Patents Assigned to SCIENTIFIQUE (CNRS)
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Patent number: 11148957Abstract: Disclosed is a method and system for recovering at least rare earth elements from within an object A consisting of at least one first rare earth portion or a mixture of rare earth elements and a second metal portion. The method includes a solvothermal treatment step that places the object in contact with a fluid for causing at least one rare earth portion and/or mixture of rare earth elements and the metal portion to oxidize in order to separate same, the value of the reaction temperature Tr is selected according to the nature of the object, the reaction following a R-M?R(X)x+M(X)y scheme, where R is the rare earth element or a mixture of rare earth elements, M is the transition metal, and (X) is a group which depends on the fluid used.Type: GrantFiled: October 13, 2016Date of Patent: October 19, 2021Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE DE ROUEN-NORMANDIE, INSTITUT NATIONAL DES SCIENCES APPLIQUEES DE ROUEN NORMANDIEInventors: Jean-Marie Le Breton, Nicolas Maât, Virginie Nachbaur
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Publication number: 20210315507Abstract: A method for the generation of a consciousness indicator for a non-communicating subject, including generating a sensory stimulation involving at least one of the five senses, the sensory stimulation having multiple consecutive stimuli including at least a first stimulus and a second stimulus relating to the same sense and different from one another, measuring an electrocardiographic signal of the subject during the generation of the sensory stimulation, extracting at least one EKG feature from the electrocardiographic signal associated to cognitive processes and generating a consciousness indicator using the EKG features as input of a classifier.Type: ApplicationFiled: September 11, 2019Publication date: October 14, 2021Applicants: ICM (INSTITUT DU CERVEAU ET DE LA MOELLE ÉPINIÈRE), INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, APHP (ASSISTANCE PUBLIQUE - HÔPITAUX DE PARIS), SORBONNE UNIVERSITÉInventors: Federico RAIMONDO, Jacobo D SITT, Lionel NACCACHE, Diego FERNANDEZ SLEZAK
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Patent number: 11142548Abstract: Disclosed are agents activating CD47 and their use in the treatment of inflammation, in particular non-resolving low grade inflammation, characterized by chronic MP infiltration, such as age-related macular degeneration. Also disclosed are pharmaceutical compositions, medicaments and kits including the agents.Type: GrantFiled: May 10, 2017Date of Patent: October 12, 2021Assignees: SORBONNE UNIVERSITE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALEInventors: Florian Sennlaub, Michael Housset, Xavier Guillonneau, José-Alain Sahel, Philippe Karoyan
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Patent number: 11141130Abstract: In order to obtain a predetermined ultrasonic wave field in a homogeneous internal part of a medium masked by an aberrating barrier, an ultrasonic lens is interposed between the emitting ultrasonic probe and the aberrating barrier. The ultrasonic lens is calculated by using a model of the medium comprising a mapping of ultrasonic wave propagation properties obtained from actual imaging of the medium such that when the ultrasound probe sends a predetermined ultrasonic wave, said predetermined wave generates the predetermined objective ultrasonic wave field in the medium.Type: GrantFiled: June 30, 2016Date of Patent: October 12, 2021Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MEDICALE)Inventors: Mickaël Tanter, Jean-François Aubry, Thomas Deffieux, Mathieu Pernot
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Patent number: 11143729Abstract: The present invention improves the quality of the magnitude and phase images produced in medical imaging, in particular in the case of multi-antenna MRI. The invention proposes to generate (28) such an image (I) by summing the complex image data (pj,{tilde over (p)}j) obtained from different antennas by weighting these data using only the diagonal elements (Rj,j) of an antenna noise covariance matrix or its inverse or pseudo-inverse matrix (Rj,j?1). A reference antenna (Ref) may be determined (24), so as to be able to replace (26), in each of these datum, a phase component specific to the acquisition antenna by a reference phase component. The reference antenna is preferably a virtual antenna formed by linear combination of the antennas of the MRI system. If significant improvements are obtained in the phase image resulting from the summation, a very clear gain is also surprisingly obtained in the magnitude image.Type: GrantFiled: October 15, 2018Date of Patent: October 12, 2021Assignees: INSTITUT DU CERVEAU ET DE LA MOELLE EPINIERE (ICM), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), ASSISTANCE PUBLIQUE—HOPITAUX DE PARIS (AP-HP), SORBONNE UNIVERSITEInventor: Mathieu Santin
