Patents Assigned to SCIENTIFIQUE (CNRS)
  • Method for post-processing liver MRI images to obtain a reconstructed map of the internal magnetic susceptibility
    Patent number: 11403752
    Abstract: In the field of obesity related disease, identification of patients with nonalcoholic steatohepatitis (NASH) would be useful to counsel them more intensively on diet and lifestyle changes and propose new pharmacological treatments. As a consequence, the inventors worked on a method for post-processing images of a region of interest of the liver for reconstructing a map of the internal magnetic susceptibility by using a Bayesian regularization approach to inverse the internal magnetic field. Such method can be implemented on computer and provides better results than other known methods for obesity related disease. This method may be applied for predicting that a subject is at risk of suffering from such disease, diagnosing a disease, identifying a therapeutic or a biomarker and screening compounds useful as a medicine.
    Type: Grant
    Filed: September 12, 2017
    Date of Patent: August 2, 2022
    Assignees: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), UNIVERSITE PARIS DIDEROT—PARIS 7, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, ASSISTANCE PUBLIQUE—HOPITAUX DE PARIS, UNIVERSITE DE VERSAILLES SAINT-QUENTIN-EN-YVELINES
    Inventors: Benjamin Leporq, Simon Lambert, Bernard Van Beers
  • Production of low carbon footprint magnesia
    Patent number: 11401168
    Abstract: A process for producing magnesia can include contacting CO2-containing emissions with a magnesium-containing material to produce magnesium carbonate; subjecting the magnesium carbonate to calcination to produce a CO2 by-product and magnesia; and recycling at least a portion of the CO2 by-product for contacting the magnesium-containing material to produce the magnesium carbonate. The magnesium-containing material can include mining residues, such as phyllosilicate or chrysotile mining residue, and the magnesium carbonate produced can include precipitated nesquehonite that is subjected to calcination to produce the magnesia.
    Type: Grant
    Filed: July 20, 2017
    Date of Patent: August 2, 2022
    Assignee: INSTITUT NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Guy Mercier, Louis-César Pasquier, Nassima Kemache, Emmanuelle Cecchi, Jean-François Blais
  • Method for determining a characteristic of a receiver in a medium, and system implementing this method
    Patent number: 11405117
    Abstract: Method for determining a characteristic of detection and/or identity information and/or location information of a receiver, wherein: a) a primary wave is emitted by an antenna, b) adjustable elements are controlled with a plurality of sets of parameters, to modify the propagation of a primary wave and/or of a secondary wave coming from the receiver, and c) signals received by the antenna are saved, and d) the characteristic of the receiver in the medium is determined based on the signals received for each set of parameters.
    Type: Grant
    Filed: May 24, 2019
    Date of Patent: August 2, 2022
    Assignees: GREENERWAVE, CENTRE NATIONAL DE LE RECHERCHE SCIENTIFIQUE—CNRS, ECOLE SUPERIEURE DE PHYSIQUE ET DE CHIMIE INDUSTRIELLES DE LA VILLE DE PARIS
    Inventors: Geoffroy Lerosey, Philipp Del Hougne, Mathias Fink, Alexandre Aubry
  • Luminescent particles based on rare earth elements and use thereof as a diagnostic agent
    Patent number: 11401463
    Abstract: The present invention concerns a luminescent particle comprising a nanoparticle of formula A1-xLnxVO4(1-y)(PO4)y??(I) in which A is selected from yttrium (Y), gadolinium (Gd), lanthanum (La), and mixtures thereof; Ln is selected from europium (Eu), dysprosium (Dy), samarium (Sm), neodymium (Nd), erbium (Er), ytterbium (Yb), and mixtures thereof; 0<x<1; and 0?y<1; characterized in that the nanoparticle on its surface has tetraalkylammonium cations in an amount such that said nanoparticle has a zeta potential, ?, of less than or equal to ?28 mV in an aqueous medium with a pH?5, more particularly with a pH?5.5, and with an ionic conductivity >100 ?S·cm?1. It also concerns a method for preparing such luminescent particles, a colloidal suspension of these particles, and the use thereof as a diagnostic agent, and also a diagnostic kit comprising such luminescent particles.
    Type: Grant
    Filed: May 18, 2018
    Date of Patent: August 2, 2022
    Assignees: ECOLE POLYTECHNIQUE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Thierry Gacoin, Maximilian Richly, Pascal Preira, Antigoni Alexandrou, Cédric Bouzigues, Rabei Mohammedi
  • Polymer membrane and methods of manufacturing thereof
    Patent number: 11401390
    Abstract: This invention relates to a polymer membrane comprising a hydrogen bond donor polymer and a hydrogen bond acceptor polymer and to the use of such membrane as the shell of a capsule. The invention also relates to a method of manufacturing a polymer membrane comprising a step of contacting an aqueous phase comprising a first polymer, and an oil phase comprising a second different polymer; wherein one polymer is a hydrogen bond donor polymer and the other polymer is a hydrogen bond acceptor polymer. The invention also relates to a method of encapsulation comprising a step of manufacturing a polymer membrane.
