Abstract: The disclosure provides a new method for the specific metabolic labeling of bacterial teichoic acids cell wall by modified choline and click chemistry, and its use in various applications such as bio-imaging, diagnostic, vaccination or bio-materials engineering.

Abstract: A system for measuring a particle beam includes a central and peripheral part and a front and back panel. The central part includes a system for producing a space charge zone to be passed through by a beam to be measured, charge carriers of a first and second type being generated by the beam when the latter passes through the space charge zone. The peripheral part includes a system for collecting at least one type of charge carrier from among the first or second type. The peripheral part surrounds the central part such that a particle beam can pass through the central part without passing through the peripheral part, an orifice being provided in back panel, in a region of the central part such that the thickness of the region, along a normal axis to the front panel is less than that of the peripheral part along the normal axis.

Abstract: The present invention relates to biofunctionalized nanoparticles and uses thereof in adoptive cell therapy. In particular, the present invention relates to a nanoparticle comprising an amount of at least one antigen and an amount of at least one antibody having specificity for a B cell receptor wherein the antigen and antibody are attached to the surface of the nanoparticle.

Abstract: The present invention relates to a genomic sequences encoding for an attenuated mutant Zika virus. The inventors have introduced some specific substitutions at very specific positions in the epidemic genomic sequence for restoring some fixation sites for miR-4279 that were originally present in the endemic genomic sequence. Moreover the inventors have additionally introduced mutation leading to the abrogation of the N-glycosylation site on the E protein which will prevent the generation of auto-antibodies responsible for Guillain-Barre syndrome. The inventors have produced additional mutations of the virus that result to a dramatic reduction of the cytopathic effects without affecting the capacity to produce high titers of virus. In particular the present invention relates to a genomic sequence characterized by the sequence represented by SEQ ID NO:1 wherein at least one site of fixation for miR-4279 is restored.

Abstract: A process for synthesizing at least one levulinate ester, said process comprising the reaction of furfuryl alcohol with at least one other alcohol in the presence of water and at least one catalyst, said furfuryl alcohol being present in a quantity of at least 5% by weight, based on the total weight of the alcohols, and said catalyst comprising at least one triflate ligand and at least one metal selected from bismuth, gallium, aluminum, tin and iron.

Abstract: The invention relates to a material comprising at least one compound having formula Bi1-xMxAg1-y-?M?yOS1-zM?z, the methods for producing said material and the use thereof as a semiconductor, such as for photovoltaic or photochemical use and, in particular, for supplying a photocurrent. The invention further relates to photovoltaic devices using said compounds.

Abstract: The present invention concerns composite biomaterials comprising ceramic and a biodegradable polymer gel, with improved bioactivity, their process of preparation and their use for orthopedics, dentistry or reconstructive surgery, in particular for use as a bone filler.

Abstract: A MRI device includes: structure applying a main magnetic field on an axis Z over a sample zone; structure emitting a magnetic field gradient and structure emitting a radiofrequency pulse, and a controller. The controller performs on the sample zone, a sequence including: a radiofrequency pulse and/or phase at each repetition; and a spatial gradient of the component along the Z axis. The controller is programmed so that, in the course of repeated applications of the pulse and of the gradient of the sequence of one and the same set: the radio frequency pulse follows, between its repeated applications, a periodic series for its amplitude and for a series U+t=v+i?v; and each repeated application of the gradient of magnetic field of the sequence a, according to a coding spatial direction, a non zero timing integral equal to A and identical for each application of gradient of this set.

Abstract: The invention relates to a device and a method to assist with the operation of an instrument by means of said device, the device and the method using leverage effects in order to calculate the data relative to any point of an instrument axis, instead of using low-accuracy sensors. Other improvements are also described that allow higher-quality usage performance for the operator, which reduces the risk of errors and simplifies the operations.

Abstract: The present invention pertains to the field of protein engineering, and provides means for obtaining stable molecules that specifically bind to a target selected amongst a large variety of ligands families. In particular, the present invention provides methods for obtaining a molecule specifically binding to a target of interest, through a combinatorial mutation/selection approach with an OB-fold protein as a starting molecule. In particular, the target of interest can be of a different chemical nature form that of the native target of the OB-fold protein used as the starting molecule.

Abstract: An apparatus for ultrasonically measuring the flow rate of a fluid in a measuring channel including fluid supply passages at its ends, this measuring channel forming a waveguide made into a solid body, comprising at each end a transducer capable of emitting or receiving ultrasounds circulating in the axis of the channel, where each transducer includes a shell transmitting the ultrasounds, comprising a waveguide facing the measuring channel, and outside this waveguide shapes orientating the ultrasounds in directions different from that of the channel.

