Patents Assigned to SINGULAR GENOMICS SYSTEMS, INC.
  • Nucleotide cleavable linkers with rigid spacers and uses thereof
    Patent number: 12680132
    Abstract: Disclosed herein, inter alia, are compounds, compositions, and methods of use thereof for sequencing a nucleic acid.
    Type: Grant
    Filed: May 6, 2021
    Date of Patent: July 14, 2026
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Ada Tong, Ronald Graham, Megha Cila, Eli N. Glezer, Zachary Terranova
  • Methods, compositions, and solid supports for multi-dimensional sequencing
    Patent number: 12680133
    Abstract: Disclosed herein, inter alia, are compositions and methods for detecting polynucleotides within a three-dimensional polymer matrix.
    Type: Grant
    Filed: April 19, 2023
    Date of Patent: July 14, 2026
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Eli N. Glezer, Daan Witters
  • In situ nucleic acid amplification
    Patent number: 12674194
    Abstract: Disclosed herein, inter alia, are novel methods pertaining to nucleic acid amplification and sequencing. Compositions for use in and produced by such methods are also provided.
    Type: Grant
    Filed: March 25, 2022
    Date of Patent: July 7, 2026
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Daan Witters, Allen Lipson, Eli N. Glezer
  • Methods and devices for manipulating biological samples
    Patent number: 12669416
    Abstract: Disclosed herein, inter alia, are devices and methods for efficient transfer and analyses of cellular material, tissue samples, such as tissue sections, using carrier substrates and devices.
    Type: Grant
    Filed: October 27, 2025
    Date of Patent: June 30, 2026
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Yuji Ishitsuka, Jaekyung Koh, Robert James Stover, Pavel Shekhtmeyster, Sandor Kovacs, Hu Cang, Valeria Rascon
  • Strand displacing amplification enzymes
    Patent number: 12668834
    Abstract: Disclosed herein, inter alia, are novel strand-displacing polymerases and methods of use thereof.
    Type: Grant
    Filed: December 21, 2022
    Date of Patent: June 30, 2026
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Souad Naji, Eli N. Glezer, Bruna Krebs Kutche, Ali Nikoomanzar, Alexander Sevy, Caleb Newman, Ryan Shultzaberger, Abrehet Abdu, Youngjin Cho, Janell J. Kosmatka
  • Silicon containing modified nucleotide analogs
    Patent number: 12637489
    Abstract: Disclosed herein, inter alia, are silicon containing cleavable linkers and compounds for use in nucleic acid sequencing.
    Type: Grant
    Filed: February 1, 2023
    Date of Patent: May 26, 2026
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Ronald Graham, Zachary Terranova
  • Modified archaeal family b polymerases
    Patent number: 12630808
    Abstract: Provided herein are modified Archaeal family B polymerases derived from the Archaeal microorganism Pyrococcus-abyssi that exhibit improved incorporation of nucleotide analogues utilized in DNA sequencing.
    Type: Grant
    Filed: September 11, 2019
    Date of Patent: May 19, 2026
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Carl W. Fuller, Eli N. Glezer, Andrew Spaventa, Souad Naji
  • High density sequencing and multiplexed priming
    Patent number: 12600962
    Abstract: Disclosed herein, inter alia, are methods and compositions for sequencing a plurality of template nucleic acids. In an aspect is provided a method of sequencing an overlapping amplification cluster, a method of sequencing different polynucleotide immobilized on a solid support, and a method of sequencing three or more populations of polynucleotides on a solid support.
    Type: Grant
    Filed: January 13, 2023
    Date of Patent: April 14, 2026
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Eli N. Glezer, Daan Witters, Niek Van Wietmarschen
  • Nucleotide cleavable linkers and uses thereof
    Patent number: 12595508
    Abstract: Disclosed herein, inter alia, are compounds, compositions, and methods of use thereof for sequencing a nucleic acid.
    Type: Grant
    Filed: March 7, 2024
    Date of Patent: April 7, 2026
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Ronald Graham, Olga Adelfinskaya, Megha Cila, Rodrigo Rodriguez
  • Multiplexed sequencing in cells and tissues
    Patent number: 12590302
    Abstract: Disclosed herein, inter alia, are methods and compositions for detecting a plurality of nucleic acids in a sample including a cell or tissue. The methods may include amplifying nucleic acid molecules in the sample and detecting the amplified nucleic acid molecules in the sample.