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Publication number: 20210309611Abstract: A compound of formula (I) or any of its pharmaceutically acceptable salt for use in the treatment and/or prevention of a RNA virus infection, and a RNA virus infection from group IV or V of the Baltimore classification wherein R3 represents a chlorine atom or a hydrogen atom, R represents a (C1-C4)alkyl group, a (C3-C6)cycloalkyl group, a halogen atom, a (C1-C5)alkoxy group, a —SO2—NRaRb group, a —SO3H group, a —OH group, a —O—SO2—ORc group or a —O—P(?O)—(ORc)(ORd) group, R1 represents (i) a CF3 group, (ii) a (C1-C10)alkyl group, (iii) a (C3-C6)cycloalkyl or a (C3-C6)heterocycloalkyl group or (iv) a phenyl group or a naphthyl group, and R2 represents a hydrogen atom, a (C1-C10)alkyl group, a (C3-C6)cycloalkyl or a (C3-C6)heterocycloalkyl group and further relates to new compounds, to pharmaceutical compositions containing them and to synthesis process for manufacturing them.Type: ApplicationFiled: July 9, 2019Publication date: October 7, 2021Applicants: ABIVAX, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE DE MONTPELLIER, INSTITUT CURIEInventors: Didier SCHERRER, Jamal TAZI, Florence MAHUTEAU-BETZER, Romain NAJMAN, Julien SANTO, Cécile APOLIT
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Patent number: 11139433Abstract: The invention concerns a solution of tungstate ions W6+ (VI) comprising as solvent at least one optionally partly etherified polyalcohol, a preparation method and uses thereof. The invention further concerns a layer comprising at least one tungsten oxide WOz comprising one or more polyoxotungstate complexes, methods for preparing the same and uses thereof, and in particular a photovoltaic device comprising said layer of material.Type: GrantFiled: January 12, 2017Date of Patent: October 5, 2021Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, COMMISSARIAT À L'ÉNERGIE ATOMIQUE ET AUX ÉNERGIES ALTERNATIVES, UNIVERSITE DE NANTESInventors: Luc Brohan, Mireille Richard-Plouet, Moustafa El Kass, Noëlla Lemaitre, Solenn Berson
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Patent number: 11139167Abstract: A method making it possible to obtain, on an upper surface of a crystalline substrate, a semipolar layer of nitride material comprising any one from among gallium, aluminium or indium, the method comprises the following steps: obtaining, on the upper surface of the crystalline substrate, a plurality of parallel grooves which extend in a first direction, one of the two opposite facets exhibiting a crystal orientation; etching a plurality of parallel slices which extend in a second direction that has undergone a rotation with respect to the first direction of the grooves in such a way as to obtain individual facets exhibiting a crystal orientation; epitaxial growth of the material from the individual facets.Type: GrantFiled: June 16, 2016Date of Patent: October 5, 2021Assignees: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUEInventors: Michel El Khoury Maroun, Guy Feuillet, Philippe Vennegues, Jesus Zuniga Perez
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Patent number: 11135319Abstract: The application relates to a compound with the following formula (I): its preparation method, its synthesis intermediates and its uses as an imaging agent of hypoxia.Type: GrantFiled: July 5, 2018Date of Patent: October 5, 2021Assignee: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUEInventors: Anne-Elodie Lafargue, Cecile Perrio
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Patent number: 11136499Abstract: The invention relates to an aqueous composition comprising a suspension of ZnO particles and a polymer stabiliser containing carboxylic acid functions and carboxylic acid salt functions.Type: GrantFiled: September 11, 2015Date of Patent: October 5, 2021Assignees: UNIVERSITE CLAUDE BERNARD LYON 1, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUEInventors: Stéphane Daniele, Audrey Valette, Thibaut Cornier
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Patent number: 11139099Abstract: The invention relates to a directional magnetic field generator with a magnetic circuit comprising: a first vertical-axis pole end (37) arranged above a horizontal plane; and at least two second pole ends (28A to 28D) symmetrically arranged on said horizontal plane, the generator further comprising coils arranged such that each magnetic circuit portion connecting two pole ends passes inside at least one coil, these coils being suitable for being connected to circuits for circulating currents of adjustable intensity in selected directions therein.Type: GrantFiled: January 5, 2017Date of Patent: October 5, 2021Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, COMMISSARIAT À L'ÉNERGIE ATOMIQUE ET AUX ÉNERGIES ALTERNATIVESInventors: Isabelle Joumard, Ricardo Sousa
