Abstract: The present invention relates to 2?-Alkynyl Substituted Nucleoside Derivatives of Formula (I): and pharmaceutically acceptable salts thereof, wherein B, X, R1, R2, R3 and R4 are as defined herein. The present invention also relates to compositions comprising at least one 2?-Alkynyl Substituted Nucleoside Derivative, and methods of using the 2?-Alkynyl Substituted Nucleoside Derivatives for treating or preventing HCV infection in a patient.
Type:
Application
Filed:
November 14, 2013
Publication date:
October 22, 2015
Applicant:
MERCK SHARP & DOHME CORP.
Inventors:
Frank Bennett, Yuhua Huang, Lingyan Wang, Stephane L. Bogen, Angela D. Kerekes, Vinay M. Girijavallabhan M. Girijavallabhan, Gabor Butora, Quang Truong, Ian Davies, Ann E. Weber
Abstract: The liquid crystal display apparatus includes a liquid crystal module that has: a liquid crystal panel, an optical sheet, a backlight, and a box-shaped housing which has an opening on its front side and houses at least the optical sheet and the backlight, which are sequentially laminated from a front side to a rear side; and a frame-shaped member that covers peripheral surface sides of the liquid crystal panel and the housing.
Abstract: The present invention provides compounds of Formula (I), which are prodrugs of trans-4-[(1R)-(6-{[4-(difluoromethyl)pyridin-2-yl]amino}-4-methyl-2,3?-bipyridin-6?-yl)-1-hydroxyethyl]cyclohexanecarboxylic acid, a potent inhibitor of Syk. The compounds are useful in the treatment and prevention of diseases mediated by the enzyme, such as asthma, COPD, rheumatoid arthritis and cancer.
Type:
Application
Filed:
November 4, 2013
Publication date:
October 22, 2015
Applicant:
Merck Sharp & Dohme Corp.
Inventors:
Andrew M. Haidle, Brandon Cash, James P. Jewell, Kerrie Spencer, Michael D. Altman, Ryan D. Otte, Alan B. Northrup
Abstract: A method for sending a long-term reference picture indicator by an electronic device is described. A long-term reference picture indicator is generated. The long-term reference picture indicator is sent. An absolute Picture Order Count (POC) corresponding to a long-term reference picture is generated. The absolute POC includes a least significant bit (LSB) value. The LSB value of the absolute POC corresponding to a long-term reference picture is sent. A used by current picture flag corresponding to a current picture is generated. The used by current picture flag in at least one parameter set is sent.
Abstract: In a portable electronic equipment, a storage unit stores a plurality of installed application software. A display unit can display an indicator individually associated with each application software. When a user uses an operation unit to perform an operation of selecting the indicator, the selected application software is started. An interface unit can connect a plurality of external equipments. A control unit is configured to, when an external equipment is connected to the interface unit, change an indicator displayed on the display or modify an arrangement of the indicator in accordance with a kind of the connected external equipment.
Abstract: The present invention relates to 4-pyridinone compounds which are inhibitors of catechol O-methyltransferase (COMT), and are useful in the treatment and prevention of neurological and psychiatric disorders and diseases in which COMT enzyme is involved. The present invention also relates to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which COMT is involved.
Type:
Application
Filed:
March 27, 2015
Publication date:
October 22, 2015
Applicant:
MERCK SHARP & DOHME CORP.
Inventors:
Scott Wolkenberg, James C. Barrow, Michael S. Poslusney, Scott T. Harrison, Wesley B. Trotter, James Mulhearn, Kausik K. Nanda, Peter J. Manley, Zhijian Zhao, Jeffrey W. Schubert, Nathan R. Kett, Amy Zartman
Abstract: Provided are a touch panel system with improved indicator detection accuracy and an electronic information device provided with the touch panel system. A touch panel system 1 includes: a touch panel 3 provided with a plurality of electrodes SL, DL; and an indicator position detection unit 5 for detecting a position of the indicator that is in contact with or close to the detection surface P, based on an output signal that is outputted by at least part of the electrodes SL, DL and shows a capacitance formed by the electrode SL. The touch panel system is characterized in that the indicator position detection unit 5 corrects detection sensitivity for each predetermined position within the detection surface P so as to correspond to a pattern of the electrodes SL, DL, and detects the position of the indicator within the detection surface P.
