Patents Assigned to SCIENTIFIQUE (CNRS)
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Publication number: 20190099106Abstract: A method for producing an MRI image, including acquiring multiple intermediate images of a subject under analysis using alternating preparation phases; synchronizing the acquisitions with a physiological variable of the subject; forming a first and a second set of intermediate images resulting from distinct preparation phases; assigning to each intermediate image a timestamp based on the time elapsed between the acquisition time of the current intermediate image and the previous intermediate image; matching intermediate images of the first set with respective intermediate images of the second set based on their timestamps being equal within a tolerance margin; producing a first candidate output image based on a function of the matched intermediate images; increasing the tolerance margin by an increment; reiterating the matching step to produce a further candidate output image; and selecting as an output image a candidate image based on the signal-to-noise ratio of the candidate image.Type: ApplicationFiled: February 27, 2017Publication date: April 4, 2019Applicants: UNIVERSITE D'AIX-MARSEILLE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUEInventors: Olivier Maciej GIRARD, Guillaume Didier David DUHAMEL, Virginie CALLOT
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Publication number: 20190101020Abstract: The object of the present invention is to produce a metal part equipped with a protection system, particularly for turbine blades for aircraft engines, having a thermal barrier that is improved in terms of thermal properties, adhesion to the part and resistance to oxidation/corrosion. In order to achieve this, the method according to the invention produces in a single step, from specific ceramics, coating layers using SPS technology. According to one embodiment, a metal part is produced according to an SPS flash sintering method and comprises a superalloy substrate (22), a metal sub-layer (21), a TGO oxide layer (25) and the thermal barrier (23) formed by said method from at least two chemically and thermally compatible ceramic layers (2a, 2b). A first ceramic (2a), referred to as the inner ceramic, is designed to have a substantially higher expansion coefficient.Type: ApplicationFiled: November 13, 2018Publication date: April 4, 2019Applicants: SAFRAN AIRCRAFT ENGINES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, INSTITUT NATIONAL POL YTECHNIQUE DE TOULOUSE, UNIVERSITE PAUL SABATIER DE TOULOUSEInventors: Juliette HUGOT, Mathieu BOIDOT, Daniel MONCEAU, Djar OQUAB, Claude ESTOURNES
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Patent number: 10246544Abstract: A method for producing an ablative resin by carrying out a reduction reaction for the reduction of a compound of formula A, followed by a polymerization reaction, formula A being the following:Type: GrantFiled: January 20, 2016Date of Patent: April 2, 2019Assignees: ARIANEGROUP SAS, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUEInventors: Gabriel M. Foyer, Ghislain C. David, Sylvain Y. Caillol, Nadia Rodriguez
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Patent number: 10248024Abstract: The invention relates to a method for making a micro- or nano-scale patterned layer of material by photolitography, comprising steps of: positioning a photomask between a light source and a layer of light sensitive material, said mask comprising a support and a layer of micro- or nano-light focusing elements fixed to the support, activating the light source so that the light source emits light radiations through the mask towards a surface of the layer of light sensitive material, developing the layer of light sensitive material so as to obtain the micro- or nano-scale patterned layer of material, wherein, during exposure of the layer of light sensitive material to light radiations, the photomask is positioned relative to the light sensitive layer so that the distance between the surface of the light sensitive layer and the layer of micro- or nano-light focusing elements is greater than a back focal length of the micro- or nano-light focusing elements.Type: GrantFiled: October 8, 2015Date of Patent: April 2, 2019Assignees: UNIV PARIS XIII PARIS-NORD VILLETANEUSE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)Inventors: Alexis Fischer, Getachew Ayenew, Azzedine Boudrioua, Jeanne Solard
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Patent number: 10247734Abstract: Multimenic lectins having a ?-propeller architecture, formed from monomer modules of approximately 30 to 60 amino acids, in which the binding sites to the glycans are situated on a given side of the proteins and the O-terminus and N-terminus ends of the peptide chains on the other side of the proteins, characterized in that they are formed from 4 to 7 monomer modules, a single, or a plurality of, or all of the adjacent modules being linked to one another by the linkers linking the N-terminus end of one module to the C-terminus end of the adjacent module.Type: GrantFiled: February 26, 2015Date of Patent: April 2, 2019Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS, UNIVERSITE JOSEPH FOURIERInventors: Anne Imberty, Aymeric Audfray, Julie Arnaud
