Abstract: A method of performing unsupervised detection of repeating patterns in a series (TS) of events (E21, E12, E5 . . . ), comprising the steps of: a) Providing a plurality of neurons (NRI-NRP), each neuron being representative of W event types; b) Acquiring an input packet (IV) comprising N successive events of the series; c) Attributing to at least some neurons a potential value (PTI-PTP), representative of the number of common events between the input packet and the neuron; d) Modify the event types of neurons having a potential value exceeding a first threshold TL; and e) generating a first output signal (OSI-OSP) for all neurons having a potential value exceeding a second threshold TF, and a second output signal, different from the first one, for all other neurons. A digital electronic circuit and system configured for carrying out such a method.
Type:
Application
Filed:
May 20, 2019
Publication date:
November 7, 2019
Applicants:
CENTRE NATIONAL DE LA RECHERCHHE SCIENTIFIQUE, CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
Inventors:
Simon Thorpe, Timothée MASQUELIER, Jacob MARTIN, Amir Reza YOUSEFZADEH, Bernabe LINARES-BARRANCO
Abstract: Provided are tricyclo-DNA (tc-DNA) AON and methods employing tc-DNA AON for modifying splicing events that occur during pre-mRNA processing. Tricyclo-DNA (tc-DNA) AON are described that may be used to facilitate exon skipping or to mask intronic silencer sequences and/or terminal stein-loop sequences during pre-mRNA processing and to target RNase-mediated destruction of processed mRNA.
Type:
Grant
Filed:
February 9, 2017
Date of Patent:
November 5, 2019
Assignees:
ASSOCIATION INSTITUT DE MYOLOGIE, SORBONNE UNIVERSITE, UNIVERSITAT BERN, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
Inventors:
Daniel Schumperli, Christian Leumann, Denis Furling, Luis Garcia, Thomas Voit
Abstract: A method of implementing organic synthesis reactions uses a composition containing a metal catalyst originating from a calcined plant. The plants can be from the Brassicaceae, Sapotaceae and Convolvulaceae family, and the metal catalyst contains metal in the M(II) form such as zinc, nickel, manganese, lead, cadmium, calcium, magnesium or copper. Examples of the organic synthesis reactions include halogenations, electrophilic reactions, cycloadditions, transesterification reactions and coupling reactions, among others.
Type:
Grant
Filed:
July 27, 2017
Date of Patent:
November 5, 2019
Assignees:
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE MONTPELLIER 2 SCIENCES ET TECHNIQUES
Abstract: A motorized, modular instrumentation device and an endoscopy system including such device. The motorized, modular instrumentation device includes at least one operational unit mounted on at least one support structure and integrating a motorized medical instrument module including, first, an elongated medical instrument with a tool arranged on one distal end, it being possible to bend the corresponding end portion of the instrument, and second, at least one electrical actuating element controlling the operation of the tool and/or the bending of the distal end portion, via transmission elements extending within the elongated body of the instrument. The actuating element(s) is/are installed in a hollow body connected to the proximal end of the instrument and the hollow body is itself arranged, with rotational guiding, within a reception housing adapted to move, at least translationally, on the support structure, the movements of the hollow body and the reception housing being motorized.
Type:
Grant
Filed:
March 8, 2013
Date of Patent:
November 5, 2019
Assignees:
UNIVERSITE DE STRASBOURG (ETABLISSEMENT PUBLIC NATIONAL A CARACTERE SCIENTIFIQUE, CULTUREL ET PROFESSIONNEL, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (ETABLISSEMENT PUBLIC NATIONAL A CARACTERE SCIENTIFIQUE ET TECHNOLOGIQUE)
Inventors:
Lucile Zorn, Philippe Zanne, Florent Nageotte, Michel De Mathelin
Abstract: The present invention concerns a positive electrode including a composite material including sulfur and carbon as an active material and its method of manufacture, a lithium-sulfur battery including such a positive electrode and its method of manufacture.
Type:
Grant
Filed:
March 9, 2015
Date of Patent:
November 5, 2019
Assignees:
BLUE SOLUTIONS, UNIVERSITE DE NANTES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
Inventors:
Margaud Lecuyer, Marc Deschamps, Joël Gaubicher, Bernard Lestriez, Dominique Guyomard
Abstract: An organic dye for a dye-sensitized solar cell (DSSC) comprising at least one electron-acceptor unit and at least one ?-conjugated unit is described. Said organic dye is particularly useful in a dye-sensitized photoelectric transformation element which, in its turn, can be used in a dye-sensitized solar cell (DSSC).
Type:
Grant
Filed:
November 14, 2014
Date of Patent:
November 5, 2019
Assignees:
ENI S.p.A., CNRS (CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE)
Inventors:
Paolo Biagini, Riccardo Po', Jean Roncali, Dora Demeter
Abstract: Nonlamellar bioresorbable microparticles to which protein substances are bonded, and a method for preparing the microparticles, comprising: (i) preparing the microparticles from at least one bioresorbable polymer without stabilizer and without surfactant; and (ii) bonding the protein substances to the microparticles obtained in step (i) without surfactant.
