Patents Assigned to SCIENTIFIQUE (CNRS)
  • Publication number: 20200031925
    Abstract: The use of differentiation marker CD32 for the detection of cellular reservoirs of a mammalian immunodeficiency virus. Also the use of the differentiation marker CD32 for making a prognosis, diagnosing a remission, and evaluating the efficacy of treatment of the mammalian immunodeficiency. A multi-specific antibody that recognizes both at least one epitope of CD32 and at least one characteristic of the lymphocyte cells, a composition including the antibody, and the use of the antibody in treatment.
    Type: Application
    Filed: September 30, 2017
    Publication date: January 30, 2020
    Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITÉ DE MONTPELLIER
    Inventors: Monsef BENKIRANE, Gael PETITJEAN, Benjamin DESCOURS
  • Publication number: 20200031884
    Abstract: Process for detecting and identifying micropeptides (miPEPs) encoded by a nucleotide sequence contained in the sequence of the primary transcript of a microRNA and use thereof for modulating gene expression.
    Type: Application
    Filed: October 8, 2019
    Publication date: January 30, 2020
    Applicants: UNIVERSITE PAUL SABATIER TOULOUSE III, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Jean-Philippe COMBIER, Dominique LAURESSERGUES, Guillaume BECARD, François PAYRE, Serge PLAZA, Jérôme CAVAILLE
  • Patent number: 10543223
    Abstract: The present invention relates to mannose derivatives of formula (I): wherein R1 represents H, CO—(C1-C6)-alkyl or CO-alkylaryl, Y represents a single bond, CH2, O, NR3, S, A represents O, NH or S, X represents H and X? represents OH or X and X? taken together with the carbon atom bearing them form a CO group, R2 represents H, a linear or branched (C1-C6)-alkyl or CF3, R3 represents H, a C1-C6 alkyl, a CO—(C1-C6)-alkyl, CF3 or COCF3, and R is as described in claim 1.
    Type: Grant
    Filed: August 5, 2016
    Date of Patent: January 28, 2020
    Assignees: ENTEROME, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE CLERMONT AUVERGNE, UNIVERSITE DE NANTES
    Inventors: Sebastien Gouin, Thibault Chalopin, Julie Bouckaert, Nicolas Barnich, Adeline Sivignon, Dimitri Alexander Alvarez-Dorta, Francois Bellamy
  • Patent number: 10545387
    Abstract: The invention relates to an electrochromic device comprising: a working electrode (2) comprising an electrochromic material containing at least one electrochromic polymer, said electrode being optionally in contact with a current collector (6); a solid electrolyte (3) which is in contact with each of said electrodes; and a counter-electrode (4) in a conductive metal material. The invention also relates to the various applications of such a device, especially for display.
    Type: Grant
    Filed: March 6, 2014
    Date of Patent: January 28, 2020
    Assignee: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Abdelaadim Danine, Cyril Faure, Guy Campet, Aline Rougier
  • Patent number: 10545109
    Abstract: A portable device includes first and second connectors capable of guiding an electromagnetic wave, a sample carrier installed between the first premier and second connectors and including a cavity housing a sample, an electronic module including an electromagnetic wave generator, and a processing system capable of analysing the electromagnetic wave exiting the second connector in order to deliver a first dielectric permittivity measurement and/or a second magnetic permeability measurement, a computer device including a control system capable of controlling the operation of the electronic module and of recovering each first or second measurement, and a portable container housing the first and second connectors, the sample carrier, the electronic module and the computer device.
    Type: Grant
    Filed: May 25, 2016
    Date of Patent: January 28, 2020
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITE D'AIX MARSEILLE, ECOLE CENTRALE DE MARSEILLE
    Inventor: Pierre Sabouroux
  • Patent number: 10544156
    Abstract: The invention concerns a compound of the following formula (I) or a pharmaceutically acceptable salt or solvate thereof as well as a pharmaceutical composition containing such a compound, and the use of such a compound as a drug, notably as a DNMT inhibitor, in particular in the treatment of cancer.
