Abstract: The present invention provides 2,6,7,8 Substituted Purines as described herein or a pharmaceutically acceptable salt thereof. The representative compounds are useful as inhibitors of the HDM2 protein. Also disclosed are pharmaceutical compositions comprising the above compounds and potential methods of treating cancer using the same.
Type:
Grant
Filed:
January 29, 2014
Date of Patent:
January 10, 2017
Assignee:
Merck Sharp & Dohme Corp.
Inventors:
Carolyn Michele Cammarano, Matthew P. Christopher, Christopher Dinsmore, Ronald J. Doll, Francesc Xavier Fradera Llinas, Chaomin Li, Michelle Machacek, Michelle Martinez, Latha G. Nair, Weidong Pan, Michael Hale Reutershan, Manami Shizuka, Dietrich P. Steinhuebel, Binyuan Sun, Christopher Francis Thompson, B. Wesley Trotter, Yaolin Wang, Liping Yang, Stephane L. Bogen, Matthew E. Voss, Jagannath Panda, Anthappan Tony Kurissery
Abstract: Novel compounds of the structural formula (I) are activators of AMP-protein kinase and may be useful in the treatment, prevention and suppression of diseases mediated by the AMPK-activated protein kinase. The compounds of the present invention may be useful in the treatment of Type 2 diabetes, hyperglycemia, metabolic syndrome, obesity, hypercholesterolemia, and hypertension.
Type:
Grant
Filed:
August 15, 2013
Date of Patent:
January 10, 2017
Assignee:
Merck Sharp & Dohme Corp.
Inventors:
James M. Apgar, Tesfaye Biftu, Ping Chen, Danqing Feng, Jacqueline D. Hicks, Ahmet Kekec, Kenneth J. Leavitt, Bing Li, Iyassu Sebhat, Xiaoxia Qian, Lan Wei, Robert R. Wilkening, Zhicai Wu
Abstract: An illumination device (1) includes: a plurality of LEDs (5) that are the light sources, the LEDs being arranged in a row in a circular shape; and a diffusion lens (6) disposed on the light-emitting side of the LEDs (5) in order to diffuse light emitted by the LEDs (5), the diffusion lens (6) being disposed so as to follow an arrangement direction of the LEDs (5) to cover these LEDs. The degree of light diffusion of the diffusion lens (6) towards the direction forming a right angle with the arrangement direction of the plurality of LEDs (5) is larger than the degree of light diffusion towards the arrangement direction of the plurality of LEDs (5).
Abstract: A semiconductor wafer is provided with a substrate, a GaN type semiconductor film which is laminated on the substrate, a plurality of element regions which are provided on the GaN type semiconductor film, a dielectric film which is laminated on the GaN type semiconductor film, and a dicing region which has a dicing groove which is provided in a lattice form without passing through the dielectric film described above so as to partition the element regions described above. Then, an end on the element region side of the dicing groove is higher or lower than a central portion of the dicing groove in a width direction in a bottom surface of the dicing groove.
Abstract: A terminal apparatus according to an embodiment is a terminal apparatus communicating with a base station apparatus, including: a data processing unit that obtains barring skip information broadcasted from the base station apparatus; and a radio resource control unit that obtains a request for setting up radio resource control connection and a cause for setting up the radio resource control connection from a higher layer of a radio resource control layer of the terminal apparatus. The barring skip information is information indicating skipping access barring against a specific call. The data processing unit outputs the barring skip information to the radio resource control unit.
Abstract: Disclosed are compounds of Formula A-a, or a salt thereof: Where “B1” and “R1” through “R5” are as defined herein, which compounds have properties for blocking Nav 1.7 ion channels found in peripheral and sympathetic neurons. Also described are pharmaceutical formulations comprising the compounds of Formula A-a or their salts, and methods of treating neuropathic pain disorders using the same.
Type:
Application
Filed:
November 24, 2014
Publication date:
January 5, 2017
Applicant:
Merck Sharp & Dohme Corp.
Inventors:
Mark E. Layton, Anthony J. Roecker, Melissa Egbertson, Kristen L. G. Jones, Dansu Li, Xiu Wang, Xuanjia Peng
Abstract: According to the present invention, there is provided a terminal device that transmits a signal to a base station apparatus through uplink, the terminal device including: a BSR generation unit that triggers a buffer status report BSR which is used for providing the base station apparatus with information on an amount of data that is available for transmission within a buffer for a first link which is used for communication between the terminal device and a different terminal device, and that cancels the triggered buffer status report; and a configuration unit that configures a first mode or a second mode, in which, in the first mode, a resource for transmitting data for the first link is scheduled by the base station apparatus, and in the second mode, the resource for transmitting the data for the first link is selected the terminal device from a resource pool, and in which, in a case where the second mode is configured, all of the triggered buffer status reports are cancelled.
Abstract: A light-emitting device includes a light-emitting portion that emits fluorescence in response to excitation light incident on a surface of the light-emitting portion, and a reflector that defines a light-emitting region on the surface of the light-emitting portion, the fluorescence being emitted from the light-emitting region. The excitation light has a top-hat energy intensity distribution on the surface of the light-emitting portion.
Type:
Application
Filed:
September 15, 2016
Publication date:
January 5, 2017
Applicant:
Sharp Kabushiki Kaisha
Inventors:
Tomohiro SAKAUE, Koji TAKAHASHI, Yoshiyuki TAKAHIRA, Yosuke MAEMURA
Abstract: There is provided a technology associated with a terminal apparatus, a base station apparatus, a communication system, a notification method, and an integrated circuit, in all of which the capability of the terminal apparatus is efficiently notified. The terminal apparatus configures multiple pieces of terminal apparatus capability information that include information indicating whether or not to support transmission of multiple physical uplink control channels in a secondary cell, and information indicating whether or not to support data transfer control that is independent of a primary cell and the secondary cell, and transmits a terminal apparatus capability message including the multiple pieces of terminal apparatus capability information, to the base station apparatus.
