Patents Assigned to Sekisui Medical Co., Ltd.
  • Patent number: 11471843
    Abstract: A stirring bar capable of reducing a dead space inside a container and efficiently using a contained liquid. A stirring bar introduced into a reagent bottle having an opening mouth portion and rotated by a magnetic force transmitted from the outside of the reagent bottle so as to stir a reagent in the reagent bottle, including: a magnet having a predetermined shape; and a main body including a magnetic member therein, in which the main body is provided with a through-hole which has an opening area corresponding to an opened area and is able to receive a nozzle in the opening area, and in which the stirring bar in a rotation state is able to receive the nozzle in a circular center area narrower than the opening area and having a diameter of an opening width of a center portion of the opening area.
    Type: Grant
    Filed: June 25, 2020
    Date of Patent: October 18, 2022
    Assignee: SEKISUI MEDICAL CO., LTD.
    Inventor: Toshiki Kawabe
  • Publication number: 20220326262
    Abstract: Provided is a method by which a titer of a coagulation factor inhibitor can be measured simply and in a short time. The present invention relates to a method for measuring a titer of a coagulation factor inhibitor. The method includes: preparing a mixed specimen containing a subject blood specimen and a normal blood specimen; heating the mixed specimen and acquiring a coagulation reaction curve for the heated mixed specimen; acquiring a coagulation reaction curve for the mixed specimen that has not been heated; calculating a parameter related to the coagulation reaction curve of the mixed specimen that has not been heated as a first parameter; calculating a parameter related to the coagulation reaction curve of the heated mixed specimen as a second parameter; and calculating a titer of a coagulation factor inhibitor in the subject blood specimen on the basis of the ratio or the difference between the first parameter and the second parameter.
    Type: Application
    Filed: April 23, 2020
    Publication date: October 13, 2022
    Applicants: SEKISUI MEDICAL CO., LTD., PUBLIC UNIVERSITY CORPORATION NARA MEDICAL UNIVERSITY
    Inventors: Toshiki KAWABE, Yukio ODA, Mari EMMI, Midori SHIMA, Keiji NOGAMI, Kenichi OGIWARA, Naruto SHIMONISHI
  • Publication number: 20220316000
    Abstract: An object of the invention is to provide an optical detection method and a quantification method of a product obtained by amplifying a target nucleic acid contained in a paper piece of a blood spot in a filter paper obtained by blotting blood on a filter paper and then drying the blood using nucleic acid amplification reaction by real-time PCR and to further provide a kit used for the methods. The invention provides a method and a kit which can optically detect and quantify a target nucleic acid from a dried blood spot in a filter paper by real-time PCR without any complicated pretreatment, by adjusting the size of the punched piece of the dried blood spot in a filter paper or the whole blood amount contained in the punched piece, the amount of the PCR reaction reagent, or performing the PCR reaction in a PCR reaction tube closed with a cap.
    Type: Application
    Filed: September 11, 2020
    Publication date: October 6, 2022
    Applicants: SEKISUI MEDICAL CO., LTD., NATIONAL CENTER FOR CHILD HEALTH AND DEVELOPMENT
    Inventors: Hiroyuki EBINUMA, Hiroaki INOUE, Toru UCHIYAMA
  • Publication number: 20220285023
    Abstract: There is provided a biliary atresia diagnosis support management system including a server, the server including a transmission/reception unit receiving an image of stool from a living body and a determination unit determining whether biliary atresia is contracted or not from the image, wherein the server further includes: a management unit including a usage fee saving unit saving received usage fees and a donation sending unit for sending a donation from the saved usage fees; and a doctor's determination request processing unit requesting a determination by a doctor if the determination unit determines that there is a suspected positive result; and if it is diagnosed that the living body needs treatment for biliary atresia as a result of a thorough examination, the server pays a donation for the treatment from the usage fees saved in the usage fee saving unit via the donation sending unit.
    Type: Application
    Filed: August 13, 2020
    Publication date: September 8, 2022
    Applicants: SEKISUI MEDICAL CO., LTD., NATIONAL CENTER FOR CHILD HEALTH AND DEVELOPMENT
    Inventors: Takeshi URAMOTO, Tetsuaki KON, Tomoyoshi SHIROSHITA, Akira MATSUI, Hideki NAKAJIMA, Hiroyuki ABE
  • Publication number: 20220267852
    Abstract: An object of the invention is to provide a primer for detecting and quantifying homozygous deletion of the SMN1 gene, the deletion of which causes SMA, using a dried blood spot in a filter paper and a method related to specific detection/quantification of the SMN1 gene using the primer.
