Patents Assigned to SCIENTIFIQUE (CNRS)
  • Surfactant compounds-clips for extraction and stabilization in solution of membrane proteins
    Patent number: 11440932
    Abstract: The present invention relates to a compound of formula (I): (I) as defined in the description. The present invention also relates to a method for extracting biological membrane-associated membrane proteins, comprising a step of bringing an aqueous solution of biological membrane-associated membrane proteins into contact with at least one compound of the invention. The present invention also relates to a method for stabilizing membrane proteins in solution in an aqueous solution, comprising a step (i) consisting in bringing an aqueous solution of a membrane protein in solution into contact with at least one compound of the invention.
    Type: Grant
    Filed: December 27, 2017
    Date of Patent: September 13, 2022
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE CLAUDE BERNARD LYON 1, UNIVERSITE GRENOBLE ALPES
    Inventors: Pierre Falson, Julien Dauvergne, Ahcène Boumendjel, Marine Peuchmaur, Kim Anh Nguyen, Sandrine Magnard
  • PROTEIN HYDROLYSATE DERIVED FROM BLUE-BACKED FISH
    Publication number: 20220279814
    Abstract: A protein hydrolysate obtained from at least one protein source from bluefish having (i) a degree of hydrolysis (DH) of at least 10%, (ii) at least 80% water-soluble protein with a molecular weight of less than 1000 Da, (iii) at least 0.3% phospholipids, and (iv) at least 0.5% DHA and EPA.
    Type: Application
    Filed: July 31, 2020
    Publication date: September 8, 2022
    Applicants: SPECIALITES PET FOOD, UNIVERSITE DE BORDEAUX, UNIVERSITÉ DE BRETAGNE OCCIDENTALE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), INSTITUT DE RECHERCHE POUR LE DEVELOPPEMENT (IRD), INSTITUT POLYTECHNIQUE DE BORDEAUX, ABYSS INGREDIENTS, INSTITUT FRANCAIS DE RECHERCHE POUR L'EXPLOITATION DE LA MER - IFREMER, INSTITUT NATIONAL DE LA RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT
    Inventors: Fabienne GUERARD, Cloé OROY, Anne LEPOUDERE, Mathilde CHATAIGNER, Patrick ALLAUME, Anne-Laure DINEL, Corinne JOFFRE, Véronique PALLET, Fabienne LE GRAND
  • NOVEL DIZOCILPINE DERIVATIVES AS PERIPHERAL NMDA RECEPTOR ANTAGONISTS
    Publication number: 20220280498
    Abstract: The present invention relates to compounds of formula (I): for use as peripheral NMDA receptor antagonists.
    Type: Application
    Filed: May 26, 2022
    Publication date: September 8, 2022
    Applicants: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITE PARIS SUD, ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS (APHP), HOPITAL MARIE LANNELONGUE
    Inventors: Sylvia COHEN-KAMINSKY, Marc HUMBERT, Sebastien DUMAS, Gilles BRU-MERCIER, Samir MESSAOUDI, Jean-Daniel BRION, Mouad ALAMI, Gilles GALVANI
  • ELASTOMER COMPOSITION
    Publication number: 20220280683
    Abstract: A composition based on triblock copolymers of the ABA type, including two styrene thermoplastic terminal blocks A, and an elastomer central block B which is a saturated olefin, and at least one polyisobutene having a very low molecular weight and optionally a diblock copolymer of AB. The present composition exhibits advantageous properties which are similar to those of silicone elastomers. Also, a dressing including such an elastomeric composition.
    Type: Application
    Filed: July 30, 2020
    Publication date: September 8, 2022
    Applicants: URGO RECHERCHE INNOVATION ET DEVELOPPEMENT, UNIVERSITE DE PAU ET DES PAYS DE L'ADOUR, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS -
    Inventors: Christophe DERAIL, Armelle RONCIN, Xavier CALLIES, Christelle Marie Aline GUILLAMAUD, Anne-Sophie DANEROL, Marie DAUX
  • Device and method for circulating liquids
    Patent number: 11434882
    Abstract: Disclosed is a device including at least one circulating zone and at least one fluid including at least one more-paramagnetic liquid and at least one less-paramagnetic liquid forming a liquid-liquid interphase, the device including at least one element generating, in the circulating zone, a magnetic field, wherein the less-paramagnetic liquid is surrounded by the more-paramagnetic liquid in the circulating zone or wherein the more-paramagnetic liquid is surrounded by the less-paramagnetic liquid in the circulating zone. Also disclosed is a method including circulating at least one less-paramagnetic liquid inside one or more circulating zones of a device including at least one circulating zone and at least one more-paramagnetic liquid in the circulating zone.