    Type: Grant
    Filed: October 3, 2016
    Date of Patent: January 28, 2020
    Assignees: PIERRE FABRE MEDICAMENT, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
    Inventors: Ludovic Halby, Yoann Menon, El Bachir Kaloun, Christophe Long, Paola B. Arimondo
  • Patent number: 10537276
    Abstract: A system and method of detecting eye movements of a subject for the diagnosis of neurological disorders. The method includes tracking eye movements of the subject, identifying microsaccades from the tracked eye movements, and characterizing microsaccade dynamics of the identified microsaccades to determine one or more parameters, such as microsaccade direction, microsaccade velocity, microsaccade magnitude, microsaccadic peak velocity-magnitude relationship, microsaccade duration, and intersaccadic intervals. The method also includes comparing the one or more determined parameters with a corresponding control parameter, assessing the comparison to determine differences between the one or more determined parameters and the corresponding control parameters, and generating a report including the diagnosis of neurological disorder based on the assessment.
    Type: Grant
    Filed: April 20, 2018
    Date of Patent: January 21, 2020
    Assignees: DIGNITY HEALTH, LE CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Stephen L. Macknik, Susana Martinez-Conde, Zoi Kapoula, Jorge Otero-Millan
  • Patent number: 10538485
    Abstract: The present disclosure relates to compound (I) wherein R1 and R2 independently represent a hydrogen atom, a (C1-C4)alkoxy group, a fluoro(C1-C4)alkoxy group, a hydroxyl group, a benzyloxy group, a di(C1-C4)alkylamino group, a pyridyl-vinyl group, a pyrimidinyl-vinyl group, a styryl group, or a —NHCOphenyl group; R3, R4 and R5 independently represent a hydrogen atom, a (C1-C4)alkyl group, a CONHR6 group, a —CONR7R8 group, a —SO2NHR6 group, or a heteroaryl group optionally substituted by a halogen atom, a —(CH2)nNR7R8 group or a hydroxy(C1-C4)alkyl group; R6 represents a hydrogen atom, a —(CHR9)m(CH2)nNR7R8 group or a (C1-C6)alkyl group optionally substituted by a hydroxyl group; or anyone of its pharmaceutically acceptable salt, for use in a method for preventing, inhibiting or treating a disease in a patient suffering thereof, said disease involving a deregulated p53. Some of said compounds are new and also form part of the disclosure.
    Type: Grant
    Filed: December 13, 2017
    Date of Patent: January 21, 2020
    Assignees: ABIVAX, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, INSTITUT CURIE, UNIVERSITE DE MONTPELLIER
    Inventors: Didier Scherrer, Jamal Tazi, Romain Najman, Florence Mahuteau, Pierre Roux
  • Patent number: 10538582
    Abstract: The present invention relates to variable domains of a camelid heavy-chain antibodies directed against a phosphorylated tau protein and conjugates thereof. The present invention also relates to the use of these domains or conjugates for treating or diagnosing disorders mediated by neurofibrillary tangles, neuropil threads or dystrophic neurites, such as tauopathies.
    Type: Grant
    Filed: September 25, 2018
    Date of Patent: January 21, 2020
    Assignees: F. HOFFMANN-LA ROCHE AG, INSTITUT PASTEUR, COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
    Inventors: Pierre Lafaye, Sylvie Bay, Benoit Delatour, Marc Dhenain, Charles Duyckaerts, Tengfei Li, Matthias Vandesquille, Christian Czech, Fiona Grueninger
  • Patent number: 10537103
    Abstract: A bactericidal or bacteriostatic composition comprising an isomer mixture of monosaccharide alkyl monoethers or monoacetals, its use in the treatment or prevention of Gram-positive bacterial infections, its use as a hygiene or dermatological product for external use and a method for disinfecting surfaces.