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Patent number: 11139474Abstract: A method for preparing a material having an Sn:Sb intermetallic phase includes at least the steps of mixing chemical elements Sn and Sb, and treating the mixture with microwaves. An electrode is manufactured by using the material having an Sn:Sb intermetallic phase; forming the material in a form of powder; mixing the powder with carbon, a binder and a solvent to form an ink; coating a current collector with the ink; and drying the electrode.Type: GrantFiled: November 16, 2016Date of Patent: October 5, 2021Assignees: HUTCHINSON, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITÉ DE MONTPELLIERInventors: David Ayme-Perrot, Philippe Sonntag, Philippe Antitomaso, Laure Monconduit, Francoise Morato-Lallemand, Philippe Girard
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Publication number: 20210300871Abstract: A compound: wherein X1 represents an alkenylene group, a —NH—CO— group, a —CO—NH— group, Y1 represents an aryl group selected from pyridyl, pyrazinyl or pyrimidinyl, X2 represents —O—, —CO—NH—, —NH—CO—NH—, —OCH2—, —NH—CO—, a divalent 5-membered heteroaromatic ring comprising 1 to 4 heteroatoms or —SO2—NH—, and Y2 represents a hydrogen atom, a hydroxyl group, a morpholinyl group, a piperidinyl group, optionally substituted by a (C1-C4)alkyl group, a piperazinyl group, optionally substituted by a (C1-C4)alkyl group, or —CR1R2R3 or alternatively X2—Y2 represents —CONRcRd, wherein Rc and Rd form, together with the nitrogen atom a heterocyclic ring, optionally substituted by one or two (C1-C4)alkyl group, by a cyclopentyl group thus forming a spirocyclopentyl, or by a trifluoromethyl group, or any of its pharmaceutically acceptable salt, for use in the treatment and/or prevention of a RNA virus infection caused by a RNA virus belonging to group IV or V of the Baltimore classification.Type: ApplicationFiled: July 9, 2019Publication date: September 30, 2021Applicants: ABIVAX, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE DE MONTPELLIER, INSTITUT CURIEInventors: Didier SCHERRER, Jamal TAZI, Florence MAHUTEAU-BETZER, Romain NAJMAN, Julien SANTO, Cécile APOLIT
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Publication number: 20210296699Abstract: The present invention relates to a solid polymer electrolyte comprising: at least one comb polymer comprising a main chain formed from 1-ethenyl- and/or 1-allyl-2,3,4,5,6-pentafluorobenzene monomers, some of the monomer units of the main chain bearing polymeric side chains based on polymers that are solvents for alkali metal or alkaline-earth metal salts; said chains being grafted in the para position of the pentafluorophenyl groups; and at least one alkali metal or alkaline-earth metal salt, in particular a lithium salt. The invention also relates to a process for preparing a solid polymer electrolyte film and to the use thereof in an electrochemical system, in particular a lithium battery.Type: ApplicationFiled: February 12, 2021Publication date: September 23, 2021Applicants: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES, UNIVERSITE GRENOBLE ALPES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUEInventors: Lionel PICARD, Thomas CLEMENT, Patrice RANNOU
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Publication number: 20210292328Abstract: The disclosure relates to benzoimidazole derivatives, acting as anticancer drugs, as well as pharmaceutical composition containing said compounds. These compounds are able to firstly inhibit the protein/protein interactions of the MAP Kinase Erk, leading to inhibition of proliferation and secondly to induce apoptosis in human cancer cell lines.Type: ApplicationFiled: September 20, 2017Publication date: September 23, 2021Applicants: CENTRE LEON BERARD, HOSPICES CIVILS DE LYON, UNIVERSITE CLAUDE BERNARD LYON 1, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)Inventors: Toufic RENNO, Isabelle COSTE-INVERNIZZI, Stéphane GIRAUD, Serge LEBECQUE