    Type: Grant
    Filed: January 19, 2018
    Date of Patent: September 6, 2022
    Assignees: UNIVERSITÉ DE STRASBOURG, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, THE PROVOST, FELLOWS, FOUNDATION SCHOLARS, AND THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY OF QUEEN ELIZABETH COLLEGE GREEN
    Inventors: Thomas Hermans, John Michael David Coey, Peter Dunne, Bernard Doudin
  • OB-fold used as scaffold for engineering new specific binders
    Patent number: 11434585
    Abstract: The present invention pertains to the field of protein engineering, and provides means for obtaining stable molecules that specifically bind to a target selected amongst a large variety of ligands families. In particular, the present invention provides methods for obtaining a molecule specifically binding to a target of interest, through a combinatorial mutation/selection approach with an OB-fold protein as a starting molecule. In particular, the target of interest can be of a different chemical nature form that of the native target of the OB-fold protein used as the starting molecule.
    Type: Grant
    Filed: January 24, 2020
    Date of Patent: September 6, 2022
    Assignees: INSTITUT PASTEUR, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Frédéric Pecorari, Pedro Alzari
  • Enantiopure terphenyls with two ortho-atropisomeric axes
    Patent number: 11434253
    Abstract: Enantiopure terphenyl presenting two ortho-located chiral axes having the following structural formula (I): their process of synthesis and their use as mono or bidentate ligands for asymmetric organometallic reactions, as organocatalysts, as chiral base and as generator, with metal, of isolable chiral metallic complexes for applications in asymmetric catalysis and others.
    Type: Grant
    Filed: December 12, 2018
    Date of Patent: September 6, 2022
    Assignees: UNIVERSITE DE STRASBOURG, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Quentin Dherbassy, Joanna Wencel-Delord, Françoise Colobert, Gaspard Hedouin
  • PROCESS OF PREPARATION OF AN AQUEOUS GEL INK WITH FIXED COLOR COMPRISING GOLD NANOPARTICLES
    Publication number: 20220275227
    Abstract: The present invention concerns a process for preparing in situ an aqueous gel ink with fixed color comprising the following steps: (i) preparing a gel-based matrix of aqueous ink comprising ester(s) of retinol represented by formula (I), and (ii) adding a solution of gold salts (Au3+) to the gel-based matrix of aqueous ink prepared in step (i), to obtain an aqueous gel ink with fixed color with gold nanoparticles dispersed therein. The present invention also relates to an aqueous gel ink with fixed color obtained according to the process of the invention, comprising said ester of retinol represented by formula (I) and gold nanoparticles. The invention finally concerns a writing instrument comprising an aqueous gel ink with fixed color according to the invention.
    Type: Application
    Filed: August 28, 2020
    Publication date: September 1, 2022
    Applicants: SOCIETE BIC, UNIVERSITE DE HAUTE ALSACE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Olivier ALBENGE, Romain METILLON, Karine MOUGIN, Feriel GHELLAL, Arnaud SPANGENBERG
  • PROCESS OF PREPARATION OF AN AQUEOUS GEL INK WITH FIXED COLOR COMPRISING GOLD NANOPARTICLES
    Publication number: 20220275226
    Abstract: The present invention concerns a process for preparing in situ an aqueous gel ink with fixed color comprising the following steps: (i) preparing a gel-based matrix of aqueous ink comprising reducing agent chosen in the group consisting of citric acid and/or derivatives of citric acid, (ii) adding a solution of gold salts, (iii) adding iron powder, (iv) adding polyvinylpyrrolidone to obtain an aqueous gel ink with fixed color, wherein the steps (ii) and (iii) can be interchanged. The present invention also relates to an aqueous gel ink with fixed color obtained according to the process of the invention, comprising citric acid and derivatives, gold nanoparticles, and iron powder. The invention finally concerns a writing instrument comprising an aqueous gel ink with fixed color according to the invention.
