Patents Assigned to SCIENTIFIQUE (CNRS)
  • Modified oligonucleotides comprising thiol functions and use thereof for detecting nucleic acids
    Patent number: 11390643
    Abstract: The present invention relates to a modified oligonucleotide having two or more thiol functions, which can be immobilized on a gold surface or on a grafted surface, in particular a surface comprising at least one carbon-carbon double bond or carbon-carbon triple bond or haloacetamide functions, preferably maleimide or acrylamide functions. The invention also relates to a method for detecting a nucleic acid in a biological sample comprising a step of detecting hybridization between a modified oligonucleotide and a target nucleic acid amplified from the biological sample. The invention relates more particularly to a method for detecting, genotyping or sequencing a pathogenic organism, preferably a virus.
    Type: Grant
    Filed: February 8, 2019
    Date of Patent: July 19, 2022
    Assignees: ETABLISSEMENT FRANÇAIS DU SANG, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITE DE MONTPELLIER, UNIVERSITE CLAUDE BERNARD LYON 1
    Inventors: Chantal Fournier-Wirth, Myriam Lereau, Jean-François Cantaloube, Jean-Jacques Vasseur, François Morvan, Albert Meyer, Julie Mayen, Carole Chaix, Carole Farre
  • Compositions useful for mucosal healing
    Patent number: 11389470
    Abstract: The present invention relates to a composition comprising at least one poloxamer compound for use in the treatment of a fistula in an individual.
    Type: Grant
    Filed: July 11, 2017
    Date of Patent: July 19, 2022
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITÉ PARIS CITÉ, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE, ASSISTANCE PUBLIQUE-HOPITAUX DE PARIS
    Inventors: Olivier Clement, Christophe Cellier, Claire Wilhelm, Florence Gazeau, Amanda Brun, Gabriel Rahmi
  • Method for forming spacers of a transistor
    Patent number: 11393689
    Abstract: A method for forming spacers on a gate pattern includes deposition of a first dielectric layer having basal portions on an active layer and side portions of the edges of the pattern; anisotropic modification of only the basal portions of the first layer, so as to obtain modified basal portions; deposition of a second dielectric layer on the first layer, also having basal and side portions; anisotropic etching of only the basal portions of the second layer, so as to remove these basal portions while conserving the side portions; and removal of the modified basal portions while conserving the first and second non-modified side portions, by selective etching of the modified dielectric material vis-à-vis the non-modified dielectric material.
    Type: Grant
    Filed: July 10, 2020
    Date of Patent: July 19, 2022
    Assignees: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITE GRENOBLE ALPES
    Inventors: Nicolas Posseme, Marceline Bonvalot, Ahmad Chaker, Christophe Vallee
  • Benzoimidazole derivatives as anticancer agents
    Patent number: 11384081
    Abstract: The disclosure relates to benzoimidazole derivatives, acting as anticancer drugs, as well as pharmaceutical composition containing said compounds. These compounds are able to firstly inhibit the protein/protein interactions of the MAP Kinase Erk, leading to inhibition of proliferation and secondly to induce apoptosis in human cancer cell lines.
    Type: Grant
    Filed: September 20, 2017
    Date of Patent: July 12, 2022
    Assignees: CENTRE LEON BERARD, HOSPICES CIVILS DE LYON, UNIVERSITE CLAUDE BERNARD LYON 1, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)
    Inventors: Toufic Renno, Isabelle Coste-Invernizzi, Stéphane Giraud, Serge Lebecque
  • Methods for adhering tissue surfaces and materials and biomedical uses thereof
    Patent number: 11383004
    Abstract: The present invention relates to methods for adhering tissue surfaces and materials and biomedical uses thereof. In particular the present invention relates to a method for adhering a first tissue surface to a second tissue surface in a subject in need thereof, comprising the steps of adsorbing a layer of nanoparticles on at least one of the tissue surfaces, and approximating the surfaces for a time sufficient for allowing the surfaces to adhere to each other. The present invention also relates to a method for adhering a material to a biological tissue in a subject in need thereof, comprising the steps of adsorbing a layer of nanoparticles on the surface of the material and/or the biological tissue and approximating the material and the biological tissue for a time sufficient for allowing the material and the biological tissue to adhere to each other.