    Type: Grant
    Filed: March 16, 2018
    Date of Patent: August 2, 2022
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, ECOLE SUPERIEURE DE PHYSIQUE ET DE CHIMIE INDUSTRIELLES DE LA VILLE, SORBONNE UNIVERSITÉ
    Inventors: Cécile Monteux, Julien Dupré De Baubigny, Mathilde Reyssat, Patrick Perrin, Nadège Pantoustier
  • Device for illuminating an object with a controlled light intensity and associated method
    Patent number: 11400311
    Abstract: The invention concerns a device 10 for illuminating an object 12 with a controlled light intensity, the light intensity being controlled when the light intensity fulfills a plurality of conditions to be fulfilled, the plurality of conditions comprising a condition relative to the intensity at a given time and a condition relative to the dose during a period of time.
    Type: Grant
    Filed: June 16, 2017
    Date of Patent: August 2, 2022
    Assignees: GENSIGHT BIOLOGICS, SORBONNE UNIVERSITÉ, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)
    Inventors: Joël Chavas, Guillaume Chenegros, Benjamin R. Benosman
  • Method for controlling an electrical transmission link including a direct current high voltage line
    Patent number: 11404878
    Abstract: The invention relates to a method for controlling an electrical transmission link (3) between first and second AC voltage buses (11, 21) comprising a high-voltage DC line (320), first and second AC/DC converters (321, 322) connected to the high-voltage DC line (320), comprising: retrieving a setpoint active power value (Pdc0) applied to a converter (321, 322); retrieving the instantaneous values V1 and V2 of the voltages on the first and second buses; wherein the setpoint active power of the first or of the second converter is modified by a value including a term ?Pdc, so as to impose new dynamics on the first and second areas, where: ?Pdc=?Pdcs+?Pdca.
    Type: Grant
    Filed: March 6, 2019
    Date of Patent: August 2, 2022
    Assignees: SUPERGRID INSTITUTE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Juan Carlos Gonzalez, Valentin Costan, Gilney Damm, Abdelkrim Benchaib, Françoise Lamnabhi-Lagarrigue, Bruno Luscan
  • Method and system for measuring the chirality of molecules
    Patent number: 11404257
    Abstract: A method for measuring the chirality of molecules in a sample of chiral molecules, the sample including at least one chemical species, the method including the steps of: introducing the sample of chiral molecules into an ionisation area; ionising the molecules by electromagnetic radiation in the ionisation area; and detecting a distribution of electrons produced by ionisation and emitted at the front and back of the ionisation area relative to the axis, z, of propagation of the electromagnetic radiation; wherein the electromagnetic radiation is elliptically polarised, the ellipticity varying continuously and periodically as a function of time, the method further including a step of: determining the chirality of the molecules from the electron distribution detected continuously as a function of time. A system is also provided for measuring the chirality of molecules using such a method.
    Type: Grant
    Filed: June 25, 2019
    Date of Patent: August 2, 2022
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE DE BORDEAUX
    Inventors: Yann Mairesse, Antoine Comby
  • Ultrasonic method and device for characterising weak anisotropic media, and ultrasonic probe assembly for such a characterisation device
    Patent number: 11399804
    Abstract: A method for characterizing an anisotropic soft medium (C) including fibers and having an outer surface (1), by observing in different propagation directions, the propagation of a divergent shear wave from a central area (10) in the anisotropic soft medium. A propagation parameter of the shear wave is inferred therefrom in each of the propagation directions, and then a direction of the fibers of the anisotropic soft medium, a rheological elasticity parameter are determined in a direction perpendicular to the fibers and a rheological elasticity parameter in the direction of the fibers.
    Type: Grant
    Filed: January 12, 2015
    Date of Patent: August 2, 2022
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.), INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), ECOLE SUPRERIEURE DE PHYSIQUE ET DE CHIMIE INDUSTRIELLES DE LA VILLE DE PARIS, UNIVERSITÉ PARIS DIDEROT—PARIS 7
    Inventors: Mickaël Tanter, Mathieu Pernot, Mathias Fink, Jean-Luc Gennisson
  • METHODS OF PRODUCING SHIGA TOXIN B-SUBUNIT (STxB) MONOMERS AND OLIGOMERS, AND USES THEREOF
    Publication number: 20220233673
    Abstract: A method of producing a monomer of a Shiga toxin B-subunit (STxB) protein or of a variant thereof by peptide chemical synthesis, as well as to a method of producing a pentamer of the STxB protein or of the variant thereof. The methods are particularly advantageous as they overcome major issues typically observed in peptide chemical synthesis, including solubility and purity issues.
