Abstract: An assembly of a drug delivery system, comprising: a first component; a second component which is configured to move linearly with respect to the first component; and, a resistance element configured to resist linear movement during transport of the first component with respect to the second component in a closed transport configuration but which is adapted to be overcome during nominal operation of the drug delivery system.

Abstract: An oral product includes a body that is wholly receivable in an oral cavity. The body includes a mouth-soluble polymer matrix, cellulosic fibers embedded in the mouth-soluble polymer matrix, and nicotine or a derivative thereof dispersed in the mouth-soluble polymer matrix. The oral product is adapted to release the nicotine or a derivative thereof from the body when the body is received within the oral cavity and exposed to saliva.

Abstract: A control system and method for a well drilling platform having a plurality well platform systems is provided. The control system includes at least one remote communication unit (RCU), and a controller. The controller is in communication with the well platform systems, and has at least one processor, and a memory device that is coupled to the processor and that stores the instructions. When executed by the processor, the instructions cause the controller to communicate with the well platform systems to receive information from one or more well platform systems and to send system control commands to the one or more well platform systems. The controller and the at least one RCU are configured to electronically communicate with one another information relating to at least one of the well platform systems.

Abstract: Dynamic caching policies and/or dynamic purging policies are provided for modifying the entry and eviction of content to the cache (e.g., storage and/or memory) of a caching server based on the current and past cache performance and/or demand. The caching server may modify or replace a configured policy when cache performance is below one or more thresholds. Modifying the caching policy may change caching behavior of the caching server by changing the conditions that control the content that is entered into cache or the content that is deferred and not entered into cache after a request. This may include assigning different probabilities for entering the same content into cache based on different caching policies. Modifying the purging policy may change eviction behavior of the caching server by changing the conditions that control the cached content that is selected and removed from cache.

Abstract: An electrical submersible pump comprising a fallback bearing protection system, the system comprising: locking member; boot pivotally connected to shaft of electrical submersible pump adjacent to locking member, wherein the boot comprises a sloped outer wall capable of forming a fluid boundary thereby diverting fallback fluid away from uppermost bearing of electrical submersible pump; ridge disposed on the sloped outer wall of the boot.

Abstract: The present disclosure provides a valve assembly comprising a valve section, a power section, and an electronics section. The valve assembly is configured to mate with a tubing sub (and/or mandrel) inserted in-line with a tubing string inserted into a wellbore. The valve allows for injection into or production from the tubing string. The valve assembly comprises an electric motor and a motor controller permitting fine control over the valve, as well as sensors which measure various parameters, such as fluid flow, valve position, pressure, temperature, and/or water cut. A cable connects the valve assembly to the surface and provides power and data telemetry and allows control of the valve assembly with a remote electronic signal. Multiple valve assemblies may be provided at spaced intervals along the tubing string and individually monitored and/or controlled by a remote location. Also disclosed is a method for operation of such valve assemblies.

Abstract: Selectable control valves and mattress systems incorporating the same are disclosed. In one embodiment, an inflatable mattress system includes a pump, a selectable control valve in fluid communication with the pump, and a mattress pad having a plurality of inflatable chambers that are in fluid communication with the selectable control valve. The selectable control valve includes a valve case having an inlet port and a plurality of supply ports, a stepper motor having a motor body that is coupled to the valve case, a rotating plate having a passage and coupled to the stepper motor, and a plurality of seal cartridges positioned within the valve case. The seal cartridges each include an engagement spring and a compliant seal, where the engagement spring maintains a load on the compliant seal such that the compliant seal forms a fluid tight seal with the rotating plate.

Abstract: A pre-set inhibiting extrusion limiter has a segmented anti-extrusion ring with a plurality of anti-extrusion ring segments supported by a stepped cone frustum. Each ring segment is retained in a run-in condition by a compression spring retained by a retainer ring held in a retainer ring groove in the respective anti-extrusion ring segments. A push ring moves the respective anti-extrusion ring segments from the run-in condition to a packer-set condition in which the anti-extrusion ring segments abut a cone frustum step of the stepped cone frustum.

Abstract: The present application provides methods for the detection and diagnosis of cancer. In one aspect, the application provides methods for detecting the presence of cancer in an individual by detecting the methylation state of a region in the promoter of the ZNF154 gene. Methods are provided for detection and diagnosis of cancer from circulating tumor DNA which are minimally invasive and have diagnostic utility across different types and sub-types of cancer. In a further aspect, bioinformatics methods are provided to analyze the methylation state of the ZNF154 promoter and relate the methylation state to the likelihood of cancer in the individual.

Abstract: The present application relates sensing reactive components in fluids by monitoring band gap changes to a material having interacted with the reactive components via physisorption and/or chemisorption. In some embodiments, the sensors of the present disclosure include the material as a reactive surface on a substrate. The band gap changes may be detected by measuring conductance changes and/or spectroscopic changes. In some instances, the sensing may occur downhole during one or more wellbore operations like drilling, hydraulic fracturing, and producing hydrocarbons.