    Type: Grant
    Filed: April 1, 2019
    Date of Patent: July 12, 2022
    Assignees: INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE), UNIVERSITÉ PARIS CITÉ, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITÉ PARIS XIII PARIS-NORD, ÉCOLE SUPÉRIEUR DE PHYSIQUE ET DE CHIMIE INDUSTRIELLES DE PARIS, SORBONNE UNIVERSITE
    Inventors: Ludwik Leibler, Anne Meddahi-Pellé, Didier Letourneur, Alba Marcellan-Parisot
  • DNA polymerase theta mutants, methods of producing these mutants, and their uses
    Patent number: 11384345
    Abstract: The invention relates to mutant DNA polymerases of the Pol theta subfamily capable of performing non-templated nucleic acid extension, or of a functional fragment of such a polymerase, methods of producing these mutant DNA polymerases, kits and methods of using these mutant DNA polymerases.
    Type: Grant
    Filed: September 20, 2018
    Date of Patent: July 12, 2022
    Assignees: INSTITUT PASTEUR, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Marc Delarue, Volahasina (Irina) Randrianjatovo Gbalou
  • Methods for predicting the survival time of patients suffering from a lung cancer
    Patent number: 11385231
    Abstract: The present invention relates to methods for predicting the survival time of patients suffering from a lung cancer.
    Type: Grant
    Filed: August 26, 2016
    Date of Patent: July 12, 2022
    Assignees: INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE SCIENTIFIQUE), UNIVERSITE DE PARIS, SORBONNE UNIVERSITE, ASSISTANCE PUBLIQUE-HOPITAUX DE PARIS (APHP)
    Inventors: Marie-Caroline Dieu-Nosjean, Wolf Herdman Fridman, Catherine Sautes-Fridman, Priyanka Devi
  • Thermal amplification of free radical polymerization induced by red to near-infrared irradiation
    Patent number: 11384167
    Abstract: The present invention relates to compositions thermally curable on demand by red to near infrared irradiation, method of using same for thermal amplification of free radical polymerizations, and articles obtained by such method. The invention also relates to the use of a heat-generating dye in association with a thermal initiator for controlling the onset of thermal free radical polymerization.
    Type: Grant
    Filed: December 20, 2018
    Date of Patent: July 12, 2022
    Assignees: UNIVERSITE DE HAUTE-ALSACE, UNIVERSITE D'AIX-MARSEILLE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Aude-Heloise Bonardi, Jacques Lalevee, Fabrice Morlet-Savary, Celine Dietlin, Didier Gigmes, Frederic Dumur
  • Medical device for olfactory stimulation
    Patent number: 11383053
    Abstract: The invention relates to a device for olfactory stimulation of a patient with a plurality of scents, said device comprising: —a source (2) of a carrier gas (G); —a plurality of scent odorization circuits, each odorization circuit (4) comprising: —a container (18) containing an odorous volatile substance (V), —a container inlet line (26), provided with a container inlet valve (28), connecting an inlet (30) of said container with said source of carrier gas, and —a container outlet line (36), provided with a container outlet valve (38), connecting an outlet (40) of said container with an exit line (12); —a control unit (8), configured to control said container inlet valve and container outlet valve according to a medical protocol.
    Type: Grant
    Filed: February 2, 2017
    Date of Patent: July 12, 2022
    Assignees: INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE CLAUDE BERNARD LYON 1, UNIVERSITE JEAN MONNET SAINT ETIENNE
    Inventors: Marc Thevenet, Patricia Viret
  • Difunctional biphenyl compounds, preparation, and uses
    Patent number: 11384195
    Abstract: A difunctional biphenyl compounds corresponding to formula (I) wherein Alk, Alk? and R are as defined in the description. These compounds are suitable as hardeners for thermosetting resins, especially epoxy resins.
    Type: Grant
    Filed: February 7, 2019
    Date of Patent: July 12, 2022
    Assignees: ARIANEGROUP SAS, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Etienne Savonnet, Brigitte Defoort, Henri Cramail, Stéphane Grelier, Etienne Grau
  • METHOD OF FORMING A COMPLEX IMAGE OF A SAMPLE
    Publication number: 20220214648
    Abstract: Method for obtaining an image of a sample (10), comprising: a) illuminating the sample using a light source (11); b) acquiring, using an image sensor (16), a first image (I1,P0) of the sample (10), said image being formed in the detection plane (P0), the first image being representative of an exposure light wave (14) propagating, from the sample, to the image sensor, along a first optical path (L1); the method comprising, following b) c) modifying an optical refractive index, between the image sensor and the sample; d) following c), acquiring a second image (I2,P0) of the sample, said image being representative of the exposure light wave (14) along a second optical path (L2); e) implementing an iterative algorithm that combines the first and second images so as to obtain an image of the sample.
