Patents Assigned to SINGULAR GENOMICS SYSTEMS, INC.
  • Methods for in situ transcriptomics and proteomics
    Patent number: 12286666
    Abstract: Disclosed herein, inter alia, are compositions and methods of use thereof for interrogating a cell.
    Type: Grant
    Filed: February 15, 2024
    Date of Patent: April 29, 2025
    Assignee: SINGULAR GENOMICS SYSTEMS, INC.
    Inventors: Eli N. Glezer, Hu Cang, Zhenmin Hong
  • In situ detection of nucleic acid molecules
    Patent number: 12286667
    Abstract: Disclosed herein, inter alia, are compositions and methods of use thereof for interrogating a cell.
    Type: Grant
    Filed: September 19, 2023
    Date of Patent: April 29, 2025
    Assignee: SINGULAR GENOMICS SYSTEMS, INC.
    Inventors: Eli N. Glezer, Hu Cang, Zhenmin Hong
  • Silicon containing detectable compounds
    Patent number: 11697736
    Abstract: Disclosed herein, inter alia, are silicon containing detectable compounds and methods of use thereof.
    Type: Grant
    Filed: May 17, 2019
    Date of Patent: July 11, 2023
    Assignee: SINGULAR GENOMICS SYSTEMS, INC.
    Inventors: Ronald Graham, Rodrigo Rodriguez
  • Systems and methods for multicolor imaging
    Patent number: 11686681
    Abstract: Disclosed herein, inter alia, are methods and systems of image analysis useful for rapidly identifying and/or quantifying features.
    Type: Grant
    Filed: June 29, 2022
    Date of Patent: June 27, 2023
    Assignee: SINGULAR GENOMICS SYSTEMS, INC.
    Inventors: Fedor Trintchouk, Eli N. Glezer
  • Spatial sequencing
    Patent number: 11680288
    Abstract: Disclosed herein, inter alia, are compositions and methods of use thereof for interrogating a sample comprising a cell.
    Type: Grant
    Filed: July 27, 2022
    Date of Patent: June 20, 2023
    Assignee: SINGULAR GENOMICS SYSTEMS, INC.
    Inventor: Eli N. Glezer
  • High density sequencing and multiplexed priming
    Patent number: 11649452
    Abstract: Disclosed herein, inter alia, are methods and compositions for sequencing a plurality of template nucleic acids.
    Type: Grant
    Filed: October 13, 2022
    Date of Patent: May 16, 2023
    Assignee: SINGULAR GENOMICS SYSTEMS, INC.
    Inventors: Eli N. Glezer, Daan Witters, Niek Van Wietmarschen
  • Nucleic acid sequencing-by-synthesis (SBS) methods that combine SBS cycle steps
    Patent number: 11591647
    Abstract: The present disclosure provides improved nucleic acid sequencing-by-synthesis (SBS) methods, related kits and reagents, and systems for performing such methods using such kits and reagents.
    Type: Grant
    Filed: March 6, 2018
    Date of Patent: February 28, 2023
    Assignee: SINGULAR GENOMICS SYSTEMS, INC.
    Inventors: Eli Glezer, Andrew Spaventa, David Barker
  • High density sequencing and multiplexed priming
    Patent number: 11578320
    Abstract: Disclosed herein, inter alia, are methods and compositions for sequencing a plurality of template nucleic acids.
    Type: Grant
    Filed: April 27, 2022
    Date of Patent: February 14, 2023
    Assignee: SINGULAR GENOMICS SYSTEMS, INC.
    Inventors: Eli N. Glezer, Daan Witters, Niek Van Wietmarschen
  • Methods and compositions for sequencing complementary polynucleotides
    Patent number: 11560590
    Abstract: Disclosed herein, inter alia, are substrates, kits, and efficient methods of preparing and sequencing two or more regions of a double-stranded polynucleotide.
    Type: Grant
    Filed: June 14, 2022
    Date of Patent: January 24, 2023
    Assignee: SINGULAR GENOMICS SYSTEMS, INC.
    Inventors: Daan Witters, Eli N. Glezer, Allen Lipson
  • Methods for in situ transcriptomics and proteomics
    Patent number: 11492662
    Abstract: Disclosed herein, inter alia, are compositions and methods of use thereof for interrogating a cell.
    Type: Grant
    Filed: August 6, 2021
    Date of Patent: November 8, 2022
    Assignee: SINGULAR GENOMICS SYSTEMS, INC.
    Inventors: Eli N. Glezer, Hu Cang, Zhenmin Hong
  • Spatial sequencing
    Patent number: 11434525
    Abstract: Disclosed herein, inter alia, are compositions and methods of use thereof for interrogating a sample comprising a cell.
    Type: Grant
    Filed: August 6, 2021
    Date of Patent: September 6, 2022
    Assignee: SINGULAR GENOMICS SYSTEMS, INC.
    Inventor: Eli N. Glezer
  • Methods for long read sequencing
    Patent number: 11225688
    Abstract: Provided herein are methods including alternating series of sequencing cycles and dark extension cycles allowing longer read lengths and addressing disadvantages of traditional nucleic acid sequencing protocols.
    Type: Grant
    Filed: December 18, 2020
    Date of Patent: January 18, 2022
    Assignee: SINGULAR GENOMICS SYSTEMS, INC.
    Inventors: Eli N. Glezer, Abrehet Abdu, Timothy Looney
  • Polynucleotide barcodes for long read sequencing
    Patent number: 11155858
    Abstract: Provided herein are methods of making, amplifying, and sequencing tagged nucleic acid complements, compositions including interposing oligonucleotide barcodes, and kits useful in obtaining long-range sequence data.
    Type: Grant
    Filed: December 18, 2020
    Date of Patent: October 26, 2021
    Assignee: SINGULAR GENOMICS SYSTEMS, INC.
    Inventors: Eli N. Glezer, Martin Maria Fabani, Ryan Shultzaberger, Bharat Sridhar, Gudrun Stengel, Christopher Jen-Yue Wei
  • Modified archaeal family B polymerases
    Patent number: 11136565
    Abstract: Provided herein are modified Archaeal family B polymerases derived from the Archaeal microorganism Pyrococcus abyssi that exhibit improved incorporation of nucleotide analogues utilized in DNA sequencing.
    Type: Grant
    Filed: September 11, 2019
    Date of Patent: October 5, 2021
    Assignee: SINGULAR GENOMICS SYSTEMS, INC.
    Inventors: Souad Naji, Carl W. Fuller, Eli Glezer, Andrew Spaventa
  • Nucleotide cleavable linkers and uses thereof
    Patent number: 10822653
    Abstract: Disclosed herein, inter alia, are compounds, compositions, and methods of use thereof for sequencing a nucleic acid.
    Type: Grant
    Filed: January 7, 2020
    Date of Patent: November 3, 2020
    Assignee: SINGULAR GENOMICS SYSTEMS, INC.
    Inventors: Ronald Graham, Olga Adelfinskaya, Megha Cila, Rodrigo Rodriguez
  • Nucleotide analogues
    Patent number: 10738072
    Abstract: Disclosed herein, inter alia, are compounds, compositions, and methods of using the same for the sequencing of a nucleic acid.
    Type: Grant
    Filed: October 24, 2019
    Date of Patent: August 11, 2020
    Assignee: SINGULAR GENOMICS SYSTEMS, INC.
    Inventors: Ronald Graham, Olga Adelfinskaya, Megha Cila, Rodrigo Rodriguez, Abrehet Abdu, Eli N. Glezer