Patents Assigned to Sekisui Medical Co., Ltd.
-
Publication number: 20210079456Abstract: An object of the present invention is to provide a method for highly sensitively detecting, and a method for quantifying, a mutant gene (mutant allele) contained at a low frequency in a nucleic acid sample containing a wild-type allele. In one-reaction system in which a first-primers set designed to flank a mutation site of a gene of interest is mixed with a second-primers set including an ASP corresponding to the mutation, an amplification product can be obtained from a low-frequency mutant gene, and quantitativeness can be ensured, by including a competitive nucleic acid suppressing an amplification reaction from a wild-type allele of the gene, selecting a certain primer concentration condition, and controlling the cycle numbers of PCR reactions using the first and second-primers sets.Type: ApplicationFiled: July 25, 2018Publication date: March 18, 2021Applicant: SEKISUI MEDICAL CO., LTD.Inventors: Hiroyuki EBINUMA, Yuriko TSUKAMOTO
-
Publication number: 20210079028Abstract: Provided is an alkyldiphenylmethane protective agent, which can prevent solidification or insolubilization of a compound by protecting a functional group of the compound to achieve easy separation and purification after a reaction.Type: ApplicationFiled: November 27, 2020Publication date: March 18, 2021Applicant: SEKISUI MEDICAL CO., LTD.Inventors: Shinya YANO, Kenta SAITO, Hideki KUBOTA
-
Publication number: 20210061820Abstract: Metal complex particle including a magnetic material and a particle size adjusting composition containing a hydrophobic polymer, with the magnetic material including a metal complex consisting of a metal ion and a ligand and having both magnetism and fluorescence, and a content of the particle size adjusting composition in the metal complex particle being less than 60 w %.Type: ApplicationFiled: December 28, 2018Publication date: March 4, 2021Applicants: SEKISUI CHEMICAL CO., LTD., SEKISUI MEDICAL CO., LTD.Inventors: Mai YAMAGAMI, Shuhei OBINATA, Takeshi WAKIYA, Maasa YAJI
-
Patent number: 10921260Abstract: An optical measuring device includes a measuring unit (an optical head and a control unit) that irradiates a detection portion of an immunochromatographic test piece with measurement light and measures light obtained from the detection portion due to the irradiation with the measurement light, and a determination unit that performs a determination regarding the immunochromatographic test piece on the basis of a determination according to a comparison of a measurement value obtained by the measuring unit with a preset threshold value, the measuring unit performs the measurement of the light obtained from the detection portion a plurality of times, and the determination unit performs a determination regarding the immunochromatographic test piece when the determination unit determines that a measurement value in an nth measurement is equal to or greater than the threshold value and also determines that a measurement value in an (n+1)th measurement is equal to or greater than the threshold value.Type: GrantFiled: October 5, 2016Date of Patent: February 16, 2021Assignees: HAMAMATSU PHOTONICS K.K., SEKISUI MEDICAL CO., LTD.Inventors: Naoyuki Honda, Kengo Sadamori, Daichi Susuki, Keigo Kohno, Motoki Morita
-
Publication number: 20210040128Abstract: An object of the present invention is to develop a protecting group, which can prevent solidification or insolubilization of a compound by protecting a functional group to achieve easy separation and purification after a reaction. A diphenylmethane compound represented by general formula (1): wherein Y represents —OR19 (wherein R19 represents a hydrogen atom or an active ester-type protecting group), —NHR20 (wherein R20 represents, for example, a hydrogen atom, a C1-6 linear or branched alkyl group, or an aralkyl group, at least one of R1 to R01 represents a group represented by formula (2): —O—R11—X-A??(2) and the others each independently represent a hydrogen atom, a halogen atom, a C1-4 alkyl group, or a C1-4 alkoxy group; R11 represents a C1-16 linear or branched alkylene group; X represents O or CONR21 (wherein R21 represents a hydrogen atom, or a C1-4 alkyl group; and A represents, for example, a group represented by formula (3).Type: ApplicationFiled: October 20, 2020Publication date: February 11, 2021Applicant: SEKISUI MEDICAL CO., LTD.Inventors: Shinya YANO, Hideki KUBOTA
-
Publication number: 20210017564Abstract: What is required is a method of producing, without treating a glycoprotein in a biological sample with a denaturing agent in advance, a selectively binding material, which specifically reacts with a glycan of a glycoprotein, a selectively binding material such as antibody thus produced by the method, and a method of specifically detecting a glycoprotein by using the selectively binding material. In order to solve the problems, the present invention produces a selectively binding material specifically reactive with a glycan of a glycoprotein by treating the glycoprotein with a glycan-specific glycan-cleaving enzyme.Type: ApplicationFiled: September 29, 2020Publication date: January 21, 2021Applicant: SEKISUI MEDICAL CO., LTD.Inventors: Tomohiro MIURA, Tomo SHIMIZU, Osamu MIYAZAKI
