Patents Assigned to SINGULAR GENOMICS SYSTEMS, INC.
  • Polynucleotide barcodes for long read sequencing
    Patent number: 12139754
    Abstract: Provided herein are methods of making, amplifying, and sequencing tagged nucleic acid complements, compositions including interposing oligonucleotide barcodes, and kits useful in obtaining long-range sequence data.
    Type: Grant
    Filed: September 27, 2021
    Date of Patent: November 12, 2024
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Eli N. Glezer, Martin Maria Fabani, Ryan Shultzaberger, Bharat Sridhar, Gudrun Stengel, Christopher Jen-Yue Wei
  • Methods for long read sequencing
    Patent number: 12123054
    Abstract: Provided herein are methods including alternating series of sequencing cycles and dark extension cycles allowing longer read lengths and addressing disadvantages of traditional nucleic acid sequencing protocols.
    Type: Grant
    Filed: December 8, 2021
    Date of Patent: October 22, 2024
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Eli N. Glezer, Abrehet Abdu, Timothy Looney
  • Linked paired strand sequencing
    Patent number: 12123055
    Abstract: Provided herein are methods for sequencing both strands of a double stranded nucleic acid fragment that improves fidelity and accuracy of a sequence determination compared to traditional next generation sequencing methods. Compositions and kits for use in the methods are also provided.
    Type: Grant
    Filed: April 22, 2022
    Date of Patent: October 22, 2024
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Eli N. Glezer, Martin Maria Fabani, Timothy Looney, Sabrina Shore, Ryan Shultzaberger, Daan Witters
  • Methods and compositions for reducing nucleotide impurities
    Patent number: 12116629
    Abstract: Disclosed herein, inter alia, are compositions and methods for depleting nucleotide impurities in nucleotide solutions.
    Type: Grant
    Filed: March 22, 2023
    Date of Patent: October 15, 2024
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Abrehet Abdu, Eli N. Glezer, Laura Ann Hale, Jiawen Li
  • Modified polymerases
    Patent number: 12110515
    Abstract: Provided herein are modified Archaeal family B polymerases derived from the Archaeal microorganism Thermococcus sp. EP1 that exhibit improved incorporation of nucleotide analogues utilized in DNA sequences.
    Type: Grant
    Filed: October 20, 2022
    Date of Patent: October 8, 2024
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Souad Naji, Carl W. Fuller, Eli N. Glezer, Andrew Spaventa
  • Methods of amplifying circular polynucleotides in situ
    Patent number: 12110550
    Abstract: Disclosed herein, inter alia, are complexes, kits, and efficient methods of sequencing two strands of a double stranded polynucleotide.
    Type: Grant
    Filed: February 27, 2024
    Date of Patent: October 8, 2024
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Daan Witters, Allen Lipson, Eli N. Glezer
  • Kinematic imaging system
    Patent number: 12099178
    Abstract: Disclosed herein, inter alia, are imaging systems, devices, and methods of use thereof.
    Type: Grant
    Filed: December 16, 2021
    Date of Patent: September 24, 2024
    Assignee: Singular Genomics Systems, Inc.
    Inventors: David Baranson, Eli N. Glezer, David L. Heiner
  • Linked paired strand sequencing
    Patent number: 12077816
    Abstract: Provided herein are methods for sequencing both strands of a double stranded nucleic acid fragment that improves fidelity and accuracy of a sequence determination compared to traditional next generation sequencing methods. Compositions and kits for use in the methods are also provided.
    Type: Grant
    Filed: October 13, 2021
    Date of Patent: September 3, 2024
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Eli N. Glezer, Martin Maria Fabani, Sabrina Shore, Daan Witters
  • Nucleic acid circularization and amplification on a surface
    Patent number: 12071665
    Abstract: Disclosed herein, inter alia, are compositions and methods for amplification of nucleic acid templates, including hybridizing a linear polynucleotide to an immobilized primer on a surface, circularizing the linear polynucleotide to form a circular polynucleotide, and extending the primer with a polymerase.
    Type: Grant
    Filed: March 1, 2023
    Date of Patent: August 27, 2024
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Daan Witters, Eli N. Glezer, Andrew King, Sabrina Shore, Ryan Shultzaberger
  • Flow cell carrier device
    Patent number: 12066370
    Abstract: The present disclosure relates to a flow cell carrier. The flow cell carrier may include a flow cell and a frame. The frame may include a pocket and a handle. The pocket may have at least one spring feature and at least one banking feature. The frame may be configured to retain the flow cell within the pocket such that a maximal surface area of the flow cell is exposed to an optical lens. Related methods and kits are also disclosed.
