Abstract: This disclosure concerns the discovery of (R,R)- and (R,S)-fenoterol analogues which are highly effective at binding ?2-adrenergic receptors. Exemplary chemical structures for these analogues are provided. Also provided are pharmaceutical compositions including the disclosed (R,R)-fenoterol and fenoterol analogues, and methods of using such compounds and compositions for the treatment of cardiac disorders such as congestive heart failure and pulmonary disorders such as asthma or chronic obstructive pulmonary disease.
Type:
Application
Filed:
March 6, 2014
Publication date:
January 14, 2016
Applicant:
The USA, as represented by the Secretary, Department of Health and Human Services
Inventors:
Irving William Wainer, Weizhong Zhu, Khalid Chakir, Rui-Ping Xiao, Darrell R. Abernethy, Farideh M. Beigi Abhari
Abstract: Patient care equipment includes a wireless coupler that transfers power and/or data between an architectural unit and the patient care equipment. The patient care equipment may also include additional wireless couplers that transfer power and/or data between first and second components of the equipment. The second component may be movable relative to the first component. A structure or hot swapping batteries is also disclosed, the swapped battery being charged on an inductive charging mat.
Type:
Application
Filed:
March 7, 2014
Publication date:
January 14, 2016
Applicant:
Hill-Rom Services, Inc
Inventors:
Charles A. HOWELL, William G. PITTENGER, Michael S. HOOD, Edward J. KOORS, Steven Alan DIXON, Richard Joseph SCHUMAN, Matthew D. MORGAN, Laurie Lee GUTZWILLER, Kelly F. WALTON
Abstract: Methods of obtaining a cell population enriched for tumor-reactive T cells, the method comprising: (a) obtaining a bulk population of peripheral blood mononuclear cells (PBMCs) from a sample of peripheral blood; (b) specifically selecting CD8+T cells that also express PD-1 and/or TIM-3 from the bulk population; and (c) separating the cells selected in (b) from unselected cells to obtain a cell population enriched for tumor-reactive T cells are disclosed. Related methods of administering a cell population enriched for tumor-reactive T cells to a mammal, methods of obtaining a pharmaceutical composition comprising a cell population enriched for tumor-reactive T cells, and isolated or purified cell populations are also disclosed.
Type:
Application
Filed:
April 30, 2013
Publication date:
January 14, 2016
Applicant:
The United States of America, as represented by the Secretary, Dept. of Health and Human Services
Abstract: A method and apparatus for aligning optical components within an optical sensor. A mask with an elongate slot formed therethrough is placed optically between an optical emitter and an optical detector of the sensor. The mask is rotated 180 degrees while the detector output is measured. As the mask is rotated, the output varies. The longitudinal position of the slot that corresponds with the maximum detector output is indicative of the transverse direction that the optical emitter must be moved relative to the optical detector for optimal alignment. A controller may operate a first actuator for translating the optical emitter with respect to the optical detector and a second actuator for rotating the mask, thereby automating the alignment process.
Abstract: Systems and methods for providing remote notifications upon the detection of certain conditions. In one embodiment, a device comprising a housing, a power unit, a liquid sensor, and a communications unit detects the presence of a liquid and initiates an alert notification that is transmitted to a remote device.
Abstract: A mobile phone number that is been provided by a customer during enrollment is verified for use. SS7 protocol data associated with the mobile phone number is collected and evaluated, and if the condition of the subscriber account associated with phone number has changed or is inconsistent with the circumstances surrounding the enrollment of the phone number, the phone number is designated as one that is not to be called.
Type:
Application
Filed:
July 13, 2015
Publication date:
January 14, 2016
Applicant:
Early Warning Services, LLC
Inventors:
Eric Woodward, Aaron Bartrim, Betty Chan-Bauza, Rodger Desai, Matt Brown, Chris Cunningham
Abstract: The invention relates to an electrolysis cell for the particularly efficient treatment of wastewater polluted with organic substances by electrooxidative degradation of the wastewater constituents contributing to the chemical oxygen demand, and also its use.