Abstract: Methods and systems for treating a subterra-nean formation. An example method comprises pumping an aerosol comprising a vaporized carrier fluid and a dispersed polyhydroxyetheramine in a wellbore penetrating the sub-terranean formation; depositing the polyhydroxyetheramine on a surface of the subterranean formation; and producing hydrocarbons from the treated subterranean formation.

Abstract: Provided is a compound of formula (I) in which Ar1, R1, U, V, W, X, and p are as described herein. Also provided are methods of using a compound of formula (I), including a method of treating cancer, a method of treating a patient with cancer cells resistant to an anti-cancer agent, and a method of inhibiting lactate dehydrogenase A (LDHA) and/or lactate dehydrogenase B (LDHB) activity in a cell.

Abstract: Compression set downhole clutch (100) can include an upper body (201), a lower body (202), and a hydraulic member (205). The upper body (201) can include at least one engagement surface (204). The lower body (202) can include at least one engagement surface (203). The at least one engagement surface (204) of the upper body (201) and the at least one engagement surface (203) of the lower body (202) can each be configured to couple with one another and rotate in unison in an engaged configuration (102). The hydraulic member (205) can be configured to be responsive to a predetermined pressure; the hydraulic member (205) can also be configured to disengage the engagement surface (204) of the upper body (201) from the engagement surface (203) of the lower body (202).

Abstract: Methods and apparatus are disclosed for retaining components in a downhole motor in the event of a mechanical separation or failure of one or more components therein. As described, the retention mechanism does not require a threaded connection to components of the mud motor drivetrain. Downhole motor assemblies including the new catch mechanism also include a structural element to engage the catch assembly and the components to which it is attached in the event of a mechanical failure within the mud motor assembly.

Abstract: Disclosed are recombinant insect ferritin nanoparticles that can be used to display two different trimeric antigens at an equal ratio. Also disclosed are nucleic acids encoding the recombinant insect ferritin nanoparticles and methods of producing the recombinant insect ferritin nanoparticles. Methods for eliciting an immune response in a subject are also provided.

Abstract: Various embodiments described herein are generally directed to techniques for identifying the availability of an enterprise to provide products, for example, banking products and/or services. Embodiments may include using an availability manager informed by resource status data to determine if an enterprise facility is available to provide at least one product. In some embodiments, at least some data used to determine the availability of an enterprise facility may be collected from sensors and/or transducers associated with the enterprise facility. Various embodiments may include using a machine learning model to analyze enterprise resource availability to determine enterprise facility availability to provide products. In some aspects described herein, at least one record may be updated with resource status information, facility availability, available product set information, and/or estimated lead time information.

Abstract: This disclosure relates generally to methods and systems for providing exactly-once transaction semantics for fault tolerant FPGA based transaction systems. The systems comprise middleware components in a server as well as client end. The server comprises Hosts and FPGAs. The FPGAs control transaction execution (the application processing logic also resides in the FPGA) and provide fault tolerance with high performance by means of a modified TCP implementation. The Hosts buffer and persist transaction records for failure recovery and achieving exactly-once transaction semantics. The monitoring and fault detecting components are distributed across the FPGA's and Hosts. Exactly-once transaction semantics is implemented without sacrificing performance by switching between a high performance mode and a conservative mode depending on component failures. PCIE switches for connectivity between FPGAs and Hosts ensure FPGAs are available even if Hosts fail.

Abstract: Aspects described herein may provide detection of a feature of an authorization code image (ACI) incorporated onto a document, thereby allowing for validation of the document. According to some aspects, these and other benefits may be achieved by an instance of a variable protocol that may specify how to generate the ACI to have a particular feature as well as how to detect the particular feature of the ACI. A recipient of the document incorporating the ACI may detect the particular feature of the ACI. If the detected feature matches an expected feature, then the ACI and the document may be determined to be authentic.

Abstract: Techniques for optimizing vehicle license plate recognition in images and their decoding include training a set of convolutional neural networks (CNNs) by using images in which license plates are identified or labeled as a whole, rather than by license plate parts or key points, and rather than by the individual, segmented characters represented thereon. The trained CNNs may operate on target images of environments to localize images of license plates included therein and determine the issuing jurisdiction and/or ordered set of characters represented on detected license plates without utilizing character segmentation and/or per-character recognition techniques. As such, license plates depicted within target images are able to be detected and decoded with greater tolerances for lighting conditions, deformations or damages, occlusions, differing image resolutions, differing angles of capture, variations of other objects depicted within the images (such as dense or changing signage), etc.

Abstract: A computer-implemented system and method for facilitating rental of a private parking space by an urban resident are provided. Motor vehicle parking spaces located in a residential area are managed through a server. Smart parking devices that are each physically proximate to least one of the parking spaces are interfaced to the server. Vehicle occupancy sensors that are also each physically proximate to least one of the parking spaces are interfaced to the server. Parking availability indicators that are each associated with at least one of the parking spaces are interfaced to the server. The parking spaces are supplemented with a private parking space under legitimate control by a resident of the residential area. Use of the private parking space is managed through the server and the smart parking device nearest to the private parking space. Parking availability the parking spaces is indicated through the nearest parking availability indicator.