    Type: Application
    Filed: June 4, 2020
    Publication date: July 28, 2022
    Applicants: INSTITUT CURIE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE), COMMISSARIAT Á L'ÉNERGIE ATOMIQUE ET AUX ÉNERGIES ALTERNATIVES (CEA), APHP (ASSISTANCE PUBLIQUE - HÔPITAUX DE PARIS), UNIVERSITY OF UTAH RESEARCH FOUNDATION
    Inventors: Anne BILLET, Frédéric SCHMIDT, Ludger JOHANNES, Denis SERVENT, Gilles MOURIER, Éric TARTOUR, Michael KAY, James M. FULCHER
  • Targeted modified TNF family members
    Patent number: 11396532
    Abstract: The present invention relates to a modified cytokine of the TNF superfamily, with reduced activity to its receptor, wherein said modified cytokine is specifically delivered to target cells. Preferably, said modified cytokine is a single chain variant of the TNF superfamily, even more preferably, one or more of the chains can-y one or more mutations, resulting in a low affinity to the receptor, wherein said mutant cytokine is specifically delivered to target cells. The targeting is realized by fusion of the modified cytokine of the TNF superfamily to a targeting moiety, preferably an antibody or antibody-like molecule. The invention relates further to the use of such targeted modified cytokine of the TNF superfamily to treat diseases.
    Type: Grant
    Filed: May 4, 2020
    Date of Patent: July 26, 2022
    Assignees: VIB VZW, UNIVERSITEIT GENT, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITÉ DE MONTPELLIER, CENTRE HOSPITALIER REGIONAL UNIVERSITAIRE DE MONTPELLIER
    Inventors: Jan Tavernier, Jennyfer Bultinck, Frank Peelman, Gilles Uze
  • Phosphocalcic cement composition comprising blood
    Patent number: 11395862
    Abstract: A bone cement paste containing a powder component comprising ?-tricalcium phosphate (?-TCP) particles having an average size greater than or equal to 9 ?m, and a liquid component comprising blood is disclosed. A method for preparation of the phosphocalcic cement composition is also disclosed.
    Type: Grant
    Filed: April 6, 2017
    Date of Patent: July 26, 2022
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE DE NANTES, ONIRIS, GRAFTYS
    Inventors: Jean-Michel Bouler, Olivier Gauthier, Bruno Bujoli, Pascal Janvier, Charlotte Mellier
  • Nickel-based superalloy, single-crystal blade and turbomachine
    Patent number: 11396686
    Abstract: The invention relates to a nickel-based superalloy comprising, in percentages by mass, 5.0 to 6.0% aluminum, 6.0 to 9.5% tantalum, 0 to 1.50% titanium, 8.0 to 10.0% cobalt, 6.0 to 7.0% chromium, 0.30 to 0.90% molybdenum, 5.5 to 6.5% tungsten, 0 to 2.50% rhenium, 0.05 to 0.15% hafnium, 0.70 to 4.30% platinum, 0 to 0.15% silicon, the remainder being nickel and unavoidable impurities. The invention also relates to a single-crystal blade comprising such an alloy and a turbomachine comprising such a blade.
    Type: Grant
    Filed: June 4, 2019
    Date of Patent: July 26, 2022
    Assignees: SAFRAN, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE DE POITIERS, ECOLE NATIONALE SUPERIEURE DE MECANIQUE AEROTECHNIQUE
    Inventors: Jérémy Rame, Jonathan Cormier
  • NOVEL COMPOUNDS, FUNCTIONALISED DIOXABOROLANE OR DIOXABORINANE DERIVATIVES, METHOD FOR PREPARING SAME AND USES THEREOF
    Publication number: 20220227790
    Abstract: The invention relates to functionalised dioxaborolane or dioxaborinane derivatives of formula (I), wherein R1 is covalently bonded to the boron atom by a carbon atom; one of R2, R3, R?3 or R4 is a radical of formula —X; or one of R1, R2, R3, R?3 or R4 is a radical of formula —X; and X is a functionalised radical. The invention relates to the method for preparing same and the uses thereof.
    Type: Application
    Filed: January 6, 2022
    Publication date: July 21, 2022
    Applicants: ECOLE SUPERIEURE DE PHYSIQUE ET DE CHIMIE INDUSTRIELLES DE LA VILLE DE PARIS, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
    Inventors: Ludwik LEIBLER, Renaud NICOLAY
  • Method for producing a microfluidic device
    Patent number: 11389793
    Abstract: The present invention relates to a method for producing a microfluidic device, in particular, a sol-gel method for producing a microfluidic device in hybrid silica glass. The invention also relates to a microfluidic device obtainable by the method as described above and to microfluidic device in hybrid silica glass comprising at least one microchannel having a depth of at least 1 ?m, preferably between 1 ?m and 1 mm, and more preferably between 10 and 100 ?m.
