Patents Assigned to SCIENTIFIQUE (CNRS)
  • Use of 3-deoxyanthocyanidins for treating occular diseases
    Patent number: 10513503
    Abstract: Disclosed is a method for the treatment, prevention and/or stabilisation of ARMD, Stargardt disease, pigmentary retinopathy and/or diabetic retinopathy, including the application of a 3-deoxyanthocyanidin of formula (I) in which R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11 and X? are as defined, with the condition that at least one of R1, R2, R3, R4 or R5 is a hydroxyl and at least one of R8, R9, R10 or R11 is a hydroxyl.
    Type: Grant
    Filed: May 27, 2016
    Date of Patent: December 24, 2019
    Assignees: BIOPHYTIS, SORBONNE UNIVERSITE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE
    Inventors: Valerie Fontaine, Rene Lafont, Jose-Alain Sahel, Stanislas Veillet
  • Method for generating high-power electromagnetic radiation
    Patent number: 10516215
    Abstract: The invention relates to a method and a device for generating high-power electromagnetic radiation. A transmission antenna of a transmission device capable of emitting an electromagnetic transmission wave is arranged in a reverberation cavity comprising openings. The method includes determining an electromagnetic temporal waveform F focused in a desired direction of focus outside the cavity; and emitting an electromagnetic transmission wave E having temporal waveform F into the cavity using the transmission device.
    Type: Grant
    Filed: October 7, 2015
    Date of Patent: December 24, 2019
    Assignee: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE-CNRS
    Inventors: Julien De La Gorgue De Rosny, Mathias Fink, Arnaud Tourin, Geoffroy Lerosey, Matthieu Dupre
  • 2?-chloro nucleoside analogs for HCV infection
    Patent number: 10513534
    Abstract: Provided herein are compounds, compositions and methods for the treatment of Flaviviridae infections, including HCV infections. In certain embodiments, compounds and compositions of nucleoside derivatives are disclosed, which can be administered either alone or in combination with other anti-viral agents. In certain embodiments, the compounds are 2?-chloro nucleosides according to Formula 2001: or a pharmaceutically acceptable salt, solvate, stereoisomeric form, tautomeric form or polymorphic form thereof, wherein B, Z and PD are as described herein.
    Type: Grant
    Filed: October 7, 2013
    Date of Patent: December 24, 2019
    Assignees: IDENIX PHARMACEUTICALS LLC, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE DE MONTPELLIER
    Inventors: Gilles Gosselin, Christophe Claude Parsy, Francois-Rene Alexandre, Houcine Rahali, Jean-Francois Griffon, Dominique Surleraux, Cyril B. Dousson, Claire Pierra, Adel M. Moussa, Benjamin Alexander Mayes, Alistair James Stewart
  • THERMOASSOCIATIVE ADDITIVE COMPOSITIONS, THE ASSOCIATION OF WHICH IS CONTROLLED, AND LUBRICATING COMPOSITIONS CONTAINING SAME
    Publication number: 20190382679
    Abstract: The invention concerns additive compositions obtained by mixing at least two thermoassociative and exchangeable compounds and at least one boronic ester compound that enables the association of these two copolymers to be controlled; a lubricating composition obtained by mixing at least one lubricating base oil, at least two thermoassociative and exchangeable compounds, and at least one boronic ester compound that enables the association of these two copolymers to be controlled; a method for adjusting the viscosity of a lubricating composition obtained by mixing at least one lubricating base oil and at least two thermoassociative and exchangeable compounds; and the use of a boronic ester compound to adjust the viscosity of a lubricating composition.