    Type: Application
    Filed: July 22, 2020
    Publication date: August 25, 2022
    Applicant: SEKISUI MEDICAL CO., LTD.
    Inventors: Hiroyuki EBINUMA, Ikumi SUZUKI
  • Publication number: 20220226752
    Abstract: Provided is a composition for mononuclear cell-containing plasma separation capable of suppressing a flow of the composition for mononuclear cell-containing plasma separation during storage, capable of satisfactorily forming a partition during centrifugation, and capable of yielding mononuclear cell-containing plasma with little admixture of blood cell components other than mononuclear cells. The composition for mononuclear cell-containing plasma separation according to the present invention contains an organic component having fluidity at 25° C. and two or more kinds of inorganic fine powders, and has a specific gravity of 1.060 or more and 1.080 or less at 25° C.
    Type: Application
    Filed: May 19, 2020
    Publication date: July 21, 2022
    Applicants: SEKISUI MEDICAL CO., LTD., TOKUYAMA SEKISUI CO., LTD
    Inventors: Kuniya KOMAI, Hironobu ISOGAWA, Hideo ANRAKU
  • Publication number: 20220221451
    Abstract: The invention aims to provide an immunochromatographic assay method in which the non-specific reaction is suppressed, and a test strip to be used in the method. The object can be achieved by an immunochromatographic assay method for an analyte, the method including using a test strip including the following (1) to (3): (1) a sample pad containing a sample application region for applying a biological sample that may contain the analyte; (2) an insoluble membrane containing at least one detection region to which a binding partner immunologically reactive with the analyte is immobilized; and (3) a conjugate containing a binding partner immunologically reactive with the analyte, the binding partner being immobilized to a label; characterized in that the conjugate is retained in a conjugate immobilization region together with an anionic surfactant.
    Type: Application
    Filed: March 19, 2020
    Publication date: July 14, 2022
    Applicant: SEKISUI MEDICAL CO., LTD.
    Inventors: Kanako AZUMA, Shohei YAJI, Motoki MORITA
  • Publication number: 20220187290
    Abstract: The invention aims to suppress non-specific reaction effectively in an immunochromatographic assay method for an analyte. The object can be achieved by an immunochromatographic assay method for an analyte, the method including using a test strip including the following (1) to (3): (1) a sample pad containing a sample application region for applying a biological sample that may contain the analyte; (2) an insoluble membrane containing at least one detection region to which a binding partner immunologically reactive with the analyte is immobilized, wherein the binding partner is immobilized to a label; and (3) a conjugate containing a binding partner immunologically reactive with the analyte, wherein the binding partner is immobilized to a label.
    Type: Application
    Filed: March 19, 2020
    Publication date: June 16, 2022
    Applicant: SEKISUI MEDICAL CO., LTD.
    Inventors: Kanako AZUMA, Shohei YAJI, Motoki MORITA
  • Publication number: 20220187287
    Abstract: Disclosed is a sensitized magnetic responsive particle including: a magnetic responsive particle having a core particle and at least one magnetic layer that is disposed on the core particle and includes microparticles of a magnetic metal and/or an oxide thereof; and a substance that is supported on the magnetic responsive Particle and interacts specifically with an analyte, wherein the coefficient of variation in the weight-average particle size of the magnetic responsive particles is 15% or less. The magnetic responsive particle provided has excellent magnetic separability.
    Type: Application
    Filed: March 25, 2020
    Publication date: June 16, 2022
    Applicant: SEKISUI MEDICAL CO., LTD.
    Inventors: Maasa YAJI, Yuya INABA, Shinichiro KITAHARA, Mitsuaki YAMAMOTO, Takeshi WAKIYA, Mai YAMAGAMI, Shuhei OBINATA
  • Publication number: 20220187323
    Abstract: The problem to be solved by the present invention is to provide a reagent that can reduce deposition of fouling in the reaction cell, by using an existing reaction cell, without affecting the composition of the reagent, in an immunoassay method using a reagent containing latex particles; and to provide an immunoassay method using the reagent. Provided is an immunoassay reagent including a latex particle, wherein the latex particle contains a halogen atom. Also provided is an immunoassay method including contacting a latex particle with a sample to be measured in a reaction cell, wherein the latex particle contains a halogen atom.
