Abstract: Provided are a method and apparatus for interpolating X-ray tomographic image data by using a machine learning model. A method of interpolating an X-ray tomographic image or X-ray tomographic composite image data includes obtaining a trained model parameter via machine learning that uses a sub-sampled sinogram for learning as an input and uses a full-sampled sinogram for learning as a ground truth; radiating X-rays onto an object at a plurality of preset angular locations via an X-ray source, and obtaining a sparsely-sampled sinogram including X-ray projection data obtained via X-rays detected at the plurality of preset angular locations; applying the trained model parameter to the sparsely-sampled sinogram by using the machine learning model; and generating a densely-sampled sinogram by estimating X-ray projection data not obtained with respect to the object on the sparsely-sampled sinogram.
Type:
Application
Filed:
November 6, 2018
Publication date:
May 9, 2019
Applicants:
Samsung Electronics Co., Ltd., Korea Advanced Institute Of Science And Technology
Inventors:
Jong Ha LEE, Ho Yeon LEE, Seung Ryong CHO
Abstract: Polyester compositions are disclosed herein, as well as methods of making and using such polyesters. In some embodiments, the polyesters are formed from monomers derived from natural oils. In some embodiments, the polyesters have lower glass transition temperatures than polyesters of comparable molecular weight.
Type:
Application
Filed:
August 13, 2018
Publication date:
May 9, 2019
Applicant:
Elevance Renewable Sciences, Inc.
Inventors:
Ashley M. Nelson, Keren Zhang, Timothy E. Long, Paul A. Bertin
Abstract: An oligomer-polymer and a lithium battery are provided. The oligomer-polymer is obtained by a polymerization of a polymerizable compound having at least one ethylenically unsaturated group and at least one active hydrogen group in the same molecule. The lithium battery includes an anode, a cathode, a separator, an electrolyte solution and a package structure, wherein the cathode includes the oligomer-polymer.
Type:
Application
Filed:
January 9, 2018
Publication date:
May 9, 2019
Applicant:
National Taiwan University of Science and Technology
Abstract: A compound of cesium fluorooxoborate, a nonlinear optical crystal of cesium fluorooxoborate, and a method of preparation and use thereof. The compound has a chemical formula of CsB4O6F and a molecular weight of 291.15. It has a crystal structure, which is prepared by a solid-state synthesis method or a vacuum encapsulation method. The crystal has a chemical formula of CsB4O6F and a molecular weight of 291.15. It belongs to an orthorhombic crystal system, with a space group of Pna21, crystal cell parameters of a=7.9241 ?, b=11.3996 ?, c=6.6638 ?, and ?=?=?=90°, and a unit cell volume of 601.95 ?3. A melt method, high temperature solution method, vacuum encapsulation method, hydrothermal method or room temperature solution method is used to grow the crystal of CsB4O6F.
Type:
Application
Filed:
July 10, 2017
Publication date:
May 9, 2019
Applicant:
XinJiang Technical Institute of Physics & Chemistry, Chinese Academy of Sciences
Inventors:
Shilie PAN, Xuefei WANG, Fangfang ZHANG, Ying WANG
Abstract: The present invention relates to pyrimidone compounds used as Lp-PLA2 inhibitors and pharmaceutical compositions thereof. The structure of the pyrimidone compounds is represented by general formula (I), wherein R1, R2, R3, X, Ar, Y and n are defined as in the specification and claims. The compounds of general formula (I) in the present invention, stereoisomers and pharmaceutically acceptable salts thereof can be used as Lp-PLA2 inhibitors for preventing, treating and/or ameliorating diseases associated with the activity of Lp-PLA2 enzyme.
Type:
Grant
Filed:
December 28, 2015
Date of Patent:
May 7, 2019
Assignee:
Shanghai Institute of Materia Medica, Chinese Academy of Sciences
Inventors:
Jianhua Shen, Yiping Wang, Xinde Chen, Wenwei Xu, Kai Wang
Abstract: The present invention relates to purine derivatives, processes for their preparation, pharmaceutical compositions, and their use in treating viral infections.
