Patents Assigned to SINGULAR GENOMICS SYSTEMS, INC.
  • Methods and compositions for sequencing complementary polynucleotides
    Patent number: 11560590
    Abstract: Disclosed herein, inter alia, are substrates, kits, and efficient methods of preparing and sequencing two or more regions of a double-stranded polynucleotide.
    Type: Grant
    Filed: June 14, 2022
    Date of Patent: January 24, 2023
    Assignee: SINGULAR GENOMICS SYSTEMS, INC.
    Inventors: Daan Witters, Eli N. Glezer, Allen Lipson
  • Silicon containing detectable compounds and uses thereof
    Patent number: 11535754
    Abstract: Disclosed herein, inter alia, are silicon containing detectable compounds and methods of use thereof. In an aspect is provided a monovalent nucleotide or monovalent nucleoside covalently bound to a monovalent form of a compound described herein (e.g., wherein the R13 moiety of a compound described herein has reacted with a bioconjugate reactive group to form a bioconjugate linker thereby covalently bonding the monovalent compound to the monovalent nucleotide or monovalent nucleoside).
    Type: Grant
    Filed: May 5, 2022
    Date of Patent: December 27, 2022
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Megha Cila, Ronald Graham, Rodrigo Rodriguez
  • Linked paired strand sequencing
    Patent number: 11519029
    Abstract: Provided herein are methods for sequencing both strands of a double stranded nucleic acid fragment that improves fidelity and accuracy of a sequence determination compared to traditional next generation sequencing methods. Compositions and kits for use in the methods are also provided.
    Type: Grant
    Filed: May 29, 2022
    Date of Patent: December 6, 2022
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Eli N. Glezer, Martin Maria Fabani, Sabrina Shore, Daan Witters
  • Modified thermoccocus polymerases
    Patent number: 11512295
    Abstract: Provided herein are modified Archaeal family B polymerases derived from the Archaeal microorganism Thermococcus sp. EP1 that exhibit improved incorporation of nucleotide analogues utilized in DNA sequences.
    Type: Grant
    Filed: September 10, 2020
    Date of Patent: November 29, 2022
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Souad Naji, Carl W. Fuller, Eli N. Glezer, Andrew Spaventa
  • Flow cell receiver and methods of use
    Patent number: 11498078
    Abstract: The present disclosure relates to a flow cell receiver. The flow cell receiver can include at least one platen, having a plurality of ports. The flow cell receiver can include magnets. The flow cell receiver can be configured to automatically align, secure, and retain a flow cell carrier containing a flow cell.
    Type: Grant
    Filed: November 25, 2020
    Date of Patent: November 15, 2022
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Sandor Kovacs, David Baranson, Eli N. Glezer
  • Methods for in situ transcriptomics and proteomics
    Patent number: 11492662
    Abstract: Disclosed herein, inter alia, are compositions and methods of use thereof for interrogating a cell.
    Type: Grant
    Filed: August 6, 2021
    Date of Patent: November 8, 2022
    Assignee: SINGULAR GENOMICS SYSTEMS, INC.
    Inventors: Eli N. Glezer, Hu Cang, Zhenmin Hong
  • Methods of sequencing circular template polynucleotides
    Patent number: 11486004
    Abstract: Disclosed herein, inter alia, are complexes, kits, and efficient methods of sequencing two strands of a double stranded polynucleotide. In embodiments, methods of sequencing a circular template polynucleotide are provided including generating immobilized extension products.
    Type: Grant
    Filed: April 12, 2022
    Date of Patent: November 1, 2022
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Daan Witters, Allen Lipson, Eli N. Glezer
  • Methods and compositions for sequencing complementary polynucleotides
    Patent number: 11486001
    Abstract: Disclosed herein, inter alia, are substrates, kits, and efficient methods of preparing and sequencing two or more regions of a double-stranded polynucleotide.
    Type: Grant
    Filed: February 7, 2022
    Date of Patent: November 1, 2022
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Daan Witters, Eli N. Glezer, Allen Lipson
  • NUCLEOTIDE CLEAVABLE LINKERS AND USES THEREOF
    Publication number: 20220332752
    Abstract: Disclosed herein, inter alia, are compounds, compositions, and methods of use thereof for sequencing a nucleic acid.
    Type: Application
    Filed: January 7, 2020
    Publication date: October 20, 2022
    Applicant: Singular Genomics Systems, Inc.
    Inventors: Ronald Graham, Olga Adelfinskaya, Megha Cila, Rodrigo Rodriguez
  • Spatial sequencing
    Patent number: 11434525
    Abstract: Disclosed herein, inter alia, are compositions and methods of use thereof for interrogating a sample comprising a cell.
