Patents Assigned to Sekisui Medical Co., Ltd.
  • Patent number: 10996217
    Abstract: A method for detecting renal disease or a method for assisting diagnosis of renal disease that is superior in sensitivity and specificity, as well as a kit that can be used therefor is provided. The present invention provides a method for detecting renal disease or a method for assisting diagnosis of renal disease comprising a step of detecting or quantifying free AIM in a biological sample derived from a test subject, as well as a kit for examining or assisting diagnosis of renal disease comprising an antibody that binds to free AIM.
    Type: Grant
    Filed: June 1, 2016
    Date of Patent: May 4, 2021
    Assignees: SEKISUI MEDICAL CO., LTD.
    Inventor: Toru Miyazaki
  • Publication number: 20210123917
    Abstract: A method for examining liver cancer or a method for assisting diagnosis of liver cancer that is superior in sensitivity and specificity, as well as a kit that can be used therefor is provided. The present invention provides a method for detecting liver cancer or a method for assisting diagnosis of liver cancer comprising a step of detecting or quantifying free AIM in a biological sample derived from a test subject, as well as a kit for examining or assisting diagnosis of liver cancer comprising an antibody that binds to free AIM.
    Type: Application
    Filed: December 28, 2020
    Publication date: April 29, 2021
    Applicants: SEKISUI MEDICAL CO., LTD., SOCIAL WELFARE ORGANIZATION "SAISEIKAI" IMPERIAL GIFT FOUNDATION INC.
    Inventors: Toru Miyazaki, Takeshi Okanoue, Noriyuki Koyama
  • Publication number: 20210079456
    Abstract: An object of the present invention is to provide a method for highly sensitively detecting, and a method for quantifying, a mutant gene (mutant allele) contained at a low frequency in a nucleic acid sample containing a wild-type allele. In one-reaction system in which a first-primers set designed to flank a mutation site of a gene of interest is mixed with a second-primers set including an ASP corresponding to the mutation, an amplification product can be obtained from a low-frequency mutant gene, and quantitativeness can be ensured, by including a competitive nucleic acid suppressing an amplification reaction from a wild-type allele of the gene, selecting a certain primer concentration condition, and controlling the cycle numbers of PCR reactions using the first and second-primers sets.
    Type: Application
    Filed: July 25, 2018
    Publication date: March 18, 2021
    Applicant: SEKISUI MEDICAL CO., LTD.
    Inventors: Hiroyuki EBINUMA, Yuriko TSUKAMOTO
  • Publication number: 20210079028
    Abstract: Provided is an alkyldiphenylmethane protective agent, which can prevent solidification or insolubilization of a compound by protecting a functional group of the compound to achieve easy separation and purification after a reaction.
    Type: Application
    Filed: November 27, 2020
    Publication date: March 18, 2021
    Applicant: SEKISUI MEDICAL CO., LTD.
    Inventors: Shinya YANO, Kenta SAITO, Hideki KUBOTA
  • Publication number: 20210061820
    Abstract: Metal complex particle including a magnetic material and a particle size adjusting composition containing a hydrophobic polymer, with the magnetic material including a metal complex consisting of a metal ion and a ligand and having both magnetism and fluorescence, and a content of the particle size adjusting composition in the metal complex particle being less than 60 w %.
    Type: Application
    Filed: December 28, 2018
    Publication date: March 4, 2021
    Applicants: SEKISUI CHEMICAL CO., LTD., SEKISUI MEDICAL CO., LTD.
    Inventors: Mai YAMAGAMI, Shuhei OBINATA, Takeshi WAKIYA, Maasa YAJI
  • Patent number: 10921260
    Abstract: An optical measuring device includes a measuring unit (an optical head and a control unit) that irradiates a detection portion of an immunochromatographic test piece with measurement light and measures light obtained from the detection portion due to the irradiation with the measurement light, and a determination unit that performs a determination regarding the immunochromatographic test piece on the basis of a determination according to a comparison of a measurement value obtained by the measuring unit with a preset threshold value, the measuring unit performs the measurement of the light obtained from the detection portion a plurality of times, and the determination unit performs a determination regarding the immunochromatographic test piece when the determination unit determines that a measurement value in an nth measurement is equal to or greater than the threshold value and also determines that a measurement value in an (n+1)th measurement is equal to or greater than the threshold value.
    Type: Grant
    Filed: October 5, 2016
    Date of Patent: February 16, 2021
    Assignees: HAMAMATSU PHOTONICS K.K., SEKISUI MEDICAL CO., LTD.