Type:
Grant
Filed:
January 30, 2017
Date of Patent:
May 7, 2019
Assignee:
Janssen Sciences Ireland UC
Inventors:
Jean-François Bonfanti, Frédéric Marc Maurice Doublet, Werner Embrechts, Jérôme Michel Claude Fortin, David Craig McGowan, Philippe Muller, Pierre Jean-Marie Bernard Raboisson
Abstract: A composite structure cured by the process of: electrically coupling a first lead to a first portion of said composite structure; electrically coupling a second lead to a second portion of said composite structure; and using an electric power source to pass electric current through said composite structure from said first portion to said second portion, wherein passing said electric current through said composite structure causes the temperature of at least a portion of said composite structure increase to a predetermined temperature.
Abstract: Systems and methods include: receiving digital event type data that define attributes of a digital event type; receiving digital fraud policy that defines a plurality of digital processing protocols; transmitting via a network the digital event data and the digital fraud policy to a remote digital fraud mitigation platform; using the digital event data to configure a first computing node comprising an events data application program interface or an events data computing server to detect digital events that classify as the digital event type; using digital fraud policy to configure a second computing node comprising a decisioning API or a decisioning computing server to automatically evaluate and automatically select one digital event processing outcome of a plurality of digital event processing outcomes that indicates a disposal of the digital events classified as the digital event type; and implementing a digital threat mitigation application process flow that evaluates digital event data.
Type:
Grant
Filed:
March 15, 2018
Date of Patent:
May 7, 2019
Assignee:
Sift Science, Inc.
Inventors:
Fred Sadaghiani, Micah Wylde, Keren Gu, Eugenia Ho, Noah Grant
Abstract: Pyrazolo-quinazoline derivatives of formula (Ia) or (Ib) as defined in the specification, and pharmaceutically acceptable salts thereof, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful, in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer.
Type:
Grant
Filed:
March 23, 2017
Date of Patent:
May 7, 2019
Assignee:
Nerviano Medical Sciences S.R.L.
Inventors:
Gabriella Traquandi, Maria Gabriella Brasca, Roberto D'Alessio, Paolo Polucci, Fulvia Roletto, Anna Vulpetti, Paolo Pevarello, Achille Panzeri, Francesca Quartieri, Ron Ferguson, Paola Vianello, Daniele Fancelli
Abstract: This disclosure relates to methods and kits, systems for screening, diagnosing and prognosing a disease, disorder, or physiological state based upon temporal measurements and analysis of gene expression in a subject.
Abstract: Polyester compositions are disclosed herein, as well as methods of making and using such polyesters. In some embodiments, the polyesters are formed from monomers derived from natural oils.
Type:
Grant
Filed:
April 13, 2017
Date of Patent:
May 7, 2019
Assignee:
Elevance Renewable Sciences, Inc.
Inventors:
Ashley M. Nelson, Keren Zhang, Timothy E. Long, Paul A. Bertin
Abstract: Flange technologies are described for a flange comprising a first and second side. Each side may include a knife edge surface disposed circumferentially around a base surface and a periphery section disposed around the knife edge surface. The knife edge surface and the periphery section are effective to define grooves therebetween. The flange may include an alloy with a relatively high thermal conductivity and yield strength. The flange may include water channels to remove heat.
Type:
Grant
Filed:
October 21, 2014
Date of Patent:
May 7, 2019
Assignee:
Brookhaven Science Associates, LLC
Inventors:
Sushil Kumar Sharma, Lewis Garth Doom, Jr., Christopher Amundsen, Muhammad Aftab Hussain, Frank A. DePaola, Frank Charles Lincoln, Charles Hetzel, Charles S. De La Parra, Paul Edward Palecek, Jr.
