Patents Assigned to SINGULAR GENOMICS SYSTEMS, INC.
  • Silicon containing modified nucleotide analogs
    Patent number: 12637489
    Abstract: Disclosed herein, inter alia, are silicon containing cleavable linkers and compounds for use in nucleic acid sequencing.
    Type: Grant
    Filed: February 1, 2023
    Date of Patent: May 26, 2026
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Ronald Graham, Zachary Terranova
  • Modified archaeal family b polymerases
    Patent number: 12630808
    Abstract: Provided herein are modified Archaeal family B polymerases derived from the Archaeal microorganism Pyrococcus-abyssi that exhibit improved incorporation of nucleotide analogues utilized in DNA sequencing.
    Type: Grant
    Filed: September 11, 2019
    Date of Patent: May 19, 2026
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Carl W. Fuller, Eli N. Glezer, Andrew Spaventa, Souad Naji
  • High density sequencing and multiplexed priming
    Patent number: 12600962
    Abstract: Disclosed herein, inter alia, are methods and compositions for sequencing a plurality of template nucleic acids. In an aspect is provided a method of sequencing an overlapping amplification cluster, a method of sequencing different polynucleotide immobilized on a solid support, and a method of sequencing three or more populations of polynucleotides on a solid support.
    Type: Grant
    Filed: January 13, 2023
    Date of Patent: April 14, 2026
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Eli N. Glezer, Daan Witters, Niek Van Wietmarschen
  • Nucleotide cleavable linkers and uses thereof
    Patent number: 12595508
    Abstract: Disclosed herein, inter alia, are compounds, compositions, and methods of use thereof for sequencing a nucleic acid.
    Type: Grant
    Filed: March 7, 2024
    Date of Patent: April 7, 2026
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Ronald Graham, Olga Adelfinskaya, Megha Cila, Rodrigo Rodriguez
  • Multiplexed sequencing in cells and tissues
    Patent number: 12590302
    Abstract: Disclosed herein, inter alia, are methods and compositions for detecting a plurality of nucleic acids in a sample including a cell or tissue. The methods may include amplifying nucleic acid molecules in the sample and detecting the amplified nucleic acid molecules in the sample.
    Type: Grant
    Filed: May 23, 2024
    Date of Patent: March 31, 2026
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Eli N. Glezer, Niek Van Wietmarschen, Daan Witters
  • Modified PH129 polymerase and uses thereof
    Patent number: 12577544
    Abstract: Disclosed herein, inter alia, are mutant enzymes, kits, and methods of use thereof.
    Type: Grant
    Filed: January 13, 2025
    Date of Patent: March 17, 2026
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Souad Naji, Alexander Sevy, Jason Cellitti, Eli N. Glezer, Bruna Krebs Kutche, Zachary Terranova, Sumit Handa
  • Modified nucleotides and uses thereof
    Patent number: 12577271
    Abstract: Disclosed herein, inter alia, are compounds, modified nucleotides, compositions, and methods of using the same.
    Type: Grant
    Filed: July 1, 2021
    Date of Patent: March 17, 2026
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Ronald Graham, Surya Adhikari, Rodrigo Rodriguez, Zachary Terranova
  • Methods for in situ transcriptomics and proteomics
    Patent number: 12577611
    Abstract: Disclosed herein, inter alia, are compositions and methods of use thereof for interrogating a cell.
    Type: Grant
    Filed: December 12, 2024
    Date of Patent: March 17, 2026
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Eli N. Glezer, Hu Cang, Zhenmin Hong
  • Imaging systems and methods useful for patterned structures
    Patent number: 12573039
    Abstract: Disclosed herein, inter alia, are methods and systems of image analysis useful for identifying and/or quantifying features in patterns.
    Type: Grant
    Filed: September 26, 2023
    Date of Patent: March 10, 2026
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Fedor Trintchouk, Eli N. Glezer
  • Detecting tumor infiltrating cells
    Patent number: 12529093
    Abstract: Disclosed herein, inter alia, are compositions and methods of use thereof for interrogating a tissue sample.