Abstract: The invention relates to a hydrocarbon hydroprocessing catalyst comprising a support based on at least one refractory oxide, at least one metal from group VIII and at least one metal from group VIB. The inventive catalyst is characterized in that it also comprises at least one organic compound having formula (I) or (II): in which each R1 represents independently an alkyl group at C1-18, an alkenyl group at C2-18, an aryl group at C6-18, a cycloalkyl group at C3-8, an alkylaryl or arylalkyl group at C7-20, or the two R1 groups together form a divalent group at C2-18, and R2 represents an alkylene group at C1-18, an arylene group at C6-18, a cycloalkylene group at C3-7, or a combination of same. The invention also relates to a method of preparing one such catalyst and to the use thereof for hydroprocessing or hydrocracking.
Type:
Application
Filed:
September 21, 2015
Publication date:
January 14, 2016
Applicants:
IFP ENERGIES NOUVELLES, TOTAL MARKETING SERVICES
Inventors:
Thierry CHOLLEY, Jean-Pierre DATH, Claude BRUN, Georges FREMY, Francis HUMBLOT
Abstract: A lubricating composition includes at least one base oil, at least one compound including a dithiocarbamate group, at least one compound including a phosphite group and at least one compound including a dithiophosphate group. The lubricating composition simultaneously has good anti-wear and extreme-pressure properties, a low coefficient of friction and good anti-seizing properties. The lubricating composition can be used for lubricating transmissions such as gearboxes, axles, preferably the manual gearboxes of motor vehicles.
Abstract: In certain instances high levels of boron is present in produced or flowback water after it has been treated. The boron or borates tend to cause the guar to cross-link and become viscous too early which may cause undue wear or other problems with the surface equipment. It has been found that in the presence of low pH the viscosifier typically does not cross-link in the presence of a borate allowing the finished water to be used to hydrate the fluid. The fluid including the now hydrated linear gel is then subject to a chelating process so that the boron may be sequestered. Once the originally present borate is sequestered a slowly soluble borate is added to cause the linear gel to cross-link at the desired point in time.
Type:
Application
Filed:
July 10, 2015
Publication date:
January 14, 2016
Applicant:
TRICAN WELL SERVICE, LTD.
Inventors:
Joseph Earl Thompson, Sarkis R. Kakadjian
Abstract: A fluid-sampling system that includes a downhole tool string with a fluid-sampling tool coupled thereto, and a fluid sampling probe coupled to the tool via a probe extension arm, the fluid sampling probe having an oval pad that contacts a borehole wall, one or more fluid inlets which receive a formation fluid, and a plurality of screens between the borehole wall and the one or more fluid inlets which filter the formation fluid. The fluid-sampling system further including one or more offset arms coupled to the tool which contact the borehole wall.
Type:
Application
Filed:
February 28, 2014
Publication date:
January 14, 2016
Applicant:
HALLIBURTON ENERGY SERVICES, INC.
Inventors:
Rohin Naveena-Chandran, Carl Bismarck Ferguson, James Patrict McBride, Alison F. Foo-Kama
Abstract: Pulsed-electric drilling systems can be augmented with multi-component electromagnetic field sensors on the drillstring, at the earth's surface, or in existing boreholes in the vicinity of the planned drilling path. The sensors detect electrical fields and/or magnetic fields caused by the electrical pulses and derive therefrom information of interest including, e.g., spark size and orientation, bit position, at-bit resistivity and permittivity, and tomographically mapped formation strictures. The at-bit resistivity measurements can be for anisotropic or isotropic formations, and in the former case, can include vertical and horizontal resistivities and an orientation of the anisotropy axis. The sensors can illustratively include toroids, electrode arrays, tilted coil antennas, magnetic dipole antennas aligned with the tool axes, and magnetometers.
Abstract: Disclosed herein are bisarylmethylthioacetamides and bisarylmethylthioethylamines useful as inhibitors of monoamine transporters. The compounds are potent and/or selective inhibitors of dopamine (DA), serotonin (5-HT), and/or norepinephrine (NE) reuptake via their respective transporters, DAT, SERT and NET. Also disclosed are methods for eliciting a wake-promoting or cognitive or attention enhancing effect and for treating substance use disorders, attention deficit (hyperactivity) disorder, depressive disorders, bipolar disorder or other neuropsychiatric disorders sleep disorders or cognitive impairment using the compounds.
