Abstract: Disclosed is a method of administering an interleukin-2 receptor (IL-2R) antagonist to a subject to treat an autoimmune disease. In particular embodiments, the IL-2R antagonist is an anti-IL-2R monoclonal antibody specific for one or more chains of the IL-2R, such as the alpha-chain, for example daclizumab. In other particular embodiments the autoimmune disease is multiple sclerosis. In certain embodiments administration of interferon-beta is combined with administration of an antagonist of the IL-2R to provide significant clinical improvement in a subject with an autoimmune disease.

Abstract: A method is disclosed. The method includes generating a verification value in response to a transaction involving a portable consumer device, where the verification value is generated using a first dynamic data element and a second dynamic data element. The verification value is sent to a service provider associated with the portable consumer device so that the service provider can verify the transaction.

Abstract: The availability of one or more agents of an institution to communicate with a user may be determined and reported to the user. An application on a user computing device may provide an indication as to how many agents are currently available to speak with the user and/or a wait time until an agent becomes available. The user computing device may display a call icon that the user may select to place a call to an available agent. The user computing device may display a call icon that the user may select to receive a callback from an available agent. Call volume statistics may be provided to the user and may be used to determine when an agent is most likely unavailable and/or most likely available.

Abstract: An apparatus for harvesting agricultural row crops having stalks, comprising a frame having a front portion and a rear portion, the frame configured for traversing along a field of row crops; a hollow arm mounted adjacent an upper section of the front portion of the frame, the hollow arm comprising a first section disposed along an incline formed by the upper section of the front portion of the frame and the ground, the first section having a first end and a second end; an inlet positioned adjacent the first end of the first section of the hollow arm, the inlet for receiving stalks of row crops; device for cutting stalks of row crops, the device for cutting stalks mounted within the first section of the hollow arm; device for engaging and conveying the stalks along the hollow arm; and a biased guide assembly for accommodating stalks of varied diameters.

Abstract: A through casing formation evaluation tool string 1000, 2000, 3000 including a conveyance string 100, a sonic array tool 200, a pulsed neutron tool 400 and one or more downhole memory modules 160, 540, 550. A method of through casing formation evaluation and casing and cementing integrity evaluation includes lowering a tool string into a cased wellbore; concurrently collecting data with the sonic array tool and pulsed neutron tool and transmitting at least a portion of the collected data via a conveyance string to a CPU located at the surface of the earth; storing a portion of the collected data in a memory module disposed in the tool string; removing the tool string from the wellbore; processing the collected data in the CPU to obtain selected rock property data about the one or more of the geologic formations and/or cement integrity.

Abstract: Systems and methods for direct and indirect measurement of the density of a fluid which exhibits sag characteristics is disclosed. The sag measurement system includes a test container for holding a fluid mixture to be analyzed and a suction port on the test container. A pump is coupled to the suction port for circulating the fluid mixture from the test container through a circulation loop. A measurement device is coupled to the circulation loop and a return port directs the fluid mixture from the circulation loop back to the test container at substantially the same vertical location as the suction port. The fluid mixture flowing through the circulation loop passes through the measurement device before returning to the test container through the return port. The measurement device is operable to monitor the particle distribution of the fluid mixture as it changes due to gravity.

Abstract: An acoustical fluid control mechanism and a method of controlling fluid flow of a working fluid with the acoustical fluid control mechanism are provided. The mechanism comprises a resonance chamber that defines a cavity. The resonance chamber has a port. The cavity is sealed from the ambient but for the port for enabling oscillatory flow of a working fluid into and out of the cavity upon exposure of the resonance chamber to an acoustic signal containing a tone at a frequency that is substantially similar to a particular resonance frequency of the resonance chamber. The mechanism further includes a rectifier for introducing directional bias to the oscillatory flow of the working fluid through the port. The rectifier has an inlet connected to the port and an outlet for transmitting the directional flow of the working fluid away from the cavity. The outlet is in fluid communication with the port of the resonance chamber at least during transmission of the directional flow of the working fluid therethrough.

Abstract: Disclosed herein is the finding that treatment with a ROCK inhibitor increases proliferation and induces immortalization of primary keratinocytes. Accordingly, provided is a method of immortalizing primary keratinocytes by exposure to a ROCK inhibitor. Also provided are immortalized primary keratinocytes produced by the described method, as well as organotypic tissue equivalents and cell cultures comprising the immortalized primary keratinocytes. Furthermore, ROCK inhibitor-treated cells show a greatly increased ability to support viral DNA replication of both “low risk” and “high risk” HPV genomes, indicating that ROCK inhibitors will be useful for studying the life cycles of a wide range of HPVs.

Abstract: A controlled aperture ball drop includes a ball cartridge that is mounted to a frac head or a high pressure fluid conduit. The ball cartridge houses a ball rail having a bottom end that forms an aperture with an inner periphery of the ball cartridge through which frac balls of a frac ball stack supported by the ball rail are sequentially dropped from the frac ball stack as a size of the aperture is increased by an aperture controller operatively connected to the ball rail.

Abstract: Cyclized peptide compounds containing the NGR motif of formula (I) or a pharmaceutically-acceptable salt thereof are disclosed. Compositions comprising the cyclized peptide compounds and methods of their use are also disclosed.

Abstract: Position indication in multiplexed downhole well tools. A method of selectively actuating and indicating a position in a well includes selecting at least one well tool from among multiple well tools for actuation by flowing direct current in one direction through a set of conductors in the well, the well tool being deselected for actuation when direct current flows through the set of conductors in an opposite direction; and detecting a varying resistance across the set of conductors as the selected well tool is actuated, the variation in resistance providing an indication of a position of a portion of the selected well tool.