Abstract: An active matrix substrate (5) is provided with mounting terminals (DT3), draw-out lines (22) connecting mounting terminals (DT4) and data bus lines (D), a first common wire (47) connected in common to the plurality of data bus lines (D), and second thin-film transistors (second switching elements) (45) connected between the draw-out lines (22) and the first common wire (47). End portions of the data bus lines (D) to which the mounting terminals (DT3) are not connected are connected to second common wires (54) via third thin-film transistors (52).
Abstract: Provided are a communication system and a communication method which efficiently control connecting and switching over for a second base station device and a terminal device and which enable traffic distribution in a communication system including a first base station device, at least one second base station device, and the terminal device which is connected to the first base station device or the second base station device. In the communication system which includes the first base station device, at least one second base station device, and the terminal device connected to the first base station device or the second base station device, a transmission unit of the first base station device transmits channels in the downlink including target base station recognition information and channels in the downlink including system information of the second base station device in order to notify whether or not a subsequent connection destination is the second base station device to the terminal device.
Abstract: The positive electrode active material of the present invention contains an lithium iron phosphate compound having such diffraction peaks that diffraction peak intensity ratios at 2?=17.2±0.5°, 2?=20.8±0.5° and 2?=25.6±0.5° are from 29 to 37, from 70 to 80 and from 85 to 94, respectively, when the diffraction peak intensity at 2?=35.6±0.5° is deemed as 100 in a powder X-ray diffractometry using Cu-K? ray as a radiation source. It becomes possible to provide a positive electrode active material that provides higher rate property and discharge capacity, and a positive electrode and a non-aqueous electrolyte secondary battery using the positive electrode active material.
Type:
Application
Filed:
October 10, 2013
Publication date:
October 22, 2015
Applicant:
SHARP KABUSHIKI KAISHA
Inventors:
Tomohisa YOSHIE, Yuichi KAMIMURA, Koji OHIRA, Motoaki NISHIJIMA
Abstract: The present invention provides a liquid crystal display device with a narrow frame region and high display quality. The liquid crystal display device of the present invention is provided with: a first substrate that has a first electrode and a third electrode; and a second substrate that has a second electrode and a fourth electrode. The first electrode has a first main wire part and a first lead-out part, the third electrode has a third main wire part and a third lead-out part, and the first main wire part and the third main wire part are disposed between a sealing member and a display region.
Abstract: The light control film includes a base material with transparency and a light control layer that is provided on a side of a surface which faces a display surface of a display panel in the base material, has a light shielding portion which is formed on one surface of the base material, and controls an emission direction of light by diffusing light which is emitted from the display surface, in which the light control layer includes a light emission end surface that contacts with the base material, a light incident end surface that faces the light emission end surface and has a larger area than an area of the light emission end surface, and a reflection surface that contacts with the light emission end surface and the light incident end surface and reflects light which is incident from the light incident end surface, a height from the light incident end surface to the light emission end surface is larger than a layer thickness of the light shielding portion, and the reflection surface reflects light to allocate
Abstract: This semiconductor device is provided with: a semiconductor film that comprises an oxide semiconductor, and includes a channel region; a first inorganic insulating film formed on the semiconductor film; a first organic insulating film formed on the first inorganic insulating film; and an inorganic film group. The inorganic film group has: a first electrode comprising an inorganic conductive film formed on the first organic insulating film; a second inorganic insulating film formed on the first electrode; and a second electrode that comprises an inorganic conductive film formed on the second inorganic insulating film, and is electrically connected to the semiconductor film via openings formed in such a manner as to penetrate the first inorganic insulating film, the first organic insulating film, the first electrode and the second inorganic insulating film. The first organic insulating film is disposed between the first inorganic insulating film and the inorganic film group.
