Patents Assigned to Shimadzu Corporation
  • Publication number: 20240027455
    Abstract: Provided is a method of assisting breast cancer diagnosis, comprising: a measuring step for measuring an amount of laminin 5 or laminin ?3 in a specimen; and an information-providing step for providing information for breast cancer diagnosis based on the amount of laminin 5 or laminin ?3 thus measured. Provided is a test kit for breast cancer comprising an anti-laminin 5 antibody or an anti-laminin ?3 antibody.
    Type: Application
    Filed: December 6, 2021
    Publication date: January 25, 2024
    Applicants: NATIONAL CANCER CENTER, SHIMADZU CORPORATION, DAI NIPPON TORYO CO., LTD.
    Inventors: Kenji TAMURA, Kazuki SUDO, Takahisa MATSUDA, Taiki YAMAJI, Koji OKAMOTO, Makoto WATANABE, Hirotaka FUJIMOTO, Taka-Aki SATO, Yuta MIYAZAWA
  • Patent number: 11879776
    Abstract: A spectroscopic detector comprises a first housing, a second housing, a camera lens housed in the first housing, and an image sensor housed in the second housing. The first housing has a first through hole formed therein. The second housing has a second through hole formed therein. The second housing is attached to the first housing so as to allow for communication between an inside of the second housing and an inside of the first housing via the first through hole and the second through hole. In a state where the second housing is attached to the first housing, a periphery of the second through hole is located inside a periphery of the first through hole.
    Type: Grant
    Filed: July 6, 2022
    Date of Patent: January 23, 2024
    Assignee: SHIMADZU CORPORATION
    Inventor: Ryuta Shibutani
  • Patent number: 11878303
    Abstract: A sample container holding mechanism is for holding a sample container 6, and includes a hook member 9 and a stopper member 10. The hook member 9 suspends and holds the sample container 6 in a state where the sample container 6 is inclined with respect to a vertical direction. The stopper member 10 restricts the rotation of the sample container 6 when the sample container 6 is rotated around the hook member 9.
    Type: Grant
    Filed: May 11, 2018
    Date of Patent: January 23, 2024
    Assignee: SHIMADZU CORPORATION
    Inventor: Shingo Fujioka
  • Patent number: 11879878
    Abstract: A gas separation system includes a separation column for separating components contained in sample gas, a sample gas supplier fluidly connected to an inlet of the separation column for supplying sample gas to the separation column, a detector fluidly connected to an outlet of the separation column, a collection tube filled with an adsorbent having a property of adsorbing a target component in the sample gas under a condition of a first temperature or less and desorbing the adsorbed target component under a condition of a second temperature or more higher than the first temperature, a temperature adjuster for adjusting a temperature of the collection tube, a collection container for collecting the target component, and a switching mechanism for switching between a state in which the collection tube is connected to an outlet of the detector and a state in which the collection tube is connected to the collection container.
    Type: Grant
    Filed: August 6, 2019
    Date of Patent: January 23, 2024
    Assignee: SHIMADZU CORPORATION
    Inventors: Tasuku Murata, Mitsuru Nishishita, Shigeo Yasui
  • Patent number: 11880374
    Abstract: A device to support work of searching document data for interpreting an information analysis result of analysis data obtained by analyzing a sample containing an analyte, includes: an acquisition unit to acquire first information for identifying the analyte from the analysis data; a reception unit to receive input of second information for searching data of a document for interpreting the information analysis result of the analysis data; an extraction unit to extract, based on the first and second information, terms relevant to the information analysis result, from among terms in data of documents in a database; a calculation unit to calculate, for each relevant term, relevance scores indicating a relevance degree between the relevant term and the first information, and a relevance degree between the relevant term and the second information; and a processing unit to obtain an index value of statistical likelihood from the relevance scores.