Abstract: Methods and systems for providing supplemental insurance to insure the deductible amount of a primary insurance policy are described. In an example, data is received about a first insurance policy of an insured party; a deductible amount of the first insurance policy is determined; a premium to insure the deductible amount is determined using a computing device and a second insurance policy for the deductible amount is offered to the insured party. In an example, the first insurance policy may be provided by a third party provider. In an example, all of the deductible amounts of the insured party's insurance policies may be added and supplemental insurance for the total deductible amount offered. In an example, the deductible amounts of a group of insured members may be added and supplemental insurance for the total deductible amount offered. In an example, the deductible amount of an insurance policy may be added to a loan.

Abstract: Peptides generated from a random library that are bound by a monoclonal antibody to Chlamydial glycolipid exoantigen (GLXA) and thus mimic this antigen are disclosed. Peptides that correspond to antigen-binding regions of an anti-idiotypic antibody (mAb2) specific for anti-GLXA antibody (Ab1) which act as molecular mimics of GLXA are also disclosed used as immunogens to induce broadly reactive genus-specific anti-chlamydial antibodies. These peptides and immunogenic DNA encoding the mAb2-like peptides, microparticle or nanoparticle formulations and other formulations of these peptides are disclosed as are methods for immunizing subjects to obtain genus-specific anti-chlamydial antibodies and to treat or prevent Chlamydia-associated or induced rheumatoid arthritis.

Abstract: Methods and compositions are provided for the use of an envelope polypeptide or a functional variant thereof from a lentivirus that is not HIV-1 as a molecular scaffold for HIV-1 epitopes. The HIV-1 epitopes can be recognized by HIV-1 binding antibodies, HIV-1 neutralizing antibodies and/or CD4-induced antibodies. Thus, methods are provided for detecting HIV-1 binding antibodies in a subject infected with HTV-1. Further provided are methods to determine an epitope for an HIV-1 binding antibody; methods to assay for an HIV-1 binding antibody; methods to identify a soluble CD4 mimic; methods to neutralize an non-HIV-1 virus; diagnostic assays to monitor HIV disease in a subject or to monitor the subject's response to immunization by a HIV vaccine; and methods to alter the neutralization potential of an HIV-1 derived CD4-induced antibody. Chimeric polypeptides, chimeric polynucleotides, kits, cells and viruses are also provided.

Abstract: A physical phantom reference to control for variability of computed tomography measurement results duplicates the density curve of blood perfusion of contrast material in a healthy aorta or large artery to normalize observed changes in healthy arterial blood perfusion when calculating the reduction in tumor blood perfusion between two examination times. In one embodiment, a plurality of compartments with different concentrations of contrast material corresponding to a density curve of blood perfusion of a healthy tissue are positioned-in a screening field of a CT machine so the CT machine images the compartments when it images the healthy tissue. In another embodiment, a pipe containing fluid receives an injection of contrast material from the injector when the injector injects the contrast material into the patient, the pipe having sections of varying diameter so the sections together correspond to a blood perfusion curve of the contrast material in a healthy tissue.

Abstract: The present invention relates generally to multi-trace electrical connectors for harsh environments. More particularly, the present invention relates to bayonet rotary electrical connectors which maintain electrical connection dynamically, and which may have replaceable connector components. This type of connector is used, for example, in drilling operations where the connector must be rotated, for example during assembly, disassembly, or operation of bottom hole equipment or sensor or communications packages, and where the electrical connection may be maintained.

Abstract: A method for treating a catalyst base that comprises a contact area of porous material. A fluid, such as a flue gas stream, can be conducted along the contact area. A catalytically relevant substance is introduced into pores of the catalyst base using a transport fluid and remains on pore wall areas after removal of the transport fluid. The introduction is carried out such that an amount of the catalytically relevant substance relative to the surface remains on the pore wall areas as a function of location within the pore and decreases within the pore after exceeding a specific pore depth. A blocking fluid can first be introduced into pore regions beyond the specific pore depth, thus blocking these regions when transport fluid containing the catalytically relevant substance is introduced.

Abstract: A method of servicing a wellbore in contact with a subterranean formation comprising placing a wellbore servicing fluid comprising a polyuronide polymer within the wellbore, contacting the wellbore servicing fluid with a divalent ion source, and allowing the wellbore servicing fluid to form a gel within the wellbore wherein the divalent ion source is located within the wellbore. A method of servicing a wellbore in contact with a subterranean formation comprising (a) placing a wellbore servicing fluid comprising a polyuronide polymer into the wellbore wherein the wellbore servicing fluid contacts a calcium ion source, (b) shutting the wellbore and allowing the servicing fluid to set into place for a period of time, and (c) repeating steps (a) and (b) until the permeability of a structure within the wellbore is reduced by about 50%.

Abstract: An apparatus for isolating a first zone from a second zone in a subterranean wellbore. The apparatus includes an outer tubular and an inner tubular disposed within the outer tubular forming an annular flow path therebetween that is in fluid communication with the first zone. The inner tubular defines a central flow path that is in fluid communication with the second zone. A sleeve having at least one seal is positioned in the annular flow path and is axially movable relative to the inner and outer tubulars between a closed position wherein the seal engages the inner tubular and an open position wherein the seal engages the outer tubular. A mandrel is slidably disposed within the inner tubular and is coupled to the sleeve. The mandrel is operable to shift the sleeve between the open position and the closed position responsive to changes in pressure within the central flow path.