    Type: Grant
    Filed: September 8, 2017
    Date of Patent: July 19, 2022
    Assignees: TOTAL SA, ECOLE NORMALE SUPERIEURE DE LYON, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE-CNRS-, UNIVERSITE CLAUDE BERNARD LYON 1
    Inventors: Michael Levant, Denis Bartolo, Stéphane Parola, Denis Chateau
  • Multivalent fucose derivatives for use as a drug
    Patent number: 11389466
    Abstract: Disclosed is a compound bearing at least two fucose moieties for its use as a drug in the prevention or treatment of infections caused by Aspergillus spp, the compound having a molecular weight included from 0.6 to 340 kDa, in particular from 0.6 to 2 kDa or from 1 to 7 kDa or from 2 to 10 kDa or from 5 to 340 kDa.
    Type: Grant
    Filed: February 15, 2018
    Date of Patent: July 19, 2022
    Assignees: UNIVERSITE DE NANTES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Sébastien Gouin, Sami Brument, Annabelle Varrot, Patrice Lepape
  • Methods and pharmaceutical compositions for the treatment of mast cell diseases
    Patent number: 11389434
    Abstract: The inventors demonstrate for the first time the activation of the Hedgehog (HH) signaling pathway in normal and abnormal human mast cells (MCs). These results prompt the inventors to explore the consequence of the inhibition of the HH pathway, especially the canonical pathway, on MC proliferation. They demonstrate that Hedgehog inhibitors inhibit proliferation and induces apoptosis of mast cells. Accordingly the present invention relates to a method of treating a mast cell disease in a patient in need there of comprising administering to the patient a therapeutically effective amount of a Hedgehog inhibitor.
    Type: Grant
    Filed: May 17, 2018
    Date of Patent: July 19, 2022
    Assignees: INSERM, FONDATION IMAGINE, UNIVERSITE PARIS DESCARTES, ASSISTANCE PUBLIQUE-HOPITAUX DE PARIS (APHP), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
    Inventors: Leila Maouche-Chretien, Christine Bodemer, Olivier Hermine, Laura Polivka
  • Method and device for depositing a coating on a continuous fibre
    Patent number: 11390952
    Abstract: A process for depositing a coating on a continuous carbon or silicon carbide fibre from a coating precursor, includes at least heating a segment of the fibre in the presence of the coating precursor in a microwave field so as to bring the surface of the segment to a temperature enabling the coating to be formed on the segment from the coating precursor.
    Type: Grant
    Filed: December 20, 2018
    Date of Patent: July 19, 2022
    Assignees: SAFRAN CERAMICS, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE DE BORDEAUX
    Inventors: Arnaud Delehouze, Eric Bouillon, Adrien Delcamp, Cédric Descamps
  • Collapsible vertical-axis wind turbine
    Patent number: 11391265
    Abstract: A collapsible wind turbine includes a turbine with a vertical axis (A). The turbine is supported by a vertical pylon, pivotably mounted about a hinge, and by linking members connecting the rotation shaft of the turbine to the pylon while maintaining a separation therebetween. The wind turbine includes: —an electricity generator of which the axis of rotation is perpendicular to the longitudinal axis of the pylon, the generator being secured to the ground; and—at least one flexible link connecting and synchronising the rotation of the generator with the rotation shaft of the turbine by linear travel of the flexible link in a closed-circuit path, so as to drive the rotation shaft of the generator by the movement of the turbine. The present structure is, in particular related to land-based wind turbines in a cyclone-prone area.
    Type: Grant
    Filed: May 14, 2019
    Date of Patent: July 19, 2022
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, INSTITUT POLYTECHNIQUE DE GRENOBLE
    Inventors: Stéphane Barre, Jean-luc Achard, Guillaume Balarac, Guillaume Maurice
  • Promoters and uses thereof
    Patent number: 11390866
    Abstract: The present invention relates to a nucleic acid sequence derived from the regulatory region of the human gamma-synuclein gene and having a promoter activity in retinal ganglion cells. The present invention also relates to expression cassettes or vectors comprising said promoter operably linked to a nucleic acid sequence encoding a polypeptide of interest as well as viral particles or host cells comprising said expression cassette or vector. The present invention also relates to the use of said expression cassettes, vectors, viral particles or cells in the treatment of ocular disease, in particular ocular disease associated with retinal ganglion cell or photoreceptor cell degeneration.
    Type: Grant
    Filed: December 5, 2016
    Date of Patent: July 19, 2022
    Assignees: SORBONNE UNIVERSITÉ, INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH
    Inventors: Deniz Dalkara, Serge Picaud, Melissa Desrosiers, Jose-Alain Sahel, Jens Duebel, Alexis Bemelmans, Botond Roska