Type:
Grant
Filed:
January 11, 2013
Date of Patent:
November 5, 2019
Assignee:
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.)
Abstract: The present invention relates to method for treating a substrate or a surface thereof bearing Si—H groups to confer to it a physical and/or biochemical surface-modified property, wherein it comprises at least a step consisting of exposing, within a liquid medium, said substrate or a surface thereof with at least a polymer, said polymer containing: at least three reactive sites able to attach to said substrate or said surface by reacting with Si—H groups and further creating covalent bonds, and at least a molecule or a part thereof able to confer said modified property to said substrate or said surface thereof, said step being carried out in efficient conditions to promote the covalent grafting of said polymer to said substrate or surface thereof and the molecular weight of said polymer being greater than 1000 g/mol.
Type:
Grant
Filed:
October 3, 2007
Date of Patent:
November 5, 2019
Assignees:
CENTRE NATIONALE DE RECHERCHE SCIENTIFIQUE, INSTITUT CURIE
Abstract: A method for detecting movements of a plurality of points (P) of a surface (21), comprising a measuring step during which an incident ultrasonic wave is emitted into the air towards the surface and an ultrasonic wave reflected into the air by the surface (21) is detected. During the measuring step, each measuring point is illuminated by the incident ultrasonic wave at a multiplicity of angles of incidence, and the reflected ultrasonic wave is detected by a network of receiving transducers (3) comprising a plurality of ultrasonic receiving transducers (3a). The movements of the surface are determined at a measuring point by determining a delay and/or a phase shift between two beam-forming signals for said measuring point.
Type:
Application
Filed:
July 10, 2017
Publication date:
October 31, 2019
Applicants:
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), ECOLE SUPÉRIEURE DE PHYSIQUE ET DE CHIMIE INDUSTRIELLES DE LA VILLE DE PARIS, SORBONNE UNIVERSITE, INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MEDICALE), UNIVERSITÉ PARIS DIDEROT - PARIS 7
Inventors:
Ros Kiri Ing, Nathan Jeger-Madiot, Mathias Fink, Thomas Similowski
Abstract: The present invention relates to a method of analysis comprising the preparation and the analysis of a sample in a flexible container without direct handling of the sample and without reopening the flexible container at the end of the preparation of the sample, and also to a container and a kit that enable the implementation of this method.
Type:
Grant
Filed:
April 3, 2015
Date of Patent:
October 29, 2019
Assignees:
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE-CNRS, PRESTODIAG, COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES
Inventors:
Roberto Calemczuk, David Carrara, Thierry Livache, Thibaut Mercey, Félix Piat, Yoann Roupioz, Sami Slimani
Abstract: The manufacture of 8-chloro-N-[4-(trifluoromethoxy)phenyl]quinolin-2-amine, or a pharmaceutically acceptable salt thereof, and use of 8-chloro-N-[4-(trifluoromethoxy)phenyl]quinolin-2-amine, or a pharmaceutically acceptable salt thereof, for treating various conditions, and/or inhibiting replication of HIV-1 in a patient infected with HIV-1, by administering to a patient in need thereof an effective quantity of 8-chloro-N-[4-(trifluoromethoxy)phenyl]quinolin-2-amine, or a pharmaceutically acceptable salt thereof.
Type:
Application
Filed:
July 3, 2019
Publication date:
October 24, 2019
Applicants:
ABIVAX, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, INSTITUT CURIE, UNIVERSITE DE MONTPELLIER
Abstract: A Frequency-tunable and slot-fed planar antenna is proposed. The antenna includes resonant patch, a first dielectric layer, a ground plane having a first slot for each linear polarization, a second dielectric layer and a transmission line having, for each first slot, an end strand extending beneath the first slot. The antenna is frequency tunable for each linear polarization through at least one variable capacitance element. The matching of the antenna varies, for each linear polarization, as a function of a bias voltage applied to the variable capacitance element(s). The antenna includes, for each linear polarization, at least one second slot extending along the first slot. The end strand of the transmission line extends between the first slot and second slots. The at least one second slot creates an additional resonance.
Type:
Grant
Filed:
March 17, 2015
Date of Patent:
October 22, 2019
Assignees:
UNIVERSITE DE RENNES 1, CNRS—CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
Abstract: Some embodiments are directed to the use of creatine kinase or fragments thereof which induce analgesia, and also to the use of pharmaceutical compositions including the same, to relieve pain.
Type:
Grant
Filed:
March 7, 2016
Date of Patent:
October 22, 2019
Assignees:
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITÉ DE STRASBOURG
Abstract: The invention relates to the use, as an extraction agent for extracting at least one rare earth from an aqueous phase including phosphoric acid, of at least one compound of the following general formula (I): where n is an integer equal to 0, 1 or 2, R1 and R2 are H or an aliphatic hydrocarbon group, one of R3 and R4 has the following formula (II): where R5 and R6 are a hydrocarbon, hydroxyl or alkoxyl group, and the other one of R3 and R4 has one of the following formulas (II?) and (III): where R5? and R6? are a hydrocarbon, hydroxyl or alkoxyl group, and R7 and R8 are H or an aliphatic hydrocarbon group. The invention also relates to a method for recovering at least one rare earth using said compound, as well as to specific compounds as such.