Abstract: A molten refractory product having the following average chemical composition, in wt % on the basis of oxides and for a total of 100%: Al2O3: balance to 100%; Fe2O3: 0.6%-5.0% and/or TiO2: 1.5%-10.0%; Fe2O3+TiO2?10.0%; Na2O+K2O: 1.0%-8.0%; SiO2: 0.2%-2.0%; CaO+BaO+SrO: ?0.5%; Other oxide species: ?1.5%. Also, a glass-melting furnace and the use of the refractory product in the glass-melting furnace.

Abstract: Disclosed is an acoustic resonance spectrometry system for analysing a sample, which includes an optical pump-probe device adapted to generate a pump beam and a probe beam, the pump beam being consisted of a series of ultra-short pump light pulses having a repetition frequency in the spectral domain of the gigahertz, the pump beam being directed towards an optoacoustic transducer to generate a periodic grating of coherent acoustic phonons in the sample, the probe beam being directed towards the sample to form a scattering beam of the probe beam on the grating of phonons, a frequency variation device being adapted to vary the repetition frequency of the pump beam in a spectral range and a photo-detection system configured to measure a scattering signal as a function of the repetition frequency in the spectral range.

Abstract: The present invention relates to the enzymatic synthesis of oligosaccharides, particularly, sialylated oligosaccharides comprising the carbohydrate moieties of the gangliosides GM3, GD3, and G.

Abstract: The present invention concerns metallated porphyrin derivatives as ligands of G-quadruplex and their novel use as anti-viral agents.

Abstract: A composition comprising synthetic mineral particles, such as silicate or phyllosilicate mineral particles, is presented. The composition can be prepared by a process in which a hydrogel precursor of the synthetic mineral particles is produced by a coprecipitation reaction between at least one compound comprising silicon, such as sodium metasilicate, and at least one compound comprising at least one metal element, such as a dicarboxylate salt of the formula M(R1—COO)2, wherein R1 is H or an alkyl group having 1 to 4 carbon atoms. The coprecipitation reaction also takes place in the presence of at least one carboxylate salt of formula R2—COOM? wherein M? is Na or K, and R2 is H or an alkyl group having 1 to 4 carbon atoms.

Abstract: Disclosed is a hybrid simulator for teaching optics or for training adjustment of an optical device. The hybrid simulator includes at least one dummy optical component physically simulating an optical device, at least one actuator device for generating or simulating an adjustment of the dummy optical component, a sensor configured for detecting an adjustment signal representative of operating the actuator device, a digital processing system including a numerical model for simulating an output numerical optical beam resulting from interaction between an input numerical optical beam and a numerical optical component representing the optical device as a function of the adjustment signal and a display system for displaying a visual signal representative of the output optical beam and/or augmented reality signals.

Abstract: A system and method for phase-readout/control and active stabilization on arbitrary interferometric phase in the optical interferometer platform is disclosed. The method makes use of a bi-colored polarization-multiplexed reference laser scheme. The disclosed scheme is based on two phase-locked reference signals with different frequencies that together remove the phase ambiguity. The two signals are polarization-multiplexed (either in free-space or optical fiber implementations) to enable easy separation and combining of these two signals through the use of polarization beam-splitters. The disclosed scheme provides a one-to-one map between phase and feedback signal levels, and enables phase-readout and stabilization even when one of the feedback-signals is at a maximum/minimum.

Abstract: A device for determining the density of volumes of material to be imaged is provided, the device comprising a gas detector having first and second chambers separated by a micro-screen, making it possible to detect a stream of ionising particles, to calculate the path of each ionising particle and the stream of ionising particles passing through the first chamber, and comprising computing means for converting the calculations of paths and streams into information on the volume density of the material to be imaged.

Abstract: The present invention relates to an engineered immune cell defective for Suv39h1. Preferably, said engineered immune cell further comprises a genetically engineered antigen receptor that specifically binds a target antigen. The present invention also relates to a method for obtaining a genetically engineered immune cell comprising a step consisting in inhibiting the expression and/or activity of Suv39h1 in the immune cell; and further optionally comprising a step consisting in introducing in the said immune cell a genetically engineered antigen receptor that specifically binds to a target antigen. The invention also encompasses said engineered immune cell for their use in adoptive therapy, notably for the treatment of cancer.