    Type: Application
    Filed: November 21, 2017
    Publication date: December 19, 2019
    Applicants: TOTAL MARKETING SERVICES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, ECOLE SUPERIEURE DE PHYSIQUE ET DE CHIMIE INDUSTRIELLES DE LA VILLE DE PARIS
    Inventors: Thibault DEROUINEAU, Fanny BRIAND, Gregory DESCROIX, Renaud NICOLAY
  • USE OF QUINOLINE DERIVATIVES FOR THE TREATMENT OF INFLAMMATORY DISEASES
    Publication number: 20190382347
    Abstract: The present disclosure relates to the use of a compound of formula (I) or anyone of its pharmaceutically acceptable salts, in the treatment and/or prevention of an inflammatory disease; wherein: means an aromatic ring wherein V is C or N and when V is N; Q is N or O, provided that R? does not exist when Q is O; R? independently represent a hydrogen atom or a group chosen among a (C1-C3)alkyl group, a halogen atom, a hydroxyl group, a —COOR1 group, a —NO2 group, a —NR1R2 group, a morpholinyl or a morpholino group, a N-methylpiperazinyl group, a (C1-C3)fluoroalkyl group, a —O—P(?O)—(OR3)(OR4) group, a (C1-C4)alkoxy group and a —CN group, and can further be a group chosen among:
    Type: Application
    Filed: August 29, 2019
    Publication date: December 19, 2019
    Applicants: ABIVAX, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, INSTITUT CURIE, UNIVERSITE DE MONTPELLIER
    Inventors: Didier SCHERRER, Jamal TAZI, Florence MAHUTEAU, Romain NAJMAN
  • Method and device for dismantling multilayer systems including at least one organic component
    Patent number: 10507597
    Abstract: Method and device for delamination/dismantling of multi-layer systems SM comprising several layers including at least one organic layer, wherein the layers are separated by interfaces, characterized in that it comprises at least the following steps: Mixing the multilayer system with a fluid composed of at least one gas having the particularity of causing the swelling of at least one of the layers and one or more non-reactive liquids having the particularity of allowing the separation of each layer unitarily or of subsets of layers composing the multilayer system without degradation of the constituents of the layers, the gas/liquid fluid being raised in temperature and pressure, Recovering separately at least one or more layers or a subset of undegraded layers.
    Type: Grant
    Filed: September 2, 2016
    Date of Patent: December 17, 2019
    Assignee: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Cyril Aymonier, Cédric Slostowski
  • Polypeptide having a polyester degrading activity and uses thereof
    Patent number: 10508269
    Abstract: The present invention relates to a new isolated polypeptide comprising an amino acid sequence having at least 75%, 80%, 85%, 90%, 95%, 99% or 100% identity to the full length amino acid sequence set forth in SEQ ID NO:1, and having a polyester degrading activity, and uses thereof.
    Type: Grant
    Filed: March 11, 2016
    Date of Patent: December 17, 2019
    Assignees: CARBIOS, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE DE POITIERS
    Inventors: Luen-Luen Li, Thierry Ferreira, Willy Aucher, Steven Colas, Linette Lionelle Kadri
  • METHOD FOR DETERMINING THE MECHANICAL PROPERTIES OF A PELVIC CAVITY, AND MEASURING DEVICE
    Publication number: 20190374119
    Abstract: The present invention provides a method (30) of determining mechanical properties of the pelvic cavity of a person or an animal, the pelvic cavity including a plurality of organs and the method comprising a step (34) during which pressure is measured at one or more points of the surface of one of the organs of said pelvic cavity, and during which, simultaneously, movements of a plurality of organs of said pelvic cavity are also measured. The present invention also provides a measuring device for measuring pressure in an organ of the pelvic cavity in order to perform the above method (30). The measuring device comprises an optical fiber pressure sensor mounted in a non-metallic housing, and a closed flexible reservoir mounted in said non-metallic housing and having a surface, in particular a flexible surface, that constitutes a pressure measuring surface.
    Type: Application
    Filed: February 20, 2018
    Publication date: December 12, 2019
    Applicants: UNIVERSITE DE LILLE, ECOLE CENTRALE DE LILLE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, CENTRE HOSPITALIER REGIONAL UNIVERSITAIRE DE LILLE, ECOLE NATIONALE SUPERIEURE D?ARTS ET METIERS
    Inventors: Mathias BRIEU, Michel COSSON, Chrystèle RUBOD DIT GUILLET, Pauline LECOMTE, Jean-François WITZ, Laurent PATROUIX
  • THERMOASSOCIATIVE AND EXCHANGEABLE COPOLYMERS, COMPOSITION COMPRISING SAME
    Publication number: 20190375930
    Abstract: Compositions resulting from the mixing of at least one copolymer A1, resulting from the copolymerization of at least one monomer functionalized by diol functions with at least one styrenic monomer, and at least one compound A2 comprising at least two boronic ester functions. They have very varied rheological properties depending on the proportion of compounds A1 and A2 used. Composition resulting from the mixing of at least one lubricating oil with such a composition of associative and exchangeable polymers and use of this composition for lubricating a mechanical part.
