 2019Applicant: Hitachi High-Tech Science CorporationInventors: Masahito Ito, Katsutoshi Shimizu
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Publication number: 20190148810Abstract: The present disclosure is related to the microwave measuring field, and in particularly to a coaxial resonant cavity and system and method for measuring the dielectric constant of material. The coaxial resonant cavity includes a coupling mechanism and a cavity body. The coupling mechanism is accommodated in the cavity body for exciting or coupling microwaves inside the cavity body. The coaxial resonant cavity further includes a probe extending out of the cavity body and being coaxial with the cavity body. The cavity body is shaped as an annular column, and a ratio of an outer radius of the annular column to an inner radius of the annular column is (3-5): 1. The present disclosure still provides a system and method for measuring the dielectric constant of material using the coaxial resonant cavity.Type: ApplicationFiled: July 19, 2017Publication date: May 16, 2019Applicant: University of Electronic Science and Technology of ChinaInventors: Yong XIANG, Cong WANG, Xuesong FENG, Fenfen LIU
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Publication number: 20190141947Abstract: The disclosure relates to systems and methods for dynamic release planning for insect release. One example method includes receiving information indicating a population of wild insects within a geographic region; determining a number of wild insects per unit area within the geographic region; placing, based on the number of wild insects per unit area, one or more insect release points based on the number of wild insects per unit area, each insect release point indicating a release of a predefined quantity of insects; and generating an insect release route through the geographic region, the insect release route passing through each insect release point.Type: ApplicationFiled: November 16, 2018Publication date: May 16, 2019Applicant: Verily Life Sciences LLCInventors: Tiantian Zha, Peter Massaro, Erika Lee
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Publication number: 20190141969Abstract: One example insect release device includes a vessel defining a volume, the vessel has first and second surfaces substantially opposite each other, the first surface defining an opening into the volume; a population of insect larvae or pupae or adult insects within the volume; and a seal positioned to obstruct the opening and adhered to the first surface. Another example insect release device includes a vessel defining a volume; a population of insect larvae or pupae or adult insects disposed within the volume; wherein the vessel is permanently sealed, and wherein release of the insect larvae or pupae or adult insects occurs upon rupture of the vessel. A further example insect release device includes a vessel defining a volume; a population of insects disposed within the volume; and a gimbal mechanism coupled to the vessel, the gimbal configured to maintain a substantially constant orientation of the vessel.Type: ApplicationFiled: November 13, 2018Publication date: May 16, 2019Applicant: Verily Life Sciences LLCInventors: Peter Massaro, Robert Sobecki, Charles Behling, Brian Wasson
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Publication number: 20190142347Abstract: A physical stability determination system includes a wearable device configured to collect sleep information, activity information and heartbeat information of a user, a data preprocessor configured to divide each of the activity information and the heartbeat information into data of a sleep area and data of an activity area, based on the sleep information, and a data processor configured to calculate a sleep state, an activity intensity or a heartbeat state of the user from the data of the sleep area and the data of the activity area. The data of the sleep area may be used to calculate the sleep state in the data processor, and the data of the activity area may be used to calculate the activity intensity or the heartbeat state in the data processor.Type: ApplicationFiled: November 8, 2018Publication date: May 16, 2019Applicant: Daegu Gyeongbuk Institute of Science and TechnologyInventors: Sang Ho Hwang, Won Seok Kang, Sang Hun Yun
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Publication number: 20190145978Abstract: Application of a phosphodiesterase PDE3A and genes thereof in judgment of a tumor treatment effect of Anagrelide. Specifically provided is usage of a PDE3A gene sequence, protein, or anti-PDE3A protein specific antibody in preparation of a diagnostic reagent or a diagnostic kit. The diagnostic reagent or kit is used for (a) judging a tumor treatment effect of Anagrelide, and/or (b) judging whether Anagrelide is appropriate for treating a tumor patient. Also provided is a corresponding detection kit.Type: ApplicationFiled: April 25, 2017Publication date: May 16, 2019Applicant: Shanghai Institute of Materia Medica, Chinese Academy of SciencesInventors: Qiang Yu, Jueyu Liu
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Publication number: 20190142322Abstract: The present application provides a Capillary number-based method of isolating circulating rare cells from a blood sample from a subject using filtration parameters determined based on the measurement of hemorheological parameters of the sample. The present application also provides a method for determining filtration parameters in a microfluidic elasto-filtration process for isolating circulating rare cells from a blood sample from a subject. The present application further provides a device for isolating circulating rare cells from a blood sample from a subject and a non-transitory computer storage medium for performing methods described in the present application.Type: ApplicationFiled: April 26, 2017Publication date: May 16, 2019Applicant: The Hong Kong University of Science and TechnologyInventors: Yi-Kuen Lee, Cong Zhao, Kashif Riaz
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Patent number: 10287327Abstract: A series of protein A mutants having high alkali resistance, and methods of using the protein A mutants are provided. The protein A mutants have a high binding affinity for regions of immunoglobulin proteins other than the complementarity determining regions. The protein A mutants can be coupled to a solid support for immunoglobulin isolation, or conjugated to a label for immunoglobulin detection. This series of protein A mutants has high chemical stability under alkaline conditions of pH 13-14, and can also be used as chromatography ligands for purification procedures that use alkaline solutions under harsh conditions, such as Clean-In-Place (CIP). Also provided are methods of immunoglobulin separation and purification, and alkali regeneration of affinity chromatography medium that uses protein A as a ligand.Type: GrantFiled: May 30, 2013Date of Patent: May 14, 2019Assignee: Nanjingjinsirui Science & Technology Biology Corp.Inventors: Hong Qian, Tao Bai, Rong Hua
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Patent number: 10290802Abstract: The forming voltage of a variable resistance device used in a non-volatile memory and the like is decreased, and repetition characteristics are improved. In an element structure in which a metal oxide film is sandwiched between a lower electrode and an upper electrode, an island-shaped/particulate region of amorphous aluminum oxide or aluminum oxycarbide is formed on the metal oxide film. Because an oxide deficiency, serving as the nucleus of a filament for implementing an on/off operation of the variable resistance device, is formed from the beginning under the island-shaped or particulate aluminum oxide or the like, the conventional creation of an oxide deficiency by high-voltage application in the initial period of forming can be eliminated. Such a region can be fabricated using a small number of cycles of an ALD process.Type: GrantFiled: January 13, 2016Date of Patent: May 14, 2019Assignee: National Insitute for Materials ScienceInventors: Toshihide Nabatame, Tadaaki Nagao
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Patent number: 10285580Abstract: A video endoscope comprises a shaft comprising a rigid, proximal-side section and a distal section that is laterally deflectable in a plane from the central longitudinal axis of the shaft. A housing is arranged at the proximal end of the shaft. A control element for controlling the deflection of the shaft is provided at the housing. A rod-like pull element extends in the shaft in an off-center fashion with respect to the central longitudinal axis. The pull element is coupled with the control element and with a distal end of the deflectable section of the shaft, wherein a movement of the pull element by the control element in the proximal direction effects a lateral deflection of the deflectable section. A push tube is provided that is arranged to encase the exterior side of the pull element. The push tube extends from the proximal connection of the pull element with the control element through the first opening into the shaft.Type: GrantFiled: April 29, 2016Date of Patent: May 14, 2019Assignees: Karl Storz SE & Co. KG, Oregon Health & Science UniversityInventors: Ansgar Brambrink, Thomas Ruegg, Dieter Huels, Christian Huber, Andreas Efinger, Martin Renner