    Type: Grant
    Filed: July 18, 2023
    Date of Patent: August 20, 2024
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Sandor Kovacs, Anson Hsu, David Baranson, John Van Doorn, Eli N. Glezer
  • Compositions and methods for nucleic acid sequencing
    Patent number: 12060605
    Abstract: Provided herein are methods and compositions for improved sequencing techniques using, for example, polymeric particles and/or three-dimensional structures.
    Type: Grant
    Filed: December 3, 2021
    Date of Patent: August 13, 2024
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Eli N. Glezer, Mohammad Vatankhah Varnosfaderani, Daan Witters, Vahid Karimkhani
  • Reducing agents and uses thereof
    Patent number: 12054506
    Abstract: Disclosed herein, inter alia, are novel reducing agents having the general formula and methods of use thereof.
    Type: Grant
    Filed: March 18, 2022
    Date of Patent: August 6, 2024
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Ronald Graham, Zachary Terranova
  • Methods and compositions for reducing nucleotide impurities
    Patent number: 12031179
    Abstract: Disclosed herein, inter alia, are compositions and methods for depleting nucleotide impurities in nucleotide solutions.
    Type: Grant
    Filed: November 1, 2021
    Date of Patent: July 9, 2024
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Abrehet Abdu, Eli N. Glezer, Laura Ann Hale, Jiawen Li
  • Spatial sequencing
    Patent number: 12006534
    Abstract: Disclosed herein, inter alia, are compositions and methods of use thereof for interrogating a sample comprising a cell.
    Type: Grant
    Filed: July 21, 2023
    Date of Patent: June 11, 2024
    Assignee: Singular Genomics Systems, Inc.
    Inventor: Eli N. Glezer
  • Silicon containing detectable compounds and uses thereof
    Patent number: 11987709
    Abstract: Disclosed herein, inter alia, are silicon containing detectable compounds and methods of use thereof. In an aspect is provided a monovalent nucleotide or monovalent nucleoside covalently bound to a monovalent form of a compound described herein (e.g., wherein the R13 moiety of a compound described herein has reacted with a bioconjugate reactive group to form a bioconjugate linker thereby covalently bonding the monovalent compound to the monovalent nucleotide or monovalent nucleoside).
    Type: Grant
    Filed: August 5, 2022
    Date of Patent: May 21, 2024
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Megha Cila, Ronald Graham, Rodrigo Rodriguez
  • Nucleotide cleavable linkers and uses thereof
    Patent number: 11970735
    Abstract: Disclosed herein, inter alia, are compounds, compositions, and methods of use thereof for sequencing a nucleic acid.
    Type: Grant
    Filed: January 7, 2020
    Date of Patent: April 30, 2024
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Ronald Graham, Olga Adelfinskaya, Megha Cila, Rodrigo Rodriguez
  • Multiport disconnect couplings
    Patent number: 11965616
    Abstract: A connector assembly is configured to fluidly and removably connect a first set of microtubes to a second set of microtubes of a microfluidic device. The connector assembly provides multiple points of contact to the microtubes to provide a secure connection between the connector assembly and the microtubes. A single gasket provides a securely aligned connection between microtubes.
    Type: Grant
    Filed: February 28, 2022
    Date of Patent: April 23, 2024
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Sandor Kovacs, David Baranson
  • Reagent cartridge
    Patent number: D1047223
    Type: Grant
    Filed: September 27, 2023
    Date of Patent: October 15, 2024
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Bandele Jeffrey-Coker, Eli N. Glezer, Anson Hsu, Cory Spivey
  • Reagent cartridge
    Patent number: D1049420
    Type: Grant
    Filed: September 27, 2023
    Date of Patent: October 29, 2024
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Bandele Jeffrey-Coker, Eli N. Glezer, Anson Hsu, Cory Spivey
  • Sample cartridge
    Patent number: D1050482
    Type: Grant
    Filed: September 27, 2023
    Date of Patent: November 5, 2024
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Bandele Jeffrey-Coker, Eli N. Glezer, Anson Hsu, Cory Spivey