    Type: Application
    Filed: March 27, 2020
    Publication date: June 16, 2022
    Applicant: SEKISUI MEDICAL CO., LTD.
    Inventors: Mieko OTA, Yuuya INABA, Hiroki KOBAYASHI, Mitsuaki YAMAMOTO
  • Publication number: 20220178915
    Abstract: The invention aims to carry out an immunoassay method for a respiratory tract virus, wherein non-specific reaction is suppressed. The object can be achieved by an immunoassay method for a respiratory tract virus, the method comprising: (A) bringing a biological sample that may contain a respiratory tract virus into contact with an anionic surfactant; (B) bringing the respiratory tract virus into contact with a conjugate, to forma first complex; (C) bringing the first complex into contact with an antibody immunologically reactive with the respiratory tract virus, to forma second complex; and (D) measuring a signal derived from the conjugate.
    Type: Application
    Filed: March 19, 2020
    Publication date: June 9, 2022
    Applicant: SEKISUI MEDICAL CO., LTD.
    Inventors: Kanako AZUMA, Shohei YAJI, Motoki MORITA
  • Publication number: 20220170917
    Abstract: A problem to be solved is to perform an immunoassay method for BG in a biological sample having a sensitivity equivalent to and a reactivity similar to a Limulus amebocyte lysate reagent. The problem can be solved by an immunoassay method for ?-D-glucan in a biological sample, comprising assaying ?-D-glucan in the biological sample by using a monoclonal antibody binding to (1?3)-?-D-glucan having a degree of polymerization of 4.
    Type: Application
    Filed: March 6, 2020
    Publication date: June 2, 2022
    Applicant: SEKISUI MEDICAL CO., LTD.
    Inventors: Ei-ichiro SUNAMURA, Osamu MIYAZAKI, Takuya YOTANI, Shinichiro KITAHARA, Manami IWASAKI
  • Publication number: 20220146537
    Abstract: To provide a method for analyzing coagulation characteristics of a blood specimen. To provide a method for analyzing a blood specimen, including: acquiring a waveform related to a coagulation rate or coagulation acceleration of a sample obtained by mixing a subject blood specimen with a reagent for measuring coagulation time; extracting multiple parameters characterizing the waveform related to a coagulation rate or a coagulation acceleration; and determining an activity level or activity abnormality of a coagulation factor in the subject blood specimen on the basis of the multiple parameters.
    Type: Application
    Filed: January 31, 2020
    Publication date: May 12, 2022
    Applicants: SEKISUI MEDICAL CO., LTD., PUBLIC UNIVERSITY CORPORATION NARA MEDICAL UNIVERSITY
    Inventors: Toshiki KAWABE, Yukio ODA, Midori SHIMA, Keiji NOGAMI, Kenichi OGIWARA
  • Publication number: 20220146529
    Abstract: A problem to be solved is to detect only free AIM in a biological sample containing complex AIM and free AIM. The problem can be solved by an immunoassay method for free AIM in a biological sample using an anti-AIM monoclonal antibody having a property of reacting with free AIM and not reacting with complex AIM, wherein the anti-AIM monoclonal antibody is an antibody binding to an epitope in the SRCR2 domain of human AIM.
    Type: Application
    Filed: January 30, 2020
    Publication date: May 12, 2022
    Applicants: SEKISUI MEDICAL CO., LTD., SOCIAL WELFARE ORGANIZATION "SAISEIKAI" IMPERIAL GIFT FOUNDATION INC.
    Inventors: Toru MIYAZAKI, Tomoko YAMAZAKI, Takeshi OKANOUE, Tomohide ASAI, Yuka KANETSUKI, Jiro HIROTA
  • Publication number: 20220133961
    Abstract: Provided is a clot adhesion preventing agent capable of suppressing adhesion of clot to the inner wall surface of a blood collection container. The clot adhesion preventing agent according to the present invention includes a polyether compound or a silicone oil, and an amino acid.
    Type: Application
    Filed: January 29, 2020
    Publication date: May 5, 2022
    Applicants: SEKISUI MEDICAL CO., LTD., TOKUYAMA SEKISUI CO., LTD.