    Type: Application
    Filed: August 28, 2020
    Publication date: September 1, 2022
    Applicants: SOCIETE BIC, UNIVERSITE DE HAUTE ALSACE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Olivier ALBENGE, Romain METILLON, Karine MOUGIN, Feriel GHELLAL, Arnaud SPANGENBERG
  • CONTINUOUS METHOD FOR NANO-EMULSIFICATION BY CONCENTRATION PHASE INVERSION
    Publication number: 20220273582
    Abstract: A continuous process for nano-emulsification that is performed by concentration phase inversion in a microfluidic reactor, including the following steps: (a) injection of an aqueous phase into a first microchannel, the first microchannel opening onto a formulation chamber, (b) injection, into a second microchannel, of a fatty phase including one or more fatty substances immiscible in the aqueous phase, and one or more surfactants, the second microchannel opening into the formulation chamber, then (c) mixing of the aqueous phase and the fatty phase in the formulation chamber, then (d) recovering, at the output of the formulation chamber, a suspension including lipid nanocapsules. Also, the lipid nanocapsules obtainable by the process, and the use of the lipid nanocapsules as nanovectors for pharmacologically active ingredients.
    Type: Application
    Filed: July 24, 2020
    Publication date: September 1, 2022
    Applicants: UNIVERSITÉ D'ANGERS, INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Brice CALVIGNAC, Jean-Christophe GIMEL, Emilie ROGER, Nicolas ROLLEY, Guillaume LEFEBVRE, Guillaume BASTIAT, Florian FOUCHET, Kévin MATHA
  • PROCESS FOR PREPARING AN AQUEOUS GEL INK WITH FIXED COLOR COMPRISING SILVER OR GOLD NANOPARTICLES
    Publication number: 20220275229
    Abstract: The invention relates a process for preparing an aqueous gel ink with fixed color comprising the following steps: (i) preparing a gel-based matrix of aqueous ink; (ii) preparing an aqueous suspension of gold or silver nanoparticles with a fixed color; (iii) adding the aqueous suspension of gold or silver nanoparticles obtained in step (ii) to the gel-based matrix of aqueous ink obtained in step (i).
    Type: Application
    Filed: August 28, 2020
    Publication date: September 1, 2022
    Applicants: SOCIETE BIC, UNIVERSITE DE HAUTE ALSACE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Olivier ALBENGE, Romain METILLON, Karine MOUGIN, Feriel GHELLAL, Arnaud SPANGENBERG
  • BONE CEMENT WITH HYALURONIC ACID
    Publication number: 20220273841
    Abstract: A bone cement composition including a powder component, a liquid component, and hyaluronic acid (HA) or a salt thereof in an amount ranging from 0.01% to 10% w/w in the powder component and/or in the liquid component. The powder component includes calcium phosphate compounds having at least alpha-tricalcium phosphate (?-TCP) and having at least calcium-deficient apatite (CDA). Also, a bone cement obtainable by a process including the following steps: (i) the preparation of a cement composition by mixing the powder component, and the liquid component and (ii) the setting of the cement composition. Further, the use in vitro or ex vivo of a bone cement composition or bone cement in the manufacture of a dental or bony implant.
    Type: Application
    Filed: July 17, 2020
    Publication date: September 1, 2022
    Applicants: GRAFTYS, UNIVERSITE DE NANTES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Enrico Javier BASTIANELLI, Jean-Michel BOULER, Bruno BUJOLI
  • PROCESS OF PREPARATION OF AN AQUEOUS GEL INK WITH VARIABLE COLOR COMPRISING SILVER NANOPARTICLES
    Publication number: 20220275228
    Abstract: The present invention concerns a process for preparing in situ an aqueous gel ink with variable color comprising the following steps: (i) preparing a gel-based matrix of aqueous ink comprising an N-Acyl-aminophenol, wherein said hydroxyl group is preferably in meta or in para position on the benzenic group, and (ii) adding a solution of silver salts to the gel-based matrix of aqueous ink prepared in step (i), to obtain an aqueous gel ink with variable color with silver nanoparticles dispersed therein. The present invention also relates to an aqueous gel ink with variable color obtained according to the process of the invention, comprising an N-Acyl-aminophenol, wherein said hydroxyl group is preferably in meta or in para position on the benzenic group and silver nanoparticles. The invention finally concerns a writing instrument comprising an aqueous gel ink with variable color according to the invention.