Type:
Grant
Filed:
May 3, 2016
Date of Patent:
October 22, 2019
Assignees:
COMMISSARIAT A L+ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE DE MONTPELLIER
Abstract: Provided is a hexabenzocoronene-based compound and a donor: acceptor layer having this compound. Also provided are processes for manufacturing this compound and to a photovoltaic cell having at least one hexabenzocoronene-based compound. The hexabenzocoronene-based compound has following formula I: wherein R1, R3, R4 and R6 are independently from each other chosen among a carboxylic (—COOH) group, a cyano (—C?N) group, an isocyano (—N+?C?) group, a cyanate (—O—C?N) group and a —F group, and R2 and R5 are, independently from each other, chosen among a poly(3-oxypentylthiophene) (P3OPT) substituent and a poly(3-hexylthiophene) (P3HT) substituent.
Type:
Grant
Filed:
March 11, 2016
Date of Patent:
October 22, 2019
Assignees:
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE DE PAU ET DES PAYS DE L'ADOUR
Inventors:
Didier Begue, Roger Clive Hiorns, Hugo Santos-Silva, Emilie Guille, Charlène Boussiron, Christine Dagron-Lartigau, Pierre Iratcabal
Abstract: The compound according to the invention is a compound of formula (1) Ax W1-yMOyO3, wherein A is chosen from the group comprising the Li, Na, NH4, K and H cations, and it is characterized in that x and y verify the relationships 0?x?1 and 0?y?0.5, and in that it has a crystalline structure of the hexagonal type with a base of WO6 octahedra, said structure having tunnels delimited by 6, 4 and 3 of said octahedra and oriented along the axis c.
Type:
Grant
Filed:
October 21, 2014
Date of Patent:
October 22, 2019
Assignees:
RHODIA OPERATIONS, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, SORBONNE UNIVERSITE
Inventors:
Valerie Buissette, Thierry Le Mercier, Julie Besnardiere, Sophie Cassaignon, David Portehault, Gilles Wallez
Abstract: A positioning device includes a planar surface, a mobile platform configured to slide along the planar surface and cables for positioning and moving the mobile platform along the planar surface. The mobile platform includes a planar bearing system located at the side of the mobile platform configured to slide along the planar surface. The planar bearing system includes a component for pushing the mobile platform against the planar surface; and a component for allowing sliding of the planar bearing system with respect to the planar surface.
Type:
Grant
Filed:
December 19, 2014
Date of Patent:
October 22, 2019
Assignees:
FUNDACIÓN TECNALIA RESEARCH & INNOVATION, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
Inventors:
Hai Yang, Jean-Baptiste Izard, Cédric Baradat, Sébastien Krut, François Pierrot, Marc Gouttefarde-Tanich, Olivier Company
Abstract: A contrast-amplifying support for the observation of a sample, comprises a transparent substrate carrying at least one absorbing layer whose complex refractive index N1=n1?jk1 and thickness are chosen in such a way that the layer behaves in the guise of antireflection layer when it is illuminated under normal incidence at an illumination wavelength ? through the substrate, the face of the layer opposite to the d substrate being in contact with a transparent so-called ambient medium whose refractive index n3 is less than that of the refractive index n0 of the substrate. Methods for producing a contrast-amplifying support and for observing a sample, or for detecting or assaying at least one chemical or biological species, using such a contrast-amplifying support are provided.
Type:
Grant
Filed:
October 17, 2014
Date of Patent:
October 15, 2019
Assignees:
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE DU MAINE
Inventors:
Dominique Ausserre, Claude Amra, Myriam Zerrad, Refahi Abou Khachfe
Abstract: A process for obtaining a mixture of C4-C8 and C9-C18 alkyl monoether of saccharide, comprising: a) a first step of acetalization or trans-acetalization of a saccharide or of a mixture of saccharides with a C4-C8 aliphatic aldehyde or the acetal thereof, b) a second consecutive or simultaneous step of acetalization or trans-acetalization of the product obtained in a) of the saccharide or mixture of saccharides with a C9-C18 aliphatic aldehyde or the acetal thereof, c) a step of catalytic hydrogenolysis of the saccharide acetals obtained, and d) a step of recovery of a mixture of C4-C8 and C9-C18 alkyl saccharide monoethers. The invention further relates to a mixture of C4-C8 and C9-C18 alkyl saccharide monoethers and the use thereof as a surfactant.
Type:
Grant
Filed:
December 3, 2015
Date of Patent:
October 15, 2019
Assignees:
TEREOS STARCH & SWEETENERS BELGIUM, UNIVERSITÉ CLAUDE BERNARD LYON 1, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
Inventors:
Charlotte Gozlan, Marie-christine Duclos, Nicolas Duguet, Marc Lemaire, Andreas Redl