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Patent number: 10250006Abstract: Disclosed is a system for generating wavelength-tunable, ultra-short light pulses within the visible or infrared light spectrum. The system includes an injection module including a light source and a wavelength-tunable spectral filter. The light source is suitable for generating short light pulses, having a duration measured in nanoseconds, within an emission spectrum having a spectral width of several tens of nanometers to several hundred nanometers. The spectral filter has a spectral width between 250 pm and 3 nm and is suitable for spectrally and temporally filtering the short light pulses such that the injection module generates wavelength-tunable, spectrally filtered, ultra-short light pulses. The system also includes at least one optical amplifier suitable for generating wavelength-tunable, ultra-short, amplified pulses based on the wavelength of the spectral filter.Type: GrantFiled: December 24, 2015Date of Patent: April 2, 2019Assignees: UNIVERSITE DE BORDEAUX, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUEInventors: Eric Cormier, Jérome Lhermite, Romain Royon, Laurent Sarger
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Patent number: 10248004Abstract: A method for the inscription of second-order nonlinear optical properties on a support including an amorphous material, the method including: heating the support within a temperature range allowing the movement of charges inside the support; applying a structured electrode to the support, generating an electrical field designed to induce the formation of non-linear optical properties on the surface of the support; and cooling the support.Type: GrantFiled: May 4, 2016Date of Patent: April 2, 2019Assignees: UNIVERSITE DE BORDEAUX, INSTITUT POLYTECHNIQUE DE BORDEAUX, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)Inventors: Marc Gaston Joseph Henri Dussauze, Evelyne Claude Fargin, Vincent Jean Paul Rodriguez, Thierry Cardinal, Frédéric Robert Adamietz
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Patent number: 10246548Abstract: The present invention relates to a composition comprising a polymeric network having at least one unit of formula (I), (II), and/or (III); wherein the composition is obtained by contacting at least one compound A comprising at least two functions selected from the group of function of formula —X—C(?O)—CHR1-C(?O)—R2, —C(?O)—C?C—R2; or —C(?O)—CR1?CR2—NR4R5; wherein at least 25% by weight of compounds A have a functionality ?5, with % by weight relative to the total weight of compounds A; with at least one compound B comprising at least one —NH2, or —NH3+ groups; wherein X, R1, R2, R3, R4, R5, L1 and L2 have the same meaning as that defined in the claims. The present invention also relates to a compound comprising at least two units and at most 5 units of formula (I), (II), and/or (III), described hereinabove.Type: GrantFiled: December 17, 2015Date of Patent: April 2, 2019Assignees: UNIVERSITEIT GENT, ECOLE SUPÉRIEURE DE PHYSIQUE ET DE CHIMIE INDUSTRIELLES DE LA VILLE DE PARIS, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE—CNRSInventors: Filip Du Prez, Johan Winne, Wim Denissen, Ludwik Leibler, Renaud Nicolaÿ
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Publication number: 20190091683Abstract: Electroacoustic device having a transducer including a piezoelectric substrate, first and second electrodes of inverse polarity having respective first and second tracks provided on said substrate, the first and second tracks spiraling around a same center (C), the transducer being configured for generating a swirling ultrasonic surface wave in the substrate.Type: ApplicationFiled: March 15, 2016Publication date: March 28, 2019Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITÉ DE LILLE, ECOLE CENTRALE DE LILLE, SORBONNE UNIVERSITEInventors: Michaël Aymeric BAUDOIN, Olivier Khalil BOU MATAR-LACAZE, Antoine Jean-Pierre RIAUD, Jean-Louis Pierre THOMAS
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Publication number: 20190094267Abstract: A method for commanding a tip of a probe is disclosed, wherein a command signal, representative of the force applied by said tip on the surface of a sample to be analyzed, includes at least one cycle successively defined by: a first step where the value of said command signal decreases from a maximum value (Smax) to a minimum value (Smin) so as to move said tip away from said surface at a predetermined distance called detachment height; a second step where the value of the command signal is maintained constant at said minimum value so as to maintain the tip at said detachment height; a third step where the value of the command signal increases from the minimum value up to said maximum value so as to bring the tip closer towards the surface to be analyzed until the tip comes into contact with the surface; and a fourth step where the value of the command signal is maintained constant at said maximum value to maintain the tip in contact with the surface to be analyzed under a constant force between the tip and tType: ApplicationFiled: September 25, 2018Publication date: March 28, 2019Applicant: CONCEPT SCIENTIFIQUE INSTRUMENTSInventor: Louis Pacheco