Abstract: The present invention provides an ON-ON switching mode liquid crystal display device capable of enabling multi-V-T within a pixel and adequately improving viewing angle properties while adequately preventing any decrease in the liquid crystal molecule rising response rate.
Abstract: The present invention relates to compounds which modulate interleukin-1 (IL-1) receptor-associated kinase 4 (IRAK4) and are useful in the prevention or treatment of inflammatory, cell proliferative and immune-related conditions and diseases. Specifically, provided herein are inhibitors of IRAK4 of Formula I and pharmaceutical compositions comprising such inhibitors, as well as methods therewith for treating IRAK4-mediated or -associated conditions or diseases.
Type:
Application
Filed:
October 3, 2013
Publication date:
October 22, 2015
Applicant:
MERCK SHARP & DOHME CORP.
Inventors:
W. MICHAEL SEGANISH, WILLIAM T. MCELROY, STEPHANIE BRUMFIELD, JASON R. HERR, LARRY YET, JINHAI YANG, JAMES P. HARDING, III, GINNY DAI HO, DEEN TULSHIAN, WENSHENG YU, MICHAEL K.C. WONG, BRIAN LAVEY, JOSEPH A. KOZLOWSKI
Abstract: The present invention provides optimized cell culture media and fed-batch cultivation processes to improve the viability and volumetric production of heterologous proteins in Pichia. The disclosed media and processes utilize a non-fermentable sugar or sugar alcohol as an osmoprotectant to improve the robustness of Pichia production strains during methanol inducible fermentation.
Type:
Application
Filed:
November 22, 2013
Publication date:
October 22, 2015
Applicant:
Merck Sharp & Dohme Corp
Inventors:
Sehoon Kim, Marc D'Anjou, Muralidhar R. Mallem, Ishaan Shandil, Adam Nylen, Nathan Sharkey, Seemab S. Shaikh
Abstract: An active matrix substrate (100A) includes a thin film transistor (20), a scanning line (11) substantially parallel to a first direction, a signal line (12) substantially parallel to a second direction which is orthogonal to the first direction, a first interlayer insulating layer (16) covering the thin film transistor, a lower layer electrode (17) provided on the first interlayer insulating layer, a dielectric layer (18) provided on the lower layer electrode, and an upper layer electrode (19) overlapping at least a portion of the lower layer electrode via the dielectric layer. A first contact hole (31) for allowing the upper layer electrode to be electrically connected to a drain electrode (24) of the thin film transistor includes a first aperture (16a) formed in the first interlayer insulating layer and a second aperture (18a) formed in the dielectric layer.
Abstract: A technique for decoding video including receiving quantized coefficient level values representative of a block of video representative of a plurality of pixels and a quantization parameter related to the block of video. The technique includes de-quantizing the quantized coefficient level values based upon the quantized coefficient level values and the quantization parameter only if the quantized coefficient level values and the quantization parameter are jointly within a predefined range of acceptable values. The technique also includes inverse transforming the dequantized coefficients to determine a decoded residue.
Type:
Grant
Filed:
November 17, 2011
Date of Patent:
October 20, 2015
Assignee:
Sharp Laboratories of America, Inc.
Inventors:
Louis Joseph Kerofsky, Kiran Misra, Christopher A. Segall
Abstract: The present invention provides a thin film transistor array substrate and a liquid crystal display device including the thin film transistor array substrate that are preferably applicable to a liquid crystal display device including the three-layered electrode structure that enables high response speed and high transmittance, and can have a high aperture ratio.
Abstract: When an image formation instruction for created document data is received, image data for a preview image corresponding to the document data is generated, the preview image based on the image data is displayed on a display, and an image is formed using data for image formation based on the image data for the preview image.