    Type: Grant
    Filed: August 6, 2021
    Date of Patent: September 6, 2022
    Assignee: SINGULAR GENOMICS SYSTEMS, INC.
    Inventor: Eli N. Glezer
  • Systems and methods for multicolor imaging
    Patent number: 11415515
    Abstract: Disclosed herein, inter alia, are methods and systems of image analysis useful for rapidly identifying and/or quantifying features.
    Type: Grant
    Filed: March 24, 2022
    Date of Patent: August 16, 2022
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Fedor Trintchouk, Eli N. Glezer
  • Linked paired strand sequencing
    Patent number: 11365445
    Abstract: Provided herein are methods for sequencing both strands of a double stranded nucleic acid fragment that improves fidelity and accuracy of a sequence determination compared to traditional next generation sequencing methods. Compositions and kits for use in the methods are also provided.
    Type: Grant
    Filed: October 13, 2021
    Date of Patent: June 21, 2022
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Eli N. Glezer, Martin Maria Fabani, Sabrina Shore, Daan Witters
  • Compositions and methods for nucleic acid sequencing
    Patent number: 11236387
    Abstract: Provided herein are methods and compositions for improved sequencing techniques using, for example, polymeric particles and/or three-dimensional structures.
    Type: Grant
    Filed: September 24, 2020
    Date of Patent: February 1, 2022
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Eli N. Glezer, Mohammad Vatankhah Varnosfaderani, Daan Witters, Vahid Karimkhani
  • Methods for long read sequencing
    Patent number: 11225688
    Abstract: Provided herein are methods including alternating series of sequencing cycles and dark extension cycles allowing longer read lengths and addressing disadvantages of traditional nucleic acid sequencing protocols.
    Type: Grant
    Filed: December 18, 2020
    Date of Patent: January 18, 2022
    Assignee: SINGULAR GENOMICS SYSTEMS, INC.
    Inventors: Eli N. Glezer, Abrehet Abdu, Timothy Looney
  • Modified nucleotides and uses thereof
    Patent number: 11174281
    Abstract: Disclosed herein, inter alia, are compounds, modified nucleotides, compositions, and methods of using the same.
    Type: Grant
    Filed: April 23, 2021
    Date of Patent: November 16, 2021
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Ronald Graham, Surya Adhikari, Rodrigo Rodriguez, Zachary Terranova
  • Polynucleotide barcodes for long read sequencing
    Patent number: 11155858
    Abstract: Provided herein are methods of making, amplifying, and sequencing tagged nucleic acid complements, compositions including interposing oligonucleotide barcodes, and kits useful in obtaining long-range sequence data.
    Type: Grant
    Filed: December 18, 2020
    Date of Patent: October 26, 2021
    Assignee: SINGULAR GENOMICS SYSTEMS, INC.
    Inventors: Eli N. Glezer, Martin Maria Fabani, Ryan Shultzaberger, Bharat Sridhar, Gudrun Stengel, Christopher Jen-Yue Wei
  • Modified archaeal family B polymerases
    Patent number: 11136565
    Abstract: Provided herein are modified Archaeal family B polymerases derived from the Archaeal microorganism Pyrococcus abyssi that exhibit improved incorporation of nucleotide analogues utilized in DNA sequencing.
    Type: Grant
    Filed: September 11, 2019
    Date of Patent: October 5, 2021
    Assignee: SINGULAR GENOMICS SYSTEMS, INC.
    Inventors: Souad Naji, Carl W. Fuller, Eli Glezer, Andrew Spaventa
  • Modified pyrococcus polymerases and uses thereof
    Patent number: 11034942
    Abstract: Provided herein are modified Archaeal family B polymerases derived from species of the Archaeal microorganism Pyrococcus that exhibit improved incorporation of nucleotide analogues utilized in DNA sequencing.
    Type: Grant
    Filed: February 27, 2020
    Date of Patent: June 15, 2021
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Souad Naji, Eli N. Glezer, Youngjin Cho, Zachary Terranova, Abrehet Abdu
  • Reagent cartridge
    Patent number: D970036
    Type: Grant
    Filed: May 5, 2022
    Date of Patent: November 15, 2022
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Bandele Jeffrey-Coker, Eli N. Glezer, Anson Hsu, Cory Spivey
  • Wash bottle
    Patent number: D970748
    Type: Grant
    Filed: May 5, 2022
    Date of Patent: November 22, 2022
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Bandele Jeffrey-Coker, Eli N. Glezer, Anson Hsu, Cory Spivey