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Catalyst compositions comprising small size molecular sieves crystals deposited on a porous material
Patent number: 10239051Abstract: A catalyst composition contains an inorganic porous material with pore diameters of at least 2 nm and of crystals of molecular sieve. The crystals of molecular sieve have an average diameter, measured by scanning electron microscopy, not bigger than 50 nm. The catalyst composition has a concentration of acid sites ranges from 50 to 1200 ?mol/g measured by TPD NH3 adsorption. An XRD pattern of the catalyst composition is the same as an XRD pattern of the inorganic porous material.Type: GrantFiled: July 3, 2014Date of Patent: March 26, 2019Assignees: TOTAL RESEARCH & TECHNOLOGY FELUY, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRSInventors: Kok-Giap Haw, Jean-Michel Goupil, Jean-Pierre Gilson, Valentin Valtchev, Nikolai Nesterenko, Delphine Minoux, Jean-Pierre Dath -
Patent number: 10238680Abstract: Provided herein are compounds, compositions, and methods for the treatment of viral infections, for example, Flaviviridae infections, including HCV infections. In certain embodiments, compounds and compositions of nucleoside derivatives are disclosed, which can be administered either alone or in combination with other anti-viral agents. In certain embodiments, the compounds are D-amino acid phosphoramidate halogeno pyrimidine nucleoside analog compounds which display remarkable efficacy and bioavailability for the treatment of, for example, HCV infection in a human. In certain embodiments, the compounds are of Formula I: or a pharmaceutically acceptable salt, solvate, stereoisomeric form, tautomeric form, or polymorphic form thereof, wherein: PD, X, R1, R2, RA, and RB are as described herein.Type: GrantFiled: November 30, 2015Date of Patent: March 26, 2019Assignees: IDENIX PHARMACEUTICALS LLC, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE DE MONTPELLIERInventors: Benjamin Alexander Mayes, Adel M. Moussa, Cyril B. Dousson, Gilles Gosselin, Claire Pierra, David Dukhan
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Patent number: 10243316Abstract: The invention relates to a method for triggering a pulsed light source, wherein it comprises at least one iteration of the following steps: receiving a control signal; determining what is called a separation time between the reception of said control signal and at least one preceding control signal; adjusting at least one control parameter of said pulsed light source depending at least on said separation; generating at least one electrical signal for triggering the pulsed light source depending on said at least one control parameter adjusted during the preceding step; and triggering the pulsed light source depending on said at least one triggering electrical signal.Type: GrantFiled: March 30, 2016Date of Patent: March 26, 2019Assignees: HORIBA ABX SAS, UNIVERSITE DE LIMOGES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUEInventors: Vincent Couderc, Roland Grando, Alexis Labruyere, Nelly Rongeat, Denisa Subtirelu
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Patent number: 10240123Abstract: The present invention relates to an ex vivo method for preparing induced paraxial mesoderm progenitor (iPAM) cells, said method comprising the step of culturing pluripotent cells in an appropriate culture medium comprising an effective amount of an activator of the Wnt signaling pathway and an effective amount of an inhibitor of the Bone Morphogenetic Protein (BMP) signaling pathway.Type: GrantFiled: August 29, 2012Date of Patent: March 26, 2019Assignees: INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE), CNRS (CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE), UNIVERSITE DE STRASBOURG, ASSOCIATION FRANCAISE CONTRE LE MYOPATHIESInventors: Olivier Pourquie, Jérôme Chal
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Publication number: 20190084903Abstract: The disclosure relates to a process for obtaining alpha-olefins by heterogeneous catalytic ethenolysis of optionally-functionalized unsaturated, in particular mono-unsaturated, olefins. The disclosure also relates to new supported catalysts that can be used in the process and to a method for preparing the supported catalysts.Type: ApplicationFiled: July 18, 2016Publication date: March 21, 2019Applicants: TOTAL RAFFINAGE CHIMIE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITE CLAUDE BERNARD LYON, ECOLE SUPERIEURE DE CHIMIE PHYSIQUE ELECTRONIQUE DE LYONInventors: Mostafa TAOUFIK, Régis GAUVIN, Laurent DELEVOYE, Pascal ROUGE, Kai Chung SZETO, Yassine BOUHOUTE, Henri STRUB