    Type: Application
    Filed: December 28, 2021
    Publication date: July 7, 2022
    Applicants: Commissariat à l'Energie Atomique et aux Energies Alternatives, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITÉ GRENOBLE ALPES
    Inventors: Marc ZELSMANN, Pierre MARCOUX, Emmanuel PICARD
  • PROCESS OF PREPARATION OF AN AQUEOUS GEL INK WITH VARIABLE COLOR COMPRISING SILVER NANOPARTICLES
    Publication number: 20220213338
    Abstract: The present invention concerns a process for preparing in situ an aqueous gel ink with variable color comprising the following steps: (i) preparing a gel-based matrix of aqueous ink comprising 0.005 to 0.1 mol·L?1 of ester(s) of retinol represented by formula (I), and (ii) adding a solution of 0.002 to 0.05 mol·L?1 silver salts (Ag+) to the gel-based matrix of aqueous ink prepared in step (i), to obtain an aqueous gel ink with variable color with silver nanoparticles dispersed therein. The present invention also relates to an aqueous gel ink with variable color obtained according to the process of the invention, comprising said ester of retinol represented by formula (I) and silver nanoparticles.
    Type: Application
    Filed: August 28, 2020
    Publication date: July 7, 2022
    Applicants: SOCIETE BIC, UNIVERSITE DE HAUTE ALSACE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Olivier ALBENGE, Romain METILLON, Karine MOUGIN, Feriel GHELLAL, Arnaud SPANGENBERG
  • Hand intended to equip a humanoid robot
    Patent number: 11376746
    Abstract: A hand intended to equip a humanoid robot, the hand includes a palm and at least one finger extending along a first axis, the hand being capable of picking up an object, the finger comprising a first phalanx linked to the palm by a first motorized pivot link and a second phalanx consecutive to the first phalanx linked to the first phalanx by a second pivot link. The finger comprises a first mechanism linking the palm to the second phalanx configured such that the rotation of the first phalanx about the second axis causes the second phalanx to rotate about the third axis, and a second mechanism linking the palm to each of the phalanges configured to actuate the finger in such a way that the finger wraps around the object to be picked up, and the second mechanism is configured to deform the first mechanism.
    Type: Grant
    Filed: July 4, 2017
    Date of Patent: July 5, 2022
    Assignees: SOFTBANK ROBOTICS EUROPE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Giulio Cerruti, Damien Chablat, Vincent Clerc, David Gouaillier
  • Microwave waveguide comprising a cavity formed by layers having conductive surfaces and a dielectric strip disposed in the cavity
    Patent number: 11380972
    Abstract: This microwave component (10) comprises a waveguide (12) comprising an upper layer, a lower layer, and a central layer (18) intermediate between the upper layer and the lower layer, said layers defining a zone (19) of propagation of an electromagnetic wave, the propagation zone (19) extending along a propagation axis, and comprising a cavity (32) bounded by the upper layer, the lower layer, and, laterally, by two opposite lateral edges (36) of the central layer (18). The waveguide (12) comprises at least one dielectric strip (28) placed in the propagation zone (19), the dielectric strip (28) being defined in one of the upper layer and the lower layer or being placed in the cavity (32) away from the lateral edges (36) of the cavity (32).
    Type: Grant
    Filed: December 5, 2018
    Date of Patent: July 5, 2022
    Assignees: UNIVERSITÉ DE BORDEAUX, INSTITUT POLYTECHNIQUE DE BORDEAUX, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, CENTRE NATIONAL D'ETUDES SPATIALES
    Inventors: Anthony Ghiotto, Frédéric Parment
  • Method of preparation of nanoparticles using mercury thiolate compounds
    Patent number: 11377590
    Abstract: A method of preparation of mercury chalcogenide nanoparticles that includes the steps of providing a precursor of mercury and mixing the precursor of mercury with a precursor of chalcogenide, wherein the precursor of mercury is a mercury thiolate. Also, mercury telluride nanoparticles and their use in an IR photodetector, an IR photoconversion device, an IR filter or an IR photodiode.
