Patents Assigned to SINGULAR GENOMICS SYSTEMS, INC.
  • Multiomic analysis device and methods of use thereof
    Patent number: 12258623
    Abstract: Disclosed herein, inter alia, are devices, compositions, kits, and methods for interrogating biological samples.
    Type: Grant
    Filed: March 2, 2023
    Date of Patent: March 25, 2025
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Sandor Kovacs, Eli N. Glezer, Christopher Frye
  • Multiomic analysis device and methods of use thereof
    Patent number: 12252740
    Abstract: A device comprising: a sample stage configured to be coupled to a microplate receiver; a microplate receiver configured to be coupled to a microplate; at least one heating element thermally coupled to the microplate receiver; a fluidics dispenser configured to dispense one or more reagents into the microplate; and an imaging system configured to detect one or more features in the microplate; and a structure physically coupled to the sample stage, the heating element, the fluidics dispenser, and the imaging system.
    Type: Grant
    Filed: July 14, 2023
    Date of Patent: March 18, 2025
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Sandor Kovacs, Eli N. Glezer, Christopher Frye
  • Systems and methods for multicolor imaging
    Patent number: 12247921
    Abstract: Disclosed herein, inter alia, are methods and systems of image analysis useful for rapidly identifying and/or quantifying features.
    Type: Grant
    Filed: May 10, 2023
    Date of Patent: March 11, 2025
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Fedor Trintchouk, Eli N. Glezer
  • Compositions and methods for nucleic acid sequencing
    Patent number: 12227799
    Abstract: Provided herein are methods and compositions for improved sequencing techniques using, for example, polymeric particles and/or three-dimensional structures.
    Type: Grant
    Filed: December 3, 2021
    Date of Patent: February 18, 2025
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Eli N. Glezer, Mohammad Vatankhah Varnosfaderani, Daan Witters, Vahid Karimkhani
  • Modified PHI29 DNA polymerases and uses thereof
    Patent number: 12227774
    Abstract: Disclosed herein, inter alia, are mutant enzymes, kits, and methods of use thereof.
    Type: Grant
    Filed: May 9, 2024
    Date of Patent: February 18, 2025
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Souad Naji, Alexander Sevy, Jason Cellitti, Eli N. Glezer, Bruna Krebs Kutche, Zachary Terranova, Sumit Handa
  • Fluorinated nucleotides and uses thereof
    Patent number: 12215124
    Abstract: Disclosed herein, inter alia, are compounds, compositions, and methods of use thereof in the sequencing a nucleic acid.
    Type: Grant
    Filed: February 20, 2019
    Date of Patent: February 4, 2025
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Ronald Graham, Andrew Spaventa, Eli Glezer
  • Nucleotide analogues
    Patent number: 12215122
    Abstract: Disclosed herein, inter alia, are compounds, compositions, and methods of using the same for the sequencing of a nucleic acid.
    Type: Grant
    Filed: November 29, 2023
    Date of Patent: February 4, 2025
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Ronald Graham, Olga Adelfinskaya, Megha Cila, Rodrigo Rodriguez, Abrehet Abdu, Eli N. Glezer
  • Cleavable disulfide linkers and uses thereof
    Patent number: 12188089
    Abstract: Disclosed herein, inter alia, are methods and cleavable compounds that minimize byproduct formation following cleavage.
    Type: Grant
    Filed: February 12, 2024
    Date of Patent: January 7, 2025
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Ronald Graham, Megha Cila
  • Multiplexed targeted amplification of polynucleotides
    Patent number: 12188088
    Abstract: Disclosed herein, inter alia, are compositions and methods for efficient amplification and sequencing of nucleic acid templates.
    Type: Grant
    Filed: June 15, 2023
    Date of Patent: January 7, 2025
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Eli N. Glezer, Daan Witters, Tung Thanh Le
  • Flow cell receiver and methods of use
    Patent number: 12179208
    Abstract: The present disclosure relates to a flow cell receiver. The flow cell receiver can include at least one platen, having a plurality of ports. The flow cell receiver can include magnets. The flow cell receiver can be configured to automatically align, secure, and retain a flow cell carrier containing a flow cell.