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Patent number: 10234706Abstract: Photonic devices for generating linearly frequency modulated arbitrary microwave signals comprise a laser, and assembly for forming the emitted signal and a photoreceiver the passband of which is in the domain of the microwave frequencies. The forming assembly comprises: a first beam splitter; a first optical channel including a frequency-shifting loop comprising a beam splitter, a first optical amplifier, an optical isolator, a first spectral optical filter and an acousto-optical frequency shifter; a second optical channel including an electro-optical frequency shifter; a second beam splitter; a second optical amplifier; and a second optical filter; the acousto-optical frequency shift, the electro-optical frequency shift and the amplification gain of the first optical amplifier being adjustable.Type: GrantFiled: October 20, 2016Date of Patent: March 19, 2019Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE GRENOBLE ALPES, INSTITUT NATIONAL DE LA RECHERCHE SCIENTIFIQUEInventors: Hugues Guillet De Chatellus, José Azana
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Patent number: 10231985Abstract: The present invention relates to the field of medicine. It more particularly relates to the use of compounds for preventing and/or treating dyslipidemia in a subject, said dyslipidemia typically being linked to the excess presence in the biological membranes, including in the biological membranes of non-adipocyte cells, of fatty acids, in particular of saturated long-chain fatty acids, and/or of sterols. The invention also relates to compositions, in particular pharmaceutical compositions and food supplements or complements, comprising such compounds, and to the uses thereof for preventing and/or treating dyslipidemia. The compounds and compositions according to the invention can in particular be advantageously used for preventing and/or treating a pathological condition selected from metabolic syndrome and/or a symptom or abnormality characteristic of metabolic syndrome, preferably for preventing or treating type 2 diabetes mellitus or hepatic steatosis.Type: GrantFiled: October 8, 2014Date of Patent: March 19, 2019Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE DE POITIERS, UNIVERSITY OF EXETERInventors: Miroslava Spanova, Thierry Ferreira, Romain Clement, Shalinee Dhayal, Noël Morgan
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Patent number: 10233213Abstract: The present description provides compositions and methods for producing therapeutic oligomeric compounds. In another aspect the description provides methods for administering the oligomeric compounds for the treatment and prevention of disease in a mammal. In particular, the disclosure relates to medicaments comprising various novel oligomeric compounds and pharmaceutically acceptable salts thereof. The compounds of the disclosure may optionally be administered with at least one of a pharmaceutically acceptable excipient, additional pharmacologically active agent or a combination thereof.Type: GrantFiled: August 31, 2016Date of Patent: March 19, 2019Assignees: UREKA SARL, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)Inventors: Gilles Guichard, Gavin W. Collie, Karolina Pulka-Ziach, Caterina Maria Lombardo, Juliette Fremaux
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Patent number: 10233912Abstract: A plasma thruster includes extraction of a stream of positive ions. The plasma thruster includes a single ionization stage; injecting ionizable gas for said ionization stage comprising injecting a first gas and an electronegative second gas; creating an RF electric field to cause the gases to ionize in the ionization stage creating a first zone called the hot zone, in the ionization stage; the first gas being distributed in the hot first zone, the second gas being distributed in a second zone less hot than said first zone; extracting a stream of negative ions and a stream of positive ions, these being both connected to the ionization stage; and the extraction of a stream of positive ions and the extraction of a stream of negative ions, ensuring that the thruster is electrically neutral.Type: GrantFiled: November 24, 2009Date of Patent: March 19, 2019Assignees: ECOLE POLYTECHNIQUE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUEInventors: Pascal Chabert, Ane Aanesland, Albert Meige, Gary Leray
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Publication number: 20190081204Abstract: A subject matter of the invention relates to a method for obtaining at least one semi-polar layer (480) of nitride (N) on an upper surface of a crystalline layer (300), the method comprising the steps of: etching parallel grooves (320) starting from the upper surface of the crystalline substrate (300), each groove (320) comprising at least one facet (310) having a crystalline orientation {111}; forming a mask (331) such that the facets (311) opposite to said facets (310) having a crystalline orientation {111} are masked and that said facets (310) having a crystalline orientation {111} are not masked; at least one first epitaxial growth phase, carried out from said non-masked facets (310) in such a way as to form a seed (440); interruption of the first epitaxial growth phase when said seed (440) has an inclined facet (442) having a crystalline orientation (0001) and an upper facet (441) having a crystalline orientation (1011); a surface treatment step comprising a modification of an upper portion of the seeType: ApplicationFiled: February 21, 2017Publication date: March 14, 2019Applicants: COMMISSARIA A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUEInventors: Guy FEUILLET, Michel EL KHOURY MAROUN, Philippe VENNEGUES, Jesus ZUNIGA PEREZ