    Type: Application
    Filed: November 21, 2017
    Publication date: December 12, 2019
    Applicants: TOTAL MARKETING SERVICES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, ECOLE SUPERIEURE DE PHYSIQUE ET DE CHIMIE INDUSTRIELLES DE LA VILLE DE PARIS
    Inventors: Thibault DEROUINEAU, Fanny BRIAND, Gregory DESCROIX, Renaud NICOLAY
  • Use of rhenium-containing supported heterogenous catalysts for the direct deoxy-dehydrated of glycerol to allyl alcohol
    Patent number: 10500567
    Abstract: The present invention relates to the use of rhenium-containing supported heterogeneous catalysts for the deoxydehydration of glycerol to allyl alcohol, as well as to a process for the production of allyl alcohol from glycerol, in the presence of such heterogeneous catalysts.
    Type: Grant
    Filed: July 27, 2016
    Date of Patent: December 10, 2019
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, ECOLE CENTRALE DE LILLE, NATIONAL INSTITUTE
    Inventors: Yoshihiro Kon, Benjamin Katryniok, Franck Dumeignil, Marcia Araque Marin, Sébastien Paul
  • Nepovirus coat protein fusion polypeptides and their use
    Patent number: 10501501
    Abstract: The present invention relates to novel fusion polypeptides and the uses thereof. The invention particularly relates to conjugated coat proteins derived from nepoviruses, virus-like particles made with such proteins, and the uses thereof. The particles of the invention can expose and/or encage molecules of interest and have utility in various fields such as the pharmaceutical, agro, or veterinary areas.
    Type: Grant
    Filed: September 9, 2016
    Date of Patent: December 10, 2019
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE DE STRASBOURG, INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE
    Inventors: Lorene Belval, Gerard Demangeat, Caroline Hemmer, Christophe Ritzenthaler
  • Method for downsampling a signal outputted by an asynchronous sensor
    Patent number: 10500397
    Abstract: Disclosed is a method for processing asynchronous signals generated by a light sensor, the sensor having a matrix of pixels, the method including: —receiving the asynchronous signals, each signal being associated with a pixel in a group of pixels in the matrix, each signal including successive events issued by the associated pixel; —upon an occurrence of an event in one of the asynchronous signals, updating an integration value associated to the group by adding an additive value to the integration value; —if the integration value is greater than a predetermined threshold, generating an event in an outputted asynchronous signal.
    Type: Grant
    Filed: July 18, 2016
    Date of Patent: December 10, 2019
    Assignees: SORBONNE UNIVERSITE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE—CNRS, INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE)
    Inventors: Ryad Benosman, Francesco Gallupi, Guillaume Chenegros, Xavier Lagorce, Christoph Posch
  • Method and kit for prognosis of OPA1 gene induced diseases, E.G. Kjers optic atrophy
    Patent number: 10501798
    Abstract: Providing Nuclear factor (erythroid-derived 2)-like 2 (NRF2)-activated genes products, e.g. SOD1 and CAT, in their use in the prognosis of an OPA1 gene- or OPA1 gene product-deficit-induced disease, or related complications, e.g. optic atrophy and optic neuropathy, in a biological sample selected from fibroblasts, epithelial cells, blood samples or a mixture thereof, of a patient affected or suspected to be affected by the disease.
    Type: Grant
    Filed: March 27, 2015
    Date of Patent: December 10, 2019
    Assignees: UNIVERSITE TOULOUSE III-PAUL SABATIER, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Noelie Davezac, Pascale Belenguer, Aurelie Millet
  • SYSTEM AND METHOD FOR PURIFYING LIQUID BY REVERSE OSMOSIS
    Publication number: 20190366271
    Abstract: A system for purifying a treated liquid, including: a treatment module, for treating the liquid and providing a purified liquid, and a residual liquid; and a means for pressurizing said treated liquid to supply said treatment module, including: a master cylinder, driven by a working fluid, and at least slave cylinder, driven by said master cylinder, receiving said treated liquid and supplying it to said treatment module; a cross section of said master cylinder is greater than a cross section of said slave cylinder so that, a greater pressure is generated on the treated liquid in the slave cylinder; and a means for pre-pressurizing the treated liquid, upstream of the pressurizing means, including: at least one master cylinder, connected to the treatment module, and driven by the residual liquid, and a slave cylinder, containing the treated liquid, driven by said master cylinder.
    Type: Application
    Filed: November 22, 2017
    Publication date: December 5, 2019
    Applicant: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Driss STITOU, Nathalie MAZET, Sylvain MAURAN
  • SYSTEM FOR BILATERAL IN-EAR EEG RECORDING WITH CLOSED-LOOP BINAURAL SENSORY STIMULATION
    Publication number: 20190366033
    Abstract: An in-ear stimulation system including a first device configured to be worn at least partially in a first ear canal of a subject and a second device configured to be worn at least partially in a second ear canal of the subject. Each of the first device and the second device includes: at least one in-ear active electrode configured to receive a bio-signal and at least one in-ear reference electrode configured to receive a bio-signal; at least one stimulation device configured for emitting at least one electrical or sensory stimulus; and an electronic system configured to detect at least one bio-signal pattern from the bio-signals measured from the electrodes.