    Inventors: Naoyuki Honda, Kengo Sadamori, Daichi Susuki, Keigo Kohno, Motoki Morita
  • Publication number: 20210040128
    Abstract: An object of the present invention is to develop a protecting group, which can prevent solidification or insolubilization of a compound by protecting a functional group to achieve easy separation and purification after a reaction. A diphenylmethane compound represented by general formula (1): wherein Y represents —OR19 (wherein R19 represents a hydrogen atom or an active ester-type protecting group), —NHR20 (wherein R20 represents, for example, a hydrogen atom, a C1-6 linear or branched alkyl group, or an aralkyl group, at least one of R1 to R01 represents a group represented by formula (2): —O—R11—X-A??(2) and the others each independently represent a hydrogen atom, a halogen atom, a C1-4 alkyl group, or a C1-4 alkoxy group; R11 represents a C1-16 linear or branched alkylene group; X represents O or CONR21 (wherein R21 represents a hydrogen atom, or a C1-4 alkyl group; and A represents, for example, a group represented by formula (3).
    Type: Application
    Filed: October 20, 2020
    Publication date: February 11, 2021
    Applicant: SEKISUI MEDICAL CO., LTD.
    Inventors: Shinya YANO, Hideki KUBOTA
  • Publication number: 20210017263
    Abstract: The antigen specificity of the antibody that recognizes a glycan antigen and is used as a tumor marker is not sufficient, and it has been a drawback that tumor marker detection using such an antibody is low in detection specificity, thereby deteriorating accuracy of cancer diagnosis. To solve the object described above, the present invention provides an antibody specifically reactive with a glycan of DUPAN-2 antigen for use as a tumor marker, and a production method thereof.
    Type: Application
    Filed: March 29, 2019
    Publication date: January 21, 2021
    Applicant: SEKISUI MEDICAL CO., LTD.
    Inventors: Tomohiro MIURA, Osamu MIYAZAKI
  • Publication number: 20210017290
    Abstract: The antigen specificity of the antibody that recognizes a glycan antigen and is used as a tumor marker is not sufficient, and it has been a drawback that tumor marker detection using such an antibody is low in detection specificity, thereby deteriorating accuracy of cancer diagnosis. To solve the object described above, the present invention provides an antibody specifically reactive with a glycan of NCC-ST-439 antigen for use as a tumor marker, and a production method thereof.
    Type: Application
    Filed: March 29, 2019
    Publication date: January 21, 2021
    Applicant: SEKISUI MEDICAL CO., LTD.
    Inventors: Tomohiro MIURA, Osamu MIYAZAKI
  • Publication number: 20210017564
    Abstract: What is required is a method of producing, without treating a glycoprotein in a biological sample with a denaturing agent in advance, a selectively binding material, which specifically reacts with a glycan of a glycoprotein, a selectively binding material such as antibody thus produced by the method, and a method of specifically detecting a glycoprotein by using the selectively binding material. In order to solve the problems, the present invention produces a selectively binding material specifically reactive with a glycan of a glycoprotein by treating the glycoprotein with a glycan-specific glycan-cleaving enzyme.
    Type: Application
    Filed: September 29, 2020
    Publication date: January 21, 2021
    Applicant: SEKISUI MEDICAL CO., LTD.
    Inventors: Tomohiro MIURA, Tomo SHIMIZU, Osamu MIYAZAKI
  • Publication number: 20210009611
    Abstract: The purpose of the present invention is to provide a protecting group which improves the solubility of a compound having a functional group protected with the protecting group in an organic solvent and which is easily separated and purified after a reaction with avoiding solidification or insolubilization.
    Type: Application
    Filed: September 25, 2020
    Publication date: January 14, 2021
    Applicant: SEKISUI MEDICAL CO., LTD.
    Inventors: Shinya YANO, Yuki WAKASUGI, Yosuke IWANAGA
  • Patent number: 10870667
    Abstract: Provided is an alkyldiphenylmethane protective agent, which can prevent solidification or insolubilization of a compound by protecting a functional group of the compound to achieve easy separation and purification after a reaction.
    Type: Grant
    Filed: November 27, 2018
    Date of Patent: December 22, 2020
    Assignee: SEKISUI MEDICAL CO., LTD.
    Inventors: Shinya Yano, Kenta Saito, Hideki Kubota
  • Publication number: 20200393472
    Abstract: Provided is a method for separating and detecting various hemoglobins including abnormal hemoglobins and thalassemia markers. A method for analyzing hemoglobins, comprising separating hemoglobins in a sample by cation exchange chromatography, wherein an eluent having a pH of 8.1 or more and an osmotic pressure of 40 mOsm/kg or less is used for separation of the hemoglobins.
    Type: Application
    Filed: April 18, 2019
    Publication date: December 17, 2020
    Applicant: SEKISUI MEDICAL CO., LTD.
    Inventors: Hiroaki TAIRA, Ei-ichiro SUNAMURA, Kohei MATSUDA, Takuya YOTANI
  • Patent number: 10851120
    Abstract: An object of the present invention is to develop a protecting group, which can prevent solidification or insolubilization of a compound by protecting a functional group to achieve easy separation and purification after a reaction. A diphenylmethane compound represented by general formula (1): wherein Y represents —OR19 (wherein R19 represents a hydrogen atom or an active ester-type protecting group), —NHR20 (wherein R20 represents, for example, a hydrogen atom, a C1-6 linear or branched alkyl group, or an aralkyl group, at least one of R1 to R10 represents a group represented by formula (2): —O—O—R11—X-A??(2) and the others each independently represent a hydrogen atom, a halogen atom, a C1-4 alkyl group, or a C1-4 alkoxy group; R11 represents a C1-16 linear or branched alkylene group; X represents O or CONR21 (wherein R21 represents a hydrogen atom, or a C1-4 alkyl group; and A represents, for example, a group represented by formula (3).