    Type: Grant
    Filed: October 9, 2023
    Date of Patent: December 31, 2024
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Sandor Kovacs, David Baranson, Eli N. Glezer
  • Methods for in SITU transcriptomics and proteomics
    Patent number: 12180542
    Abstract: Disclosed herein, inter alia, are compositions and methods of use thereof for interrogating a cell.
    Type: Grant
    Filed: August 2, 2022
    Date of Patent: December 31, 2024
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Eli N. Glezer, Hu Cang, Zhenmin Hong
  • Device for tissue section immobilization and retention
    Patent number: 12181388
    Abstract: Disclosed herein, inter alia, are devices and methods for transfer and analyses of tissue sections using carrier substrates.
    Type: Grant
    Filed: April 1, 2024
    Date of Patent: December 31, 2024
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Yuji Ishitsuka, Zhenmin Hong, Eli N. Glezer, Hu Cang, William Dempsey, Weiqiao Ding, Jaekyung Koh, Mohammad Vatankhah Varnosfaderani
  • Manipulating and detecting biological samples
    Patent number: 12158402
    Abstract: Disclosed herein, inter alia, are compositions and methods for efficient transfer and analyses of cellular material, tissue samples, such as tissue sections, using carrier substrates.
    Type: Grant
    Filed: February 1, 2024
    Date of Patent: December 3, 2024
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Yuji Ishitsuka, Zhenmin Hong, Eli N. Glezer, Hu Cang, William Dempsey, Weiqiao Ding, Jaekyung Koh, Mohammad Vatankhah Varnosfaderani
  • Nucleotide analogues
    Patent number: 12145960
    Abstract: Disclosed herein, interalia, are compounds, compositions, and methods of using the same for the sequencing of a nucleic acid.
    Type: Grant
    Filed: October 24, 2019
    Date of Patent: November 19, 2024
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Ronald Graham, Olga Adelfinskaya, Megha Cila, Rodrigo Rodriguez, Abrehet Abdu, Eli N. Glezer
  • Polynucleotide barcodes for long read sequencing
    Patent number: 12139754
    Abstract: Provided herein are methods of making, amplifying, and sequencing tagged nucleic acid complements, compositions including interposing oligonucleotide barcodes, and kits useful in obtaining long-range sequence data.
    Type: Grant
    Filed: September 27, 2021
    Date of Patent: November 12, 2024
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Eli N. Glezer, Martin Maria Fabani, Ryan Shultzaberger, Bharat Sridhar, Gudrun Stengel, Christopher Jen-Yue Wei
  • Methods of sequencing circular template polynucleotides
    Patent number: 12139759
    Abstract: Disclosed herein, inter alia, are methods of detecting or sequencing circular template polynucleotides on a solid support and/or in cells and tissues.
    Type: Grant
    Filed: September 22, 2022
    Date of Patent: November 12, 2024
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Daan Witters, Allen Lipson, Eli N. Glezer
  • Sample cartridge
    Patent number: D1050482
    Type: Grant
    Filed: September 27, 2023
    Date of Patent: November 5, 2024
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Bandele Jeffrey-Coker, Eli N. Glezer, Anson Hsu, Cory Spivey
  • Microplate assembly
    Patent number: D1066732
    Type: Grant
    Filed: November 10, 2023
    Date of Patent: March 11, 2025
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Bandele J. Jeffrey-Coker, Eli N. Glezer, Yuji Ishitsuka
  • Microplate assembly
    Patent number: D1066735
    Type: Grant
    Filed: November 10, 2023
    Date of Patent: March 11, 2025
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Bandele J. Jeffrey-Coker, Eli N. Glezer, Yuji Ishitsuka
  • Microplate
    Patent number: D1067462
    Type: Grant
    Filed: October 30, 2023
    Date of Patent: March 18, 2025
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Bandele J. Jeffrey-Coker, Eli N. Glezer, Yuji Ishitsuka