-
Publication number: 20210017290Abstract: The antigen specificity of the antibody that recognizes a glycan antigen and is used as a tumor marker is not sufficient, and it has been a drawback that tumor marker detection using such an antibody is low in detection specificity, thereby deteriorating accuracy of cancer diagnosis. To solve the object described above, the present invention provides an antibody specifically reactive with a glycan of NCC-ST-439 antigen for use as a tumor marker, and a production method thereof.Type: ApplicationFiled: March 29, 2019Publication date: January 21, 2021Applicant: SEKISUI MEDICAL CO., LTD.Inventors: Tomohiro MIURA, Osamu MIYAZAKI
-
Publication number: 20210017263Abstract: The antigen specificity of the antibody that recognizes a glycan antigen and is used as a tumor marker is not sufficient, and it has been a drawback that tumor marker detection using such an antibody is low in detection specificity, thereby deteriorating accuracy of cancer diagnosis. To solve the object described above, the present invention provides an antibody specifically reactive with a glycan of DUPAN-2 antigen for use as a tumor marker, and a production method thereof.Type: ApplicationFiled: March 29, 2019Publication date: January 21, 2021Applicant: SEKISUI MEDICAL CO., LTD.Inventors: Tomohiro MIURA, Osamu MIYAZAKI
-
Publication number: 20210009611Abstract: The purpose of the present invention is to provide a protecting group which improves the solubility of a compound having a functional group protected with the protecting group in an organic solvent and which is easily separated and purified after a reaction with avoiding solidification or insolubilization.Type: ApplicationFiled: September 25, 2020Publication date: January 14, 2021Applicant: SEKISUI MEDICAL CO., LTD.Inventors: Shinya YANO, Yuki WAKASUGI, Yosuke IWANAGA
-
Patent number: 10870667Abstract: Provided is an alkyldiphenylmethane protective agent, which can prevent solidification or insolubilization of a compound by protecting a functional group of the compound to achieve easy separation and purification after a reaction.Type: GrantFiled: November 27, 2018Date of Patent: December 22, 2020Assignee: SEKISUI MEDICAL CO., LTD.Inventors: Shinya Yano, Kenta Saito, Hideki Kubota
-
Publication number: 20200393472Abstract: Provided is a method for separating and detecting various hemoglobins including abnormal hemoglobins and thalassemia markers. A method for analyzing hemoglobins, comprising separating hemoglobins in a sample by cation exchange chromatography, wherein an eluent having a pH of 8.1 or more and an osmotic pressure of 40 mOsm/kg or less is used for separation of the hemoglobins.Type: ApplicationFiled: April 18, 2019Publication date: December 17, 2020Applicant: SEKISUI MEDICAL CO., LTD.Inventors: Hiroaki TAIRA, Ei-ichiro SUNAMURA, Kohei MATSUDA, Takuya YOTANI
-
Patent number: 10851120Abstract: An object of the present invention is to develop a protecting group, which can prevent solidification or insolubilization of a compound by protecting a functional group to achieve easy separation and purification after a reaction. A diphenylmethane compound represented by general formula (1): wherein Y represents —OR19 (wherein R19 represents a hydrogen atom or an active ester-type protecting group), —NHR20 (wherein R20 represents, for example, a hydrogen atom, a C1-6 linear or branched alkyl group, or an aralkyl group, at least one of R1 to R10 represents a group represented by formula (2): —O—O—R11—X-A??(2) and the others each independently represent a hydrogen atom, a halogen atom, a C1-4 alkyl group, or a C1-4 alkoxy group; R11 represents a C1-16 linear or branched alkylene group; X represents O or CONR21 (wherein R21 represents a hydrogen atom, or a C1-4 alkyl group; and A represents, for example, a group represented by formula (3).Type: GrantFiled: June 19, 2017Date of Patent: December 1, 2020Assignee: SEKISUI MEDICAL CO., LTD.Inventors: Shinya Yano, Hideki Kubota
-
Publication number: 20200355679Abstract: To provide an immunochromatographic test device capable of accurate diagnosis even when an excess sample is introduced. Provided is the immunochromatographic test device consisting: a test strip; a lower housing including a plurality of support bases that support the test strip; and an upper housing including a dropping hole for dropping a sample into the test strip and a detection window in a direction in which the sample introduced from the dropping hole develops on the test strip, wherein a width of the support base that supports portion of the test strip exposed from the detection window is smaller than a width of the test strip, or wherein among the plurality of support bases, the width of the support base arranged on the lower housing between a position corresponding to the detection window and a position corresponding to the dropping hole is larger than the width of the test strip.Type: ApplicationFiled: December 14, 2018Publication date: November 12, 2020Applicant: SEKISUI MEDICAL CO., LTD.Inventors: Kanako AZUMA, Shinya OKUYAMA, Kazunori SAITO, Keigo KOHNO, Motoki MORITA