    Type: Grant
    Filed: September 18, 2020
    Date of Patent: July 5, 2022
    Assignees: NEXDOT, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, SORBONNE UNIVERSITE
    Inventors: Emmanuel Lhuillier, Nicolas Goubet
  • Dizocilpine derivatives as peripheral NMDA receptor antagonists
    Patent number: 11376245
    Abstract: The present invention relates to compounds of formula (I) for use as peripheral NMDA receptor antagonists.
    Type: Grant
    Filed: June 13, 2017
    Date of Patent: July 5, 2022
    Assignees: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITE PARIS SUD, ASSISTANCE PUBLIQUE—HOPITAUX DE PARIS (APHP), HOPITAL MARIE LANNELONGUE
    Inventors: Sylvia Cohen-Kaminsky, Marc Humbert, Sebastien Dumas, Gilles Bru-Mercier, Samir Messaoudi, Jean-Daniel Brion, Mouad Alami, Gilles Galvani
  • Process for the preparation of nanoparticles
    Patent number: 11377366
    Abstract: The present invention relates to a “safety-by-design” method for the preparation of nanoparticles, to a method for the preparation of a nanocomposite material, and to the use of a direct liquid injection device so as to prepare nanoparticles or nanocomposite materials in a “safety-by-design” process.
    Type: Grant
    Filed: July 26, 2017
    Date of Patent: July 5, 2022
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, INSTITUT NATIONAL POLYTECHNIQUE DE TOULOUSE
    Inventors: Myrtil Kahn, Yohan Champouret, Richard Clergereaux, Constantin Vahlas, Anne-Francoise Mingotaud, Guillaume Carnide
  • Estimating in situ stress field
    Patent number: 11378717
    Abstract: It is proposed a method which comprises providing a geomechanical model of the geological environment, measurements of a first geological attribute each performed at a respective first position of the geological environment, constraints on a second geological attribute related to a yield criterion and each assigned to a respective second position of the geological environment, and a geomechanical simulator. The method also comprises determining the stress field derivable from the data outputted by the geomechanical simulator taking as input the geomechanical model and an optimal set of one or more boundary conditions. This provides an improved solution for estimating in situ stress field of a geological environment.
    Type: Grant
    Filed: March 14, 2019
    Date of Patent: July 5, 2022
    Assignees: TOTAL SE, ASSOCIATION SCIENTIFIQUE POUR LA GEOLOGIE ET SES APPLICATIONS
    Inventors: Pierre Thore, Antoine Mazuyer
  • Method for fabricating a monocrystalline structure
    Patent number: 11380543
    Abstract: A substrate is provided with a monocrystalline silicon-germanium layer with a first surface covered by a protective oxide obtained by wet process and having a degradation temperature. The protective oxide is transformed into fluorinated salt which is then eliminated. The substrate is placed in a processing chamber at a lower temperature than the degradation temperature and is subjected to a temperature ramp up to a higher temperature than the degradation temperature. The first surface is annealed in a hydrogen atmosphere devoid of silicon, germanium and precursors of the materials forming the target layer. When the temperature ramp is applied, a silicon precursor is inserted in the processing chamber between a loading temperature and the degradation temperature to deposit a monocrystalline buffer layer. A mono-crystalline target layer is deposited by chemical vapour deposition.
    Type: Grant
    Filed: December 17, 2019
    Date of Patent: July 5, 2022
    Assignees: COMMISSARIAT À L'ÉNERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES, UNIVERSITÉ GRENOBLE ALPES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Pierre-Edouard Raynal, Pascal Besson, Jean-Michel Hartmann, Virginie Loup, Laurent Vallier
  • 6-Substituted 3-Fluoro-2-Pyridinaldoxime, 3-Fluoro-2-pyridine hydroxamic acid, and 3-Fluoro-2-Pyridinamidoxime scaffolds
    Patent number: 11370772
    Abstract: Disclosed is a compound of formula (II), as well as to a process for preparing the compounds of formula (II) by a chemoselective Sonogashira reaction. It also relates to a pharmaceutical composition including at least one compound of formula (II) and at least one pharmaceutically acceptable support. Finally, it relates to the use of such a compound as a medicine, preferably in the treatment of a nervous and/or respiratory failure due to intoxication with at least one organophosphorous nerve agent; in the treatment of neurological diseases such as Alzheimer's disease; and/or in the treatment of cancer; and/or for use as antiviral drug.
    Type: Grant
    Filed: October 17, 2018
    Date of Patent: June 28, 2022
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITÉ DE STRASBOURG
    Inventors: Rachid Baati, Jagadeesh Yerri, José Dias