Patents Assigned to SINGULAR GENOMICS SYSTEMS, INC.
  • Multiport disconnect couplings
    Patent number: 11965616
    Abstract: A connector assembly is configured to fluidly and removably connect a first set of microtubes to a second set of microtubes of a microfluidic device. The connector assembly provides multiple points of contact to the microtubes to provide a secure connection between the connector assembly and the microtubes. A single gasket provides a securely aligned connection between microtubes.
    Type: Grant
    Filed: February 28, 2022
    Date of Patent: April 23, 2024
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Sandor Kovacs, David Baranson
  • Nucleotide analogues
    Patent number: 11958877
    Abstract: Disclosed herein, interalia, are compounds, compositions, and methods of using the same for the sequencing of a nucleic acid.
    Type: Grant
    Filed: March 6, 2023
    Date of Patent: April 16, 2024
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Ronald Graham, Olga Adelfinskaya, Megha Cila, Rodrigo Rodriguez, Abrehet Abdu, Eli N. Glezer
  • Cleavable disulfide linkers and uses thereof
    Patent number: 11946103
    Abstract: Disclosed herein, inter alia, are methods and cleavable compounds that minimize byproduct formation following cleavage.
    Type: Grant
    Filed: August 14, 2023
    Date of Patent: April 2, 2024
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Ronald Graham, Megha Cila
  • Amplification oligonucleotides
    Patent number: 11932905
    Abstract: Disclosed herein, inter alia, are polynucleotides, supports, kits, and methods of use thereof for amplifying, immobilizing, and sequencing polynucleotides.
    Type: Grant
    Filed: March 17, 2023
    Date of Patent: March 19, 2024
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Ryan Shultzaberger, Allen Lipson, Daan Witters
  • Methods and compositions for sequencing complementary polynucleotides
    Patent number: 11913071
    Abstract: Disclosed herein, inter alia, are substrates, kits, and efficient methods of preparing and sequencing two or more regions of a double-stranded polynucleotide.
    Type: Grant
    Filed: January 13, 2023
    Date of Patent: February 27, 2024
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Daan Witters, Eli N. Glezer, Allen Lipson
  • Imaging systems and methods useful for patterned structures
    Patent number: 11900595
    Abstract: Disclosed herein, inter alia, are methods and systems of image analysis useful for identifying and/or quantifying features in patterns.
    Type: Grant
    Filed: May 5, 2021
    Date of Patent: February 13, 2024
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Fedor Trintchouk, Eli N. Glezer
  • Methods for in situ transcriptomics and proteomics
    Patent number: 11891656
    Abstract: Disclosed herein, inter alia, are compositions and methods of use thereof for interrogating a cell.
    Type: Grant
    Filed: June 14, 2022
    Date of Patent: February 6, 2024
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Eli N. Glezer, Hu Cang, Zhenmin Hong
  • Modified pyrococcus polymerases and uses thereof
    Patent number: 11891633
    Abstract: Provided herein are modified Archaeal family B polymerases derived from species of the Archaeal microorganism Pyrococcus that exhibit improved incorporation of nucleotide analogues utilized in DNA sequencing.
    Type: Grant
    Filed: March 22, 2021
    Date of Patent: February 6, 2024
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Souad Naji, Eli N. Glezer, Youngjin Cho, Zachary Terranova, Abrehet Abdu
  • Linked paired strand sequencing
    Patent number: 11891660
    Abstract: Provided herein are methods for sequencing both strands of a double stranded nucleic acid fragment that improves fidelity and accuracy of a sequence determination compared to traditional next generation sequencing methods. Compositions and kits for use in the methods are also provided.
    Type: Grant
    Filed: November 17, 2022
    Date of Patent: February 6, 2024
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Eli N. Glezer, Martin Maria Fabani, Sabrina Shore, Daan Witters
  • Engineered enzymes and uses thereof
    Patent number: 11884943
    Abstract: Provided herein are modified Archaeal family B polymerases derived from species of the Archaeal microorganism Pyrococcus that exhibit improved incorporation of nucleotide analogues utilized in DNA sequencing.
    Type: Grant
    Filed: October 5, 2021
    Date of Patent: January 30, 2024
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Souad Naji, Eli N. Glezer, Youngjin Cho, Zachary Terranova, Abrehet Abdu
  • Nanoarrays and methods of use thereof
    Patent number: 11884977
    Abstract: Disclosed herein, inter alia, are nanoarrays and methods of use thereof.
    Type: Grant
    Filed: February 17, 2023
    Date of Patent: January 30, 2024
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Eli N. Glezer, Vahid Karimkhani, Shahed Kay, Mohammad Vatankhah Varnosfaderani, Daan Witters
  • Nucleotide analogues
    Patent number: 11878993
    Abstract: Disclosed herein, interalia, are compounds, compositions, and methods of using the same for the sequencing of a nucleic acid.
    Type: Grant
    Filed: April 4, 2023
    Date of Patent: January 23, 2024
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Ronald Graham, Olga Adelfinskaya, Megha Cila, Rodrigo Rodriguez, Abrehet Abdu, Eli N. Glezer
  • Amplification oligonucleotides
    Patent number: 11859244
    Abstract: Disclosed herein, inter alia, are polynucleotides, supports, kits, and methods of use thereof for amplifying, immobilizing, and sequencing polynucleotides.
    Type: Grant
    Filed: March 17, 2023
    Date of Patent: January 2, 2024
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Ryan Shultzaberger, Allen Lipson, Daan Witters
  • Modified polymerases and uses thereof
    Patent number: 11851687
    Abstract: Provided herein are modified Archaeal family B polymerases derived from species of the Archaeal microorganism Pyrococcus that exhibit improved incorporation of nucleotide analogues utilized in DNA sequencing.
    Type: Grant
    Filed: March 19, 2021
    Date of Patent: December 26, 2023
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Souad Naji, Eli N. Glezer, Youngjin Cho, Zachary Terranova, Abrehet Abdu
  • Modified family B polymerases
    Patent number: 11845923
    Abstract: Provided herein are modified Archaeal family B polymerases derived from the Archaeal microorganism Pyrococcus abyssi that exhibit improved incorporation of nucleotide analogues utilized in DNA sequencing.
    Type: Grant
    Filed: July 7, 2021
    Date of Patent: December 19, 2023
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Souad Naji, Carl W. Fuller, Eli Glezer, Andrew Spaventa
  • Sample cartridge
    Patent number: D1005517
    Type: Grant
    Filed: February 13, 2023
    Date of Patent: November 21, 2023
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Bandele Jeffrey-Coker, Eli N. Glezer, Anson Hsu, Cory Spivey
  • Lid for a reagent cartridge
    Patent number: D1007002
    Type: Grant
    Filed: December 30, 2022
    Date of Patent: December 5, 2023
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Bandele Jeffrey-Coker, Eli N. Glezer, Anson Hsu, Cory Spivey
  • Microplate
    Patent number: D1010856
    Type: Grant
    Filed: May 26, 2022
    Date of Patent: January 9, 2024
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Bandele J. Jeffrey-Coker, Eli N. Glezer, Yuji Ishitsuka
  • Microplate assembly
    Patent number: D1013204
    Type: Grant
    Filed: May 26, 2022
    Date of Patent: January 30, 2024
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Bandele J. Jeffrey-Coker, Eli N. Glezer, Yuji Ishitsuka
  • Microplate assembly
    Patent number: D1013205
    Type: Grant
    Filed: May 26, 2022
    Date of Patent: January 30, 2024
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Bandele J. Jeffrey-Coker, Eli N. Glezer, Yuji Ishitsuka