    Type: Grant
    Filed: May 9, 2022
    Date of Patent: January 23, 2024
    Assignees: Shimadzu Corporation, OSAKA UNIVERSITY
    Inventors: Shinji Kanazawa, Satoshi Shimizu, Fumio Matsuda
  • Patent number: 11879879
    Abstract: A mass spectrum generation section (22) generates an original mass spectrum at a peak of a target compound based on data acquired through analysis on a sample. A background spectrum generation section (23) generates a background spectrum in accordance with each of a plurality of predetermined background acquisition conditions. A difference mass spectrum calculation section (25) obtains a difference mass spectrum by subtracting the each background spectrum from the original mass spectrum, and a spectrum similarity calculation section (27) calculates a similarity between each difference mass spectrum and a standard mass spectrum of a candidate compound selected from a spectrum library (28). A compound identification section (29) identifies the candidate compound as the target compound if the highest similarity exceeds a predetermined threshold.
    Type: Grant
    Filed: January 30, 2017
    Date of Patent: January 23, 2024
    Assignee: SHIMADZU CORPORATION
    Inventors: Kazuhiro Kawamura, Yukihiko Kudo
  • Patent number: 11879877
    Abstract: A binary pump includes a switching valve that can be switched to a state (first state or second state) in which only one of a first pump part and a second pump part is connected to an output part, and a state (third state) in which both the first pump part and the second pump part are connected to the output part, and has a function of preventing a backflow of liquid by switching a state of the switching valve, in particular, a function of preventing a backflow of liquid when liquid delivery is performed by using both the first pump and the second pump.
    Type: Grant
    Filed: March 16, 2018
    Date of Patent: January 23, 2024
    Assignee: SHIMADZU CORPORATION
    Inventor: Shinichi Fujisaki
  • Patent number: 11874290
    Abstract: In a sample pretreatment device, a container storage section (2) holds multiple containers, including a first well plate having wells in an N×M matrix form and a second well plate having N elongated wells whose length corresponds to M wells in one row of the first well plate or M elongated wells whose length corresponds to N wells in one column of the first well plate. A dispensing section (3) includes: a platform (30) on winch containers can be placed; a pipette unit (311, 312) including an M-channel tip corresponding to M wells in one row of the first well plate or an N-channel tip corresponding to N wells in one column of the first well plate; and a pump unit (313) for suctioning/ejecting a liquid from/into a container on the platform through the pipette unit. A transfer section (4) transfers containers between the container storage section and the platform. A controller (5) controls operations of the dispensing section and the transfer section.
    Type: Grant
    Filed: November 3, 2021
    Date of Patent: January 16, 2024
    Assignee: SHIMADZU CORPORATION
    Inventors: Naoki Kaneko, Ritsuko Yoda, Akihito Korenaga
  • Patent number: 11874205
    Abstract: A gas chromatograph comprises a sample gas generation unit, separation column, and detector. Multiple gas sources serve as carrier gases to transport sample gas to the separation column. A switching component connects the gas sources to the sample gas generation unit based on user-input information. This information is stored in a gas type memory, which aids a gas type identification component in determining the carrier gas type by monitoring the switching component's status and referring to the stored data.
    Type: Grant
    Filed: December 30, 2020
    Date of Patent: January 16, 2024
    Assignee: SHIMADZU CORPORATION
    Inventors: Ayaka Kisaka, Yasuhiro Kimoto, Yu Nagao
  • Patent number: 11874172
    Abstract: A Fourier transform infrared spectrophotometer includes a main interferometer, a control interferometer, an infrared detector, a control light detector, a waveplate, and a support member. The waveplate is disposed on an optical path of a control light beam and between a fixed mirror or a moving mirror and a beam splitter. The support member supports the waveplate. An outer perimeter of the waveplate includes a supported region supported by the support member and a released region spaced apart from the support member.
    Type: Grant
    Filed: February 18, 2022
    Date of Patent: January 16, 2024
    Assignee: Shimadzu Corporation
    Inventors: Hideaki Katsu, Hiromasa Maruno
  • Patent number: 11874257
    Abstract: A mass spectrometry device includes a vacuum container in which an ionizer, a mass separator and a detector are arranged, and includes an opening-closing portion that is provided at the vacuum container and switches between a locked state of being locked in a close state and an unlocked state by a difference in pressure between inside and outside of the vacuum container, and a cooling gas introducer that introduces a cooling gas for cooling the ionizer into the vacuum container such that the opening-closing portion is kept in the locked state.
