Abstract: A medical imaging and/or radiotherapy apparatus incorporates a display for projecting a visible image to a patient lying on a patient table. A projector that projects the visible image moves in tandem with the patient table, so that it appears relatively motionless to the patient. In exemplary embodiments, the projector projects the visible image within a patient tunnel of the medical apparatus, including in some embodiments, an extended field of view medical imaging apparatus. In other exemplary embodiments, the projector projects the visible image on a screen above the patient table of a tunnel-less medical apparatus. The projector remains outside the imaging line of response of detectors within the imaging field or outside of the radiotherapy beam zone, to avoid potential degradation of the captured diagnostic image or degradation of the radiotherapy beam.

Abstract: By identifying locations of contrast agent response, an intensity-based metric of contrast agent signal is used to control a duration of microbubble destruction with a medical ultrasound scanner. Feedback from motion of the transducer may be used to indicate when a user perceives enough destruction. A combination of both an intensity-based metric and transducer motion may be used to control the duration of bursting.

Abstract: For partial volume correction, the partial volume effect is simulated using patient-specific segmentation. An organ or other object of the patient is segmented using anatomical imaging. For simulation, the locations of the patient-specific object or objects are sub-divided, creating artificial boundaries in the object. A test activity is assigned to each sub-division and forward projected. The difference of the forward projected activity to the test activity provides a location-by-location partial volume correction map. This correction map is used in reconstruction from the measured emissions, resulting in more accurate activity estimation with less partial volume effect.

Abstract: Frequency is swept in acoustic radiation force impulse (ARFI) scanning. Different frequencies are used at different times during the ARFI. For example, different frequencies are focused to different depths in the ARFI transmit beam. Since the frequency sweep is used for the ARFI pushing pulse rather than a transmit pulse for which echoes are received, the rate of change of the frequency is not dictated by the speed of sound. The rate of change of the frequency may be adjustable or set based on other factors, such as the type of tissue. In combination with a time varying focal position, the frequency sweep may better compensate for loss as compared to a focus sweep alone. The frequency sweep may better compensate for loss as compared to a single point focus ARFI.

Abstract: Disclosed herein is a combined multi-modality biomarker method for identification and treatment of a disease comprising performing quantitative and/or semi-quantitative molecular imaging on a patient; where the semi-quantitative imaging includes a cut-off; measuring a first plurality of parameters from the quantitative and/or semi-quantitative molecular imaging; simultaneously or sequentially performing a liquid biopsy on the patient; measuring a second plurality of quantitative and/or semi-quantitative molecular parameters from the liquid biopsy; developing an algorithm that combines one or more of the first plurality of parameters and one or more of the second plurality of parameters; where the algorithm is operative to identify a disease and/or predict a course of treatment and/or monitoring the patient; and treating the patient with the course of treatment generated by the algorithm.

Abstract: A system and method include storage of an echo signal power spectrum of a reference phantom for a fundamental frequency band and an echo signal power spectrum of the reference phantom for a harmonic frequency band, acquisition of an echo signal power spectrum of a region of tissue for the fundamental frequency band and an echo signal power spectrum of the region of tissue for the harmonic frequency band, determination of a first backscatter coefficient based on the echo signal power spectrum of the region of tissue for the fundamental frequency band and the echo signal power spectrum of the reference phantom for the fundamental frequency band, determination of a second backscatter coefficient based on the echo signal power spectrum of the region of tissue for the harmonic frequency band and the echo signal power spectrum of the reference phantom for the harmonic frequency band, and determination of a non-linearity of the region of tissue based on the first backscatter coefficient and the second backscatter co

Abstract: A system and method includes input of a plurality of sets of training data to a neural network to generate a plurality of sets of output data, determination of a first loss based on the plurality of sets of output data and on the plurality of sets of ground truth data, determination if a second loss based on the plurality of sets of output data and one or more physics-based constraints, and modification of the neural network based on the first loss and the second loss.

Abstract: A system and method include training of an artificial neural network to generate a simulated attenuation-corrected reconstructed volume from an input non-attenuation-corrected reconstructed volume, the training based on a plurality of non-attenuation-corrected volumes generated from respective ones of a plurality of sets of two-dimensional emission data and on a plurality of attenuation-corrected reconstructed volumes generated from respective ones of the plurality of sets of two-dimensional emission data.

Abstract: A method of estimating energy-based scatter content in PET list-mode data is provided.