    Type: Application
    Filed: January 19, 2018
    Publication date: December 5, 2019
    Applicants: ICM (INSTITUT DU CERVEAU ET DE LA MOELLE ÉPINIÈRE), APHP (ASSISTANCE PUBLIQUE - HÔPITAUX DE PARIS), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, SORBONNE UNIVERSITE, INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE)
    Inventors: Michel LE VAN QUYEN, Alexis GENIN, Alexis STEINER, Mario VALDERRAMA, Miguel NAVARRETE
  • Gene electrotransfer into skin cells
    Patent number: 10493154
    Abstract: The present invention relates to methods for transferring a nucleic acid in vivo into skin cells wherein the nucleic acid is injected by intradermal (ID) injection and is electrically transferred into skin cells with a single pulse of a High Voltage, followed, after a defined lag time, by a single pulse of Low Voltage.
    Type: Grant
    Filed: October 28, 2014
    Date of Patent: December 3, 2019
    Assignees: INVECTYS, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Pierre Langlade Demoyen, Thierry Huet, Christelle Liard, Jessie Thalmensi, Luis M. Mir, Christophe Calvet
  • BNP (1-32) epitope and antibodies directed against said epitope
    Patent number: 10495649
    Abstract: The present invention relates to a polypeptide carrying a human BNP(1-32) epitope according to Formula (I): a1-R1—X1—FGRKMDR—X2—R2-a2 as well as ligands specific of the FGRKMDR epitope.
    Type: Grant
    Filed: October 7, 2016
    Date of Patent: December 3, 2019
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.), BIO-RAD EUROPE GMBH
    Inventors: Francois Rieunier, Isabelle Giuliani, Sylvie Villard-Saussine
  • Force sensor
    Patent number: 10495531
    Abstract: Disclosed is a force sensor, including: at least one measurement cell, each measurement cell being filled with a filling material in which at least one inclusion of a substance is embedded; for each cell, at least one light source arranged in order to illuminate the inclusion embedded in this cell; for each cell, a measurement system including at least one optical measurement point arranged in order to capture light originating from the inclusion embedded in this cell; for each cell, a unit arranged in order to convert optical signals originating from the measurement system of this cell to a signal representative of a force exerted on this cell, this signal being dependent on a movement of the inclusion embedded within the filling material of this cell.
    Type: Grant
    Filed: August 11, 2016
    Date of Patent: December 3, 2019
    Assignees: MUSEUM NATIONAL D'HISTOIRE NATURELLE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, SORBONNE UNIVERSITE, UNIVERSITE PARIS DIDEROT-PARIS 7
    Inventors: Séverine Toussaint, Artémis Llamosi
  • MULTIELEMENT METHOD AND DEVICE FOR TESTING PARTS WITH ULTRASOUND
    Publication number: 20190360969
    Abstract: A method for nondestructively testing a part comprising an elongate microstructure is disclosed.
    Type: Application
    Filed: January 23, 2018
    Publication date: November 28, 2019
    Applicants: SAFRAN, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, ECOLE SUPERIEURE DE PHYSIQUE ET DE CHIMIE INDUSTRIELLES DE LA VILLE DE PARIS
    Inventors: Aurélien Baelde, Frédéric Jenson, Mathias Fink, Jérôme Laurent, Claire Prada
  • Orally available compounds, a process for preparing the same and their uses as anti-adhesive drugs for treating induced inflammatory bowel diseases such as crohn's disease
    Patent number: 10485811
    Abstract: Orally available compounds, a process for preparing the same and their uses as anti-adhesive drugs for treating E. coli induced inflammatory bowel diseases such as crohn's disease.
    Type: Grant
    Filed: January 23, 2015
    Date of Patent: November 26, 2019
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE D'AUVERGNE, UNIVERSITE DES SCIENCES ET TECHNOLOGIES DE LILLE 1, UNIVERSITE DE NANTES, INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE)
    Inventors: Julie Bouckaert, Sebastien Gouin, Adeline Sivignon, Arlette Darfeuille-Michaud, Rostyslav Bilyy, Dimitri Alvarez-Dorta, Nao Yamakawa, Tetiana Dumych