    Type: Grant
    Filed: February 15, 2019
    Date of Patent: January 16, 2024
    Assignee: SHIMADZU CORPORATION
    Inventors: Ryo Kageyama, Takeshi Uchida, Masaru Nishiguchi, Manabu Shimomura
  • Publication number: 20240011951
    Abstract: A sampling needle (21) is inserted into a sample container (12) by a needle-driving mechanism (23) to collect a sample liquid from the sample container. A depth information acquirer (52) acquires insertion depth information, i.e., a piece of information concerning an insertion depth of the sampling needle into the sample container. A needle-rinsing length setter (54) sets a needle-rinsing length which is an insertion length of the sampling needle into a rinse storage tank (30) having an open top, based on the insertion depth information. A controller (51) controls the needle-driving mechanism so that a portion of the sampling needle extending from the tip of the sampling needle over the needle-rinsing length is inserted into the rinse storage tank. The needle-rinsing length setter is configured to set a shorter needle-rinsing length for a smaller insertion depth of the sampling needle into the sample container, to shorten the needle-cleaning time.
    Type: Application
    Filed: May 29, 2023
    Publication date: January 11, 2024
    Applicant: SHIMADZU CORPORATION
    Inventor: Tatsuya OBE
  • Publication number: 20240011960
    Abstract: An ultraviolet ray emitter includes an inner tube, an outer tube arranged around the inner tube, the outer tube defining between the outer tube and the inner tube, a discharge space where discharge gas is sealed, a pair of electrodes that causes discharge in the discharge space, and an auxiliary light source that assists excitation of discharge gas by emitting light to discharge gas from the outside of the outer tube. The outer tube is less likely to allow passage therethrough of ultraviolet light generated by excitation of discharge gas than the inner tube but allows passage therethrough of light having a wavelength emitted from the auxiliary light source.
    Type: Application
    Filed: May 6, 2021
    Publication date: January 11, 2024
    Applicant: SHIMADZU CORPORATION
    Inventors: Yoshiaki NIEDA, Yuichi MASUDA, Masahito YAHATA, Tatsuya KATAOKA
  • Publication number: 20240012016
    Abstract: An analysis system includes a gripper arm for conveying a sample container, and a controller for controlling the gripper arm. The gripper arm includes a first gripper and a second gripper for holding the sample container by pinching the sample container, a drive mechanism that changes a size of a gripping space between the first gripper and the second gripper, and a photoelectric sensor for emitting light to the gripping space to detect the light from the gripping space. The controller determines the presence or absence of the sample container in the gripping space based on the presence or absence of a detection signal of the photoelectric sensor.
    Type: Application
    Filed: June 23, 2023
    Publication date: January 11, 2024
    Applicant: SHIMADZU CORPORATION
    Inventor: Motomu HINOOKA
  • Patent number: 11867187
    Abstract: A vacuum pump comprises: a rotor cylindrical portion; a motor configured to rotate the rotor cylindrical portion; a stator cylindrical portion, the rotor cylindrical portion and the stator cylindrical portion together forming a screw groove pump; a base housing the rotor cylindrical portion and the stator cylindrical portion; a heater configured to heat the base or the stator cylindrical portion; a cooling device attached to the base; and a cover member arranged at an outer peripheral side of the stator cylindrical portion and an outer peripheral side of the base, covering the base through an air insulating layer, and contacting the cooling device.