Abstract: A pruning robot system, which comprises: a signal tag device (2) for detecting and storing information of trees and crops and positioning information, and assisting positioning; a robot (1) comprising a central processing device (10) for storing and analyzing data information of each part of the robot (1) and issuing action instructions to each part of the robot (1), and a positioning and navigating device (11) for positioning and navigating the robot (1), and for planning a path and providing obstacle-avoiding navigation for the robot (1) according to an electronic map; a cloud platform terminal (3), which is in connection and communication with the central processing device (10) of the robot (1) and is used for storing data of trees and crops as well as detection data of the robot (1), and for planning a path for the robot (1) through computing and experimenting according to the information data; a map building device (4) for building a three-dimensional electronic map corresponding to the plantation throug
Type:
Grant
Filed:
May 26, 2014
Date of Patent:
May 7, 2019
Assignee:
Institute of Automation Chinese Academy of Sciences
Inventors:
Zhen Shen, Mengzhen Kang, Jiantong Li, Feiyue Wang
Abstract: A method of isolating at least one phenanthroindolizidine alkaloid, in particular with telomerase inhibitory activity, from Tylophora atrofolliculata is used to isolate and obtain for example about six to eight phenanthroindolizidine alkaloids, including at least four new phenanthroindolizidine alkaloids which have not been previously isolated. Experimental tests confirmed an exceptional telomerase inhibitory activity of the phenanthroindolizidine alkaloids isolated. A pharmaceutical composition includes at least one phenanthroindolizidine alkaloid and at least one pharmaceutical tolerable excipient. Still further, a method of treating a subject suffering from cancer includes administering at least one phenanthroindolizidine alkaloid isolated from Tylophora atrofolliculata. Also, a method of treating a subject suffering from cancer includes administering to the subject at least one phenanthroindolizidine alkaloid having certain formula.
Type:
Grant
Filed:
April 29, 2016
Date of Patent:
May 7, 2019
Assignee:
Macau University of Science and Technology
Abstract: Anti-PD-1 antibodies are disclosed. Also disclosed are pharmaceutical compositions comprising such antibodies, and uses and methods using the same.
Type:
Grant
Filed:
October 27, 2015
Date of Patent:
May 7, 2019
Assignee:
Agency For Science, Technology and Research
Abstract: A composite cathode active material, including a nickel-based lithium transition metal oxide secondary particle, the nickel-based lithium transition metal oxide secondary particle including a coating layer containing lithium and cobalt on a surface of a primary particle of the secondary particle.
Type:
Grant
Filed:
December 17, 2015
Date of Patent:
May 7, 2019
Assignees:
SAMSUNG SDI CO., LTD., UNIST (Ulsan National Institute of Science and Technology)
Inventors:
Kwanghwan Cho, Jaephil Cho, Hyejung Kim
Abstract: Ultrasound-guided needle procedures require skills that are challenging to master, especially considering the need to manipulate 3-D structures while observing 2-D images (or even 3-D images). A pre-clinical assessment and training apparatus, methods, and systems are described herein. Targeting tasks require participants to contact target models designed to test various skills. Performance is compared between those with experience in ultrasound-guided medical procedures and those without experience, using at least one targeting task likely to be beneficial for assessment.
Abstract: Polyester compositions are disclosed herein, as well as methods of making and using such polyesters. In some embodiments, the polyesters are formed from monomers derived from natural oils. In some embodiments, the polyesters are highly branched polymers, such as highly branched polymers that have low viscosity at higher molecular weights.
Type:
Grant
Filed:
April 13, 2017
Date of Patent:
May 7, 2019
Assignee:
Elevance Renewable Sciences, Inc.
Inventors:
Ashley M. Nelson, Keren Zhang, Timothy E. Long, Paul A. Bertin
Abstract: The present invention relates to certain compounds (e.g., imidazopyrazine, imidazopyridine, imidazopyridazine and imidazopyrimidine compounds) that act as inhibitors of the MAP kinase interacting kinases MNK2a, MNK2b, MNK1a, and MNK1b. The present invention further relates to pharmaceutical compositions comprising these compounds, and to the use of the compounds for the preparation of a medicament for the prophylaxis and treatment of diseases (e.g., proliferative diseases (e.g., cancer), neurodegenerative diseases (e.g., Alzheimer's disease), metabolic diseases (e.g. diabetes), neurodevelopmental disorders (e.g. autism), or psychiatric disorders (e.g. schizophrenia or anxiety)) as well as methods of treating these diseases.
Type:
Grant
Filed:
October 17, 2014
Date of Patent:
May 7, 2019
Assignee:
Agency for Science, Technology and Research
Abstract: The invention provides compositions and methods for identifying autism and autism spectrum disorders in humans. The invention also includes compositions and methods for identifying unique gene expression profiles in children with regressive autism spectrum disorder (ASD) and ileocolitis.