Patents Assigned to Sekisui Medical Co., Ltd.
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Publication number: 20240125784Abstract: The problem addressed by the present invention is to provide an immunological assay method using a monoclonal antibody and a kit including the monoclonal antibody, which can be used for assaying ICTP without requiring special facilities. This problem can be solved by a method for immunological assay of type I collagen C-terminal telopeptide in a biological sample, including contacting type I collagen C-terminal telopeptide with a monoclonal antibody that recognizes an amino acid sequence represented by GFDFSFLP (SEQ ID NO: 1) as an epitope.Type: ApplicationFiled: March 23, 2022Publication date: April 18, 2024Applicant: SEKISUI MEDICAL CO., LTD.Inventors: Shiomi HORIUCHI MORISHITA, Rikako OGASAWARA, Tomohide ASAI, Osamu MIYAZAKI
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Publication number: 20240077504Abstract: A method for estimating a cause of coagulation time prolongation includes 1) detecting a coagulation reaction end point Pe in a coagulation reaction curve of a subject blood specimen having a prolonged coagulation time; 2) calculating T(X), wherein T(X) represents a measurement point or time at which the coagulation reaction curve reaches X % of Pe, and X is a variable of greater than 0 and equal to or less than 100; and 3) estimating a cause of coagulation time prolongation of the subject blood specimen based on a form of T(X).Type: ApplicationFiled: March 4, 2022Publication date: March 7, 2024Applicant: SEKISUI MEDICAL CO., LTD.Inventors: Toshiki KAWABE, Yukio ODA
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Publication number: 20240027476Abstract: Provided is a blood coagulation reaction analysis method. The method includes measuring a blood coagulation reaction of a subject specimen and acquiring first data for calculating a blood coagulation time of the subject specimen and second data for estimating a blood coagulation abnormality factor of the subject specimen, wherein the acquiring of the second data includes: obtaining a first derivative V(i) of a coagulation reaction curve R(i); and determining a point pk where V(i) assumes Xk before reaching a maximum value of V(i), Vmax, and a point qk where V(i) assumes Xk after reaching Vmax.Type: ApplicationFiled: September 8, 2021Publication date: January 25, 2024Applicant: SEKISUI MEDICAL CO., LTD.Inventors: Toshiki KAWABE, Yukio ODA
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Publication number: 20240011013Abstract: Provided is a nucleic acid purification method capable of efficiently purifying a nucleic acid. The nucleic acid purification method including the steps of: mixing a nucleic acid with an antifoaming agent and a coprecipitation agent; and purifying the nucleic acid, in which the antifoaming agent is at least one of a nonionic surfactant and a silicone antifoaming agent.Type: ApplicationFiled: September 3, 2021Publication date: January 11, 2024Applicants: SEKISUI MEDICAL CO., LTD., SEKISUI CHEMICAL CO., LTD.Inventors: Sou YAMAGUCHI, Katsura UCHIDA, Tatsunori TAKAMATSU, Takamasa KOUNO, Takuya KINOSHITA
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Patent number: 11867694Abstract: The present invention relates to latex particles for measurement reagents, said latex particles having a coefficient of variation in particle diameters of 10% or less and an average particle diameter of 250 to 1000 nm. Each of the latex particles contains 20% by weight or more of a compound having a refractive index of 1.60 or more. The depth of a supernatant is 5 mm or less when a liquid dispersion having a solid matter concentration of 1% by weight, which is prepared by dispersing the latex particles in ultrapure water, is placed in a tubular 10-ml measuring cylinder having a body inner diameter of 10.8 mm and is then allowed to leave for 10 days. According to the particles, a measurement of a measurement sample can be performed at a high sensitivity even when the concentration of a substance to be tested in the measurement sample is low.Type: GrantFiled: May 24, 2018Date of Patent: January 9, 2024Assignee: SEKISUI MEDICAL CO., LTD.Inventors: Satoru Sugimoto, Takeshi Wakiya, Shinichiro Kitahara, Maasa Yaji, Yuya Inaba
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Publication number: 20230393156Abstract: A method for detecting a blood coagulation reaction, comprising: 1) measuring a blood coagulation reaction of a subject blood specimen and acquiring a first derivative V(i) of a coagulation reaction up to a latest measurement point; 2) calculating areas under the curve (AUCs) before the peak and after the peak, wherein a top of the peak of V(i) is cVmax(k) which is a maximum value of V(i); and 3) detecting cVmax(k) as Vmax which is a true maximum value of V(i) when the pre-peak AUC and the post-peak AUC are both equal to or higher than a first threshold AUCth1 and a period L during which the pre-peak AUC and the post-peak AUC have continued to be a constant value reaches a predetermined length.Type: ApplicationFiled: October 29, 2021Publication date: December 7, 2023Applicant: SEKISUI MEDICAL CO., LTD.Inventors: Toshiki KAWABE, Kengo ONISHI