    Type: Application
    Filed: August 28, 2020
    Publication date: September 1, 2022
    Applicants: SOCIETE BIC, UNIVERSITE DE HAUTE ALSACE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Olivier ALBENGE, Romain METILLON, Karine MOUGIN, Feriel GHELLAL, Arnaud SPANGENBERG
  • PROCESS OF PREPARATION OF AN AQUEOUS GEL INK WITH FIXED COLOR COMPRISING SILVER NANOPARTICLES
    Publication number: 20220275225
    Abstract: The present invention concerns a process for preparing an aqueous gel ink with fixed color comprising the following steps: (i) preparing a gel-based matrix of aqueous ink; (ii) preparing an aqueous suspension of silver nanoparticles with a fixed color by mixing silver salts with: —water, —a mixture of at least an alkali metal or alkaline earth metal salt of citrate, —an oxidizing agent, preferably hydrogen peroxide H2O2, —and polyvinylpyrrolidone; (iii) adding under agitation the aqueous suspension of silver nanoparticles obtained in step (ii) to the gel-based matrix of aqueous ink obtained in step (i), to obtain an aqueous gel ink with fixed color with silver nanoparticles dispersed therein.
    Type: Application
    Filed: August 28, 2020
    Publication date: September 1, 2022
    Applicants: SOCIETE BIC, UNIVERSITE DE HAUTE ALSACE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Olivier ALBENGE, Romain METILLON, Karine MOUGIN, Feriel GHELLAL, Arnaud SPANGENBERG
  • PROCESS OF PREPARATION OF AN AQUEOUS GEL INK WITH FIXED COLOR COMPRISING SILVER NANOPARTICLES
    Publication number: 20220275230
    Abstract: The present invention concerns a process for preparing an aqueous gel ink with fixed color comprising the following steps: (i) preparing a gel-based matrix of aqueous ink; (ii) preparing an aqueous suspension of silver nanoparticles with fixed color by mixing silver salts with: water, a mixture of at least an alkali metal or alkaline earth metal salt of citrate, preferably an alkali citrate salt and an alkali metal hydride, preferably NaBH4, a further reducing agent, preferably ascorbic acid, and oxidizing agent, preferably hydrogen peroxide H2O2 (iii) adding under agitation the aqueous suspension of silver nanoparticles obtained in step (ii) to the gel-based matrix of aqueous ink obtained in step (i), to obtain an aqueous gel ink with fixed color with silver nanoparticles dispersed therein
    Type: Application
    Filed: August 28, 2020
    Publication date: September 1, 2022
    Applicants: SOCIETE BIC, UNIVERSITE DE HAUTE ALSACE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Olivier ALBENGE, Romain METILLON, Karine MOUGIN, Feriel GHELLAL, Arnaud SPANGENBERG
  • COMPLEMENT ACTIVE FRAGMENT-LOADED THREE-DIMENSIONAL BIOMATERIAL FOR DENTAL AND/OR OTHER TISSUE REGENERATION
    Publication number: 20220273850
    Abstract: A three-dimensional biomaterial including particles encapsulating at least one complement active fragment dispersed therein. Also, a process of manufacturing of the three-dimensional biomaterial with at least one biocompatible and/or resorbable polymer and the particles. The three-dimensional biomaterial is useful for tissue regeneration, especially with regards to dental pulp, dentin, periodontal and gingival tissues, as well as bones tissues.
    Type: Application
    Filed: July 31, 2020
    Publication date: September 1, 2022
    Applicants: SEPTODONT OU SEPTODONT SAS OU SPECIALITES SEPTODONT, UNIVERSITÉ D'AIX MARSEILLE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Imad ABOUT, Gilles RICHARD, Madison BERGMANN, Charlotte JEANNEAU, Mounir DJOUDI
  • ENZYMATIC BIOCATHODE, METHOD FOR PRODUCING IT AND FUEL BIOCELL AND BIOSENSOR COMPRISING THIS ENZYMATIC BIOCATHODE
    Publication number: 20220275420
    Abstract: A biomass-based enzymatic biocathode based on glucose, monosaccharide, ketone or aldehyde includes a collector conductor support, conductive particles disposed on and bound to said collector conductor support, and an aldose reductase disposed on said conductive particles, being bound thereto by adsorption and accessible at the surface of the monosaccharide, ketone or aldehyde reagent that is to be reduced when the biocathode is operational.