    Type: Grant
    Filed: July 11, 2024
    Date of Patent: January 20, 2026
    Assignee: Singular Genomics Systems, Inc.
    Inventor: Eli N. Glezer
  • Detecting molecules in tissues
    Patent number: 12486532
    Abstract: Disclosed herein, inter alia, are compositions and methods of use thereof for interrogating a tissue sample.
    Type: Grant
    Filed: April 24, 2024
    Date of Patent: December 2, 2025
    Assignee: Singular Genomics Systems, Inc.
    Inventor: Eli N. Glezer
  • Chemical and thermal assisted nucleic acid amplification methods
    Patent number: 12473588
    Abstract: Disclosed herein, inter alia, are novel methods pertaining to nucleic acid amplification and detection. Devices, compositions, and kits for use in such methods are also provided.
    Type: Grant
    Filed: January 27, 2023
    Date of Patent: November 18, 2025
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Allen Lipson, Daan Witters, Eli N. Glezer
  • Compositions and methods for nucleic acid sequencing
    Patent number: 12460261
    Abstract: Provided herein are methods and compositions for improved sequencing techniques using, for example, polymeric particles and/or three-dimensional structures.
    Type: Grant
    Filed: December 19, 2024
    Date of Patent: November 4, 2025
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Eli N. Glezer, Mohammad Vatankhah Varnosfaderani, Daan Witters, Vahid Karimkhani
  • Modified archaeal family B polymerases
    Patent number: 12454683
    Abstract: Provided herein are modified Archaeal family B polymerases derived from the Archaeal microorganism Pyrococcus abyssi that exhibit improved incorporation of nucleotide analogues utilized in DNA sequencing.
    Type: Grant
    Filed: November 2, 2023
    Date of Patent: October 28, 2025
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Souad Naji, Carl W. Fuller, Eli N. Glezer, Andrew Spaventa
  • Devices useful for sample manipulation
    Patent number: 12442729
    Abstract: Disclosed herein, inter alia, are devices and methods for efficient transfer and analyses of cellular material, tissue samples, such as tissue sections.
    Type: Grant
    Filed: November 7, 2024
    Date of Patent: October 14, 2025
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Sandor Kovacs, Yuji Ishitsuka, Kevin Marshall, Jaekyung Koh
  • Methods and systems for multidimensional imaging
    Patent number: 12422656
    Abstract: A multi-depth confocal imaging system includes at least one light source configured to provide excitation beams and an objective lens. The excitation beams are focused into a sample at a first plurality of focus depths along an excitation direction through the objective lens. An image sensor receives emissions from the sample via the objective lens, wherein the emissions define foci relative to the image sensor at a second plurality of focus depths.
    Type: Grant
    Filed: June 7, 2023
    Date of Patent: September 23, 2025
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Hu Cang, Eli N. Glezer
  • Multiomic analysis device and methods of use thereof
    Patent number: 12421541
    Abstract: Disclosed herein, inter alia, are devices, compositions, kits, and methods for interrogating biological samples.
    Type: Grant
    Filed: February 7, 2025
    Date of Patent: September 23, 2025
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Sandor Kovacs, Eli N. Glezer, Christopher Frye
  • Reagent cartridge
    Patent number: D1094768
    Type: Grant
    Filed: September 30, 2022
    Date of Patent: September 23, 2025
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Bandele Jeffrey-Coker, Eli N. Glezer, Anson Hsu, Cory Spivey
  • Template array
    Patent number: D1098488
    Type: Grant
    Filed: February 5, 2024
    Date of Patent: October 14, 2025
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Valeria Rascon, Yuji Ishitsuka
  • Microplate receiver frame
    Patent number: D1101192
    Type: Grant
    Filed: October 30, 2023
    Date of Patent: November 4, 2025
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Bandele J. Jeffrey-Coker, Eli N. Glezer, Yuji Ishitsuka