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Publication number: 20230358767Abstract: An object of the present invention is to provide a method for measuring an object to be measured in a specimen by an enzymatic method, the measurement method being able to suppress the positive influence of peroxide derived from the specimen. More specifically, an object of the present invention is to provide a measurement method and a measurement reagent that can suppress elevation in value regardless of whether or not the specimen is a catalase-free specimen.Type: ApplicationFiled: September 10, 2021Publication date: November 9, 2023Applicant: SEKISUI MEDICAL CO., LTD.Inventors: Satoshi MACHIDA, Hiroki OSAKO, Kouji YAMAMOTO, Yuuri HAYAKAWA
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Publication number: 20230340572Abstract: An object of the present invention is to provide a more sensitive detection method and quantification method in a method for detecting a target nucleic acid using the PALSAR method.Type: ApplicationFiled: January 29, 2021Publication date: October 26, 2023Applicant: SEKISUI MEDICAL CO., LTD.Inventors: Akane OOMORI, Masako OSAWA
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Publication number: 20230341371Abstract: Provided is a blood analysis method including: acquiring coagulation reaction data on a blood specimen; calculating a parameter related to a centroid point from a differential curve of the coagulation reaction data; and evaluating coagulation properties of the blood specimen using the parameter related to the centroid point.Type: ApplicationFiled: July 15, 2021Publication date: October 26, 2023Applicant: SEKISUI MEDICAL CO., LTD.Inventors: Toshiki KAWABE, Yukio ODA
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Publication number: 20230341423Abstract: Provided is a blood coagulation time measurement method. In the method, reaction X(i) is acquired through smoothing and zero-point adjustment of a measured value P(i) for coagulation reaction of a blood specimen, and then an integration ratio Z(i) of the reaction X(i) is acquired. These values are used to calculate an index for coagulation time Tc calculation, and it is determined whether or not the index satisfies the criteria. The procedure is sequentially repeated until an index that satisfies the criteria is obtained.Type: ApplicationFiled: December 25, 2020Publication date: October 26, 2023Applicant: SEKISUI MEDICAL CO., LTD.Inventor: Toshiki KAWABE
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Publication number: 20230333070Abstract: Provided is an inspection chip with simplified channel switching structure, which is generally complicated.Type: ApplicationFiled: September 14, 2021Publication date: October 19, 2023Applicants: SEKISUI CHEMICAL CO., LTD., SEKISUI MEDICAL CO., LTD.Inventors: Shoutarou KOBARU, Takamasa KOUNO, Nobuhiko INUI, Kazuhiko IMAMURA, Sou YAMAGUCHI, Katsura UCHIDA, Tatsunori TAKAMATSU
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Publication number: 20230266337Abstract: An object of the present invention is to provide a TARC-containing composition with high storage stability. Provided is a composition including TARC (Thymus and activation-regulated chemokine) and one or more selected from the group consisting of a sugar fatty acid ester-type nonionic surfactant, a polyoxyethylene-polyoxypropylene block copolymer-type nonionic surfactant, and a polyoxyethylene alkylamine-type nonionic surfactant and being in liquid form. The aforementioned object is achieved by the composition.Type: ApplicationFiled: July 9, 2021Publication date: August 24, 2023Applicant: SEKISUI MEDICAL CO., LTD.Inventors: Akiko MATSUMOTO, Tomoyuki USUI, Yuka SUZUKI, Kengo FUJIMURA
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Publication number: 20230258657Abstract: An object of the present invention is to provide a TARC-containing composition with high storage stability. Provided is a composition including TARC (Thymus and activation-regulated chemokine) and a polymer having 2-methacryloyloxyethyl phosphorylcholine as a structural unit, and being in liquid form. The aforementioned object is achieved by the composition.Type: ApplicationFiled: July 9, 2021Publication date: August 17, 2023Applicant: SEKISUI MEDICAL CO., LTD.Inventors: Kengo FUJIMURA, Tomoyuki USUI, Yuka SUZUKI, Akiko MATSUMOTO
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Patent number: 11719689Abstract: There is provided a composition for separating blood serum or blood plasma that can inhibit bubbling during sterilization, and can inhibit the occurrence of phase separation during storage. The composition for separating blood serum or blood plasma according to the present invention comprises a (meth)acrylic acid ester-based polymer, a silica fine powder, and a silicone oil, wherein the (meth)acrylic acid ester-based polymer has fluidity at room temperature, and has a weight average molecular weight of 15000 or more and 100000 or less.Type: GrantFiled: December 25, 2018Date of Patent: August 8, 2023Assignee: SEKISUI MEDICAL CO., LTD.Inventors: Ryusuke Okamoto, Kuniya Komai
