Patents Assigned to SINGULAR GENOMICS SYSTEMS, INC.
  • Flow cell receiver and devices
    Patent number: 11813615
    Abstract: The present disclosure relates to a flow cell receiver. The flow cell receiver can include at least one platen, having a plurality of ports. The flow cell receiver can include magnets. The flow cell receiver can be configured to automatically align, secure, and retain a flow cell carrier containing a flow cell.
    Type: Grant
    Filed: October 11, 2022
    Date of Patent: November 14, 2023
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Sandor Kovacs, David Baranson, Eli N. Glezer
  • Amplification oligonucleotides
    Patent number: 11802307
    Abstract: Disclosed herein, inter alia, are polynucleotides, supports, kits, and methods of use thereof for amplifying, immobilizing, and sequencing polynucleotides.
    Type: Grant
    Filed: March 17, 2023
    Date of Patent: October 31, 2023
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Ryan Shultzaberger, Allen Lipson, Daan Witters
  • Nucleic acid delivery scaffolds
    Patent number: 11795505
    Abstract: Disclosed herein, inter alia, are degradable nanoparticles, nanoarrays, and methods of use thereof in nucleic acid sequencing.
    Type: Grant
    Filed: March 9, 2023
    Date of Patent: October 24, 2023
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Mark Kalaj, Daan Witters
  • Methods and compositions for sequencing complementary polynucleotides
    Patent number: 11788133
    Abstract: Disclosed herein, inter alia, are substrates, kits, and efficient methods of preparing and sequencing two or more regions of a double-stranded polynucleotide.
    Type: Grant
    Filed: October 21, 2022
    Date of Patent: October 17, 2023
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Daan Witters, Eli N. Glezer, Allen Lipson
  • Nucleic acid sequencing-by-synthesis (SBS) methods that combine SBS cycle steps
    Patent number: 11773439
    Abstract: The present disclosure provides improved nucleic acid sequencing-by-synthesis (SBS) methods, related kits and reagents, and systems for performing such methods using such kits and reagents.
    Type: Grant
    Filed: November 4, 2022
    Date of Patent: October 3, 2023
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Eli N. Glezer, Andrew Spaventa, David Barker
  • Spatial sequencing
    Patent number: 11753678
    Abstract: Disclosed herein, inter alia, are compositions and methods of use thereof for interrogating a sample comprising a cell.
    Type: Grant
    Filed: October 12, 2022
    Date of Patent: September 12, 2023
    Assignee: Singular Genomics Systems, Inc.
    Inventor: Eli N. Glezer
  • Flow cell carrier and methods of use
    Patent number: 11747262
    Abstract: The present disclosure relates to a flow cell carrier. The flow cell carrier may include a flow cell and a frame. The frame may include a pocket and a handle. The pocket may have at least one spring feature and at least one banking feature. The frame may be configured to retain the flow cell within the pocket such that a maximal surface area of the flow cell is exposed to an optical lens. Related methods and kits are also disclosed.
    Type: Grant
    Filed: November 25, 2020
    Date of Patent: September 5, 2023
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Sandor Kovacs, Anson Hsu, David Baranson, John Van Doorn, Eli N. Glezer
  • Methods and systems for multidimensional imaging
    Patent number: 11714271
    Abstract: A multi-depth confocal imaging system includes at least one light source configured to provide excitation beams and an objective lens. The excitation beams are focused into a sample at a first plurality of focus depths along an excitation direction through the objective lens. An image sensor receives emissions from the sample via the objective lens, wherein the emissions define foci relative to the image sensor at a second plurality of focus depths.
    Type: Grant
    Filed: March 10, 2022
    Date of Patent: August 1, 2023
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Hu Cang, Eli N. Glezer
  • Silicon containing detectable compounds
    Patent number: 11697736
    Abstract: Disclosed herein, inter alia, are silicon containing detectable compounds and methods of use thereof.
    Type: Grant
    Filed: May 17, 2019
    Date of Patent: July 11, 2023
    Assignee: SINGULAR GENOMICS SYSTEMS, INC.