    Type: Grant
    Filed: May 23, 2024
    Date of Patent: March 31, 2026
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Eli N. Glezer, Niek Van Wietmarschen, Daan Witters
  • Modified PH129 polymerase and uses thereof
    Patent number: 12577544
    Abstract: Disclosed herein, inter alia, are mutant enzymes, kits, and methods of use thereof.
    Type: Grant
    Filed: January 13, 2025
    Date of Patent: March 17, 2026
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Souad Naji, Alexander Sevy, Jason Cellitti, Eli N. Glezer, Bruna Krebs Kutche, Zachary Terranova, Sumit Handa
  • Modified nucleotides and uses thereof
    Patent number: 12577271
    Abstract: Disclosed herein, inter alia, are compounds, modified nucleotides, compositions, and methods of using the same.
    Type: Grant
    Filed: July 1, 2021
    Date of Patent: March 17, 2026
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Ronald Graham, Surya Adhikari, Rodrigo Rodriguez, Zachary Terranova
  • Methods for in situ transcriptomics and proteomics
    Patent number: 12577611
    Abstract: Disclosed herein, inter alia, are compositions and methods of use thereof for interrogating a cell.
    Type: Grant
    Filed: December 12, 2024
    Date of Patent: March 17, 2026
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Eli N. Glezer, Hu Cang, Zhenmin Hong
  • Imaging systems and methods useful for patterned structures
    Patent number: 12573039
    Abstract: Disclosed herein, inter alia, are methods and systems of image analysis useful for identifying and/or quantifying features in patterns.
    Type: Grant
    Filed: September 26, 2023
    Date of Patent: March 10, 2026
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Fedor Trintchouk, Eli N. Glezer
  • Detecting tumor infiltrating cells
    Patent number: 12529093
    Abstract: Disclosed herein, inter alia, are compositions and methods of use thereof for interrogating a tissue sample.
    Type: Grant
    Filed: July 11, 2024
    Date of Patent: January 20, 2026
    Assignee: Singular Genomics Systems, Inc.
    Inventor: Eli N. Glezer
  • Detecting molecules in tissues
    Patent number: 12486532
    Abstract: Disclosed herein, inter alia, are compositions and methods of use thereof for interrogating a tissue sample.
    Type: Grant
    Filed: April 24, 2024
    Date of Patent: December 2, 2025
    Assignee: Singular Genomics Systems, Inc.
    Inventor: Eli N. Glezer
  • Chemical and thermal assisted nucleic acid amplification methods
    Patent number: 12473588
    Abstract: Disclosed herein, inter alia, are novel methods pertaining to nucleic acid amplification and detection. Devices, compositions, and kits for use in such methods are also provided.
    Type: Grant
    Filed: January 27, 2023
    Date of Patent: November 18, 2025
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Allen Lipson, Daan Witters, Eli N. Glezer
  • Compositions and methods for nucleic acid sequencing
    Patent number: 12460261
    Abstract: Provided herein are methods and compositions for improved sequencing techniques using, for example, polymeric particles and/or three-dimensional structures.
    Type: Grant
    Filed: December 19, 2024
    Date of Patent: November 4, 2025
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Eli N. Glezer, Mohammad Vatankhah Varnosfaderani, Daan Witters, Vahid Karimkhani
  • Modified archaeal family B polymerases
    Patent number: 12454683
    Abstract: Provided herein are modified Archaeal family B polymerases derived from the Archaeal microorganism Pyrococcus abyssi that exhibit improved incorporation of nucleotide analogues utilized in DNA sequencing.
    Type: Grant
    Filed: November 2, 2023
    Date of Patent: October 28, 2025
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Souad Naji, Carl W. Fuller, Eli N. Glezer, Andrew Spaventa
  • Microplate receiver frame
    Patent number: D1101192
    Type: Grant
    Filed: October 30, 2023
    Date of Patent: November 4, 2025
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Bandele J. Jeffrey-Coker, Eli N. Glezer, Yuji Ishitsuka