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Patent number: 11702688Abstract: An object of the present invention is to provide a novel method for designing a primer ensuring reactivity and discriminatory power in a method for detecting a single base substitution based on an ASP-PCR method and to provide a method for easily detecting multiple point mutations within overlapping amplicons, particularly, two adjacent single base substitutions. The single base substitutions can easily be detected by using a mutant primer in which the base of the third nucleotide from the 3? end corresponds to the base of a mutant nucleotide of a single base substitution contained in a nucleic acid sample, in which the base of the second nucleotide from the 3? end is not complementary to the base of the corresponding nucleotide of the nucleic acid, and in which the bases of the other nucleotides are complementary to the bases of the corresponding nucleotides of the nucleic acid.Type: GrantFiled: March 29, 2017Date of Patent: July 18, 2023Assignee: SEKISUI MEDICAL CO., LTD.Inventors: Hiroyuki Ebinuma, Katsura Uchida, Yuriko Tsukamoto
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Publication number: 20230213497Abstract: Provided is a method for accurately measuring coagulation time of blood specimens showing various coagulation reactions. The method for measuring blood coagulation time includes acquiring coagulation reaction P(i) of a subject specimen and reaction velocity V(i); calculating a calculation start point Te by using the ratio of the V(i) to maximum reaction velocity as an index; and calculating time Tc giving P(Tc)=P(Te)×N % (0<N<100) and determining the Tc as the blood coagulation time.Type: ApplicationFiled: April 7, 2021Publication date: July 6, 2023Applicant: SEKISUI MEDICAL CO., LTD.Inventor: Toshiki KAWABE
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Publication number: 20230183674Abstract: Provided is a method for purifying a nucleic acid capable of easily purifying a nucleic acid and efficiently recovering the nucleic acid. The method for purifying a nucleic acid including a step of bringing a sample containing a nucleic acid into contact with an extraction solution containing a metal cation to prepare an extraction solution containing the nucleic acid, a step of bringing the extraction solution containing the nucleic acid into contact with an anionic adsorbent 4 to cause the nucleic acid to adsorb to the anionic adsorbent 4, a step of bringing a wash solution having a pH of 5.0 or less into contact with the anionic adsorbent 4 to wash the anionic adsorbent 4 to which the nucleic acid is adsorbed, and a step of bringing a recovery solution having a pH of 6.0 or more into contact with the anionic adsorbent 4 to isolate the nucleic acid from the anionic adsorbent 4.Type: ApplicationFiled: May 19, 2021Publication date: June 15, 2023Applicants: SEKISUI MEDICAL CO., LTD., SEKISUI CHEMICAL CO., LTD.Inventors: Sou YAMAGUCHI, Katsura UCHIDA, Takamasa KOUNO, Tatsunori TAKAMATSU, Takuya KINOSHITA
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Publication number: 20230175067Abstract: It is intended to provide a rapid, convenient, and highly accurate method for determining the prognosis of cancer. The present invention provides a method for determining a tissue having renal cell carcinoma, comprising: (1) subjecting sample DNA to ion exchange chromatography, wherein the sample DNA is obtained by treating target genomic DNA prepared from a renal tissue of a subject with bisulfite, followed by PCR amplification; (2) calculating a derivative value of a detection signal of the chromatography; and (3) determining the renal tissue as being a tissue having renal cell carcinoma having poor prognosis when the derivative value calculated in the step (2) has two or more maximums.Type: ApplicationFiled: July 14, 2022Publication date: June 8, 2023Applicants: NATIONAL CANCER CENTER, SEKISUI MEDICAL CO., LTD.Inventors: Yae KANAI, Eri ARAI, Yuriko KEMOTO, Takuya YOTANI
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Patent number: 11668708Abstract: A method for avoiding the influence of a blood sample on a measurement error in a latex agglutination immunoassay. The measurement error caused by a blood sample in a latex agglutination immunoassay can be reduced by a method which includes a step of bringing the sample into contact, in a liquid phase, with latex particles carrying a substance having a specific affinity for an analyte in the presence of imidazole.Type: GrantFiled: September 29, 2017Date of Patent: June 6, 2023Assignee: SEKISUI MEDICAL CO., LTD.Inventors: Kengo Fujimura, Junichi Kondou, Mitsuaki Yamamoto
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Publication number: 20230158505Abstract: A specimen collection container is provided, the specimen collection container being capable of suppressing a change in a mixing ratio of a specimen collected to a liquid contained even when a long period of time has elapsed after manufacturing. A specimen collection container according to the present invention is a specimen collection container into which a specimen is collected, the specimen collection container including: a container main body having an opening; a plug attached to the opening; a barrier film disposed on an outer surface of the container main body; and a liquid contained in the container main body, the barrier film having a water vapor transmission rate at 40° C. and 90% RH of 0.8 g/(m2·day) or less.Type: ApplicationFiled: March 23, 2021Publication date: May 25, 2023Applicants: SEKISUI MEDICAL CO., LTD., TOKUYAMA SEKISUI CO., LTD.Inventors: Takaya UCHIYAMA, Kuniya KOMAI, Masatoshi NIUNOYA, Yuuki GOTOU, Hironobu ISOGAWA