    Inventors: Ronald Graham, Rodrigo Rodriguez
  • Systems and methods for multicolor imaging
    Patent number: 11686681
    Abstract: Disclosed herein, inter alia, are methods and systems of image analysis useful for rapidly identifying and/or quantifying features.
    Type: Grant
    Filed: June 29, 2022
    Date of Patent: June 27, 2023
    Assignee: SINGULAR GENOMICS SYSTEMS, INC.
    Inventors: Fedor Trintchouk, Eli N. Glezer
  • Spatial sequencing
    Patent number: 11680288
    Abstract: Disclosed herein, inter alia, are compositions and methods of use thereof for interrogating a sample comprising a cell.
    Type: Grant
    Filed: July 27, 2022
    Date of Patent: June 20, 2023
    Assignee: SINGULAR GENOMICS SYSTEMS, INC.
    Inventor: Eli N. Glezer
  • High density sequencing and multiplexed priming
    Patent number: 11649452
    Abstract: Disclosed herein, inter alia, are methods and compositions for sequencing a plurality of template nucleic acids.
    Type: Grant
    Filed: October 13, 2022
    Date of Patent: May 16, 2023
    Assignee: SINGULAR GENOMICS SYSTEMS, INC.
    Inventors: Eli N. Glezer, Daan Witters, Niek Van Wietmarschen
  • Nanoarrays and methods of use thereof
    Patent number: 11629380
    Abstract: Disclosed herein, inter alia, are nanoarrays and methods of use thereof.
    Type: Grant
    Filed: August 5, 2022
    Date of Patent: April 18, 2023
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Eli N. Glezer, Vahid Karimkhani, Shahed Kay, Mohammad Vatankhah Varnosfaderani, Daan Witters
  • Nucleic acid sequencing-by-synthesis (SBS) methods that combine SBS cycle steps
    Patent number: 11591647
    Abstract: The present disclosure provides improved nucleic acid sequencing-by-synthesis (SBS) methods, related kits and reagents, and systems for performing such methods using such kits and reagents.
    Type: Grant
    Filed: March 6, 2018
    Date of Patent: February 28, 2023
    Assignee: SINGULAR GENOMICS SYSTEMS, INC.
    Inventors: Eli Glezer, Andrew Spaventa, David Barker
  • High density sequencing and multiplexed priming
    Patent number: 11578320
    Abstract: Disclosed herein, inter alia, are methods and compositions for sequencing a plurality of template nucleic acids.
    Type: Grant
    Filed: April 27, 2022
    Date of Patent: February 14, 2023
    Assignee: SINGULAR GENOMICS SYSTEMS, INC.
    Inventors: Eli N. Glezer, Daan Witters, Niek Van Wietmarschen
  • Reagent cartridge
    Patent number: D979093
    Type: Grant
    Filed: May 5, 2022
    Date of Patent: February 21, 2023
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Bandele Jeffrey-Coker, Eli N. Glezer, Anson Hsu, Cory Spivey
  • Sample cartridge
    Patent number: D981591
    Type: Grant
    Filed: May 5, 2022
    Date of Patent: March 21, 2023
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Bandele Jeffrey-Coker, Eli N. Glezer, Anson Hsu, Cory Spivey
  • Flow cell carrier
    Patent number: D983404
    Type: Grant
    Filed: November 25, 2020
    Date of Patent: April 11, 2023
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Sandor Kovacs, Anson Hsu, David Baranson, John Van Doorn, Eli N. Glezer
  • Strip tube for a reagent cartridge
    Patent number: D1001310
    Type: Grant
    Filed: December 30, 2022
    Date of Patent: October 10, 2023
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Bandele Jeffrey-Coker, Eli N. Glezer, Anson Hsu, Cory Spivey
  • Sample cartridge
    Patent number: D1005517
    Type: Grant
    Filed: February 13, 2023
    Date of Patent: November 21, 2023
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Bandele Jeffrey-Coker, Eli N. Glezer, Anson Hsu, Cory Spivey