Abstract: A terminal device configured to communicate with a base station device includes a higher layer processing unit that configures a mode of periodic channel state information reporting, and a transmission unit that periodically performs feedback of channel state information on a physical uplink control channel by using the mode. A period and an offset in the channel state information reporting are determined based on a parameter given in a first table in a case of frequency division duplexing, or based on a parameter given in a second table in a case of carrier aggregation for frequency division duplexing and time division duplexing where a primary cell has a frame structure type-2. In the case of the frequency division duplexing, a mapping of the parameter for the period and the offset is defined in the first table.
Abstract: A battery is provided with an associated method for transporting metal-ions in the battery using a low temperature molten salt (LTMS). The battery comprises an anode, a cathode formed from a LTMS having a liquid phase at a temperature of less than 150° C., a current collector submerged in the LTMS, and a metal-ion permeable separator interposed between the LTMS and the anode. The method transports metal-ions from the separator to the current collector in response to the LTMS acting simultaneously as a cathode and an electrolyte. More explicitly, metal-ions are transported from the separator to the current collector by creating a liquid flow of LTMS interacting with the current collector and separator.
Type:
Grant
Filed:
August 1, 2012
Date of Patent:
January 3, 2017
Assignee:
Sharp Laboratories of America, Inc.
Inventors:
Yuhao Lu, Sean Andrew Vail, Gregory M. Stecker, Jong-Jan Lee
Abstract: A base station is provided in which a terminal efficiently controls a demodulation reference signal for a data signal transmitted from the base station in a wireless communication system in which the base station and the terminal communicates with each other. The base station that performs a communication with the terminal includes a data signal generation unit that generates a data signal for terminal, and a demodulation reference signal for a data signal multiplexing unit that multiplexes a demodulation reference signal for a data signal, which is a known signal for demodulating the data signal, into the data signal. The scramble code included in the demodulation reference signal for the data signal is generated based on a first scramble ID and a second scramble ID that are notified from the base station to the terminal.
Abstract: A touch panel controller of the invention is provided with a driving unit which drives drive lines and causes a linear sum signal based on charges accumulated in respective electrostatic capacitances to be output from a sense line, and a correction processing unit which corrects influence on a change in the electrostatic capacitances by a parasitic capacitance which exists in the sense line. Thereby, it is possible to provide the touch panel controller and an electronic device capable of performing estimation of an electrostatic capacitance value more correctly by correcting the influence of the parasitic capacitance which exists in the sense line.
Abstract: A light-emitting device includes a light-emitting section, a lens, and a movement control section, the movement control section changing an illumination position and a spot size of a laser beam in the light-emitting section by changing a relative position of the lens with respect to the light-emitting section.
Abstract: Improves light extraction efficiency. A light emitting device 1 using a white resin molding package 5 integrally molded with lead frames 3, 4 constituting an electrode corresponding to one or a plurality of light emitting element 2 and white resin, wherein an area in a plane view of a white resin surface on a reflective surface that is level with amounting surface of the light emitting element 2 is configured to be larger than total area in a plane view occupied by surfaces of the lead frames 3, 4 and the light emitting element. Further, a step section is formed on the surfaces of lead frames 3, 4, white resin is filled in the step section, and the area of white resin surface on a reflective surface where the light emitting element 2 is mounted is increased.
Abstract: A display device (1) includes (i) a display panel (12) including a polarizing plate (18) on a surface of the display panel (12) and (ii) a touch panel (20) including a birefringent base material (31) on which a Y electrode pattern (32) and an X electrode pattern (33) are provided. Polarized light which has exited from the polarizing plate (18) enters the birefringent base material (31). The display device (1) includes an antireflection layer (28) which reduces reflection of the polarized light. The antireflection layer (28) is provided on a first surface of the touch panel (20) which first surface is opposite to a second surface of the touch panel (20) which second surface faces the display panel (12).
Abstract: A method for receiving a radio resource control (RRC) message by a user equipment (UE) is described. The method includes receiving, from a first evolved Node B (eNB), an RRC connection reconfiguration (RRCConnectionReconfiguration) message including data radio bearer (DRB) configuration parameters for remapping a DRB that is established on a master cell group (MCG) to a secondary cell group (SCG).
Abstract: A coding device and a decoding device are configured to include an estimated prediction mode deciding section (122a) including: a reference block selecting section (1223a) for selecting a reference block for use in estimating an intra-prediction mode for a subject block; an estimating number deciding section (1222a) for deciding an estimating number of estimated values to be estimated for the intra-prediction mode; and an estimated prediction mode deriving section (1221a) for estimating, based on a reference block, the estimating number of estimated values of the prediction mode.
Abstract: A mobile station (MS) obtains a parameter, performs transmission of a preamble, and sets a counter incremented based on transmission of the preamble. The MS is able to indicate a random access problem corresponding to one transmission timing cell group in a case where the counter reaches the parameter +1 and the transmission of the preamble is performed on the one transmission timing cell group, where the one transmission timing cell group being one of the plurality of transmission timing cell groups, and the MS is able to not indicate a random access problem corresponding to another transmission timing cell group in a case where the counter reaches the parameter +1 and the transmission of the preamble is performed on the another transmission timing cell group, where the another transmission timing cell group being one of the plurality of transmission timing cell groups.