    Type: Grant
    Filed: March 22, 2022
    Date of Patent: January 9, 2024
    Assignee: Shimadzu Corporation
    Inventor: Tomoki Yasuda
  • Patent number: 11869759
    Abstract: After performing an analysis on a standard sample for a predetermined time, a plurality of ion optical elements such as an ion guide are sequentially selected one by one, and a direct-current voltage having a polarity different from that at the time of analysis is temporarily applied. Meanwhile, intensity data of ions having a specific m/z are continuously collected. After thus collecting the data, the ratio of the ion intensities before and after application of direct-current voltages having different polarities is calculated for each ion optical element, and it is determined whether or not the ratio is equal to or larger than a predetermined threshold value.
    Type: Grant
    Filed: May 31, 2018
    Date of Patent: January 9, 2024
    Assignee: SHIMADZU CORPORATION
    Inventor: Manabu Ueda
  • Publication number: 20240003928
    Abstract: A controller (14) slows down and stops a turret (12) when a sensor 33 detects a first detection target portion (31) in a detection area (34). The controller (14) acquires information corresponding to the movement distance (D1) of the first detection target portion (31) from the start of slowdown of the turret (12) to the stop of the turret (12). The controller (14) moves the first detection target portion (31) in a second direction (A2) by the movement distance (D1). The controller (14) moves the first detection target portion (31) in the second direction (A2) to a second position (P6) outside the detection area (34). The controller (14) moves the turret (12) to move the first detection target portion (31) in a first direction (A1) from the second position (P6) to an origin (P0).
    Type: Application
    Filed: December 3, 2020
    Publication date: January 4, 2024
    Applicant: SHIMADZU CORPORATION
    Inventor: Tomonori NOZAWA
  • Patent number: 11860138
    Abstract: An analysis method includes: subjecting a sample to liquid chromatography; performing first mass spectrometry of the sample subjected to the liquid chromatography to detect a first ion corresponding to cholesteryl ester and a second ion corresponding to cholesteryl ester peroxide; and analyzing a degree of oxidation of the sample based on a ratio between an intensity of the detected first ion and an intensity of the detected second ion.
    Type: Grant
    Filed: March 8, 2019
    Date of Patent: January 2, 2024
    Assignee: SHIMADZU CORPORATION
    Inventor: Masaki Yamada
  • Patent number: 11862445
    Abstract: An imaging mass spectrometer includes: a storage configured to acquire and store data constituting a first imaging graphic indicating an ion intensity distribution in a specific one or plurality of m/z or m/z ranges based on data obtained by mass spectrometry for a sample; a Raman imaging data acquisition unit configured to acquire and store data constituting one or plurality of second imaging graphics obtained by Raman analysis that is a type different from mass spectrometry for the sample; a signal intensity normalization processor configured to perform data conversion processing of normalizing signal intensity in one or plurality of first and second imaging graphics; an adjustment processor configured to perform data processing of aligning spatial resolutions of the one or plurality of first and second imaging graphics; and a statistical analysis processor configured to execute statistical analysis processing on images and to classify the first and second imaging graphics.
    Type: Grant
    Filed: February 14, 2019
    Date of Patent: January 2, 2024
    Assignee: SHIMADZU CORPORATION
    Inventor: Shinichi Yamaguchi
  • Patent number: 11862451
    Abstract: An orthogonal acceleration time-of-flight mass spectrometer (1) includes: an ion ejector (123) which ejects measurement-target ions in a predetermined direction; an orthogonal accelerator (132) which accelerates ions in a direction orthogonal to the direction in which the ions are ejected; a ring electrode (131) located between the ion ejector and the orthogonal accelerator, the ring electrode having an opening for allowing ions to pass through and arranged so that the central axis (C2) of the opening is shifted from the central axis (C1) of the ion ejector in a direction along the axis of the acceleration of the ions by the orthogonal accelerator; a reflectron electrode (134) which creates a repelling electric field for reversing the direction of the ions accelerated by the orthogonal accelerator; and an ion detector (135) which detects ions after the direction of flight of the ions is reversed by the reflectron electrode.
    Type: Grant
    Filed: May 10, 2022
    Date of Patent: January 2, 2024
    Assignee: SHIMADZU CORPORATION
    Inventors: Takuya Suzumura, Daisuke Okumura, Tomoya Kudo