Type:
Application
Filed:
March 7, 2014
Publication date:
January 14, 2016
Applicant:
THE UNITED STATES OF AMERICA, AS REPRESENTED BY TH SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICE
Inventors:
AMY HAUCK NEWMAN, OLUYOMI M OKUNOLA-BAKARE, JIANJING CAO
Abstract: A method for providing multiple users with security access to an electronic system is provided. The method comprising: providing a plurality of parent security roles, wherein each parent security role includes a plurality of transactions authorized to be performed in the electronic system, providing a plurality of child security roles, wherein each child security role is derived from one of the plurality of parent security roles, setting up the multiple users in the electronic system and their associated user passwords, assigning one of the plurality of child security roles to each of the multiple users to provide the multiple users with security access to the electronic system at once, and providing each of the multiple users with security access to the electronic system, via the associated user password, in accordance with the child security role assigned to the user.
Abstract: Systems, methods, and software for determining a thickness of a well casing are described. In some aspects, the thickness of the well casing is determined based on results of comparing a measured waveform and model waveforms. The measured waveform and model waveforms are generated based on operating an acoustic transmitter and an acoustic receiver within a wellbore comprising the well casing.
Type:
Application
Filed:
July 15, 2014
Publication date:
January 14, 2016
Applicant:
Halliburton Energy Services, Inc.
Inventors:
Tianrun Chen, Yibing Zheng, Tatiana Gilstrap, Arthur Chuen Hon Cheng, Robert Eric Epstein, Zhijuan Zhang
Abstract: A downhole fluid flow control system includes a fluidic module having a turbine chamber. A flow control turbine is rotatably disposed within the turbine chamber. The flow control turbine is operable to provide fluid discriminating flow resistance such that a pressure drop for a desired production fluid passing through the fluidic module is less than a pressure drop for an undesired production fluid passing through the fluidic module. For example, the flow control turbine is operable generate a greater pressure drop in water produced therethrough as compared to oil produced therethrough due to differences in the density, viscosity or other property of the produced fluid.
Abstract: A method, an apparatus and a computer readable medium for generating an image of a subsurface based on seismic data corresponding to at least two different times, for a same surveyed area are provided. A cost function, which is a sum over the seismic data vintages of a norm of differences between data and model predicted multiples, is minimized subject to minimizing residual multiples that are differences of corresponding multiples belonging to different vintages among the seismic data vintages.
Abstract: An example method may include determining a first planned stimulation location within the formation. The first planned stimulation location may be based, at least in part, on a pre-determined model of a formation. A borehole in the formation may be drilled with a downhole tool. The first planned stimulation location may be adjusted based, at least in part, on data received at the downhole tool. Additionally, the downhole tool may stimulate the formation at the adjusted first planned stimulation location. A second stimulation location also may be determined based on data received at the downhole tool after stimulation of the formation at the adjusted first planned stimulation location.
Type:
Grant
Filed:
February 21, 2013
Date of Patent:
January 12, 2016
Assignee:
Halliburton Energy Services, Inc.
Inventors:
Stewart H. Fowler, Jr., Amit Sharma, Curtis E. Wendler, Keith E. Holtzman
Abstract: A system, method, and computer-usable medium are disclosed for authenticating a financial transaction terminal, such as an automated teller machine. A user provides financial account data, such as an account number, which is then combined with a unique identifier of the financial transaction terminal to generate terminal authentication data. The terminal authentication data is provided to a terminal authentication system, which extracts the financial account data and the unique identifier of the financial transaction terminal. The unique identifier of the financial transaction terminal is compared to a list of authentic financial transaction terminal identifiers. If its authenticity is confirmed, then a shared secret corresponding to the user's financial account data is provided to the authenticated financial transaction terminal. The user is queried as to the authenticity of the shared secret.
Type:
Grant
Filed:
March 19, 2009
Date of Patent:
January 12, 2016
Assignee:
United Services Automobile Association (USAA)
Abstract: An electrical connector includes a conductive shell having a chamber and having a mating end and a cable end. An insert assembly is received in the chamber and includes a module having a plurality of channels. The module is conductive and provides peripheral electrical shielding entirely around each of the channels for an entire length of each of the channels. The module engages and is electrically commoned with the shell. The insert assembly also includes insulator housings each holding a pair of contacts. The insulator housings are received in corresponding channels and electrically insulate the contacts from the module. Each pair of contacts is electrically shielded from each other pair of contacts by the module. A backshell is coupled to the cable end of the shell and holds the insert assembly in the chamber of the shell.