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Patent number: 11123701Abstract: A process including introducing, into a device, an aqueous fluid containing at least one inorganic salt, the water of the aqueous fluid being in supercritical conditions or close to the supercritical range in the device, and measuring the concentration or the amount of inorganic salt in the device, this measurement preferably being carried out before the entry of the inorganic salt into the device, Then bringing the inorganic salt into contact with an aqueous flow containing at least one hydroxide salt to obtain in the device an aqueous fluid mixture containing an inorganic salt and a hydroxide salt and adjusting the concentration or amount of the hydroxide salt as a function of the concentration or amount of the inorganic salt needed to at least partially solubilize the inorganic salt. Preferably the measurement of the concentration or the amount of inorganic salt leaving the device is also performed.Type: GrantFiled: November 16, 2018Date of Patent: September 21, 2021Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, ECOLE NAT SUPERIEURE ARTS ET METIERS ENSAM, UNIVERSITÉ DE BORDEAUX, INSTITUT POLYTECHNIQUE DE BORDEAUXInventor: Cyril Aymonier
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Patent number: 11123561Abstract: A treatment system for stimulating the vagus nerves is described, comprising the following elements: —a detection and control unit (20); —at least one detection probe (10d, 10g) connected to the detection and control unit and intended to be applied to at least one of the two vagus nerves of a patient; —means (24) provided in the detection and control unit for detecting a phenomenon of mass discharge of action potentials in at least one vagus nerve using the detection probe or detection probes; —stimulation probes (10d, 10g) for stimulating vagus nerves, and—means (24) provided in the detection and control unit that are capable, in response to the detection of a mass discharge, of applying predefined asymmetric stimulation signals to said stimulation probes capable of causing a depolarization and/or hyperpolarization of the vagus nerves and of blocking the conduction of the action potentials at least in the efferent direction.Type: GrantFiled: February 13, 2017Date of Patent: September 21, 2021Assignees: UNIVERSITE DE RENNES 1, INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA REC, CNRS (CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, CHU DE RENNES (CENTRE HOSPITALIER UNIVERSITAIRE DEInventors: Alfredo Hernandez, Benoit Martin, Arnaud Biraben
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Patent number: 11124617Abstract: This invention relates to the direct grafting of a calixarene mostly onto the surface of a material, as well as to a grafting process, and certain calixarene intermediates useful for carrying the grafting process.Type: GrantFiled: April 4, 2019Date of Patent: September 21, 2021Assignees: UNIVERSITE LIBRE DE BRUXELLES (ULB), CENTER NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITE DE RENNES 1, UNIVERSITE DE PARISInventors: Ivan Jabin, Alice Mattiuzzi, Corinne Lagrost, Philippe Hapiot, Olivia Reinaud
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Electron-beam lithography process adapted for a sample comprising at least one fragile nanostructure
Patent number: 11127565Abstract: Disclosed is a lithography process on a sample including at least one structure and covered by at least a lower layer of resist and a upper layer of resist the process including: using an optical device to image or determine, in reference to the optical device, a position of the selected structure and positions of markers integral with the sample; using an electron-beam device, imaging or determining the position of each marker in reference to the electron-beam device; deducing the position of the selected structure in reference to the electron-beam device; exposing to an electron beam the upper layer of resist above the position of the selected structure to remove all the thickness of the upper layer of resist above the position of the selected structure but none or only part of the thickness of the lower layer of resist above the position of the selected structure.Type: GrantFiled: February 12, 2018Date of Patent: September 21, 2021Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, SORBONNE UNIVERSITE, UNIVERSITE PARIS DIDEROT—PARISInventors: Agnès Maitre, Amit Raj Dhawan, Pascale Senellart, Cherif Belacel -
Patent number: 11125751Abstract: The use of differentiation marker CD32 for the detection of cellular reservoirs of a mammalian immunodeficiency virus. Also the use of the differentiation marker CD32 for making a prognosis, diagnosing a remission, and evaluating the efficacy of treatment of the mammalian immunodeficiency. A multi-specific antibody that recognizes both at least one epitope of CD32 and at least one characteristic of the lymphocyte cells, a composition including the antibody, and the use of the antibody in treatment.Type: GrantFiled: September 30, 2017Date of Patent: September 21, 2021Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITÉ DE MONTPELLIERInventors: Monsef Benkirane, Gael Petitjean, Benjamin Descours