    Type: Application
    Filed: July 27, 2020
    Publication date: September 1, 2022
    Applicants: UNIVERSITÉ GRENOBLE ALPES, INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MEDICALE - INSERM, GRENOBLE INP (INSTITUT NATIONAL POLYTECHNIQUE), CNRS - CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Abdelkader ZEBDA, Philippe CINQUIN, Donald MARTIN, Thomas SORANZO
  • Devices and methods for conveying and controlling light beams for lensless endo-microscopic imagery
    Patent number: 11428924
    Abstract: According to one aspect, the invention relates to a device for transporting and controlling light beams for endo-microscopic imaging without a lens on the distal side comprising a single-mode optical fibre bundle (40) on the distal side, wherein each single-mode optical fibre is intended to receive an elementary light source and to emit a light beam at a distal end; a single-mode optical fibre section (50) arranged at the distal end of the optical fibre bundle and intended to receive the light beams emitted by the single-mode optical fibres of the optical fibre bundle; an optical phase control device arranged on the side of the proximal end of the single-mode optical fibres.
    Type: Grant
    Filed: April 4, 2017
    Date of Patent: August 30, 2022
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE—CNRS, Ecole Centrale de Marseille (ECM), Université d'Aix-Marseille (AMU)
    Inventors: Hervé Rigneault, Esben Ravn Andresen, Siddarth Sivankutty
  • Metal organic frameworks for the capture of volatile organic compounds
    Patent number: 11426704
    Abstract: The use of porous crystalline solids constituted of a metal-organic framework (MOF) for the capture of polar volatile organic compounds (VOCs). In particular, the MOF of interest are material having an average pores sizes of 0.4 to 0.6 nm and an hydrophobic core formed by a metal oxide and/or hydroxide network connected by linkers, the linkers being selected from the group including (i) C6-C24 aromatic polycarboxylate linkers, such as benzyl or naphtyl di-, tri- or tetracarboxylate, and (ii) C6-C16 polycarboxylate aliphatic linkers; the linkers bearing or not apolar fluorinated groups, e.g. —(CF2)n—CF3 groups, n being a integer from 0 to 5, preferably 0 ou 3, and/or apolar C1-C20 preferably C1-C4 alkyl groups, e.g. —CH3 or —CH2—CH3, grafted directly to the linkers and pointing within the pores of the MOF.
    Type: Grant
    Filed: September 12, 2018
    Date of Patent: August 30, 2022
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, ECOLE NORMALE SUPERIEURE DE PARIS, ECOLE SUPERIEURE DE PHYSIQUE ET DE CHIMIE INDUSTRIELLES DE LA VILLE DE PARIS, UNIVERSITÉ DE VERSAILLES—SAINT-QUENTIN-EN-YVELINES, INSTITUTO SUPERIOR TÉCNICO
    Inventors: Christian Serre, Moisés L. Pinto
  • Compounds useful for treating cancer
    Patent number: 11427566
    Abstract: A compound of formula (I): wherein A and A? independently represent a phenylene group or a pyridylene group; R2 is a hydrogen atom or a (C1-C4)alkyl group; R3 is a 2-pyridyl group, 3-pyridyl group, a 4-pyridyl group, a 2-pyrimidinyl group, a 4-pyrimidinyl group or a 5-pyrimidinyl group; R4 is a carbonyl group or a sulfonyl group; and R5 is a —NH—(CH2)a—NR6R7 group or a 4-methylpiperazinyl group, with a being an integer from 1 to 4, R6 and R7 representing independently a (C1-C4)alkyl group, or R6 and R7 together with the nitrogen atom to which they are linked forming a heterocycle group which is chosen among a 4-methylpiperazinyl group, a morpholino group, a pyrrolidinyl group and a piperidino group; or any one of its pharmaceutically acceptable salt.
    Type: Grant
    Filed: April 15, 2020
    Date of Patent: August 30, 2022
    Assignees: ABIVAX, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, INSTITUT CURIE, UNIVERSITE DE MONTPELLIER
    Inventors: Pierre Roux, Florence Mahuteau, Romain Najman, Gilles Gadea, Jamal Tazi, Didier Scherrer, Carsten Brock, Nathalie Cahuzac