Patents Assigned to Smith Kline & French Laboratories Limited
  • Pharmacologically active compounds
    Patent number: 4438127
    Abstract: Amidinoformic acids and amidinosulphinic acids which are histamine H.sub.2 -antagonists. Two specific compounds of the present invention are N-[2-(5-methyl-4-imidazolylmethylthio)-ethyl]amidinoformic acid and N-methyl-N'-[2-(5-methyl-4-imidazolylmethylthio)ethyl]amidiniosulphinic acid.
    Type: Grant
    Filed: March 7, 1983
    Date of Patent: March 20, 1984
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Graham J. Durant, Charon R. Ganellin, Rodney C. Young
  • Alkoxypyridyl alkylamines
    Patent number: 4426526
    Abstract: The compounds are alkoxypyridine compounds which are histamine H.sub.2 -antagonists. Two specific compounds of the present invention are N-cyano-N'-methyl-N"-[2-((3-methoxy-2-pyridyl)methylthio)ethyl]guanidine and 1-methylamino-1-[2-((3-methoxy-2-pyridyl)methylthio)ethylamino]-2-nitroeth ylene.
    Type: Grant
    Filed: November 19, 1980
    Date of Patent: January 17, 1984
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Graham J. Durant, Charon R. Ganellin, George S. Sach
  • Sulphoxides
    Patent number: 4413130
    Abstract: The compounds are sulphoxides of heterocyclicthioalkylthioureas, ureas and guanidines which are useful to produce inhibition of histamine H-2 receptors.
    Type: Grant
    Filed: March 26, 1982
    Date of Patent: November 1, 1983
    Assignee: Smith Kline & French Laboratories Limited
    Inventor: George R. White
  • 2-Heterocyclic alkylamino-3-nitropyrroles
    Patent number: 4407808
    Abstract: 3-Nitro-2-substituted aminopyrroles are histamine H.sub.2 -receptor antagonists. The 2- position substituent is a fully-unsaturated heterocyclyl alkyl group preferably with alkyl group interrupted by sulfur or oxygen. The 4- and 5- positions of the pyrrole ring can also be substituted.
    Type: Grant
    Filed: January 28, 1982
    Date of Patent: October 4, 1983
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Michael L. Roantree, Rodney C. Young
  • Nitro-substituted dihydropyrroles and tetrahydropyridines, compositions, compounds, and medicinal use
    Patent number: 4405624
    Abstract: 2,3-Unsaturated nitrogen-containing heterocyclic compounds with a 3-nitro group and a 2-heterocyclyl alkylamino group. The alkyl group of 2-position substituents is preferably interrupted by sulfur or oxygen. The compounds of the invention are preferably dihydropyrroles or tetrahydropyrridines or pyrimidines. The compounds of the invention are histamine H.sub.2 -receptor antagonists.
    Type: Grant
    Filed: December 2, 1981
    Date of Patent: September 20, 1983
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Michael L. Roantree, Rodney C. Young
  • Heterocyclic thioureas, isothioureas, guanidines and nitromethylene-amidines
    Patent number: 4405621
    Abstract: The compounds are C.sub.2 -C.sub.8 straight chain alkanes terminally substituted, symmetrically or unsymmetrically, by N-(N'-substituted guanidino), N-(N',N"-disubstituted guanidino), N-(N'-substituted thioureido), N-(nitromethylene amidino) or S-(N-substituted isothioureido)groups. Two compounds of the invention are 1,3-bis-[N'-(2-(5-methyl-4-imidazolylmethylthio)ethyl)guanidino]propane and 1,3-bis-[S-(N-2-(5-methyl-4-imidazolylmethylthio)ethyl)isothioureido]p ropane. The compounds of this invention are inhibitors of H-2 histamine receptors.
    Type: Grant
    Filed: June 11, 1981
    Date of Patent: September 20, 1983
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Graham J. Durant, Charon R. Ganellin
  • Pharmacologically active compounds
    Patent number: 4399142
    Abstract: Heterocyclic compounds which are inhibitors of histamine activity, in particular, inhibitors of H-2 histamine receptors. A specific compound of this invention is 2-[2-(4-methyl-5-imidazolymethylthio)ethylamino]-4-pyrimidone.