    Type: Grant
    Filed: June 19, 2017
    Date of Patent: December 1, 2020
    Assignee: SEKISUI MEDICAL CO., LTD.
    Inventors: Shinya Yano, Hideki Kubota
  • Publication number: 20200355679
    Abstract: To provide an immunochromatographic test device capable of accurate diagnosis even when an excess sample is introduced. Provided is the immunochromatographic test device consisting: a test strip; a lower housing including a plurality of support bases that support the test strip; and an upper housing including a dropping hole for dropping a sample into the test strip and a detection window in a direction in which the sample introduced from the dropping hole develops on the test strip, wherein a width of the support base that supports portion of the test strip exposed from the detection window is smaller than a width of the test strip, or wherein among the plurality of support bases, the width of the support base arranged on the lower housing between a position corresponding to the detection window and a position corresponding to the dropping hole is larger than the width of the test strip.
    Type: Application
    Filed: December 14, 2018
    Publication date: November 12, 2020
    Applicant: SEKISUI MEDICAL CO., LTD.
    Inventors: Kanako AZUMA, Shinya OKUYAMA, Kazunori SAITO, Keigo KOHNO, Motoki MORITA
  • Patent number: 10830771
    Abstract: Disclosed is a means of enabling the construction of a more accurate PIVKA-II immunoassay system using monoclonal antibodies against human prothrombin. The PIVKA-II assay method according to the present invention comprises measuring PIVKA-II in a sample by an immunoassay using an anti-PIVKA-II antibody or an antigen-binding fragment thereof which specifically binds to PIVKA-II and a mixture of a first anti-prothrombin antibody or an antigen-binding fragment thereof which recognizes hydrophilic PIVKA-II molecules and a second anti-prothrombin antibody or an antigen-binding fragment thereof which recognizes hydrophobic PIVKA-II molecules.
    Type: Grant
    Filed: October 6, 2016
    Date of Patent: November 10, 2020
    Assignees: FUJIREBIO INC., SEKISUI MEDICAL CO., LTD.
    Inventors: Yoshiyuki Kitamura, Katsumi Aoyagi
  • Publication number: 20200348227
    Abstract: Provided are a carbon isotope analysis device high in partial pressure of carbon dioxide isotope in gas sent into as optical resonator, and high in sensitivity performance and analytical accuracy, and an analysis method by use of the carbon isotope analysis device. A carbon isotope analysis device including a carbon dioxide isotope generator provided with a combustion unit that generates gas containing carbon dioxide isotope from carbon isotope, and a carbon dioxide isotope purifying unit; a spectrometer including an optical resonator having a pair of mirrors, and a photodetector that determines intensity of light transmitted from the optical resonator; a carbon dioxide trap including a cooler for freezing the carbon dioxide isotope, the carbon dioxide trap being disposed between the carbon dioxide isotope generator and the spectrometer; and a light generator.
    Type: Application
    Filed: January 22, 2019
    Publication date: November 5, 2020
    Applicants: SEKISUI MEDICAL CO., LTD., NATIONAL UNIVERSITY CORPORATION TOKAI NATIONAL HIGHER EDUCATION AND RESEARCH SYSTEM
    Inventors: Atsushi SATOU, Tetsuo IGUCHI, Hideki TOMITA, Norihiko NISHIZAWA
  • Patent number: 10822357
    Abstract: The purpose of the present invention is to provide a protecting group which improves the solubility of a compound having a functional group protected with the protecting group in an organic solvent and which is easily separated and purified after a reaction with avoiding solidification or insolubilization.
    Type: Grant
    Filed: August 25, 2016
    Date of Patent: November 3, 2020
    Assignee: SEKISUI MEDICAL CO., LTD.
    Inventors: Shinya Yano, Yuki Wakasugi, Yosuke Iwanaga
  • Publication number: 20200325163
    Abstract: Provided is an alkyldiphenylmethane protective agent, which can prevent solidification or insolubilization of a compound by protecting a functional group of the compound to achieve easy separation and purification after a reaction.
    Type: Application
    Filed: November 27, 2018
    Publication date: October 15, 2020
    Applicant: SEKISUI MEDICAL CO., LTD.
    Inventors: Shinya YANO, Kenta SAITO, Hideki KUBOTA
  • Patent number: D909589
    Type: Grant
    Filed: April 8, 2019
    Date of Patent: February 2, 2021
    Assignee: SEKISUI MEDICAL CO., LTD.
    Inventors: Keigo Kohno, Motoki Morita, Saori Nozaki, Masato Nishikawa, Kumiko Yuki, Shun Sakai