Abstract: A method of manufacturing a collimator (134) on a three-dimensional printer (510) includes obtaining design specifications (536) for the collimator, the design specifications including a channel perimeter pattern and an overall collimator thickness, determining a first quantity of deposit layer permutation types based on the channel perimeter pattern, determining a respective second quantity of permutation layer elements (310, 320, 330) for each respective one of the deposit layer permutations, generating respective sets of sequences for each respective one of the deposit layer permutations, the number of sets equal to the respective second quantity for the corresponding deposit layer permutations, assembling the respective sets of sequences into a three-dimensional print file (538), providing the three-dimensional file to the three-dimensional printer, and manufacturing the collimator by depositing additive layers of material based on contents of the three-dimensional file.

Abstract: Disclosed are a method and apparatus for making a radioisotope and a composition of matter including the radioisotope. The radioisotope is made by exposing a material to neutrons from a portable neutron source.

Abstract: Asymmetry is provided for the pushing pulse in acoustic radiation force impulse (ARFI) imaging. MI is based on the negative pressure. By increasing the positive pressure more than the negative pressure, the magnitude of displacement may be increased without exceeding the MI limit. Similarly, negative voltages depole while positive do not, so using an ARFI or pushing pulse with asymmetric positive-to-negative peak pressures or voltages allows for generation of greater magnitude of displacement without harm to the transducer.

Abstract: A framework for automatically finding an organ in image data. In accordance with one aspect, a predetermined view of the organ is approximated by transforming the original image data to generate transformed image data. A best-match region in the transformed image data that best matches a synthesized geometric shape may then be found. The best-match region may be transformed into a volume space of the original image data to generate a location of the organ.

Abstract: A method and an ultrasound system are provided for generating transmission signals of an ultrasound probe used in a contrast-enhanced ultrasound image mode. The ultrasound system generates a pair of pulse control signals n and n+1 and a damping compensation pulse control signal, generates a pair of pulses n and n+1 having polarities opposite to each other and a damping compensation pulse having a polarity opposite to that of the n+1-th pulse based on the pair of pulse control signals and the damping compensation pulse control signal, transmits transmission signals including the pair of pulses and the damping compensation pulse, generates an ultrasound signal based on the transmission signals, transmits the ultrasound signal to a target object, and acquires echo signals for forming a contrast-enhanced ultrasound image of the target object. The damping compensation pulse is successively generated after generating the pair of pulses.

Abstract: Methods for simulating, and correcting for, doubly scattered annihilation gamma-ray photons in both time-of-flight (TOF) and non-TOF positron emission tomography scan data are disclosed.

Abstract: A framework for motion correction in medical image data. In accordance with one aspect, one or more anatomical ranges where motion is expected are identified in a localizer image of a subject. Image reconstruction with motion correction may be performed based on medical image data within the one or more anatomical ranges to generate motion corrected image data. The motion corrected image data may then be combined with non-motion corrected image data to generate final image data.

Abstract: Using computer-assisted classification and/or computer-assisted segmentation with or without monitoring the field of view for change, the workflow for ultrasound imaging may be made more efficient. The classification and/or segmentation is used to perform a next act in the sequence of acts making up the ultrasound examination. Rather than requiring a user to determine the act and implement the act, the ultrasound scanner determines and implements the act based on the identification and/or location of an imaged object. For example, the identification of the object as a kidney using a machine-learnt classifier triggers a color flow scan, and the location of the object determines a placement for the color flow region of interest (ROI), avoiding the user having to perform the ROI initiation and/or placement and increasing workflow efficiency.

Abstract: A system and method include acquisition of a plurality of event data associated with an object, each of the plurality of event data associated with a position and a time, assigning of each event data to one of a plurality of time-based frames based on a time associated with the event data, each of the plurality of time-based frames associated with a respective time period, assigning of each event data to one of a plurality of motion-based frames based on a time associated with the event data, each of the plurality of motion-based frames associated with a respective time period associated with a respective motion state, determination of a confidence score based on the plurality of time-based frames of event data and on the plurality of motion-based frames of event data, and presentation of the confidence score and a control selectable to initiate motion-correction of the event data.

Abstract: For denoising in SPECT, such as qSPECT, machine learning is used to relate settings to noise structure. Given the SPECT imaging arrangement for a patient, the machine-learned model estimates the structure of the noise. This noise structure may be used to denoise the reconstructed representation.

Abstract: Embodiments can provide a medical imaging patient bed with an integrated electronic ruler system, comprising a light strip, mounted to the medical imaging bed; a trough comprising an open end and a closed end, mounted to the medical imaging bed and oriented such that the light strip is bounded by the open end and the closed end of the trough; a laser distance meter attached to the open end of the trough; a microcontroller; and a power source configured to provide power to the light strip, laser distance meter, and microcontroller; wherein the microcontroller is configured to illuminate the light strip after one or more distance measurements are received from the laser distance meter when an object is inserted into the trough; wherein a position of the illumination of the light strip corresponds to the one or more distance measurements received from the laser distance meter.