    Inventor: Kuniya KOMAI
  • Publication number: 20220127314
    Abstract: An object is to provide a leucine-rich ?2 glycoprotein composition comprising leucine-rich ?2 glycoprotein and having excellent preservation stability. The object can be achieved by a leucine-rich ?2 glycoprotein composition comprising leucine-rich ?2 glycoprotein and having a pH of 7.0 to 9.3.
    Type: Application
    Filed: October 8, 2019
    Publication date: April 28, 2022
    Applicants: SEKISUI MEDICAL CO., LTD., NATIONAL INSTITUTES OF BIOMEDICAL INNOVATION, HEALTH AND NUTRITION
    Inventors: Shigeo TAKAYAMA, Tetsuji NAKA, Satoshi SERADA
  • Publication number: 20220120762
    Abstract: A problem to be solved is to further improve the specificity for free AIM of an antibody specifically reacting with free AIM and to diagnose NASH without imposing a burden on patients and medical staffs. The problem can be solved by an immunoassay method for free AIM in a biological sample containing complex AIM and free AIM, and the method comprises bringing the biological sample into contact with an antibody specifically reacting with free AIM in a presence of an anti-IgM antibody.
    Type: Application
    Filed: January 30, 2020
    Publication date: April 21, 2022
    Applicants: SEKISUI MEDICAL CO., LTD., SOCIAL WELFARE ORGANIZATION "SAISEIKAI" IMPERIAL GIFT FOUNDATION INC.
    Inventors: Toru MIYAZAKI, Takeshi OKANOUE, Tomohide ASAI, Yuka KANETSUKI, Jiro HIROTA
  • Publication number: 20220107318
    Abstract: A problem to be solved is to improve the specificity of an anti-AIM antibody for free AIM in a biological sample containing complex AIM and free AIM. The problem can be solved by an immunoassay method for measuring an amount of free AIM in a biological sample containing complex AIM and free AIM, and the method comprises bringing the biological sample into contact with an anti-AIM antibody in the presence of an anti-IgM antibody.
    Type: Application
    Filed: January 30, 2020
    Publication date: April 7, 2022
    Applicants: SEKISUI MEDICAL CO., LTD., SOCIAL WELFARE ORGANIZATION "SAISEIKA" IMPERIAL GIFT FOUNDATION INC.
    Inventors: Toru MIYAZAKI, Takeshi OKANOUE, Tomohide ASAI, Yuka KANETSUKI, Jiro HIROTA
  • Publication number: 20220090048
    Abstract: Provided is a nucleic acid isolation method whereby it becomes possible to extract a nucleic acid in a simple manner without the need to use an alcohol. A nucleic acid isolation method, comprising the steps of: mixing a specimen containing a nucleic acid with an extraction solution to disperse the nucleic acid in the extraction solution; bringing the extraction solution containing the nucleic acid into contact with an anionic adsorbent; bringing a washing solution into contact with the anionic adsorbent; and bringing a collection solution into contact with the anionic adsorbent, the extraction solution containing a protein denaturant, the washing solution containing a basic compound and having a pH value equal to or less than a pKa value of a conjugate acid of the basic compound, and the collection solution having a pH value equal to or more than the pKa value of the conjugate acid of the basic compound.
    Type: Application
    Filed: January 17, 2020
    Publication date: March 24, 2022
    Applicants: SEKISUI CHEMICAL CO., LTD., SEKISUI MEDICAL CO., LTD.
    Inventors: Takamasa KOUNO, Nobuhiko INUI, Tsutomu NAKAMURA, Tomoya SASAKI, Sou YAMAGUCHI, Katsura UCHIDA
  • Patent number: 11275085
    Abstract: A problem of the present invention is to provide an immunochromatographic test strip avoiding agglutination of colloidal gold while red blood cells in whole blood are agglutinated and then separated and removed in the case of using polybrene as a hemagglutinating agent and the colloidal gold conjugates as a detection reagent, and to provide immunochromatography using the test strip. To solve the problem, the present inventors reviewed the composition of the existing reagent itself from a completely different viewpoint rather than the selection of type or amount of polyanions, and as a result of extensive study on each element, the inventors surprisingly found that agglutination of colloidal gold may be suppressed by using a particular additive without neutralization by polyanions.
    Type: Grant
    Filed: August 13, 2019
    Date of Patent: March 15, 2022
    Assignee: SEKISUI MEDICAL CO., LTD.
    Inventors: Keigo Kohno, Mayumi Yoshida, Mitsuaki Yamamoto, Shinya Yokokawa, Marie Asami