    Type: Grant
    Filed: March 31, 1982
    Date of Patent: August 16, 1983
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Graham J. Durant, John C. Emmett, Charon R. Ganellin
  • Pharmacologically active compounds
    Patent number: 4395419
    Abstract: Amidinoformic acids and amidinosulphinic acids which are histamine H.sub.2 -antagonists. A specific compound of this invention is N-[2-(3-(1,2,5)-thiadiazolylmethylthio)ethyl]amidinoformic acid.
    Type: Grant
    Filed: August 10, 1981
    Date of Patent: July 26, 1983
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Graham J. Durant, Charon R. Ganellin, Rodney C. Young
  • Pharmaceutical tablet
    Patent number: D269711
    Type: Grant
    Filed: June 3, 1981
    Date of Patent: July 12, 1983
    Assignee: Smith Kline & French Laboratories Limited
    Inventor: Geoffrey D. Tovey
  • Pharmaceutical tablet
    Patent number: D269712
    Type: Grant
    Filed: June 3, 1981
    Date of Patent: July 12, 1983
    Assignee: Smith Kline & French Laboratories Limited
    Inventor: Geoffrey D. Tovey
  • Pharmaceutical tablet
    Patent number: D269713
    Type: Grant
    Filed: June 3, 1981
    Date of Patent: July 12, 1983
    Assignee: Smith Kline & French Laboratories Limited
    Inventor: Geoffrey D. Tovey
  • Pharmaceutical tablet
    Patent number: D269714
    Type: Grant
    Filed: June 3, 1981
    Date of Patent: July 12, 1983
    Assignee: Smith Kline & French Laboratories Limited
    Inventor: Geoffrey D. Tovey
  • Pharmaceutical tablet
    Patent number: D269715
    Type: Grant
    Filed: June 3, 1981
    Date of Patent: July 12, 1983
    Assignee: Smith Kline & French Laboratories Limited
    Inventor: Geoffrey D. Tovey
  • Pharmaceutical tablet
    Patent number: D269717
    Type: Grant
    Filed: June 3, 1981
    Date of Patent: July 12, 1983
    Assignee: Smith Kline & French Laboratories Limited
    Inventor: Geoffrey D. Tovey
  • Pharmaceutical tablet
    Patent number: D269718
    Type: Grant
    Filed: June 3, 1981
    Date of Patent: July 12, 1983
    Assignee: Smith Kline & French Laboratories Limited
    Inventor: Geoffrey D. Tovey
  • Pharmaceutical tablet
    Patent number: D269719
    Type: Grant
    Filed: June 3, 1981
    Date of Patent: July 12, 1983
    Assignee: Smith Kline & French Laboratories Limited
    Inventor: Geoffrey D. Tovey
  • Pharmaceutical tablet
    Patent number: D269720
    Type: Grant
    Filed: June 3, 1981
    Date of Patent: July 12, 1983
    Assignee: Smith Kline & French Laboratories Limited
    Inventor: Geoffrey D. Tovey
  • Pharmaceutical tablet
    Patent number: D269721
    Type: Grant
    Filed: June 3, 1981
    Date of Patent: July 12, 1983
    Assignee: Smith Kline & French Laboratories Limited
    Inventor: Geoffrey D. Tovey
  • Pharmaceutical tablet
    Patent number: D269722
    Type: Grant
    Filed: June 3, 1981
    Date of Patent: July 12, 1983
    Assignee: Smith Kline & French Laboratories Limited
    Inventor: Geoffrey D. Tovey
  • Pharmaceutical tablet
    Patent number: D269723
    Type: Grant
    Filed: June 3, 1981
    Date of Patent: July 12, 1983
    Assignee: Smith Kline & French Laboratories Limited
    Inventor: Geoffrey D. Tovey