-
Patent number: 10830771Abstract: Disclosed is a means of enabling the construction of a more accurate PIVKA-II immunoassay system using monoclonal antibodies against human prothrombin. The PIVKA-II assay method according to the present invention comprises measuring PIVKA-II in a sample by an immunoassay using an anti-PIVKA-II antibody or an antigen-binding fragment thereof which specifically binds to PIVKA-II and a mixture of a first anti-prothrombin antibody or an antigen-binding fragment thereof which recognizes hydrophilic PIVKA-II molecules and a second anti-prothrombin antibody or an antigen-binding fragment thereof which recognizes hydrophobic PIVKA-II molecules.Type: GrantFiled: October 6, 2016Date of Patent: November 10, 2020Assignees: FUJIREBIO INC., SEKISUI MEDICAL CO., LTD.Inventors: Yoshiyuki Kitamura, Katsumi Aoyagi
-
Publication number: 20200348227Abstract: Provided are a carbon isotope analysis device high in partial pressure of carbon dioxide isotope in gas sent into as optical resonator, and high in sensitivity performance and analytical accuracy, and an analysis method by use of the carbon isotope analysis device. A carbon isotope analysis device including a carbon dioxide isotope generator provided with a combustion unit that generates gas containing carbon dioxide isotope from carbon isotope, and a carbon dioxide isotope purifying unit; a spectrometer including an optical resonator having a pair of mirrors, and a photodetector that determines intensity of light transmitted from the optical resonator; a carbon dioxide trap including a cooler for freezing the carbon dioxide isotope, the carbon dioxide trap being disposed between the carbon dioxide isotope generator and the spectrometer; and a light generator.Type: ApplicationFiled: January 22, 2019Publication date: November 5, 2020Applicants: SEKISUI MEDICAL CO., LTD., NATIONAL UNIVERSITY CORPORATION TOKAI NATIONAL HIGHER EDUCATION AND RESEARCH SYSTEMInventors: Atsushi SATOU, Tetsuo IGUCHI, Hideki TOMITA, Norihiko NISHIZAWA
-
Patent number: 10822357Abstract: The purpose of the present invention is to provide a protecting group which improves the solubility of a compound having a functional group protected with the protecting group in an organic solvent and which is easily separated and purified after a reaction with avoiding solidification or insolubilization.Type: GrantFiled: August 25, 2016Date of Patent: November 3, 2020Assignee: SEKISUI MEDICAL CO., LTD.Inventors: Shinya Yano, Yuki Wakasugi, Yosuke Iwanaga
-
Publication number: 20200325163Abstract: Provided is an alkyldiphenylmethane protective agent, which can prevent solidification or insolubilization of a compound by protecting a functional group of the compound to achieve easy separation and purification after a reaction.Type: ApplicationFiled: November 27, 2018Publication date: October 15, 2020Applicant: SEKISUI MEDICAL CO., LTD.Inventors: Shinya YANO, Kenta SAITO, Hideki KUBOTA
-
Publication number: 20200232977Abstract: The present invention is directed to a method for avoiding the influence of a blood sample on a measurement error in a latex agglutination immunoassay. The measurement error caused by a blood sample in a latex agglutination immunoassay can be reduced by a method which includes a step of bringing the sample into contact, in a liquid phase, with latex particles carrying a substance having a specific affinity for an analyte in the presence of imidazole.Type: ApplicationFiled: September 29, 2017Publication date: July 23, 2020Applicant: SEKISUI MEDICAL CO., LTD.Inventors: Kengo FUJIMURA, Junichi KONDOU, Mitsuaki YAMAMOTO
-
Publication number: 20200216909Abstract: It is intended to provide highly sensitive and specific, rapid, and convenient method for evaluating a risk of hepatocellular carcinoma. The method for evaluating a risk of hepatocellular carcinoma comprises: (1) amplifying bisulfite-treated DNA derived from a liver tissue of a subject, wherein the DNA comprises a CpG site of an exon region of MGRN1 gene; (2) subjecting the obtained amplification product to ion exchange chromatography; and (3) determining whether or not the DNA is DNA obtained from a subject having a high risk of development of hepatocellular carcinoma on the basis of a peak shape of a detection signal of the chromatography.Type: ApplicationFiled: August 23, 2018Publication date: July 9, 2020Applicants: NATIONAL CANCER CENTER, SEKISUI MEDICAL CO., LTD.Inventors: Yae KANAI, Eri ARAI, Takuya YOTANI, Ei-ichiro SUNAMURA
-
Patent number: D909589Type: GrantFiled: April 8, 2019Date of Patent: February 2, 2021Assignee: SEKISUI MEDICAL CO., LTD.Inventors: Keigo Kohno, Motoki Morita, Saori Nozaki, Masato Nishikawa, Kumiko Yuki, Shun Sakai