    Type: Grant
    Filed: December 17, 2015
    Date of Patent: January 21, 2020
    Assignees: TEREOS STARCH & SWEETENERS BELGIUM, UNIVERSITÉ CLAUDE BERNARD LYON 1, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Charlotte Gozlan, Dorine Belmessieri, Marie-Christine Duclos, Nicolas Duguet, Marc Lemaire, Gérard Lina, Oana Dumitrescu, Andreas Redl
  • Patent number: 10538617
    Abstract: Fatty acid polyester derivatives of polyglycosides formed from a polyol having between 2 and 10 hydroxy functions, the 2 hydroxy functions or at least 2 of these hydroxy functions being bound to the anomeric carbon of a reducing carbohydrate that is identical or different for each hydroxy group and selected from the monosaccharides and disaccharides, in which at least one of the other hydroxy groups of the monosaccharide or the disaccharide is esterified by a lipid derivative bearing at least one double bond optionally originating from a vegetable or animal oil, from a mixture of vegetable or animal oils, the double bond or the at least one of the double bonds of the lipid derivative being functionalized by a group selected from the epoxy, amine, alcohol and acid groups, and use thereof in particular in reaction formulations for the production of polymer materials.
    Type: Grant
    Filed: July 21, 2015
    Date of Patent: January 21, 2020
    Assignees: UNIVERSITE DE MONTPELLIER, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Stéphane Patry, Jean-Pierre Habas
  • Patent number: 10539577
    Abstract: The present invention relates to the diagnosis of acquired sensory neuronopathies (SNN), and to the treatment of these disorders.
    Type: Grant
    Filed: July 26, 2017
    Date of Patent: January 21, 2020
    Assignees: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE JEAN MONNET SAINT ETIENNE, UNIVERSITE CLAUDE BERNARD LYON 1, HOSPICES CIVILS DE LYON, CENTRE HOSPITALIER UNIVERSITAIRE DE SAINT ETIENNE
    Inventors: Jerome Marc Claude Honnorat, Jean-Christophe Antoine, Jean-Philippe Camdessanche, Nadia Boutahar, Veronique Annie Rogemond
  • Publication number: 20200017892
    Abstract: Embodiments of the present disclosure relate to mutant yeast strains, in particular mutant Yarrowia strains, capable of producing medium chain fatty acids compared to the parent oleaginous yeast strain from which said mutant oleaginous yeast strain derives. Embodiments of the present disclosure also relate to means and methods for obtaining these mutant yeast strains.
    Type: Application
    Filed: January 8, 2018
    Publication date: January 16, 2020
    Applicants: INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE, INSTITUT NATIONAL DES SCIENCES APPLIQUEES DE TOULOUSE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Florence Bordes, Coraline Rigouin, Alain Marty, Marc Gueroult, Isabelle Andre, Sophie Barbe, Benjamin Percheron, Christian Croux, Fayza Daboussi
  • Patent number: 10533161
    Abstract: A NADPH oxidase (Nox) protein includes a domain including 3 to 7 transmembrane helices, and an amino acid sequence including at least 2 bis-histidyl motifs, wherein each of the bis-histidyl motifs consists of 2 histidine residues separated by 12, 13 or 14 amino acid residues. The Nox protein may be produced by a method that includes solubilizing a solution of cells expressing the Nox protein using a detergent from the maltoside family to suspend the Nox protein in the solution.
    Type: Grant
    Filed: April 22, 2015
    Date of Patent: January 14, 2020
    Assignees: UNIVERSITE GRENOBLE ALPES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Jérôme Dupuy, Christine Hajjar, Mickaël Cherrier, Franck Fieschi
  • Patent number: 10534132
    Abstract: Some embodiments are directed to a method for manufacturing photonic waveguides and to photonic waveguides manufactured by this method.
    Type: Grant
    Filed: December 18, 2015
    Date of Patent: January 14, 2020
    Assignees: UNIVERSITÉ DE FRANCHE-COMTÉ, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Nadège Courjal, Fabien Henrot, Ètienne Fizaine, Clément Guyot
  • Patent number: 10535445
    Abstract: The invention relates to a process for preparing an electrically conductive composite film, in particular in the form of a self-supported film or of a prepreg, comprising at least one thermoplastic polymer resin and electrically conductive particles chosen from a) graphene, carbon nanotubes, carbon nanofibres, and mixtures thereof; and b) filiform metal nanoparticles; to a process for preparing an electrically conductive laminated composite structure comprising such an electrically conductive composite film; to said electrically conductive composite film, to said electrically conductive laminated composite structure, and also to the uses thereof.
    Type: Grant
    Filed: July 20, 2015
    Date of Patent: January 14, 2020
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE TOULOUSE III—PAUL SABATIER
    Inventors: Antoine Lonjon, Eric Dantras, Colette Lacabanne
  • Patent number: 10533046
    Abstract: The present disclosure relates to a human CK8 antigen peptide, an antibody, or antibody fragment thereof, or a humanized antibody, specifically binding the peptide having the amino acid sequence of SEQ ID No. 29, a fragment of CK-8. Said molecules can be used use in the detection and/or treatment of tumors whose cells express CK8 protein, in particular the peptide of sequence according to SEQ ID No.29, on their surface.
    Type: Grant
    Filed: August 10, 2015
    Date of Patent: January 14, 2020
    Assignees: INTERNATIONA—DRUG—DEVELOPMENT—BIOTECH, UNIVERSITE CLAUDE BERNARD LYON 1, HOSPICES CIVILS DE LYON, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), CENTRE LEON BERARD
    Inventors: Marie Alexandra Albaret, Jean-Jacques Diaz, Hichem Claude Mertani, Jean-Christophe Saurin, Claudine Vermot-Desroches, Boris Vuillermoz
  • Publication number: 20200011572
    Abstract: Thermoregulated multilayer material characterized in that it comprises at least one substrate and one thermoregulated layer, said thermoregulated multilayer material having: for ? radiation of between 0.25 and 2 ?m, an absorption coefficient ?m?0.8; and, for incident ? radiation of between 7.5 and 10 ?m, a reflection coefficient ?m: ?m?0.85, when the temperature T of said multilayer material 1 is ?100° C.; ?m between 0.3 and 0.85, when the temperature T of said multilayer material is between 0 and 400° C.
    Type: Application
    Filed: March 12, 2018
    Publication date: January 9, 2020
    Applicants: VIESSMANN FAULQUEMONT, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITÉ DE LORRAINE
    Inventors: David Mercs, Fabien Capon, Nicolas Portha, Alexis Boileau
  • Publication number: 20200010852
    Abstract: The present invention relates to compositions and methods, in particular to methods based on systemic injection of rAAV, for delivering genes to cells of the central nervous system in mammals, such as brain neurons or glial cells, and in particular to motor neurons or glial cells of the spinal cord The invention also relates to methods of treating motor neuron disorders in mammals by expression of therapeutic genes. The invention stems from the unexpected discovery that peripheral injection of AAV vectors leads to a bypass of the blood brain barrier and a massive infection of motor neurons. The invention may be used in any mammal, including human subjects.
    Type: Application
    Filed: August 9, 2019
    Publication date: January 9, 2020
    Applicants: GENETHON, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventor: Martine BARKATS
  • Publication number: 20200010410
    Abstract: A bis-urea compound of general formula (IV): The compound is useful as a thermo-thickening agent in a non-polar liquid such as engine lubricating oil or thermosetting varnish. Also, a method for preparing the thermo-thickening compound. Further, a composition comprising the thermo-thickening compound and a non-polar liquid.
    Type: Application
    Filed: December 12, 2017
    Publication date: January 9, 2020
    Applicants: SORBONNE UNIVERSITE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Virgile AYZAC, Laurent BOUTEILLER, Matthieu RAYNAL, Benjamin ISARE